• Journal of Digital Convergence
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• v.20 no.2
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• pp.225-239
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• 2022

This study investigated the effect of digital agriculturalization factors on business performance with the use of financial support as a moderating variable for agricultural firm workers. The factors of digital agriculture were divided into digital technology innovation orientation, administration innovation orientation, healthiness of ecosystem and entrepreneurship orientation, and business performance was set as a dependent variable. 212 questionnaires collected from workers in agricultural businesses located across the country were used for empirical analysis. Analysis results using SPSS v22.0 and Process macro v3.4 are as follows: First, digital technology innovation orientation, administration innovation orientation, and entrepreneurship orientation have a significant effect on business performance, and the effect of ecosystem health on business performance is appeared to be insignificant. Second, the use of financial support was found to significantly moderating the relationship between digital technology innovation orientation and business performance, entrepreneurship orientation and business performance. On the other hand, it was found that the relationship between operational innovation orientation, business performance, and healthiness of ecosystem and business performance were not significantly moderated In addition, as a follow-up study, a study on the mediation model formed by the discovery of mediators and a study for a moderated mediation analysis through a conditional process model with additional mediators are required.

• Journal of Korea Technology Innovation Society
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• v.14 no.spc
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• pp.1128-1151
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• 2011

With the rapid change in technology, it is important to create business opportunities from technology. Many leading companies have tried to improve their competence from capturing those opportunities, which is called TOD (Technology Opportunity Discovery) activities in this research, by identifying emerging technologies or assessing economic and market potential of technologies. Academics have also been interested in the TOD activities but most of the previous studies have focused on developing methodologies or guidelines for TOD. Little effort was given to understanding the current status of TOD activities, which is indispensible to develop effective methodologies for TOD. Therefore, this study aims to investigate the current states of TOD activities, particularly focusing on SMEs, which are the main actors of national innovation system. For the purpose of investigation, firstly, TOD process was defined, and then, based on the process, three main activities of TOD, which include identifying the motivation of TOD, collecting information for TOD, and analyzing the collected information activities for TOD, were examined using a survey method. Finally, the analysis results were used to understand the SMEs' needs and difficulties on TOD activities. Research findings are expected to provide useful information for the future studies on TOD and also can be used to develop a policy for SMEs.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10483-10487
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• 2015

Heptaphylline derivatives are carbazoles in Clausena harmandiana, a medicinal plant that is utilized for headache, stomach ache, and other treatments of illness. The present study examined the effects of heptaphylline and 7-methoxyheptaphylline on apoptosis of human colon adenocarcinoma cells (HT-29 cell line). Quantification of cell viability was performed using cell proliferation assay (MTT assay) and of protein expression through immunoblotting. The results showed that only heptaphylline, but not 7-methoxyheptaphylline, significantly significantly activated cleaved of caspase-3 and poly (ADP-ribose) polymerase (PARP-1) which resulted in HT-29 cell death. We found that heptaphylline activated BH3 interacting-domain death agonist (Bid) and Bak, proapoptotic proteins. In contrast, it suppressed X-linked inhibitor-of-apoptosis protein (XIAP), Bcl-xL and survivin, inhibitors of apoptosis. In addition, heptaphylline inhibited activation of NF-${\kappa}B$/p65 (rel), a regulator of apoptotic regulating proteins by suppressing the activation of Akt and $IKK{\alpha}$, upstream regulators of p65. The findings suggested that heptaphylline induces apoptosis in human colon adenocarcinoma cells.

• Journal of Microbiology and Biotechnology
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• v.23 no.6
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• pp.779-784
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• 2013

Leptospirosis is a worldwide zoonosis of global concern caused by Leptospira interrogans. The availability of ligand libraries has facilitated the search for novel drug targets using chemogenomics approaches, compared with the traditional method of drug discovery, which is time consuming and yields few leads with little intracellular information for guiding target selection. Recent subtractive genomics studies have revealed the putative drug targets in peptidoglycan biosynthesis pathways in Leptospira interrogans. Aligand library for the murD ligase enzyme in the peptidoglycan pathway has also been identified. Our approach in this research involves screening of the pre-existing ligand library of murD with related protein family members in the putative drug target assembly in the peptidoglycan biosynthesis pathway. A chemogenomics approach has been implemented here, which involves screening of known ligands of a protein family having analogous domain architecture for identification of leads for existing druggable protein family members. By means of this approach, one murC and one murF inhibitor were identified, providing a platform for developing an anti-leptospirosis drug targeting the peptidoglycan biosynthesis pathway. Given that the peptidoglycan biosynthesis pathway is exclusive to bacteria, the in silico identified mur ligase inhibitors are expected to be broad-spectrum Gram-negative inhibitors if synthesized and tested in in vitro and in vivo assays.

• STI Policy Review
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• v.3 no.1
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• pp.96-116
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• 2012

The establishment of Institut Pasteur Korea (IP-K) has been an intercultural experiment, which transplanted a French research organization with many foreign researchers into Korea to grow a new institution as a long-term collaboration. The Mission of the newly founded institute has been to develop more effective ways of generating value with basic life science research in the face of a world-wide Pharma crisis. The challenges have been i.) to invent new technologies and approaches in drug discovery, ii.) to convince the Korean stakeholders of their inherent value, iii.) to induce Pharma industry to adopt the new technologies and iv.) to create a context in the Korean R&D landscape where the new institute could contribute tangible benefits. If Institut Pasteur Korea has succeeded in all counts, then due to a somewhat skewed and unlikely set of cultural complementarities between Korea and France. The abstract and conceptual French approach was matched by Korean pragmatism, linearity and relentless improvement towards the defined development goal. IP-K has become an example for innovation made in Korea, which is now re-imported into Europe. As the project could arguably not have succeeded in either partner county alone, it highlights the benefits of longterm, in depth international collaborations.

• East Asian Journal of Business Economics (EAJBE)
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• v.8 no.4
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• pp.29-43
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• 2020

Purpose - Although it has been 10 years since the university technology holding company was launched, it is currently facing operational limitations. The purpose of this study is to study the growth strategy of university technology holding companies by investigating the status and problems of university technology holding companies. Research design, data, and methodology - In this study, the status of university technology holding companies was analyzed based on the survey data issued by the University Technology Holding Companies Association. Due to the lack of research on university technology holding companies, policy alternatives were suggested by examining problems based on literature research. Result - In this study, an alternative to strengthening the competitiveness of technology holding companies and supporting policies was suggested. As a result of the research, it was discovered as a policy alternative to enhance the independence of technology-owned subsidiaries, develop outstanding talents, and expand the marketing of support programs to create results based on technology holding companies. Conclusion - In previous studies, alternatives to technology commercialization policies have been suggested, but studies on the role and status of detailed technology holding companies are insufficient, and the operation system of technology holding companies and discovery of future growth models are insufficient compared to overseas cases. Therefore, in this study, various policy innovation measures are presented as examples.

• Journal of Korea Society of Industrial Information Systems
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• v.29 no.2
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• pp.169-190
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• 2024

The purpose of this study is to design an effective innovation model for communication-centered public services, based on the case of Korea Midland Power Co., Ltd (KOMIPO). This study analyzed customer and employee participation activities at KOMIPO, focusing on communication activities to derive the best practices. The study comprised of the following stages: (1) Preparation stage to assess the current situation and promote change management; (2) Problem-solving stage for improving public services; (3) Problem-solving stage for improving work processes; (4) Problem-solving stage for strengthening collaboration, and (5) Design stage for an innovation model. Based on the results of this study, an innovation model was developed for public services by applying the double-diamond design process. The proposed model presents a process structure, which is derived through an iterative process of primary divergence (discovery) and convergence (definition), and secondary divergence (development) and convergence (delivery). This study also proposed the possibility of applying the Idea-Power-Plant activities of KOMIPO's best practices to the proposed model. While this study proposed an innovation model for communication-centered public services through the analysis of a specific public company, the results of the study provide broad insights for effective operations management through efficient communication based on the participation of customers and employees in public institutions.

• International Journal of Computer Science & Network Security
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• v.21 no.6
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• pp.71-76
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• 2021

Education is one of the pillars of sustainable development. For this reason, the discovery of useful information in its process of adaptation to new challenges is treated with care. This paper aims to present the initiation of a process of exploring the data collected from the results obtained by Romanian students at the BBaccalaureate (the Romanian high school graduation) exam, through data mining methods, in order to try an in-depth analysis to find and remedy some of the causes that lead to unsatisfactory results. Specifically, a set of public data was collected from the website of the Ministry of Education, on which several classification methods were tested in order to find the most efficient modeling algorithm. It is the first time that this type of data is subjected to such interests.

• Food Science and Industry
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• v.55 no.1
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• pp.74-94
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• 2022

With the discovery of metabolic mechanisms of alcohol fermentation and acetic acid fermentation in the 1800s and 1900s, the history of traditional vinegar became a turning point for changing to the history of science and technology. Since then, innovation in vinegar production has occurred, and the era of full-scale mass industrialization has opened. The most modern method, submerged fermentation, has improved the vinegar production process to produce much higher quality vinegar and provide vinegar with high productivity and quality uniformity. Innovative research for vinegar production is underway as various approaches have been developed to increase fermentation efficiency, reduce costs, and shorten fermentation time due to the trend of combining existing technologies and advanced technologies. Now that the development of the vinegar industry is currently focused on vinegar engineering, multidisciplinary approaches in various fields such as microbiology, chemistry, food technology, process engineering, and molecular biology are needed.

• Journal of Smart Tourism
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• v.4 no.1
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• pp.19-29
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• 2024

The objective of this article is to create a model of integrated management from the framework modeling of a digital collaborative network supported by knowledge engineering to make heritage site in the Brazil more effective. It is an exploratory and qualitative research with thematic analysis as technique of data analysis from the collaborative network, digital platform, world heritage, and tourism themes. The snowballing approach was chosen, and the mapping and classification of relevant studies was developed with the use of the spreadsheet tool and the Mendeley® software. The results show that the collaborative network model oriented towards strategic objectives should be supported by a digital platform that provides a technological environment that adds functionalities and digital platform services with the integration of knowledge engineering techniques and tools, enabling the discovery and sharing of knowledge in the collaborative network.