• YAKHAK HOEJI
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• v.60 no.3
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• pp.135-140
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• 2016

Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone, which is associated with stabilization of many oncogenic proteins for cancer cell survival. Hsp90 is overexpressed 2-10 fold higher in cancer cells than normal cells. Due to its potential to simultaneously disable multiple signaling pathway, Hsp90 has been identified as a validated target for cancer therapy. Accordingly, we designed and synthesized 2',4'-dimethoxychalcone derivatives to inhibit Hsp90 chaperone function. Among 2',4'-dimethoxychalcone derivatives, we found that compound 1g disrupted Hsp90 chaperoning function and impaired the growth of cancer cells. These findings indicated that 1g could serve a potential lead compound to target Hsp90 in cancer chemotherapy.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.9 no.2
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• pp.115-120
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• 2015

This study applied a cox proportional hazard model for analysis, using data of the Panel Survey of Employment for the Disable from the first to fifth years. The purpose of the study is to make a policy suggestion necessary for the support of employment for the disabled, by analyzing important factors affecting employment of the unemployed disabled according to the unemployment period. Results of the analysis were: a model that considered all the sociodemographic, obstructive and social environmental factors was verified; the higher subjective SES of the disabled, the higher employment rate of the unemployed disabled; compared to the severely disabled, the slightly disabled had more advantages for employment; and relatively the lower unearned income, the higher employment rate. This study suggested based on these results limitations and implications of the study.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.29 no.6
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• pp.1375-1382
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• 2019

The latest version of commercial protector, Themida, has been updated, it is impossible to apply a normalized unpacking mechanism from previous studies by disable the use of a virtual memory allocation that provides initial data to be tracked. In addition, compared to the previous version, which had many values that determined during execution and easy to track dynamically, it is difficult to track dynamically due to values determined at the time of applying the protector. We will look at how the latest version of Themida make it difficult to normalize the API wrapping process by adopted techniques and examine the possibilities of applying the unpacking techniques to further develop an automated unpacking system.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.12
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• pp.2753-2762
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• 2013

Recently the paradigm of cyber attacks is changing due to the information security technology improvement. The cyber attack that uses the social engineering and targets the end users has been increasing as the organization's systems and networks security controls have been tightened. The 91% of APT(Advanced Persistent Threat) which targets an enterprise or a government agency to get the important data and disable the critical service starts with the spear phishing email. In this paper, we analysed the security threats and characteristics of the spear phishing in detail and explained why the technical solutions are not enough to prevent spear phishing attacks. Therefore, we proposed the administrative prevention methods for the spear phishing attack.

• Proceedings of the KIEE Conference
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• 2003.11c
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• pp.349-352
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• 2003

A personal low-frequency stimulator is a portable device to relax muscle pains of a person. The stimulator generates combined low-frequency pulses to be applied to pads attached to painful muscles. This paper reports a development of such device with its characteristic analyses. The major components of our stimulator are MCU, high-voltage generating circuit part, high-voltage switching circuit part, input switch part and display unit. High-voltage generating circuit is designed by using a boost converter circuit and allows user control of the output voltage. High-voltage switching circuit, controlled by MCU, generates output voltage to be applied to pads. Input switch part is composed of power supply, intensity selection, mode selection and memory. Display unit adopts a text LCD module to display modes, Intensity, output frequency and user set-up time. Our designed safety circuit, to protect human body from possible electric shock, slowly increases the output voltage to the selected output intensity. It continuously checks the output pulse shape and disable the output when dangerous pulses are detected. This paper also shows some experimental results.

• Journal of Korean Academy of Dental Administration
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• v.11 no.1
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• pp.70-77
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• 2023

This study surveyed and analyzed attitudes toward people with disabilities, awareness of considerations in dental treatment for individuals with disabilities, the need for education on dental treatment for people with disabilities, and the educational requirements for dental hygienists working in dental medical institutions. The study was conducted to highlight the importance of dental treatment education for people with disabilities and to provide foundational data for future dental treatment education programs targeting dental hygienists. A total of 221 dental hygienists working in dental care institutions nationwide participated in a self-administered online questionnaire from November 2 to 15, 2022. This study concludes that there is a significant correlation between the attitudes of dental hygienists toward the disabled, their recognition of considerations in dental treatment for the disabled, the need for education on dental treatment for the disabled, and their educational experience in providing dental treatment for the disabled. In order to improve these factors, it is important to implement and expand systematic dental care education for people with disabilities in the school curriculum, as well as in supplementary education and seminars.

• Journal of the Korean Electrochemical Society
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• v.17 no.2
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• pp.79-85
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• 2014

Silicon (Si) has been investigated as promising negative-electrode (anode) materials because its theoretical specific capacity of 4200 mAh/g for $Li_{4.4}Si$ is far higher than that of carbonaceous anodes in current commercial products. However, in practice, the application of Si to Li-ion batteries is still quite challenging because Si suffers from severe volume expansion and contraction and lead to a continuous solid electrolyte interphase (SEI)-filming process by cracking of Si. This process consumes the limited $Li^+$ source, builds up thick and unstable SEI layer on the Si active materials, and will eventually disable the cell. Since unstable SEI reduces electrochemical performance and thermal stability of the Si anode, the surface chemistry of the anode should be modified by using a functional additive. It is found that lithium bis(oxalato)borate (LiBOB) as an additive effectively protected the Si anode surface, improved capacity retention when stored at $60^{\circ}C$, and alleviated exothermic thermal reactions of fully lithiated Si anode.

• Journal of Korean Library and Information Science Society
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• v.44 no.1
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• pp.99-122
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• 2013

With the recent opening of The National Library for Individuals with Disabilities, interests in library services for the disable have been increasing. For the purpose of promoting library services for the disabled all the more, the study is to provide cooperative plans in policy between the social welfare and the library and information service based on library perceptions of social workers as specialists in disability and welfare fields. Cooperative plans in policy provided by this study are as follows: (1) The unique communication channel between librarians and social workers should be constructed through social networks. (2) Public relations on the value and necessity of both the library and librarians should be enhanced. (3) Education on the expertise of the social welfare for librarians should be enriched. (4) Clear-cut identities between librarian's and social worker's tasks should be established.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.10 no.4
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• pp.267-272
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• 2016

In the era of ultra high speed information communication technology represented by Smart phone and Tablet PC, the disable and the aged people came to be in a position of so-called 'relatively weak people' in the field of information communication due to inconvenience of use and difference in information acquisition and processing ability. Thus, a survey was conducted on Smart phone accessibility items based on previous studies of the disabled with crippled disorder, brain lesions, myelopathy and muscular disabilities having more inconvenience relatively in their use of smart phone due to upper limb dysfunctions. Especially, people with upper limb dysfunctions with relatively weak grip had big inconvenience in the conditions of uses requiring actions such as grabbing and rotating the devices, and due to the characteristics of touch screen input method of Smart phone, they had big inconvenience due to a lack of a guidance for keyboard in input. As a result of questionnaires by the type of disability, it turned out that severe myelopathy causes the most inconvenience in using smart phone.

• Convergence Security Journal
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• v.14 no.3_1
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• pp.65-70
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• 2014

The aim of this study is to suggest the fitness Avatar model for increasing physical activities in individuals with SCI(spinal cord injury). With the increasing of the disable, the ratio of individuals with SCI is also increasing. Avatar is a movable image that represents a person in a virtual reality environment or in cyberspace. With the expansion of new technology, such as video games and virtual reality, there has been an increase in the interest of using virtual reality in therapy. It is not easy for individuals with SCI to access tho sports facilities due to paraplegia. The increasing physical activities based on virtual reality will be the most innovative and future-oriented approach. First, building a system and establishing a comprehensive support system is essential to activate and spread variety of physical activities for individuals with SCI. Second, providing a appropriate feedback and identifying the effect of intervention will be considered.