• Title/Summary/Keyword: Disable

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Butein Disrupts Hsp90's Molecular Chaperoning Function and Exhibits Anti-proliferative Effects Against Drug-resistant Cancer Cells

  • Seo, Young Ho
    • Bulletin of the Korean Chemical Society
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    • v.34 no.11
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    • pp.3345-3349
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    • 2013
  • Hsp90 shows great promise as a therapeutic target due to its potential to disable multiple signaling pathways simultaneously. In this study, we discovered that a natural product, butein moderately inhibited the growth of drug-resistant cancer cells (A2780cis and H1975), and brought about the degradation of oncogenic Hsp90 client proteins. The study demonstrated that butein would be a therapeutic lead to circumvent drug-resistance in cancer chemotherapy. The structure-based screening, synthesis, and biological evaluation of butein are described herein.

A Study on the Differences of Dietary Habits between Normal and Handicapped Children in Incheon Area (인천지역 정상아동과 장애아동간의 식습관 비교 연구)

  • 황미경;김영아
    • Korean journal of food and cookery science
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    • v.13 no.2
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    • pp.192-203
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    • 1997
  • The purpose of this study is to investigate the difference of dietary habits between normal and handicapped children. This study was performed with 166 normal children and 154 handicapped children in Incheon area. There was very significant differences of dietary habits between normal and handicapped children, but there was no significant difference in disable type.

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Considerations on Design with related to passenger convenience facilities and safety of Diesel Multiple Unit for Intercity (Intercity 동차의 승객편의장치 설계 고려사항)

  • Park, Sung-Il;Park, Keong-Bong;Jung, Gwang-Moo
    • Proceedings of the KSR Conference
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    • 2008.11b
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    • pp.529-535
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    • 2008
  • Recently a rolling stock has been requiring more convenience facilities for passenger as well as satisfied the basic functions. The convenience facilities design take into consideration safety factor, convenience and easy accessible for disable passenger. In a point of view, convenience facilities should be considered and designed as well as related safety. This paper describes points to be considered on design with related to convenience facilities and safety factor of Diesel Multiple Unit for Intercity through the IRISH DMU.

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Address Auto-Resolution Network System for Neutralizing ARP-Based Attacks (ARP 기반 공격의 무력화를 위한 주소 자동 결정 네트워크 시스템)

  • Jang, RhongHo;Lee, KyungHee;Nyang, DaeHun;Youm, HeungYoul
    • KIPS Transactions on Computer and Communication Systems
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    • v.6 no.4
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    • pp.203-210
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    • 2017
  • Address resolution protocol (ARP) is used for binding a logical address to a physical address in many network technologies. However, since ARP is an stateless protocol, it always abused for performing ARP-based attacks. Researchers presented many technologies to improve ARP protocol, but most of them require a high implementation cost or scarify the network performance for improving security of ARP protocol. In this paper, we present an address auto-resoultion (AAR) network system to neutralize the ARP-based attacks. The AAR turns off the communication function of ARP messages(e.g. request and reply), but does not disable the ARP table. In our system, the MAC address of destination was designed to be derived from destination IP address so that the ARP table can be managed statically without prior knowledge (e.g., IP and MAC address pairs). In general, the AAR is safe from the ARP-based attacks since it disables the ARP messages and saves network traffics due to so.

Comparative Analysis of the Use of a Pedestrian Facility for Non-Mobility Handicapped and Mobility Handicapped in Urban Rail Station (일반인과 교통약자의 도시철도 역사의 보행시설 이용에 관한 비교분석)

  • HwangBo, Hyun;Jung, Hun-Young;Kim, Hyun-Woong
    • Proceedings of the KSR Conference
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    • 2011.05a
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    • pp.757-762
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    • 2011
  • As our society is becoming an aging society, there is an increasing number of the elderly. Recently, mobility handicapped like the elderly and the disable take part in many social activities. It is required public transportation systems for them. Already, the traffic policy for mobility handicapped including pregnant woman and child, has been established in many cities. Particularly, the convenience of mobility for the handicapped in the urban rail stations is depend on a pedestrian facilities like escalators and elevators. The pedestrian facilities have been built in urban rail stations without rules for mobility handicapped. To make the more convenient and more safe stations, the more study about mobility handicapped and non-mobility handicapped is needed. This paper preferentially discusses the pedestrian facilities with other convenience facilities in urban rail stations. This paper explains also their preference, relative satisfaction and importance for the convenience facilities including the a pedestrian facilities in urban rail stations and makes clear the difference between both groups.

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Ultra-small Form-Factor Helix on Pad-Type Stage-Bypass WCDMA Tx Power Amplifier Using a Chip-Stacking Technique and a Multilayer Substrate

  • Yoo, Chang-Hyun;Kim, Jung-Hyun
    • ETRI Journal
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    • v.32 no.2
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    • pp.327-329
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    • 2010
  • A fully integrated small form-factor HBT power amplifier (PA) was developed for UMTS Tx applications. For practical use, the PA was implemented with a well configured bottom dimension, and a CMOS control IC was added to enable/disable the HBT PA. By using helix-on-pad integrated passive device output matching, a chip-stacking technique in the assembly of the CMOS IC, and embedding of the bulky inductive lines in a multilayer substrate, the module size was greatly reduced to 2 mm ${\times}$ 2.2 mm. A stage-bypass technique was used to enhance the efficiency of the PA. The PA showed a low idle current of about 20 mA and a PAE of about15% at an output power of 16 dBm, while showing good linearity over the entire operating power range.

Recent R&D Trends of Anti-Drone Technologies (안티 드론 기술 동향)

  • Choi, S.H.;Chae, J.S.;Cha, J.H.;Ahn, J.Y.
    • Electronics and Telecommunications Trends
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    • v.33 no.3
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    • pp.78-88
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    • 2018
  • As the unmanned aerial vehicle industry and its related technologies grow each year, the number of abuse cases caused by drones is increasing. In addition to the invasion of privacy caused by indiscriminate photography, terrorism using unmanned aerial vehicles, which have a low detection probability, high location accuracy, and the capability of targeting people or places, as well as carrying chemicals, radiation materials, and small bombs, is becoming a significant problem around the world. Accordingly, many companies are developing anti-drone solutions that consist of various technologies such as radar, EO/IR cameras, and RF jammers to detect and disable unmanned aerial vehicles. This article briefly introduces the recent R&D trends and technical levels of anti-drone technologies.

Investigation of anomalous hardening in NiAl Single crystals at intermediate temperatures (중간온도 영역에서의 NiAl 단결정 이상 경화거동에 대한 연구)

  • Yang Chulho
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.06a
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    • pp.1390-1393
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    • 2005
  • The hardening model based on the dislocation mechanics is employed to study the experimentally observed high tensile elongations of NiAl along the [110] orientation at intermediate temperatures. In the hardening model proposed, a mobility of dislocation is assumed to be restricted to glide through the slip plane by forest dislocation and thermally activated cross-slip event. Overall deformation behavior of NiAl was greatly influenced by temperature-dependent dislocation mobility that both experimental and simulated yield stresses decreased as temperature increased. The results of simulation showed anomalous hardening behaviors analogous to those of experiment at certain circumstances. This behavior occurred due to the hardening contributions generated by cross-slip events that disable the dislocation motion in the primary slip systems. By comparing simulation results with experiments, it is confirmed that the proposed hardening model can represent anomalous tensile elongations due to the hardening by forest dislocations and cross-slip events.

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A Study on Welding of Dissimilar Materials for Van-Ramp Design and Production (승합차의 램프 디자인과 제작을 위한 이종재료의 접합)

  • Lee, Jung-Hyun;Kim, In-Cheol
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.20 no.4
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    • pp.434-439
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    • 2011
  • There are about 2.4million disabled in Korea, 2009. Also, Korean society entered into an aging society. Therefore disable and elderly are getting more involved in our society. This study proposes simple ramp design for wheel chair users and welding method and condition for manufacturing. In the middle of ramp, screw jack and motor are installed so that ramp can be moved left and right side. To make the ramp moves easily, ramp was fixed by installing LM guide on both sides. Ramp production for using Nd:YAG laser certain dissimilar welding in stainless steel sheet and cold reduced carbon steel. The output was fixed by 3kW, the speed was increased to 2~7m/min, Argon was used as shielding gas and the flow rate was changed to 10~30L/min. The proper welding condition is the output 3kW and welding speed 2~5m/min.

Development of Motorized Wheelchair INMEL-VII for Model of Practical Use (전동화 수동 휠체어의 실용화 모델 INMEL-VII의 개발)

  • Kim, Y.Y.;Kim, J.M.;Yang, K.M.;Jeong, D.M.;Hong, S.H.
    • Proceedings of the KOSOMBE Conference
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    • v.1994 no.05
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    • pp.92-95
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    • 1994
  • We developed electric wheelchair INMEL-VI which is motorized wheelchair for practical use. The field test results of long time show some problems to disabled in daily use. INMEL-VII is designed to solve the problems of INMEL-VI and to adjust condition by the Korean Industrial Standards about the motorized wheelchair. Especially, it is improved to have durability, driving safety, and convenience of manipulating. In the driving field test in indoors and outdoors, it has been estimated to have a high practical use for powered walking aids to disable's daily life.

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