• Title/Summary/Keyword: Directly observed treatment

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The Feasibility Study on the Direct Use of the MC-derived Physical Quantities to Determine the Model Parameters of RTPS with -Model-Based Photon Dose Calculation Algorithm (모델기반 광자선량 계산방식을 사용하는 전산화치료계획장치의 모델변수 결정에 있어 몬테카를로 모사법에 의해 유도된 방사선 물리량의 직접 적용 가능성에 대한 연구)

  • 강세권;박희철;배훈식;조병철
    • Progress in Medical Physics
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    • v.15 no.2
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    • pp.77-83
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    • 2004
  • The commissioning of a model-based treatment planning system requires many parameters to fit the measured depth doses and transverse profiles. For the commissioning of the Pinnacle$^3$ system, through the Monte Carlo (MC) simulation, the necessary parameters, including the photon spectrum, contaminant electrons, off-axis softening and fluency of photons, were observed. Through the simulation the parameters contained valuable information, but the calculated results of the Pinnacle$^3$ using the MC-derived parameters showed discrepancies with those measured for the off-axis softening and the fluency of photons. Even though the MC calculation produces reasonable values for the commissioning, the thorough physical basis of the Pinnacle$^3$'s commissioning process is needed in order to directly use the MC derived parameters.

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The Avoidance of Microsurgical Complications in the Extradural Anterior Clinoidectomy to Paraclinoid Aneurysms

  • Son, Hee-Eon;Park, Moon-Sun;Kim, Seong-Min;Jung, Sung-Sam;Park, Ki-Seok;Chung, Seung-Young
    • Journal of Korean Neurosurgical Society
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    • v.48 no.3
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    • pp.199-206
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    • 2010
  • Objective : Paraclinoid segment internal carotid artery (ICA) aneurysms have historically been a technical challenge for neurovascular surgeons. The development of microsurgical approach, advances in surgical techniques, and endovascular procedures have improved the outcome for paraclinoid aneurysms. However, many authors have reported high complication rates from microsurgical treatments. Therefore, the present study reviews the microsurgical complications of the extradural anterior clinoidectomy for treating paraclinoid aneurysms and investigates the prevention and management of observed complications. Methods : Between January 2004 and April 2008, 22 patients with 24 paraclinoid aneurysms underwent microsurgical direct clipping by a cerebrovascular team at a regional neurosurgical center. Microsurgery was performed via an ipsilateral pterional approach with extradural anterior clinoidectomy. We retrospectively reviewed patients' medical charts, office records, radiographic studies, and operative records. Results : In our series, the clinical outcomes after an ipsilateral pterional approach with extradural anterior clinoidectomy for paraclinoid aneurysms were excellent or good (Glasgows Outcome Scale : GOS 5 or 4) in 87.5% of cases. The microsurgical complications related directly to the extradural anterior clinoidectomy included transient cranial nerve palsy (6), cerebrospinal fluid leak (1), worsened change in vision (1), unplanned ICA occlusion (1), and epidural hematoma (1). Only one of the complications resulted in permanent morbidity (4.2%), and none resulted in death. Conclusion : Although surgical complications are still reported to occur more frequently for the treatment of paraclinoid aneurysms, the permanent morbidity and mortality resulting from a extradural anterior clinoidectomy in our series were lower than previously reported. Precise anatomical knowledge combined with several microsurgical tactics can help to achieve good outcomes with minimal complications.

Effect of Different Pressing Processes and Density on Dimensional Stability and Mechanical Properties of Bamboo Fiber-based Composites

  • Zhang, Ya-Hui;Huang, Yu-Xiang;Ma, Hong-Xia;Yu, Wen-Ji;Qi, Yue
    • Journal of the Korean Wood Science and Technology
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    • v.46 no.4
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    • pp.355-361
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    • 2018
  • In this study, the dimensional stability and mechanical properties of bamboo fiber-based composites (BFBCs) were studied at two pressing manufacturing processes, i.e., hot- and cold- pressing, and were compared with three density parameters (1.0, 1.1, and $1.2kg/m^3$). Width swelling ratio (WSR), thickness swelling ratio (TSR), and water absorption ratio (WAR) were calculated for water immersions of 4 and 28 h. WSR, TSR, and WAR for specimens immersed for 28 h were higher than those for 4 h treatment, which shows that the immersion time has a significant influence on the dimensional stabilities of BFBCs. Moreover, the positive linear relations between density and dimensional were observed at both the pressing ways, indicating that the WSR, TSR, and WAR decreased with an increase in the density of BFBCs. The compressive strength, shear strength, modulus of rupture (MOR), and modulus of elasticity (MOE) were determined. The compressive strength, MOR, and MOE of hot-pressed specimens were significantly higher than those for the cold-pressed specimens, which are also directly proportional to density. Moreover, the samples with the highest density of $1.2kg/m^3$ performed high values on mechanical properties in both the manufacturing methods.

Acclimatization and Growth Characteristics of Plantlets of Eleutherococcus senticosus Maxim Cultured by Bioreactor (생물반응기에서 배양한 가시오갈피 유식물체의 순화 및 생육특성)

  • Li, Cheng-Hao;Lim, Jung-Dae;Kim, Myong-Jo;Kim, Na-Young;Yu, Chang-Yeon
    • Korean Journal of Medicinal Crop Science
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    • v.13 no.4
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    • pp.133-137
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    • 2005
  • Experiments were conducted to find the optimal acclimatization conditions for Eleutherococcus senticosus plantlets regenerated from bioreactor cultured somatic embryos, various acclimatizing conditions were compared regarding both survival rate and growth of the plantlets. Among the various temperature and artificial soil tested, the highest survival rate (88%) was observed when plantlets were acclimatized in Klasmann bed soil at $10^{\circ}C$ When in vitro plantlets directly transplanted to field environment, shading treatment was necessary and 50% shading was more effective than 30% shading. Transplanting season were also important for successful acclimatization of in vitro cultured plantlets, transplanted on March 20 with 50% shading exhibited the best survival rate and further growth.

A Case of Radiation Bronchitis Induced Massive Hemoptysis after High-Dose-Rate Endobronchial Brachytherapy

  • Lee, Seok Jeong;Lee, Jong-Young;Jung, Soon Hee;Lee, Shun Nyung;Lee, Ji-Ho;Kim, Chong Whan;Jung, Saehyun;Jung, Ye-Ryung;Lee, Won-Yeon
    • Tuberculosis and Respiratory Diseases
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    • v.73 no.6
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    • pp.325-330
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    • 2012
  • High-dose-rate endobronchial brachytherapy (HDREB) have been used as the treatment of early endobronchial cancer, as well as for palliation of advanced cancer. However, fatal hemoptysis can occur after HDREB at the rate of 7~32%. We report a case of massive hemoptysis due to radiation bronchitis developed after HDREB. A 67-year-old man was treated with HDREB for early endobronchial cancer on the left upper lobe bronchus. He complained of persistent cough from 4 weeks after completion of HDREB. Radiation bronchitis was observed on the bronchoscopy at 34 weeks, and it was progressed from mucosal swelling and exudate formation to necrosis and ulceration without local relapse. In addition, he died of massive hemoptysis after 15 months. The patient had no sign or radiologic evidences to predict the hemoptysis. This case implies that HDREB directly contributes to an occurrence of a fatal hemoptysis, and follow-up bronchoscopy is important to predict a progression of radiation bronchitis and fatal hemoptysis.

Preparation of $Ga_2O_3:Eu^{3+}$ phosphors by homogeneous precipitation (균일침전법에 의한 $Ga_2O_3:Eu^{3+}$ 형광체의 제조)

  • 천민호;박인용;이종원;김선태
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.12 no.3
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    • pp.149-156
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    • 2002
  • Europium-activated $Ga_2O_3$ phosphor powders were prepared by homogeneous precipitation method. The resulting powders were characterized by means of TG/DTA, XRD, FT-IR and SEM, Two kinds of powders formed were the crystalline GaOOH and the amorphous-like $\gamma$-$Ga_2O_3$ phases. When the urea concentration was below 0,5 M, rod-like micrometer-sized GaOOH powders were formed. They were transformed via $\alpha$-$Ga_2O_3$ to $\beta$-$Ga_2O_3$ phases under heat treatment. On the other hand, the nanometer-sized $\gamma$-$Ga_2O_3$ powders were formed with urea concentrations higher than 1.0 M, and they were directly changed into $\beta$-$Ga_2O_3$.Photoluminescence (PL) spectra were observed at room temperature, and PL intensities of nanometer-sized $Ga_2O_3$ : $Eu^{3+}$ powders around 610 nm were higher than those of micrometer-sized ones.

Transformation of Korean Ginseng (Panax ginseng C.A. Meyer) with Salt Toleranc SAL1 Gene (염류내성관련 SAL1 유전자에 의한 인삼 형질전환)

  • In, Jun-Gyo;Yang, Deok-Chun
    • Korean Journal of Medicinal Crop Science
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    • v.13 no.1
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    • pp.57-62
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    • 2005
  • Salt-tolerant transgenic Panax ginseng plants were produced by introducing the SAL1 geue (3'(2'), 5'-bis-phosphate nucleotidase) that confers tolerance to the salts through Agrobacterium tumefaciens co-cultivation. Cotyledon explants of immature ginseng zygotic embryos cultured on Murashige and Skoog medium lacking growth regulators formed somatic embryos directly with below 10%, but the 74% tranformation rate were observed at the treatment of phytohormone with 1.0 mg/l 2,4-D and 0.5 mg/l kinetin. Somatic embryos were initially cultured on MS medium supplemented with 250 mg/l cefotaxime for 3 weeks and subsequently subcultured five times to a medium containing 100 mg/l kanamycin and 250 mg/l cefotaxime. Upon development into the cotyledonary stage, these somatic embryos were transferred to on the medium containing 50 mg/l kanamycin and 10 mg/l gibberellic acid to induce germination and strong selection. Integration of the transgene into the plants was confirmed by polymerase chain reaction with specific primers. The ginseng transformants with well-developed shoots and roots were successfully acclimatized in a greenhouse when they were planted in soil.

Effect of Dietary Thyroid Hormone on Growth Performance, Body Composition, Serum Thyroid Hormone Concentration and Energy Metabolism of Broiler Chicks (갑상선 호르몬의 경구투여가 육계의 사양성적, 체조성, 혈청 호르몬 농도 및 에너지 대사에 미치는 영향)

  • 가천흥;김창혁;채병조;이영철
    • Korean Journal of Poultry Science
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    • v.26 no.4
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    • pp.237-245
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    • 1999
  • This study was conducted to investigate the effect of dietary thyroid hormone (T$_3$and T$_4$) on growth, feed conversion ratio and serum T$_3$or T$_4$concentration of broiler chicks. Zero to six week-old broiler chicks were randomly allocated into seven treatment groups for feeding trials with three replication : control, T$_3$(0.1), T$_3$(1.0), T$_3$(5.0), T$_4$(0.1), T$_4$(1.0), T$_4$(5.0) ppm group. Concentrations of T$_3$and T$_4$in serum were analyzed. The weight gain of T$_3$(1.0), T$_3$(5.0) and T$_4$(5.0) groups were significantly lower than that of control. No statistically significant adverse effect was observed in other groups (p〉0.05). Feed intake was significantly lower in T$_3$(0.1, 1.0 and 5.0) and T$_4$(5.0) than in control group (p〈0.05), and the feed conversion ratio had a similar trend to the feed intake change. The contents of liquid and abdominal fat pad in carcass were significantly decreased in all T$_3$and T$_4$groups (p〈0.05). T$_3$and T$_4$concentration in serum was significantly increased at over 1.0ppm of the hormone supplementation level. As T$_3$addition level increased, T$_4$concentration in serum reduced ; however, T$_3$in serum was directly proportional during fasted were slightly increased when T$_3$or T$_4$was added to broiler diets.

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A COMPARATIVE STUDY OF SHEAR BOND STRENGTH OF FLOWABLE RESIN ASSOCIATED WITH DENTIN ADHESIVE SYSTEMS WITH THERMOCYCLING EFFECT (상아질접착제와 열순환에 따른 유동성 레진의 전단결합강도 비교 연구)

  • Nam Ki-Young
    • The Journal of Korean Academy of Prosthodontics
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    • v.44 no.4
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    • pp.383-393
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    • 2006
  • Statement of problem : Limited research on flowable resin has been undertaken on its application directly on dentin associated with the adhesive systems. Purpose : This study was to evaluate the shear bond strengh and fracture aspect of flowable resin on human dentin with various types of dentin bonding adhesives with thermo cycling effect. Materials and methods: Filtek-Flow(3M ESPE, USA) was used as flowable resin and Eighty human molars were randomly divided into 4 groups : three dentin bonding adhesives (Scotchbond-Multipurpose : 3-step contentional system, One-Step : One-bottle system. Prompt L-Pop : All-in-one, self-etching primer) and 32% etching treatment without bonding adhesive as a control group. For evaluating their durability of bonding, each group was subdivided : storaging in the water at 37$^{\circ}C$(24 hours) and thermocycling (0$^{\circ}C$-55$^{\circ}C$, 30 seconds intervals, 1000 cycle). Shear bond strength tests were performed and resin-dentin interface and fracture mode were observed. Results were analysed by one-way ANOVA and Scheffe's multiple range test. Results and Conclusion : 1. At 0 cycle, the mean shear bond strength of One-Step exhibited the highest value of all groups(p<0.05), and there were no significant differences between Prompt L-Pop and Scotchbond-Multipurpose, Scotchbond-Multipurpose and control(p>0.05). After 1000 thermocycling, One-Step exhibited higher value than other groups(p<0.05), and there were no significant differences among other groups (p>0.05). 2. The shear bond strength of each group was significantly decreased after thermocycling except Scotchbond-Multipurpose (p>0.05). 3. The most common failure mode was adhesive type and mixed type, next in order.

DIRECT CURRENT EFFECT ON THE BONE FORMATION AND OSSEOINTEGRATION AROUND TPS-IMZ IMPLANT (미소 전류 자극이 TPS-IMZ 임프란트 주위의 골유착과 골형성에 미치는 영향)

  • Park, Sang-Won;Yang, Hong-So
    • The Journal of Korean Academy of Prosthodontics
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    • v.34 no.4
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    • pp.722-745
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    • 1996
  • The purpose of this study is to investigate the effect of constant direct current electrical stimulation in healing the bone defects and surrounding tissues of the endo-oseous(TPS-IMZ) implants. Implants were inserted in the femur of adult dogs. Then a constrant direct current of approximately $10{\mu}A$ was applied. Artificial bone defects were prepared on one side of the implant site. Experimental groups were divided into 4 : control group : bone defect without treatment group I : bone defect filled with hydroxyapatite powders group II : bone defect, in which a negative and positive electrodes were inserted 5mm apart from both sides of the implant group III : bone defect, in which negative current was directly connected to the IMZ implant and a positive electrode was placed 10mm apart from the implant The animals were sacrificed in the 1st, 2nd, 4th and 8th week after implantation for the light microscopic examination. The results obtained were as follows : 1. In electrically stimulated experimental groups, new bone formation and osseointegration around implants were accelerated. 2. Group III showed the greatest activity in new bone formation. Osteoconductivity around HA particles was observed in group 1. 3. The defect area of the control group was healed by forming new bone, which grew from the underlying cancellous bone. The defect areas of the electrically stimulated experimental groups were healed by newly formed bone, which grew upward from the cancellous bone and downward from the periosteum. 4. 8 weeks after implantation, all the groups showed good osseointegration between the surrounding bone and implants.

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