• Korean Journal of Acupuncture
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• v.33 no.4
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• pp.204-212
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• 2016

Objectives : The aim of the study is to investigate the effects of moxibustion on the pain behavior and expression of TRPM8 in the dorsal root ganglion(DRG) in the rat model of ambient cold(AC) exposed osteoarthritis(OA). Methods : OA was induced by the injection of $50{\mu}l$ of 2% monosodium iodoacetate(MIA) into the knee joint cavity. To examine the level of pain, weight bearing forces(WBFs) of affected limb was measured. For the AC exposure, the animals were housed in 6 h/day at $4^{\circ}C$ for 14 days after MIA injection. Moxibustion treatment was performed at EX-LE4 and EX-LE5 with 5 cons(1, 7 or 10 mg) per day for 13 days from 5 days after MIA injection. The expressions of TRPM8 in DRG were measured by western blotting analysis. Results : The WBFs of MIA-AC group were decreased significantly compared to MIA group at 2, 3, 6, 7, 8 and 9 days after arthritis induction. After the first 6 h-AC exposure, expressions of TRPM8 in MIA-AC group were increased significantly compared to those of naive group. After moxibustion treatment, only the WBFs of 7 mg treated group were restored significantly. Moreover, the over-expressions of TRPM8 were attenuated by the moxibustion treatment in AC exposed rats. Conclusions : The data suggest that AC can increase arthritic knee pain via up-regulated TRPM8 and moxibustion treatment improve the arthritic pain via modulation of TRPM8 expression in DRG in the rat model of AC exposed MIA induced arthritis.

• Fashion & Textile Research Journal
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• v.10 no.6
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• pp.979-988
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• 2008

The purpose of this study is to analyze the lower body size and forms of married women in their thirties who have experienced pregnancy and parturition. Their measurements derived from the direct anthropometry and indirect photographic measures were compared to those of 20's. Improving consumer satisfaction for missy brand, especially in fitness of skirt and pants, some lower body classification were presented. The results were as follows : 1. The characteristics of lower body showed many differences by individuals especially in depth, girth, length and angle measures rather than height and breadth measures. Many items including index, calculations and angles revealed significant differences compared to those of 20's. Several breadth items, crotch length had distinct increase than those of women in twenties. Flattened buttocks side silhouette from waist to hip, buttocks drooping and decrease of inclination implied the influence of pregnancy, parturition and aging. 2. We hardly find out sizing system differences between missy brand and miss brand. Based on waist and hip girth measurements of subjects, sizing system of missy apparel wasn't suitable for their body size. Excessive drop(hip girth-waist girth) of missy brands, 25~30 cm, was almost the same to the drop of miss brands. 3. To improve the size satisfaction of missy women, we classified the lower body into 5 types according to drop, buttocks angle and hip length. Type 1 was small waist with large buttocks projection, and hip length was close to an average. Type 2 was small waist with medium buttocks projection, and the hip length was close to an average. Type 3 was medium waist, with average projection of the buttocks and hip length. Type 4 was large waist, projection of the buttocks and the hip length were close to an average. Type 5 was large waist, projection of the buttocks was small and the hip length was close to an average.

• Journal of Korean Society of Rural Planning
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• v.19 no.1
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• pp.109-122
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• 2013

The rapid rural urban migration and aging has generated an over-depopulation problems in rural areas since the 1980s. The purpose of this study constructs the marginal size of rural over-depopulated village through the analysis of the residential disparities such as farmer's ratio, basic life service accessibility, and levels of social and economic factors for each village community. This marginal scale could support evaluating diverse rural policies, which have been planned to apply to the rural development programs at the village level. The major challenges for over-depopulated villages are the lack of basic facilities, production infrastructures and inactive communities in the village. Therefore, the quantitative analysis of rural residential disparities according to rural village scale can provide the criteria for rural over-depopulated villages. We utilized Korea Agricultural Survey Data(2010) including specific residential condition of village level. The present study adopt multinomial-logit model for quantitative analysis of different village scales and decomposition techniques to separate the direct effect by the village scale factor from the endowment effects by regional or area characteristics, and residual effect by unknown factors. The present study found that the minimum scale of a rural over-depopulated village was 40 and 60 houses for the respective conditions of farmer's ratios less than 50% and greater than 75%. It was concluded based on the study findings that threshold scale could support evaluating the diverse rural policies, which have been planned to apply to the rural development programs at the village level.

• Journal of Korean Physical Therapy Science
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• v.9 no.1
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• pp.25-36
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• 2002

Objectives: This study was conducted to find out risk factors related to elderly hip fracture, so that the result could provide basic data to establish prevention programs for hip fracture among the elderly. Methods: The data were collected from 199 cases hospitalized in 4 university hospitals in Pusan from January, 1996 to December, 1998, 193 healthy controls who visited elderly facilities in Pusan. The data were obtained from medical records and by using questionnaires through telephone contact or direct personal interview with the subjects or their family, and were analyzed for 2-test and multiple logistic regression. The risk factors were shown with odds ratios and their 95% confidence intervals. Results: In univariate analysis, the odds ratio of hip fracture risk was estimated to be 1.9 for the elderly aged 75 years as compare with those aging less than 65 years; 42 for those with job as compared with those without job; 3.3 for those with more than 6 children as compared with those with one or two children. For the variables related to physical characteristics, small height (p=0.015), light weight (p=0.000), and low BMI (p=0.014) were risk factors for elderly hip fracture. Sane variables related to health, such as previous history of illness (OR=3.3.), abnormal blood pressure (OR=1.6), previous fracture history (OR=22), lower limbs weakness (OR=12.1) and gait disturbance (OR=42.6), were significantly associated with the risk of hip fracture. In multiple logistic regression, risk factors for hip fracture were age, having job, lower limb weakness and previous history of illness. The adjusted odds ratios of hip fracture risk among the elderly were age (OR=1.1), having jobs (OR=11.7), weak lower limb (OR=10.8) and previous history of illnesses (OR=3.3), respectively. Conclusion: This study suggests that the plan for improving the daily living environment for the elderly systematically should be implemented to avoid the chances of fall, and that programs encouraging to practice regular exercise for physical activity and to promote health of the elderly should be developed.

• Journal of the East Asian Society of Dietary Life
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• v.21 no.3
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• pp.451-462
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• 2011

The purpose of this study was to examine the level of concern and the level of knowledge of endocrine disruptors, and the level of dietary behaviors to decrease exposure to endocrine disruptors, to determine the factors affecting the level of knowledge and behaviors, and to assess the causal relationship between them. The data were collected from 579 adults in Seoul, Incheon, Daejeon, Daegu, Busan and Gwangju provinces. Frequencies, t tests, analysis of variance, Cronbach's alpha, Pearson's correlation coefficient analysis, multiple regression analyses, and path analysis were carried out by SPSS for Win V.18.0. The results of this study were as follows: The level of concern about endocrine disruptors was higher than the medium level. The respondents were most concerned about a container of cup ramen among products related to foods. The levels of both knowledge and behaviors in order to decrease exposure to endocrine disruptors in dietary life were not high. The factors affecting the level of knowledge of endocrine disruptors were educational level, attendance in education for endocrine disruptors, and concern about endocrine disruptors. On the other hand, sex, age, concern about endocrine disruptors, and the level of knowledge of endocrine disruptors affected the level of behaviors to decrease exposure toward endocrine disruptors. The results of the path analysis showed that educational level and education of endocrine disruptors had an indirect influence on the level of behaviors in order to decrease exposure to endocrine disruptors in dietary life. The concern about endocrine disruptors had both a direct and an indirect effect on the level of behaviors to decrease exposure to endocrine disruptors in dietary life. In addition, sex, age and the level of knowledge of endocrine disruptors directly affected the level of behaviors to decrease exposure to endocrine disruptors in dietary life.

• Journal of the Korean Home Economics Association
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• v.41 no.6
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• pp.1-12
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• 2003

The purpose of this study were to analyze the anthropometric data of feet of Korean women with aging, to categorize the women's foot shapes, and to compare the shoe size according to the foot shapes in order to provide the basic information for more comfortable shoes. Subjects of this study were 181 women over age 20. They were measured with the direct measurement method and the indirect measurement method. 26 items were measured from the right foot and 6 items were taken on foot outline. Factor analysis, cluster analysis, analysis of variance, post-hoc test, and cross tabs were peformed for statistical analysis of the data by SPSS program. There were significant differences in height items, breadth items, girth items, and angle items by subjects' age. The older subjects' feet were wide and thick with big deformity on toes. The arch height of the older ones was low. This implicates that the degree of deformity on toes, the foot ratio, the foot girth, the foot breath and the arch height as well as the foot length are needed to be considered in developing comfortable shoes. Nine foot construction factors were extracted by the factor analysis of anthropometric measurements; foot size factor, heel and instep factor, malleolus lateralis factor, malleolus medialis factor, foot shape factor, shape of toes factor, heel height factor, big toe height factor, and internal factor. On the basis of the cluster analysis, three different foot shapes were categorized. Type 1 was large and wide foot with little deformity on little toe. Type 2 was medium foot with deformation of big toe, and with the lowest arch height. Type 3 was small and narrow foot with the highest arch height. Distribution of shoe size according to the foot shape was analyzed. The ball of foot breath was of wide distribution than the ball of foot girth. This implicates that girth items and breath items of the foot should be enclosed for the same foot length in the shoe sizing system.

• Journal of the Korean Institute of Rural Architecture
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• v.13 no.3
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• pp.21-28
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• 2011

This paper was able to indicate to the results the following thing that attempted a required potential development demand, through the contents and cost analysis in Rural Community Development Project. Nowadays, Rural Areas comparatively have a lot of development demands related to improvements environmental of residence life and construction of Urban-Rural Exchange Facility, on the other and, there is comparatively a few facilities demands regarding agriculture production. Demand is cold storage facilities and agricultural products direct sale facilities expansion to be able to raise value added of agricultural products as facilities related comparatively a little agriculture production, and an improvement of residence life comparatively has a lot of repair environmental uninhabited house repair, river-front and the roadside, rest shelter creation demands. However, that should be forecasted so that aging of rural, population decrease and development demand is caused by a lot of issues such as maintenances operation of many Urban-Rural Exchange Facilities and a similar program and content has a lot of them in bilateral adjacent zones. Therefore, in the future plan shall attempt efficiency operating facilities and a program through characterization and network of zone so that facilities and program can have complementary relation in the adjacent zones. And item development and an investor are necessary regarding new labor force supply for continuous value maintenance of space and returning to the farm that there were the reverse agriculture production and Amenity which are an rural village. Furthermore, developmental plan of rural village is necessary through the demand analyses that a citizen wishing for things.

• Bulletin of the Korean Chemical Society
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• v.34 no.2
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• pp.447-452
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• 2013

In this study we report a new method for the synthesis of a silica monolithic column bed with bimodal pores (throughpores and mesopores). The template induced synthesis method was used to direct bimodal pores simultaneously instead of the usual post base-treating method. Block polymer Pluronic F127 was chosen as a dual-function template to form hierarchically porous silica monolith with both macropores and mesopores. This is a simplification of the method of monolithic column preparation. Poly(ethylene glycol) was used as a partial substitute for F127 can effectively prevent shrinkage during the monolith aging process without losing much surface area (944 $m^2/g$ to 807 $m^2/g$). More importantly, the resultant material showed a much narrower mesopore size (centered at 6 nm) distribution than that made using only F127 as the template reagent, which helps the mass transfer process. The solvent washing method was used to remove the remaining organic template, and it was proved to be effective enough. The new synthesis method makes the fabrication of the silica monolithic column (especially capillary column) much easier. All the structure parameters indicate that monolith PFA05 prepared by the above method is a good material for separation, with the merits of much higher surface area than usual commercial HPLC silica particles, suitable mesopore volume, narrow mesopore size distribution, low shrinkage and it is easily prepared.

• IMMUNE NETWORK
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• v.9 no.3
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• pp.106-113
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• 2009

Background: We previously demonstrated remarkable differences in the expression of IL-8/CXCL8 in aortic tissues and vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) compared to VSMC from normotensive Wistar-Kyoto rats (WKY). In the present study, we investigated the direct effect of IL-8/CXCL8 on expression of 12-lipoxygenase (LO), a hypertensive modulator, in SHR VSMC. Methods: Cultured aortic VSMC from SHR and WKY were used. Expression of 12-LO mRNA was determined by real-time polymerase chain reaction. Phosphorlyation of ERK1/2 and production of 12-LO and angiotensin II subtype 1 ($AT_1$) receptor were assessed by Western blots. IL-8/CXCL8-stimulated DNA synthesis was determined by measuring incorporation of [$^3H$]-thymidine. And effect of IL-8/CXCL8 on vascular tone was determined by phenylephrine-induced contraction of thoracic aortic rings. Results: Treatment with IL-8/CXCL8 greatly increased 12-LO mRNA expression and protein production compared to treatment with angiotensin II. IL-8/CXCL8 also increased the expression of the $AT_1$ receptor. The increase in 12-LO induced by IL-8/CXCL8 was inhibited by treatment with an $AT_1$ receptor antagonist. The induction of 12-LO mRNA production and the proliferation of SHR VSMC by IL-8/CXCL8 was mediated by the ERK pathway. The proliferation of SHR VSMC and the vascular contraction in the thoracic aortic ring, both of which were induced by IL-8/CXCL8, were inhibited by baicalein, a 12-LO inhibitor. Conclusion: These results suggest that the potential role of IL-8/CXCL8 in hypertensive processes is likely mediated through the 12-LO pathway.

• Journal of Microbiology and Biotechnology
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• v.16 no.10
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• pp.1605-1612
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• 2006

Interleukin (IL)-18, a member of the family of IL-l cytokine, is one of the principal inducers of $interferon-{\gamma}(IFN-{\gamma})$ in T lymphocytes and natural killer cells. The objective of the present study was to evaluate the effect of IL-18 on the expression of chemokine IP-10 (CXCL-10) mRNA in mouse peritoneal macrophages. IL-18 had very weak direct effect or synergistic effect with IL-12 on the expression of IP-10 mRNA in C57BL/6 mouse peritoneal macrophages. However, IL-18 pretreatment was found to playa cooperative role in the expression of lipopolysaccharide (LPS)-induced IP-10 mRNA. For the expression of LPS-induced IP-10 mRNA, the synergistic effect was detected after 16 h of IL-18 pretreatment prior to LPS stimulation. The expression level of CD14 in cells stimulated with LPS was not changed by IL-18 pretreatment, and the level of $IFN-{\gamma}$ production during IL-18 pretreatment plus LPS stimulation was barely discernible ($0.36{\pm}0.31pg/ml$). Namely, the synergistic effect of IL-18 pretreatment was not related to a change of LPS receptor, CD14 expression, and the production of $IFN-{\gamma}$ by the interaction between IL-18 and LPS. The synergistic effect of IL-18 pretreatment on the expression of LPS-induced IP-10 was related to not NF-kB but AP-1 activation, and associated with the extracellular signal-regulated kinase (ERK) pathway, one of the mitogen-activated protein kinase signaling pathways. These results provide useful information that may elucidate the mechanisms underlying the effect of IL-18 on the expression of IP-10 mRNA.