• Computers and Concrete
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• v.1 no.1
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• pp.31-46
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• 2004

A methodology is presented for computing stresses in structural concrete members exposed to fire. Coupled heat and moisture migration simulations are used to establish temperature, pore pressure, and liquid-saturation state variables within near-surface zones of heated concrete members. Particular attention is placed on the use of coupled heat and multiphase fluid flow simulations to study phenomena such as moisture-clogging. Once the state variables are determined, a procedure for combining the effects of thermal dilation, mechanical loads, pore pressure, and boundary conditions is proposed and demonstrated. Combined stresses are computed for varying displacement boundary conditions using data obtained from coupled heat and moisture flow simulations. These stresses are then compared to stresses computed from thermal analyses in which moisture effects are omitted. The results demonstrate that moisture migration has a significant influence on the development of thermal stresses.

• Geomechanics and Engineering
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• v.16 no.6
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• pp.619-626
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• 2018

A simple prediction procedure was investigated for calculating the stresses and displacements of a circular opening. Unlike existed approaches, the proposed approach starts each step with a radius increment. The stress for each annulus could be obtained analytically, while strain increments for each step can be determinate numerically from the compatility equation by finite difference approximation, flow rule and Hooke's law. In the successive manner, the distributions of stresses and displacements could be found. It should be noted that the finial radial stress and displacement were equal to the internal supporting pressure and deformation at the tunnel wall, respectively. By assuming different plastic radii, GRC and the evolution curve of plastic radii and internal supporting pressures could be obtained conveniently. Then the real plastic radius can be calculated by using linear interpolation in the evolution curve. Some numerical and engineering examples were performed to demonstrate the accuracy and validity for the proposed procedure. The comparisons results show that the proposed procedure was faster than that in Lee and Pietrucszczak (2008). The influence of annulus number and dilation on the accuracy of solutions was also investigated. Results show that the larger the annulus number was, the more accurate the solutions were. Solutions in Park et al. (2008) were significantly influenced by dilation.

• Journal of Veterinary Clinics
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• v.41 no.1
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• pp.43-48
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• 2024

A two-year-old, intact female Golden Retriever had previously been diagnosed with a portosystemic shunt (PSS) during an ultrasonographic examination at a local animal hospital. The serum biochemistry revealed elevated liver enzymes and bile acid levels. The abdominal radiographic examination revealed mild serosal detail loss and microhepatica, while abdominal ultrasonography revealed mild ascites and high-velocity flow to the caudal vena cava (CVC) suspected as a PSS. The gallbladder was not observed within the hepatic parenchyma during ultrasonography. Computed tomography (CT) revealed an absent gallbladder and dilation of the common bile duct (CBD). Dilations of the gastroduodenal, splenic, colic and renal veins were also observed. A dilated left phrenico-abdominal vein that entered the CVC was previously misinterpreted as a PSS on the ultrasound examination. Based on the imaging examinations, the dog was diagnosed with congenital gallbladder agenesis associated CBD dilation.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.1
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• pp.107-127
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• 2018

Objectives : The present study investigated the anti-obese and blood flow improvement activities of aqueous extracts of ginseng berry (GBe) on the mild diabetic obese mice as compared with metformin. Methods : After end of 56 days of continuous oral administrations of GBe 150, 100 and 50 mg/kg, or metformin 250 mg/kg, anti-obese and blood flow improvement effects - the changes of body weights, body and abdominal fat density by in live dual-energy x-ray absorptionmetry (DEXA), tail bleeding time, prothrombin time (PT), activated partial thromboplastin time (aPTT), serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) levels, aorta and serum cyclic guanosine monophosphate (cGMP), nitric oxide (NO) and endothelin (ET)-1 levels, aorta phosphorylated PI3K (pPI3K), phosphorylated Akt (pAkt) and phosphorylated p38 MAPK (pp38 MAPK) levels were systemically analyzed. In addition, aorta vascular dilation and constriction related gene mRNA expressions - PI3K, Akt, eNOS, p38 MAPK and ET-1 were also analyzed by realtime RT-PCR. Results : The obesity and related blood flow impairment, induced by 84 days of continuous HFD supply, were significantly inhibited by 56 days of continuous oral treatment of GBe 150, 100 and 50mg/kg, dose-dependently, and they also dramatically normalized the changes of the aorta vascular dilation and constriction related gene mRNA expressions, also dose-dependently. Especially, GBe 150 mg/kg constantly showed favorable inhibitory activities against type II diabetes related obesity and vascular disorders through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities, as comparable to those of metformin 250 mg/kg in HFD mice. Conclusion : By assessing the key parameters for anti-obese and blood flow improvement activities on the HFD-induced mild diabetic obese mice, the present work demonstrated that GBe 150, 100 and 50 mg/kg showed favorable anti-obese and blood flow improvement effects in HFD-induced type II diabetic mice, through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities.

• Tunnel and Underground Space
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• v.10 no.1
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• pp.45-58
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• 2000

Cyclic shear test system, which is capable of measuring flow rate inside rock joint, was established to investigate the hydraulic behavior of rough rock joints under various loading conditions. Laboratory hydraulic tests during compression and shear were conducted for artificial rough rock joints. Prior to tests, aperture characteristics of specimens were examined by measuring surface topography. Permeability changes under compression were well approximated with several hydraulic model. Hydraulic behavior conformed to dilation characteristics in the first stage, and permeability increased with increase of dilation. As the shear displacement progressed, flow rate became somewhat constant due to gouge production and offset of apertures. Hydraulic behavior under cyclic shear loading was also influenced by the degradation of asperities and gouge production. In addition. the relation between hydraulic aperture and mechanical aperture under compression and shear loading was investigated and compared.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2009.06a
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• pp.187-187
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• 2009

Opening of fractures induced by shear dilation or normal deformation can be a significant source of fracture permeability change in fractured rock, which is important for the performance assessment of geological repositories for spent nuclear fuel. As the repository generates heat and later cools the fluid-carrying ability of the rocks becomes a dynamic variable during the lifespan of the repository. Heating causes expansion of the rock close to the repository and, at the same time, contraction close to the surface. During the cooling phase of the repository, the opposite takes place. Heating and cooling together with the, virgin stress can induce shear dilation of fractures and deformation zones and change the flow field around the repository. The objectives of this work are to examine the contribution of thermal stress to the shear slip of fracture in mid- and far-field around a KBS-3 type of repository and to investigate the effect of evolution of stress on the rock mass permeability. In the first part of this study, zones of fracture shear slip were examined by conducting a three-dimensional, thermo-mechanical analysis of a spent fuel repository model in the size of 2 km $\times$ 2 km $\times$ 800 m. Stress evolutions of importance for fracture shear slip are: (1) comparatively high horizontal compressive thermal stress at the repository level, (2) generation of vertical tensile thermal stress right above the repository, (3) horizontal tensile stress near the surface, which can induce tensile failure, and generation of shear stresses at the comers of the repository. In the second part of the study, fracture data from Forsmark, Sweden is used to establish fracture network models (DFN). Stress paths obtained from the thermo-mechanical analysis were used as boundary conditions in DFN-DEM (Discrete Element Method) analysis of six DFN models at the repository level. Increases of permeability up to a factor of four were observed during thermal loading history and shear dilation of fractures was not recovered after cooling of the repository. An understanding of the stress path and potential areas of slip induced shear dilation and related permeability changes during the lifetime of a repository for spent nuclear fuel is of utmost importance for analysing long-term safety. The result of this study will assist in identifying critical areas around a repository where fracture shear slip is likely to develop. The presentation also includes a brief introduction to the ongoing site investigation on two candidate sites for geological repository in Sweden.

• Journal of Veterinary Clinics
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• v.33 no.5
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• pp.304-306
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• 2016

A 12-month-old, 3.0-kg, male, Scottish fold cat was referred to Irion animal hospital with dyspnea and cardiac murmur. In radiograph, right-sided cardiomegaly and pleural effusion were identified. In echocardiographic examination, abnormal stenotic region was identified in right ventricle and dilation of right atrium and concentric hypertrophy of interventricular septum and the free wall of right ventricle were also identified. In the stenotic region, abnormal muscular band was identified. The turbulent flow was identified in infundibular region of right ventricular outflow tract with color-Doppler examination and high velocity flow (4.0 m/s) was also identified in stenotic region. With these results, double-chambered right ventricle (DCRV) was diagnosed.

• Physical Therapy Rehabilitation Science
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• v.1 no.1
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• pp.6-12
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• 2012

Objective: Coenzyme (CoQ10) is an enzymatic co factor used in normal cellular metabolism. Recent evidence shows that in people with heart disease it can reverse endothelial cell damage in the blood vessels. It is also a potent antioxidant. Design: One group pretest-posttest design. Methods: In the present study, endothelial function was evaluated using the response to occlusion and heat before and 2 weeks after administration of CoQ10, 300 mg/day. Thirty Eight subjects, who are physical therapy students, participated in a series of experiments to see if taking 300 mg of CoQ10 daily for 2 weeks would impact resting blood flow in the forearm skin and the blood flow response to 4 minutes of vascular occlusion and the response to local heat ($42^{\circ}C$) for 6 minutes. Results: The results showed that, for this population, there was no difference in the response to heat. However, the response to occlusion was improved after administration of CoQ10. Conclusions: It would appear that in a young population CoQ10 has no effect on the nitric oxide vasodilator pathway in skin but does influence other vasodilator pathways.

• Tunnel and Underground Space
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• v.31 no.5
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• pp.333-359
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• 2021

Gases such as hydrogen and radon can be generated around the canister in high-level radioactive waste disposal systems due to several reasons including the corrosion of metal materials. When the gas generation rate exceeds the gas diffusion rate in the low-permeability bentonite buffer, the gas phase will form and accumulate in the engineered barrier system. If the gas pressure exceeds the gas entry pressure, gas can migrate into the bentonite buffer, resulting in pathway dilation flow and advective flow. Because a sudden occurrence of dilation flow can cause radionuclide leakage out of the engineered barrier of the radioactive waste disposal system, it is necessary to understand the gas migration behavior in the bentonite buffer to quantitatively evaluate the long-term safety of the engineered barrier. Experimental research investigating the characteristics of gas migration in saturated bentonite and research developing numerical models capable of simulating such behaviors are being actively conducted worldwide. In this technical note, previous gas injection experiments and the numerical models proposed to verify such behaviors are introduced, and the future challenges necessary for the investigation of gas migration are summarized.

• Korean Journal of Veterinary Service
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• v.40 no.3
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• pp.215-217
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• 2017

A 3-year-old chow chow dog with abdominal distention was referred to the Veterinary Teaching Hospital of Chungnam National University. The dog was diagnosed as Cor triatriatum dexter based on echocardiographic results, which demonstrated an abnormal membrane partitioning the right atrium. Echocardiography also revealed turbulent intra-atrial blood flow between the two chambers of the atrium. The dog was treated with balloon dilatation to enlarge the perforation in the abnormal membrane and to improve blood flow. As a result, although the membrane remained, increased perforation reduced the turbulent intra-atrial blood flow. Clinically the patient improved and eventually was discharged. This case is the first domestic Korean clinical veterinary report on the use of balloon valvuloplasty to treat Cor triatriatum dexter in a dog.