• Korean Journal of Occupational Health Nursing
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• v.22 no.1
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• pp.66-74
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• 2013

Purpose: This study examined the relationships among menopausal symptom, self-efficacy, health promoting behaviors, and investigated factors affecting health promoting behaviors of teachers with middle-aged women experiencing menopause. Methods: From September to October 2012, a convenience sample of 252 subjects aged 40 to 60 years was recruited from 8 elementary schools, 3 middle schools and 5 high schools. The data analysis was done by ANOVA and stepwise multiple regression. Results: Menopausal symptom of subjects was slightly lower than general middle aged women and the average level of health promoting behaviors was similar to general middle aged women. Health promoting behaviors were differentiated by severity of menopausal symptom, not by menstruation state. Menopausal symptom was negatively related to health promoting behaviors. The most significant factor affecting health promoting behaviors was self efficacy (14.3%). The combination of self efficacy, menopausal symptom, and elementary school teachers accounted for 20.1% of health promoting behavior. Conclusion: When developing health promotion program for teachers with middle-aged women, such program should consider self-efficacy, menopausal symptom, and school type.

• Journal of Korean Clinical Nursing Research
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• v.27 no.1
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• pp.109-119
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• 2021

Purpose: The purpose of this study was to identify and analyze the characteristics of nurses' medication errors during three years. Methods: Retrospective survey study design was used to analyze medication errors by nurses among patient safety accidents. Data were collected for three years from January, 2017 to December, 2019. Data were analyzed using frequency, percentage, 𝑥²-test, and logistic regression with SPSS 26.0 program. Results: Of a total 677 medication errors, 40.6% were caused by nurses. Among the medication errors, near miss (n=154, 56.0%), intravenous bolus injection (n=170, 61.8%), wrong dose (n=102, 37.1%) and carelessness for repetitive work (n=98, 35.6%) were the most common. Medication errors differed by department, and nurses' career, and patient safety accident type. The results of the logistic regression analysis showed that the risk factors of adverse events were medication of fluids (OR=3.93, 95% CI: 1.26~12.27), insulin subcutaneous injection (OR=39.06, 95% CI: 4.58~333.18), and occurrence of extravasation/infiltration (OR=7.26, 95% CI: 1.85~28.53). Conclusion: The simplest and most effective way to prevent medication errors is to keep 5 right, and a differentiated education program according to department and nurse career is needed rather than general education programs. Hospital-level integrated interventions such as a medication barcode system or a team nursing method are also necessary.

• Reproductive and Developmental Biology
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• v.31 no.4
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• pp.241-248
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• 2007

Epigenetic modification dependent DNA methyltransferases (DNMTs) play an important role in tissue- and stage-specific gene regulation and normal mammalian development. In this study, we show that DNMTs are expressed at different levels during hematopoietic stem cell (HSC) differentiation to proerythrocytes. DNMT1, DNMT3A, and DNMT3B were highly expressed at day 7 after differentiation. We used specific siRNA as a tool to probe the relationship between the expression of DNMTs and erythropoietic differentiation. When introduced siRNA of DMNT1 and DMNT3b in human $CD34^+$ cells, these more differentiated into erythrocytes. This was confirmed by glycophorin A (GPA) positive cell analysis and globin gene expression. $GPA^+$ cells increased up to $20{\sim}30%$, and ${\gamma}$- and ${\epsilon}$-globin genes increased in siRNA transfected cells. Therefore, our data suggest that suppression of DNA methylation can affect positively differentiation of HSC and may contribute to expression of erythrocyte lineage genes including GPA and globins.

• The Journal of the Korea Contents Association
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• v.18 no.3
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• pp.160-171
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• 2018

The purpose of this study is to present segmentation strategies by analyzing SMEs' perceptions of SME support program. That's why we used the research report of the NST(National Research Council of Science & Technology), which is advanced cooperation way between GRIs and SMEs based on market demand. As a result of this study, it was found that there is a difference in the demand for the SME support program depending on the type of cooperation and the cooperation experience with GRIs. This implies that a differentiated support strategy is required for the establishment of successful partnership between GRIs and SMEs. The result of this study suggests the direction of open collaborative ecosystem formation in the future based on the support strategies of each cluster. And it is expected to help SMEs improve the competitiveness and efficiency of support through effective customization support do.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.35 no.2
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• pp.73-81
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• 2013

Purpose: Smad4 is a central mediator for transforming growth factor-${\beta}$/bone morphogenetic protein ($TGF-{\beta}/BMP$) signals, which are involved in regulating cranial neural crest cell formation, migration, proliferation, and fate determination. Accumulated evidences indicate that $TGF-{\beta}/BMP$ signaling plays key roles in the early tooth morphogenesis. However, their roles in the late tooth formation, such as cellular differentiation and matrix formation are not clearly understood. The objective of this study is to understand the roles of Smad4 in vivo during enamel and dentin formation through tissue-specific inactivation of Smad4. Methods: We generated and analyzed mice with dental epithelium-specific inactivation of the Smad4 gene (K14-Cre:$Smad4^{fl/fl}$) and dental mesenchyme-specific inactivation of Smad4 gene (Osr2Ires-Cre:$Smad4^{fl/fl}$). Results: In the tooth germs of K14-Cre:$Smad4^{fl/fl}$, ameloblast differentiation was not detectable in inner enamel epithelial cells, however, dentin-like structure was formed in dental mesenchymal cells. In the tooth germs of Osr2Ires-Cre:$Smad4^{fl/fl}$ mice, ameloblasts were normally differentiated from inner enamel epithelial cells. Interestingly, we found that bone-like structures, with cellular inclusion, were formed in the dentin region of Osr2Ires-Cre:$Smad4^{fl/fl}$ mice. Conclusion: Taken together, our study demonstrates that Smad4 plays a crucial role in regulating ameloblast and odontoblast differentiation, as well as in regulating epithelial-mesenchymal interactions during tooth development.

• Journal of Biomedical Engineering Research
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• v.36 no.4
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• pp.103-108
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• 2015

Discrimination of Parkinson's disease (PD) from Essential tremor (ET) is often misdiagnosed in clinical practice. Since tremor is time-varying signal, and dominant and harmonic frequencies are shown in tremor only with moderate or severe symptom, there are some limitations to use frequency related features. Moreover, patients with PD or ET can suffer from both resting tremor and postural tremor. In this study, 28 patients with PD and 17 patients with ET were enrolled. Tremor was measured with accelerations on the more affected hand during resting and postural conditions. The ratio of root mean square (RMS) of resting tremor to RMS of postural tremor, the mean coefficients of autocorrelation function (ACF), and the mean of differences of two adjacent coefficients of ACF at resting and postural were calculated and compared between PD and ET. The performance showed 98% accuracy with support vector machine and leave-one-out cross validation. In addition, the method accurately differentiated the patients with tremor-dominant PD from patients with ET, with 100% accuracy. Therefore, the developed algorithm can assist clinicians in diagnosing and categorizing patients with tremor, especially, patients with mild symptom or the early stage of a disease, for proper treatment.

• Journal of Digital Convergence
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• v.14 no.6
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• pp.167-175
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• 2016

This study analyzed empirically the same data through SPSS statistic(regression analysis) and AMOS program(structural equation model) used for cause and effect analysis. The result of empirical analysis was as follows. The different outcome of coefficients and p-values were deducted. Especially, in the mediated effect testing, meanwhile, SPSS statistic(regression analysis) pictured mediated effect, AMOS program(structural equation model) did not picture mediated effect on the reject zone of null hypothesis(absolute t-value and C.R.-value were nearby 1.96). Eventually, this study showed that what program used determined the outcomes of coefficients and p-values(In particular, the outcomes were differentiated further in the increasing measurement error) though using the same data.

• Journal of Gifted/Talented Education
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• v.26 no.4
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• pp.587-609
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• 2016

The purpose of this study is to analysis the cognitive frame of the expert on musically talented in the Pop music audition program. Consequently, this article found that each expert has difference priority. Myself(PA), voice(YA), tune(YO) are used frequently. In comparison with standard frame, all experts refer to creative area in priority. But, they lack in motive area. Also, there are areas which don't treat in standard frame. And to conclude, pop music audition program has creative and personal characteristic. If not, it doesn't give prominence to differentiated messages and last in the global market. Based on the result of this study, this paper suggests the following: Firstly, it needs devices that support areas which fall short of selection. Secondly, it requires new frame which modifies the details of standard frame.

• Journal of Animal Reproduction and Biotechnology
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• v.36 no.4
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• pp.270-284
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• 2021

The vomeronasal organ (VNO) is critical for reproduction and social behavior in ruminants, including cattle. The present study examined the structure of the VNO and its epithelial cells in neonatal and adult Korean native cattle (Hanwoo), Bos taurus coreanae, using immunohistochemistry and lectin histochemistry. Histologically, the VNO comprised two types of epithelia: medial vomeronasal sensory (VSE) and lateral vomeronasal non-sensory epithelia (VNSE). Numerous blood vessels and nerve bundles were observed within the vomeronasal cartilage encased lamina propria. Immunohistochemistry revealed high expression level of protein gene product9.5 and moderate expression level of olfactory marker protein in the neuroreceptor cells of the VSE and occasionally in some ciliated cells of the VNSE in both neonates and adults. The properties of the glycoconjugates in the VNO were investigated using 21 lectins, most of which were expressed at varied intensities in the VSE and VNSE, as well as in the lamina propria. Several lectins exhibited variations in their intensities and localization between neonatal and adult VNOs. This study is the first descriptive lectin histochemical examination of the VNO of Korean native cattle with a focus on lectin histochemistry, confirming that the VNO of Korean native cattle is differentiated during postnatal development.

• Journal of Digital Convergence
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• v.20 no.5
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• pp.833-846
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• 2022

This study was conducted to identify nutrition knowledge, eating behaviors, and the need for an integrated program to improve eating behaviors according to residential type of female college students. Data were collected from March 16 to April 16, 2021, using online self-report questionnaires and the final 217 data were used. To analyze data, frequencies and percentages, means and standard deviations, independent sample t-test, and ANOVA were conducted using SPSS WIN 26.0. The results showed that home residents had better eating behaviors than those living in rented rooms. Moreover, the demand for an integrated eating behavior improvement program for disease and health information topic was higher among home residents and participants in rented rooms than among those living in dormitories. When developing an integrated program for improving eating behaviors among female college students, it is essential to apply a differentiated intervention program that considers residential type.