• 환경위생공학
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• 제6권2호
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• pp.17-31
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• 1991

The effects of environmental agents on health are great concern for all. It was recognized that each human has differential susceptibility to environmental effects. Susceptibility are changed by many factors includin gdevelopmpntal processes, genetic factors, nutritional stratus, preexisting disease conditions, life style and personal habits. Of all factors nutritional factors seem to be the area most modifiable. Consequently, It is an area that must be more thoroughly evaluated. In this paper, nutrient and environment interactions are reviewed briefly with published literatures. This paper deals with the influence of micronutrients(energy, protein and fat), Vitamins (vitamin 4, vitamin B-complex, vitamin C, vitamin D and vitamin I) and Minerals(calcium, iron, selenium, zinc and other minerls) on environmental effects. The role of arch nutrient was assessed in modifyine the expression of environmental pollutant toxicity with available litertures. In each nutrient section, the effect of environment was considered in following agents : heavy metals(lead, cadmium, mercury, silver and etc), inorganic agents(nitwits, sulfite, fluoride and etc), organic agents(benzene, carbon tatra-chloride, aflatoxin, auto dye, dialbrin etc), Irritant gas(ozone, carbon monooxide and etc), physical agents(X-irradiation, ultra violet, temperature and noise) and insectcides. The extent to which nutritional status modifies environmental effects 3nd its converse, how envirollments affects nutritional status is very complex. In deed, at the present time there are more than 50 chelnical/phycical agents that affect the nutrient metabolism and/or have their toxicity either directly diminished or enhanced by nutrients of those agents, small number of agents for each nutrients have sufficient evidence to warrant any reasonable degree of confidence in their hypothesized associtation. With these information at this present time it is hard to conclude that the recommended dietary allowance for each nutrient should be reconsidered.

• BMB Reports
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• 제46권10호
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• pp.501-506
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• 2013

Oligodendrocyte precursor cells (OPCs) are most susceptible to oxidative stress in the brain. However, the cause of differences in susceptibility to oxidative stress between OPCs and mature oligodendrocytes (mOLs) remains unclear. Recently, we identified in vivo that ${\alpha}B$-crystallin (aBC) is expressed in mOLs but not in OPCs. Therefore, we examined in the present study whether aBC expression could affect cell survival under oxidative stress induced by hydrogen peroxide using primary cultures of OPCs and mOLs from neonatal rat brains. Expression of aBC was greater in mOLs than in OPCs, and the survival rate of mOLs was significantly higher than that of OPCs under oxidative stress. Suppression of aBC by siRNA transfection resulted in a decrease in the survival rate of mOLs under oxidative stress. These data suggest that higher susceptibility of OPCs than mOLs to oxidative stress is due, at least in part, to low levels of aBC expression.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2923-2928
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• 2015

Background: Gallbladder carcinoma (GBC) has been stated as an Indian disease, with the highest number of cases being reported from certain districts of northeast India, which has an ethnically distinct population. Unfortunately there are no scientific reports on the underlying molecular mechanisms associated with the pathogenesis of the disease from this region. Aim: The present study evaluated the role of differential expression of human telomerase reverse transcriptase (hTERT) in the development of gall bladder anomalies. Materials and Methods: Blood and tissue samples were collected from patients undergoing routine surgical resection for clinically proven cases of gallbladder disease {cholelithiasis (CL, n=50), cholecystitis (CS, n=40) and GBC (n=30) along with adjacent histopathologically proved non-neoplastic controls (n=15)} with informed consent. Whole blood was also collected from age and sex matched healthy controls (n=25) for comparative analysis. Differential hTERT mRNA expression was evaluated by semi-quantitative rt-PCR and real-time PCR based analysis using ${\beta}$-actin as an internal control. Evaluation of differential hTERT protein expression was studied by Western blot analysis and immunoflourescence. Statistical analysis for differential expression and co-relation was performed by SPSSv13.0 software. Results: Gallbladder anomalies were mostly prevalent in females. The hTERT mRNA and protein expression increased gradiently from normal

• 한국지반환경공학회 논문집
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• 제13권12호
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• pp.5-16
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• 2012

우리나라는 세종과학기지에 이어 두 번째로 남극에 과학기지를 건설하는 사업을 진행하고 있다. 남극은 영구동토지역으로 분류되지만 일부 지반의 상부에는 활동층이 존재한다. 이 활동층이 동결되면 동결팽창으로 인해 지반의 융기가 발생하고 구조물에 부가적인 응력이 유발되어 구조물 안정에 심각한 영향을 미치게 된다. 그러므로 남극 기지 건설지에 대한 동상 특성을 파악하는 것은 구조물의 수명 및 안정성을 확보하기 위해 필수적이라고 할 수 있다. 본 연구의 목적은 남극 제2기지 건설지에 대한 동상민감성을 정량적으로 평가하고 흙 입자의 크기와 부동수분량이 동상에 미치는 영향을 파악하는 것이다. 이를 위해 동남극 테라노바만 주변 기지 건설지 표층에서 채취한 흙 시료에 대해 기본물성실험과 부동수분실험, 동상실험을 수행하였다. 동상실험의 경우 공시체 상부에 냉기를 주입하고 하부에는 물을 지속적으로 공급하여 동상이 발생하도록 유도하였다. 동상실험으로부터 공시체의 동상량과 동상비, 동상속도를 도출하였고, 실험 결과가 흙 입자의 크기 및 부동수분량과 어떤 상관관계가 있는지 분석하였다. 분석 결과 채취한 시료의 미세분 함량이 일정비율을 넘으면 흙 시료의 동상이 크게 발생하였고, 동결토 내의 부동수분에 따라 동상정수는 영향을 받는 것으로 나타났다. 본 연구는 동남극 테라노바만 흙 시료에 대하여, 동결토의 동상에 중요한 영향인자인 흙 입자의 크기 및 부동수분량과 동상량 사이의 관계를 실험적으로 규명하였다는 데에 그 의의가 있다.

• The Korean Journal of Pain
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• 제2권2호
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• pp.189-193
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• 1989

The analgesic effects of epidural morphine were evaluated on various types of cancer-related pain in forty-eight adult patients. Epidural morphine injections were given via an epidural catheter introduced to an epidural level corresponding to the pain area. Pain relief was classified as excellent, fair, or poor by subjective scoring and by the subsequent need for systemic analgesics. Thirty-two patients of all the patients became pain-free. In sixteen patients, pain relief was complete only for one or two of various types of pain with a certain dose of epidural morphine, The best result was obtained when the pain was continuous and originated from deep somatic structures. Based on the results, the ranking order of different types of cancer pain with regard to their susceptibility to epidural morphine was as follows: 1) Continuous somatic pain 2) Continuous visceral pain 3) Intermittent somatic pain 4) Intermittent visceral pain The differential effects of epidural morphine on cancer-related pain may suggest that various types of noxious stimuli involve different kinds of opioid receptors which differ in affinity to morphine, and that there are some pain-mediating systems which function independently of opioid mechanisms.

• 헤리티지:역사와 과학
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• 제45권3호
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• pp.160-173
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• 2012

본 연구는 동대문운동장에서 출토된 조선시대 기와의 선후관계, 유물제작기법 및 기술적 속성을 파악하기 위하여 기와의 물리적 화학적 특성 연구를 실시하였다. 기와의 물리적 특성 연구를 위해 흡수율, 비중, 전암대자율, 시차열분석을 실시하였으며, 화학적 특성 연구를 위해 중성자 방사화분석(NAA), 미세조직관찰, X-선 회절분석(XRD) 등을 실시하였다. 기와편 22점의 중성자방사화분석 및 통계분석결과 각각 기와시료는 다른 시대에 서로 다른 제작지에서 생산된 것으로 뚜렷하게 구분되었다. 또한 희토류원소의 출토지별 평균값을 비교해 보아도 각각 서로 다른 조성의 차이를 보이는데 이는 산지가 다른 점토광물을 이용하여 제작하였다는 것을 의미한다. XRD 및 편광현미경 관찰결과 기와의 주요 성분은 석영과 장석이었으며 부분적으로 운모와 일라이트(Illite)가 나타났다. XRD 분석결과 $1000^{\circ}C$의 부근에서 소성되었을 때 나타나는 뮬라이트(mullite)광물 조성이 나타났으며, 시차열분석에서는 $900^{\circ}C$ 부근에서 완만한 발열피크가 나타났다. 이를 토대로 기와의 소성온도를 추정한 결과, 기와는 $900{\sim}1000^{\circ}C$에서 소성이 이루어진 것으로 보인다. 전암대자율 평균값으로 비교분석하였을 때 출토지별 분류는 나타나지 않았지만 문양이 파상문, 태상문, 어골문, 격자문, 횡선문인 경우 0.2~0.78(${\times}103$ SI unit)의 낮은 전암 대자율이 나타나는 특징이 있다. 전체 흡수율은 대체적으로 14%~21% 범위를 보였으며 이는 조선시대 전통기와에서 나타나는 흡수율 14~18%와 유사한 범위를 보이고 있다. 기와시료의 비중은 대체적으로 1.4~2.5g/cm3의 범위를 보여 출토지에 따른 비중 차이가 나타나지 않았다.

• The Plant Pathology Journal
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• 제18권4호
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• pp.210-215
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• 2002

Four field experiments were carried out from 1998 to 1999 and from 1999 to 2000 growing seasons of potato to investigate the relationship between leafminers and Alternaria alternata. The experiments established differential susceptibility among potato varieties to alternaria leaf necrosis, relationship between leafminer infestation and the level of necrosis, use of insecticides to reduce leafminer and leaf necrosis damages, and use of polyester fleece to eliminate leafminer and eventually reduce leaf necrosis. Results of the study indicate that control of leafminer is of primary importance because this will automatically lead to control of the damage caused by A. alternata.

• Asian-Australasian Journal of Animal Sciences
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• 제1권1호
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• pp.13-19
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• 1988

Effect of vitamin E and selenium supplementation on immunity was studied in newborn Jersey and buffalo calves. The supplement contained 500 mg vitamin E and $200\;{\mu}g$ selenium; and was fed daily from birth to day 30. Differences in weight gain, total leucocytic count, differential leucocytic count, antibody titre and susceptibility to disease were found to be nonsignificant between supplemented and control calves during the study period of 3 months. Vitamin E seemed to enhance the recovery from disease in buffalo calves. Buffalo calves were found to be more sensitive to selenium toxicity than Jersey calves.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 춘계 학술논문 발표대회 1부
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• pp.131-132
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• 2011

This study analyzes the yearly-best delivered size range of truck mixer based on the specified mix, Water to Binder Ratio, aggregate proportion and unit amount with statistical method targeting on Kyeongi and Kyeongsang province and compares with the similar materials of Japan to propose as a basic standard for the quality control of mixer truck. As a result, in case of the Water to Binder Ratio of these areas, it is higher than Japan's due to the excessive safety rate reflecting the changes of differential value impact and unit amount, and the unit amount's standard deviation is very large by reflecting the changes of the amount used and chemical admixture susceptibility. In case of aggregate proportion, the frequency rate is about 50%, which is very similar value with Japan's one.

• Archives of Pharmacal Research
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• 제5권2호
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• pp.87-91
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• 1982

In order to develop an analytical method for amikacin and butirosin in presence of their parent antibiotics, kanamycin A and ribostamycin, high-performance liquid chromatographic technique and microbioassay method were evaluated and compared. Using high performance liquid chromatography, two acylated antibiotics, amikacin and butirosin was partially separated from their parent antibiotics, to provide a qualitative analytical method. In microbioassay using Pseudomonas aeruginosa TI-13, a producer of aminoglycoside-3-phosphotransferase I, only acylated antibiotics were selectively analyzed when paper disc-susceptibility assay was used. The standard curve showed a good correlation between the response and odse in semilogarithmic plat with correlation coefficients above 0.96, and analytical deviation from expected dose was within 10%.