• 한국정보통신학회논문지
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• 제21권8호
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• pp.1619-1625
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• 2017

민간에 상용화된 GNSS (Global Navigation Satellite System) 시스템은 정밀 PNT 서비스가 요구되는 분야에 적용하기 위한 요구 성능을 충족시키지 못한다. 따라서 일반적으로 위치 정밀도와 무결성 등을 향상시키기 위한 보정 시스템들이 다양하게 이용되고 있다. MSAS는 일본의 SBAS형 보정시스템이다. 본 논문에서는 일본의 MSAS 시스템이 한반도 영역에서 어떤 특성을 보이는지 분석하였다. 먼저, 시뮬레이션과 실험을 바탕으로 DGNSS 항법신호 및 항법파라미터 분석에 목적을 두고 수행하였다. 분석결과, MSAS 지상감시국과 한반도 남해안 수신점에서 3차원 위치 결정에 필요한 충분한 수의 항법위성이 동시에 관측되었으며, 수신점에서 MSAS 위성의 신호가 안정적으로 유지됨을 확인하였다. 또한 MSAS 3차원 위치 정밀도는 2m (2drms) 수준으로 세계적으로 사용되고 있는 범용의 DGNSS 수준과 유사함을 확인하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.1988-1989
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• 2007

Polyethylene is widely used as the insulator for power cable. To investigate the conduction mechanism for power cable insulation under ac high field, it is very important to acquire the dissipation current under actual running field. Recently, we have developed the unique system, which make possible to observe the nonlinear dissipation current waveform. In this system, to observe the nonlinear properties with high accuracy, capacitive current component is canceled by using inverse capacitive current signal instead of using the bridge circuit for canceling it. We have already reported that the dissipation currents of $40\;{\mu}m$ thick LDPE film at 10 kV/mm and over 140 Hz, it starts to show nonlinearity and odd number's harmonics were getting large. To investigate the conduction mechanis ms in this region, especially space charge effect, various kinds of estimation, such as time variations of instantaneous resistivity for one cycle, FFT spectra of dissipation current waveforms and so on, has been examined. As the results of these estimations, it was found that the dissipation current will depend on not only the instantaneous value of electric field but also the time differential of applied electric field due to taking a balance between applied field and internal field. Furthermore, two large peaks of dissipation current for each half cycle were observed under certain condition. In this paper, to clarify the reason why it shows two peaks for each half cycle, the film thickness dependences of dissipation current waveforms were observed by using the three different thickness LDPE films.

• 대한관절경학회지
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• 제13권3호
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• pp.276-279
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• 2009

건초 섬유종은 수부나 상지에서 발생하는 양성 연부조직 종양으로 관절내에서 발생하는 경우는 아주 드물다. 대부분 천천히 자라는 섬유성 결절 조직으로 조직학적으로는 산재한 섬유모세포및 치밀한 기질과 미세 혈관세포들로 구성된다. 저자들은 54세 남자환자의 관절와 상완 관절 후상방 관절막에서 기시한 건초 섬유종을 경험하였다. 자기 공명 영상에서 저 강도 신호의 결절성 종물로 관찰되었으며 관절경하에서 절제하여 조직검사로 확진하였다. 관절내 건초 섬유종은 견관절 관절경 시술시 관절 내에서 관찰될 수 있는 종양의 하나로 감별해야 할 것으로 사료된다. 있는 술식으로 전방십자인대 수술시 좋은 치료 선택의 하나로 사료된다.

• Archives of Pharmacal Research
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• 제22권3호
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• pp.243-248
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• 1999

Sialic acids are key determinants for biological processes, such as cell-cell interaction and differentiation. Sialyltransferases contribute to the diversity in carbohydrate structure through their attachment of sialic acid in various terminal positions on glycolipid and glycoprotein (N-linked and O-linked) carbohydrate groups. Gal$\beta$ 1,3(4)GlcNAc $\alpha$2,3-sialyltransferase (ST3Gal III) is involved in the biosynthesis of $sLe^{X}$ and sLe^{a}$ known as selection ligands and tumor-associated carbohydrate structures. The appearance and differential distribution of ST3Gal III mRNA during mice embryogenesis [embryonic (E) days; E9, E11, E13, E15] were investigated by in situ hybridization with digoxigenin-labeled RNA probes coupled with alkaline phosphatase detection. On E9, all tissues were positive for ST3Gal III mRNA expression whereas ST3Gal III mRNA on E11 was not detected throughout all tissues. On E13, ST3GAl III mRNA was expressed in different manner in various tissues. In this stage, ST3Gal III mRNA was positive only in the liver, pancreas and bladder. On E15, specific signal for ST3GAl III was detected in the liver, lung and forebrain. These results indicate that ST3Gal III is differently expressed at developmental stages of mice embryo, and this may be importantly related with regulation of organogenesis in mice.

• Clinical and Experimental Pediatrics
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• 제64권7호
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• pp.355-363
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• 2021

Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose: This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes. Methods: Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n=4; steroid-resistant nephrotic syndrome [SRNS], n=2; and healthy adult individuals [control], n=2) were generated using microarray analysis. Results: Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 up-regulated, 47 down-regulated) in SSNS and 139 genes (78 up-regulated, 61 down-regulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS). Pathway analysis of the significant (P≤0.05, -1≤ log2 FC ≥1) differentially expressed genes identified the transforming growth factor-β and Janus kinase-signal transducer and activator of transcription pathways to be involved in both SSNS and SRNS. DGE analysis of SSNS versus SRNS identified 2,350 genes with values of P≤0.05, and a heatmap of corresponding expression values of these genes in each subject showed clear differences in SSNS and SRNS. Conclusion: Our study observations indicate that, although podocyte injury follows similar pathways in different clinical subgroups, the pathways are modulated differently as evidenced by the heatmap. Such transcriptome profiling with a larger cohort can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.

• 해양환경안전학회지
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• 제27권2호
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• pp.402-408
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• 2021

위성신호 반사계측(GNSS-Reflectometry) 기술은 위성으로부터 전송되는 신호의 지표면 혹은 해수면에 반사되는 신호를 측정하여 분석하는 기법으로서, 해수면 높이측정, 태풍 및 기상이변, 그리고 토양의 수분 및 적설량 측정 등에 활용되고 있다. 본 논문에서는 GNSS-R 기술의 해양 활용확대와 그 가능성을 살펴보기 위하여, 위성신호의 신호대잡음비를 이용하는 GNSS-R 기술의 개념과 측정원리에 대해 설명하고, 국제적인 활용 사례를 조사하여 제시하였다. 특히 GNSS-R 기술을 기존 DGNSS 기준국 및 상시관측소 인프라를 이용하여 해양안전 및 환경 모니터링에 활용 가능할 뿐만 아니라, 지상 및 해양기준국, 위성기반, 해상선박 탑재 측면에서의 해양 응용 가능분야를 조사하여 제안하였다.

• Imaging Science in Dentistry
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• 제51권2호
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• pp.149-154
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• 2021

Purpose: This study aimed to investigate the computed tomography and magnetic resonance imaging features of giant cell tumors in the temporomandibular joint region to facilitate accurate diagnoses. Materials and Methods: From October 2007 to June 2020, 6 patients (2 men and 4 women) at Yonsei University Dental Hospital had histopathologically proven giant cell tumors in the temporomandibular joint. Their computed tomography and magnetic resonance imaging findings were reviewed retrospectively, and the cases were classified into 3 types based on the tumor center and growth pattern observed on the radiologic findings. Results: The age of the 6 patients ranged from 25 to 53 years. Trismus was found in 5 of the 6 cases. One case recurred. The mean size of the tumors, defined based on their greatest diameter, was 32 mm (range, 15-41 mm). The characteristic features of all cases were a heterogeneously-enhancing tumorous mass with a lobulated margin on computed tomographic images and internal multiplicity of signal intensity on T2-weighted magnetic resonance images. According to the site of origin, 3 tumors were bone-centered, 2 were soft tissue-centered, and 1 was peri-articular. Conclusion: Computed tomography and magnetic resonance imaging yielded a tripartite classification of giant cell tumors of the temporomandibular joint according to their location on imaging. This study could help clinicians in the differential diagnosis of giant cell tumors and assist in proper treatment planning for tumorous diseases of the temporomandibular joint.

• 전기전자학회논문지
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• 제25권2호
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• pp.302-308
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• 2021

본 논문에서는 영상 처리용 12-비트의 10-MS/s 파이프라인 아날로그-디지털 변환기(ADC: analog-to-digital converter)가 제안된다. 제안된 ADC는 샘플-홀드 증폭기, 3개의 stage, 3-비트 플래시 ADC, 그리고 digital error corrector로 구성된다. 각 stage는 4-비트 flash ADC와 multiplying digital-to-analog ADC로 구성된다. 고해상도의 ADC를 위해 제안된 샘플-홀드 증폭기는 gain boosting을 이용하여 전압 이득을 증가시킨다. 제안된 파이프라인 ADC는 1.8V 공급전압을 사용하는 180nm CMOS 공정에서 설계되었고 차동 1V 전압을 가지는 1MHz 사인파 아날로그 입력신호에 대해 10.52-비트의 유효 비트를 가진다. 또한, 약 5MHz의 나이퀴스트 사인파 입력에 대해 측정된 유효비트는 10.12 비트이다.

• Ocean and Polar Research
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• 제44권3호
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• pp.209-220
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• 2022

Carbonic anhydrase (CA) is a key controller of the carbon concentrating mechanism (CCM), and is known to be affected by ambient pH and CO₂ compositions. Herein, we characterized three novel CAs genes (PmCA1, 2, and 3) from the marine dinoflagellate Prorocentrum minimum, and evaluated the relative expressions of the PmCAs and photosynthetic genes PmatpB and PmrbcL under different pH conditions. Each PmCA was predicted to have amino acid residues constituting the zinc binding site. With signal peptide, PmCA1 and PmCA2 were predicted to be intracellular CAs located in the cytoplasm and chloroplast membrane, respectively. On the other hand, PmCA3 was predicted to be extracellular CA located in the plasma membrane. Also, PmCA1 was classified into the beta family, and PmCA2 and PmCA3 were classified into the alpha family via phylogenic analysis. The photosynthesis efficiency of P. minimum was similar at pH 7 to 9, and decreased significantly at pH 6 and pH 10. Overall, relative gene expression levels of the three PmCAs decreased at low pH, and increased as pH increased. Photosynthesis related genes, PmatpB and PmrbcL, showed similar expression patterns to those of PmCAs. These results suggest that changes in seawater pH may affect photosynthesis and CO₂ metabolism in marine dinoflagellates.

• Journal of Forest and Environmental Science
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• 제26권2호
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• pp.83-94
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• 2010

Chinese fir (Latin name: Cunninghaimia lanceolata) is one of the major commercial coniferous trees. Most of Chinese fir forests are managed in successive rotation sites, which lead productivity to decline. Autotoxicity is the important reason for soil degradation of Chinese fir plantation, especially, phenolic acids are considered as the major allelopathic toxins which induce autotoxicity in Chinese fir rotation stands. We performed here proteomic approach to investigate the response of proteins in Chinese fir leaves to salicylic acid. The tube plantlets of Chinese fir clone were treated with 120 mg/L salicylic acid for 1, 3 and 5th day. 2-DE, coupled with MALDI-TOF-TOF/MS, was used to separate and identify the responsive proteins. We found 12, 7, and 12 candidate protein spots that were up- or down-regulated by at least 2.5 fold after 1, 3, and 5th day of the stress, respectively. Of these protein spots, 16 spots were identified successfully. According to the putative physiological functions, these proteins were categorized into five classes (1) the proteins involved in protein stability and folding, including 26S proteome, Grp78, Hsp70, Hsp90 and PPIase; (2) the protein involved in photosynthesis and respiration, including OEC 33 kDa subunit, GAPDH; (3) the protein related to cell endurance to acid, F-ATPase; (4) the protein related to cytoskeleton, tubulin; (5) the protein related to protein translation: prolyl-tRNA synthetase. These results give new insights into autotoxic substance stress response in Chinese fir leaves and provide preliminary footprints for further studies on the molecular signal mechanisms induced by the stress.