• 센서학회지
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• 제22권2호
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• pp.136-143
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• 2013

In the study, novel blood pressure estimation method was proposed to improve the accuracy of oscillometric method. The proposed algorithm estimated the blood pressure by comparing and analyzing the point variation aspect of dicrotic notch on pulsating waveform during each cardiac cycle. The waveforms of each cardiac cycle were extracted by maximum points. The extracted pulsating waveforms were applied by re-sampling, end-matching, and normalization. The systolic and diastolic blood pressures were estimated by point variation aspect of dicrotic notch. The blood pressures, which were estimated from proposed algorithm, were compared and analyzed by blood pressures from oscillometric methods and auscultation. The systolic blood pressure from oscillometric methods were +0.88 mmHg more than proposed algorithm, and 1.875 less than the diastolic blood pressures from proposed algorithm. The systolic and diastolic blood pressures from auscultation were 2.89 mmHg and 3.44 mmHg less than the blood pressures from proposed algorithm. As the errors between blood pressures from proposed algorithm, oscillometric method and auscultation were less than 5 mmHg, the proposed algorithm was effective.

• Journal of Biosystems Engineering
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• 제33권6호
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• pp.438-445
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• 2008

The purpose of this study was to develop a measurement model based on PLS (Partial least square) method for blood pressures. Measurement system for blood pressure signals consisted of pressure sensor, va interface and embedded module. A mercury sphygmomanometer was connected with the measurement system through 3-way stopcock and used as reference of blood pressures. The blood pressure signals of 20 subjects were measured and tests were repeated 5 times per each subject. Total of 100 data were divided into a calibration set and a prediction set. The PLS models were developed to determine the systolic and the diastolic blood pressures. The PLS models were evaluated by the standard methods of the British Hypertension Society (BHS) protocol and the American Association for the Advancement of Medical Instrumentation (AAMI). The results of the PLS models were compared with those of MAA (maximum amplitude algorithm). The measured blood pressures with PLS method were highly correlated to those with a mercury sphygmomanometer in the systolic ($R^2=0.85$) and the diastolic blood pressure ($R^2=0.84$). The results showed that the PLS models were the effective tools for blood pressure measurements with high accuracy, and satisfied the standards of the BHS protocol and the AAMI.

• 대한지역사회영양학회지
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• 제10권5호
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• pp.633-644
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• 2005

The body mass index, blood pressures and blood profiles of adults, who worked at three colleges in the Daejeon area, were evaluated for use in developing well-balanced menus at their workplace cafeterias and/or in creating nutrition education programs tailored to their health statuses. The data analyzed were from physical examinations performed in 2002 and in 2004 by the National Health Insurance Corporation. Overall, levels of systolic and diastolic blood pressure and serum cholesterol were lower in the 2004 samples than in those of 2002, but most samples in 2004 showed higher levels of SGOT. In 2002, statistical differences occured in the levels of blood pressure and serum cholesterol among age groups, but not in 2004. And in 2004, the older the age group, the higher the BMI. Among subjects in their twenties, three variables (systolic and diastolic blood pressure, and serum cholesterol) showed statistical differences; this increased to four variables (systolic and diastolic blood pressure, blood glucose and serum cholesterol) among subjects in their thirties and to six variables (Hb, SGOT, systolic and diastolic blood pressure, blood glucose and serum cholesterol) among those in their forties, followed by a decline to four variables (systolic and diastolic blood pressure, Hb and serum cholesterol) among subjects in their fifties. In general, the results of physical examinations showed improvements in blood pressure and blood profiles in 2004 in comparison with results in 2002. The level of SGOT was the exception. Despite these improvements, of those employees who had physical examinations in 2004, $5.2\%$ had high blood glucose and $18.1\%$ hypertension, $27.9\%$ hypercholesterolemia, $8.3\%$ registered abnormal liver functions, and $31.3\%$ were classified as overweight and obese. Moreover, because some vulnerable blood profiles were found in the older age groups, various programs, including nutrition education, and/or development of healthful diets as well as excercise activities, may be needed within their workplaces.

• 한국식품영양학회지
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• 제30권2호
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• pp.257-268
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• 2017

The purpose of this research was to evaluate the correlation between obesity, threshold of salty taste, optimal saltiness and blood pressure in middle school students in a fishing village. The subjects were 115 boys and 103 girls in middle school in a fishing village. The BMI index and systolic and diastolic blood pressures of subjects were measured, and the subjects were divided into a normal and obese group according to their BMI. The threshold of salty taste and salt preference for a semisolid dish (steamed egg dish), liquid dish (bean sprout soup), and a solid dish (raw radish salad), were estimated by sensory evaluation. Calorie intake was measured using the weighing plate method. The boys in the obese group showed significantly higher systolic and diastolic blood pressures than those in the normal, but girls did not. Furthermore, calorie intakes of the boys in the obese group were significantly higher than those in the normal group, but this was not shown in girls. On the threshold of salty taste, both boys and girls in the obese group needed higher concentration of salt than those in the normal group. The threshold of salty taste were significantly positively correlated with systolic pressure and diastolic pressure in boys. Regarding the salt preference in the steamed egg dish, bean-sprout soup, and raw radish salad, both boys and girls in the obese group preferred higher concentrations. The higher concentration they preferred, the higher the systolic and diastolic pressures were in boys, but only systolic blood pressure was higher in girls. From these results, it is evident that a nutritional education program is needed in school to help restricting middle school students salt consumption and decreasing obesity to prevent hypertension.

• 대한의용생체공학회:의공학회지
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• 제30권6호
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• pp.510-515
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• 2009

In this paper, variable characteristic ratio algorithm based on oscillometric method is proposed to enhance the accuracy of blood pressure measurement. We combined the slope-based approach and fuzzy inference technique to change the characteristic ratios of height-based method. The proposed algorithm was assessed on 255 measurements from 85 subjects and compared with the conventional height-based algorithm. The testing results showed that the developed algorithm achieved an overall grade A for both systolic and diastolic blood pressures according to the BHS protocol. And, mean standard deviation between the observers and the developed algorithm were 5.71mmHg and 6.29mmHg for systolic and diastolic pressures respectively, which also fulfilled the AAMI criteria. In conclusion, this algorithm was successfully developed and recommended for further clinical trials with the wider adult population.

• Journal of Community Nutrition
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• 제8권2호
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• pp.63-68
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• 2006

This research analyzed the hematological index and health related habits such as alcohol drinking, smoking and exercise, by classifying 539 middle-aged men (age: 40 - 59) into a normal weight group, an overweight group and an obese group, according to BMI (body mass index). As a result, 33.6% (n = 181) of subjects had a BMI of 23 or less and 30.2% (n = 163) were overweight and 36.2% (n = 195) were obese (BMI > 25). The average systolic/diastolic blood pressures of total subjects were 130.96mmHg and 80.38mmHg, respectively. And the average pressure of normal subjects was 126.85/77.57mmHg, which was significantly lower than in overweight and obese subjects. Diastolic blood pressure shows significant differences among the three groups. The overall average cholesterol level of normal subjects was 193.81mg/dl, which was significantly lower than those in overweight subjects. Those in obese subjects were significantly higher than in overweight subjects. The GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyrutic transaminase), ${\gamma}$-GTP (gamma-glutamyl transpeptidase) levels of obese subjects were significantly higher than in the overweight subjects. Frequency of alcohol drinking showed no significant difference among the groups. The smoking ratio in the obese group was higher than in the normal and overweight groups. The ratio of smokers was 53.1 %, and the alcohol drinking ratio was 81.0% of the total subjects. The frequency of drinking showed significant correlations with systolic blood pressure (p < 0.05) and diastolic blood pressures (p < 0.01) and ${\gamma}$-GTP (p < 0.01). The duration of smoking showed a negative correlation (p < 0.01) with diastolic blood pressure, total cholesterol and ${\gamma}$-GTP. On the other hand, exercising frequency showed negative correlations with blood glucose, ${\gamma}$-GTP and GPT(p < 0.01). These hematological indices were correlated with health related habits such as alcohol drinking, smoking and lack of exercise, and to be the cause of chronic diseases. Therefore, proper nutritional education is needed to establish advisable health related habits to maintain proper body weight. (J Community Nutrition 8(2): 63-68, 2006)

• 대한임상검사과학회지
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• 제52권1호
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• pp.45-52
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• 2020

고혈압은 종종 심혈관 질환 및 신장 질환으로 이어지며 전 세계적으로 중요한 문제이다. 유전적으로 많은 단일 염기 다형성이 고혈압과 관련이 있다. 많은 GWAS 연구에서 ATP2B1 유전자가 혈압과 연관성이 높다는 것을 발견했다. 본 연구에서는 한국인 994명을 대상으로 수축기 혈압, 이완기 혈압과 ATP2B1 유전자의 SNP와 연관성을 분석하였다. 또한, BMI수치에 따라 하위그룹으로 계층화하여 차이가 있는지 확인하고자 하였다. 다중선형회귀분석에서 수축기 혈압 및 이완기 혈압과 가장 높은 통계적 유의성을 보인 SNP를 선정하였다. 수축기 혈압과 이완기 혈압에서의 one-way analysis of variance를 시행하였고, 고혈압 발생 위험에 대한 다중로지스틱회귀분석을 시행하였다. 다중로지스틱회귀분석은 연령 기준으로 구분하여 시행하였으며, 연령, BMI, 공복 시 혈당을 통제한 방법에서 비교하였다. 수축기 혈압에서는 4개의 SNP (rs10506974, rs7136259, rs17249754, rs17836882)가, 이완기 혈압에서는 6개의 SNP(rs10506974, rs10777237, rs7136259, rs17249754, rs1371075, rs10506983)가 유의하게 관련성을 보였다. 추가적으로, 유전자형(genotype)에 따른 분석에서는 남성에게서 고혈압 위험에 대한 유의한 odd ratio 값을 보였다. 본 연구는 ATP2B1 다형성이 수축기 혈압과 이완기 혈압에 영향을 미치는 것을 제안한다.

• Food Science and Biotechnology
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• 제17권1호
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• pp.156-160
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• 2008

This study was conducted to evaluate the hypotensive properties of the extract of Chinese balloon flower (Platycodon grandiflorum)'s root. In the studies for calcium channel-blocking using Xenopus oocytes, the ethanol-extract ($26.2{\pm}5.2%$) showed higher activity than water-extract. Twenty female rats were fed 25, 35, and 45 mg/kg BW/day of the ethanol-extract for 14 days to observe the changes in blood pressures and heart pulses. Ethanol-extract decreased the systolic, diastolic, and mean blood pressures of the rats. Especially, the rats fed with 45 mg/kg BW/day of the ethanol-extract showed significant decreases in the blood pressures. These results suggested that a decrease in blood pressures was due to the extension of a blood vessel with calcium channel-blocking by ethanol-extract of Chinese balloon flower. Forty %-ethanol showed the highest efficiency for ethanol-extraction of Chinese balloon flower.

• Journal of Preventive Medicine and Public Health
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• 제21권1호
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• pp.99-112
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• 1988

1개 의과대학 본과 제 1,2,3학년 279명을 대상으로 1987년 3월중순부터 4월초순에 걸쳐 프레밍헴 A형행동양상척도(FTA)의 신뢰도와 타당도 그리고 사회심리학적인 변수와 혈압과의 관계를 조사해서 다음의 결과를 얻었다. SCL-90-R과 FTA의 신뢰도는 $0.57{\sim}0.91$의 범위였고 FTA의 요인분석에서 정열적경쟁요인(hard-driving competitiveness factor)과 조급요인(impatience factor)이 추출되었다. FTA의 총점은 비교체중이 클수록, 농촌출신이면 높은 경향을 보였으나 유의성은 없었고 SCL90-R과는 우울, 불안, 적대감, 편집증, 정신증하위척도와 비교적 낮은 유의한 정상관관계를 보였다. 혈압과의 단일 변수 분석에서 수축기혈압은 남자에서 비교체중과 가족력이 유의했고 남녀 공히 경제상태에 따른 차이가 있었다. 확장기혈압은 남자에서 비교체중과 음주량이 유의했고 여자에서는 비교체중이 유의한 상관관계를 보였다. 비교 체중의 영향을 제거하고서는 남자에서 음주량이 확장기혈압과 경제상태가 수축기혈압과 유의한 관계를 보였다. 단계적추가분석법에 의한 중회귀분석 결과 남자에서는 수축기혈압에서 비교체중과 경제상태가 중요변수로 선정되었고 확장기혈압에서는 비교체중과 음주량이 선정되었다. Alpha가 0.1수준에서는 수축기혈압에 SCL-90-R의 우울증 하위척도가 추가 선정되었다. 여자에서 수축기혈압은 경제상태와 비교체중이 선정되었고 확장기혈압에서도 비교체중이 선정되었으나 대상자 수가 적어서 불안정했다. FTA와 혈압과는 남녀 공히 관련이 없었다.

• 대한간호학회지
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• 제30권2호
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• pp.282-292
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• 2000

A meta-analysis of 14 quasi-experimental studies was conducted to compare the effect of size on various relaxation therapies applied to patients and health volunteer students. These studies were selected from theses, dissertations and papers that have been done between 1982 to 1993. Also They have a randomized or nonequivalent control group in a pre test-post test design. The studies were evaluated in different ways; 1) types of relaxation therapy, 2) total amount of time of relaxation therapy, and 3) types of outcome variables. For a group of homogenious studies, the weighted mean effect size and standard error were estimated. Some findings are summarized as follows : 1. Jacobson relaxation therapy had a larger effect on systolic and diastolic blood pressures than on state anxiety. 2. For the total time of relaxation therapy, (longer than 60 minutes) had a much larger effect in decreasing systolic and diastolic blood pressures than in the case of a time period shorter than 60 minutes. 3. Relaxation therapy applied to surgery patients also had a larger effect in decreasing state anxiety than when applied to other patients.