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Calcium Channel-blocking Activity of Chinese Balloon Flower (Platycodon grandiflorum) for Producing Blood Pressure-lowering Functional Foods  

Kang, Yoon-Seok (Department of Bioscience and Biotechnology, Konkuk University)
Hong, Kwon-Pyo (Department of Bioscience and Biotechnology, Konkuk University)
Jung, Dong-Chae (Department of Bioscience and Biotechnology, Konkuk University)
Hong, Sung-Won (Department of Bioscience and Biotechnology, Konkuk University)
Lee, Jun-Ho (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University)
Nah, Seung-Yeal (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University)
Lim, Yoong-Ho (Department of Bioscience and Biotechnology, Konkuk University)
Bae, Dong-Ho (Department of Bioscience and Biotechnology, Konkuk University)
Publication Information
Food Science and Biotechnology / v.17, no.1, 2008 , pp. 156-160 More about this Journal
Abstract
This study was conducted to evaluate the hypotensive properties of the extract of Chinese balloon flower (Platycodon grandiflorum)'s root. In the studies for calcium channel-blocking using Xenopus oocytes, the ethanol-extract ($26.2{\pm}5.2%$) showed higher activity than water-extract. Twenty female rats were fed 25, 35, and 45 mg/kg BW/day of the ethanol-extract for 14 days to observe the changes in blood pressures and heart pulses. Ethanol-extract decreased the systolic, diastolic, and mean blood pressures of the rats. Especially, the rats fed with 45 mg/kg BW/day of the ethanol-extract showed significant decreases in the blood pressures. These results suggested that a decrease in blood pressures was due to the extension of a blood vessel with calcium channel-blocking by ethanol-extract of Chinese balloon flower. Forty %-ethanol showed the highest efficiency for ethanol-extraction of Chinese balloon flower.
Keywords
Chinese balloon flower; calcium channel-blocking; blood pressure; heart pulse; hypotensive property;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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