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Calcium Channel-blocking Activity of Chinese Balloon Flower (Platycodon grandiflorum) for Producing Blood Pressure-lowering Functional Foods  

Kang, Yoon-Seok (Department of Bioscience and Biotechnology, Konkuk University)
Hong, Kwon-Pyo (Department of Bioscience and Biotechnology, Konkuk University)
Jung, Dong-Chae (Department of Bioscience and Biotechnology, Konkuk University)
Hong, Sung-Won (Department of Bioscience and Biotechnology, Konkuk University)
Lee, Jun-Ho (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University)
Nah, Seung-Yeal (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University)
Lim, Yoong-Ho (Department of Bioscience and Biotechnology, Konkuk University)
Bae, Dong-Ho (Department of Bioscience and Biotechnology, Konkuk University)
Publication Information
Food Science and Biotechnology / v.17, no.1, 2008 , pp. 156-160 More about this Journal
Abstract
This study was conducted to evaluate the hypotensive properties of the extract of Chinese balloon flower (Platycodon grandiflorum)'s root. In the studies for calcium channel-blocking using Xenopus oocytes, the ethanol-extract ($26.2{\pm}5.2%$) showed higher activity than water-extract. Twenty female rats were fed 25, 35, and 45 mg/kg BW/day of the ethanol-extract for 14 days to observe the changes in blood pressures and heart pulses. Ethanol-extract decreased the systolic, diastolic, and mean blood pressures of the rats. Especially, the rats fed with 45 mg/kg BW/day of the ethanol-extract showed significant decreases in the blood pressures. These results suggested that a decrease in blood pressures was due to the extension of a blood vessel with calcium channel-blocking by ethanol-extract of Chinese balloon flower. Forty %-ethanol showed the highest efficiency for ethanol-extraction of Chinese balloon flower.
Keywords
Chinese balloon flower; calcium channel-blocking; blood pressure; heart pulse; hypotensive property;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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연도 인용수 순위
1 Godfraind T. Alternative mechanism for the potentiation of the relaxation evoked by isoprenaline in aortae from young and aged rats. Eur. J. Pharmacol. 53: 273-279 (1979)   DOI   ScienceOn
2 Reuter H, Beeler GW. Calcium current and activation of contraction in ventricular myocardial fibres. Science 162: 399-401 (1969)
3 Godfraind T. Actions of Nifedipine on calcium fluxes and contraction in isolated ratarteries. J. Pharmacol. Exp. Ther. 224: 443-450 (1983)
4 Liu F, Fung MC. Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides. Life Sci. 64: 39-48 (1999)
5 Hah J-S, Kang B-S, Kang D-H. Effect of Panax Ginseng alcohol extract on cardiovascular system. Yonsei Med. J. 19: 2-9 (1978)
6 Seog H-M, Jung C-H, Kim Y-S, Park S-H. Phenolic acids and antioxidant activities of wild ginseng (Panax ginseng C.A. Meyer) leaves. Food Sci. Biotechnol. 14: 371-374 (2005)
7 Lee Y-H, Kim Y-J, Kim H-I, Cho H-Y, Yoon G-H. Potent HAT inhibitory effect of aqueous extract from bellflower (Platycodon grandiflorum) roots on androgen receptor-mediated transcriptional regulation. Food Sci. Biotechnol. 16: 457-462 (2007)   과학기술학회마을
8 Sonkusare S, Palade PT, Marsh JD, Telemaque S, Pesic A, Rusch NJ. Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implications. Vasc. Pharmacol. 44: 131- 142 (2006)   DOI   ScienceOn
9 Jeong S-M, Lee J-H, Yoon I-S, Nah S-Y. Gene cloning, tissue distribution, and its characterization of $Ca^{++}$-activated $Cl^{-}$ channel activated by ginsenosides in Xenopus laevis oocytes. J. Ginseng Res. 29: 167-175 (2005)   과학기술학회마을   DOI
10 Kerekgyarto C, Virag L, Chihara G, Fachet J. Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan. Int. Immunopharmacol. 18: 347-353 (1996)   DOI   ScienceOn
11 Kanamasa K, Kimura A, Miyataka M. Incidence of cancer in postmyocardial infarction patients treated with short-acting nifedipine and diltiazem, secondary prevention group. Cancer 85: 1369-1374 (1996)   DOI   ScienceOn
12 Shimizu Y, Kataoka M, Seto H, Kido J, Nagata T. Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis. J. Periodontol. 73: 863-867 (2002)
13 Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: A metaanalysis in individual data for one million adults in 61 prospective studies. Prospective studies collaboration. Lancet 360: 1903-1913 (2002)   DOI   ScienceOn
14 Fatehi M, Rashidabady T, Zahra FH. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J. Ethnopharmacol. 84: 199-203 (2003)   DOI   ScienceOn
15 Mark SP, Woo M-N, Vuksan VM. Korean red ginseng lowers blood pressure in individuals with hypertension. Am. J. Hypertens. 17: 33- 38 (2004)
16 Lim D-Y, Kim B-C, Lee E-B. Comparison of vasodilator effect of Platycodin D and D3 in rats. Korean J. Physiol. Pharmacol. 7: 149- 155 (2003)
17 Godfraind T, Govoni S. Recent advances in the pharmacology of $Ca^{++}$ and $K^{+}$ channels. J. Pharmacol. Sci. 16: 1-4 (1995)
18 Godfraind T, Miller RC. Specificity of actions of Ca entry blockers, a comparision of their actions in rat arteries and in human coronary. Circ. Res. 43: 251-256 (1983)
19 Sung H-Y, Lim Y-J, Choi Y-S. Soy isoflavones do not alter the effects of fructooligosaccharide on the intestinal ecosystem of colon-cancer model rats. Food Sci. Biotechnol. 15: 931-936 (2006)   과학기술학회마을
20 Katz AM. Physiology of Heart. 2nd ed. Raven Press, New York, NY, USA. pp. 35-38 (1992)
21 Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force. Kluwer Academic, Dordrecht, Netherlands. pp. 26-27 (1991)
22 Furchgott RF. Sprial-cut strip of rabbit aorta for in vitro studies of response of arterial smooth muscle. Method Med. Res. 8: 177-186 (1976)
23 Bolton RB. Mechanism of action or transmitters and other substances on smooth muscle. Physiol. Rev. 59: 606-718 (1979)   DOI
24 Fleckenstein A, Tritthart FB, Herbst A, Grun G. A new group of competitive Ca-antagonist (Iproveratril, D600, prenylamine) with highly potent inhitory effect on excitation-contraction coupling in mammalian myocardium. Pflueg. Arch. Eur. J. Phy. 307: R25-R32 (1969)
25 Han S-B, Kim Y-H, Lee C-W, Park S-M, Lee H-Y, Ahn K-S. Characteristic imunostimulation by angelan isolated from Angelica gigas Nakai. Int. Immunopharmacol. 40: 39-48 (1998)   DOI   ScienceOn
26 Kubota Y, Umegaki K, Kagota S, Tanaka N, Nakamura K, Kunitomo M, Shinozuka K. Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats. Biol. Pharm. Bull. 29: 1756-1758 (2006)   DOI   ScienceOn
27 Lee E-B. A comparison of experimental pharmacological effects of crude platycodin with clinical indication of Platycodi radix. J. Pharm. Soc. Jpn. 93: 1188-1194 (1973)   DOI
28 Zhang YJ. Application and progress of calcium antagonist. Prog. Cardioangiol. 16: 43-51 (1995)
29 Kim K-S, Ezaki O, Ikemoto S, Hitakura M. Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia. J. Nutr. Sci. 41: 485-491 (1995)
30 Franklin SS, Gustin W, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation 103: 1245-1249 (2001)   DOI   ScienceOn
31 Godfraind T, Dieu D. The inhibition by flunarizine of the norepinephine-evoked contraction and calcium influx in rat aorta and mesenteric arteies. J. Pharmacol. Exp. Ther. 217: 510-515 (1881)
32 Harder DR, Brann L, Halpern W. Altered membrane electrical properties of smooth muscle cells from small cerebral arteries of hypertensive rats. Blood Vessels 20: 154-160 (1983)
33 Kim K-S, Seo E-K, Lee Y-C, Lee T-Y, Cho Y-W, Ezaki O, Kim CH. Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats. J. Nutr. Biochem. 11: 420- 424 (2000)   DOI   ScienceOn
34 Franklin SS, Gustin W, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation 96: 308- 315 (1997)   DOI   ScienceOn