• 대한청각학회지
• /
• 제23권2호
• /
• pp.83-88
• /
• 2019

Background and Objectives: Mild cognitive impairment (MCI) is a disorder that usually occurs in the elderly, leading to dementia in some progressive cases. The purpose of this study is to examine the utility of central auditory processing tests as early diagnostic tools for identifying the elderly with MCI. Subjects and Methods: This study was conducted on 20 elderly patients with MCI and 20 healthy matched peers. The speech perception ability in a quiet environment and in the presence of background noise and also temporal resolution were assessed by using Speech Perception in Noise (SPIN) and Gap in Noise (GIN) tests, respectively. Results: The results indicated that the ability to understand speech in a quiet environment did not differ significantly between the two groups. However, SPIN at the three signal-to-noise ratios and the temporal resolution scores were significantly different between the two groups (p<0.001). Conclusions: Individuals with MCI appear to have poorer speech comprehension in noise and a lower temporal resolution than those of the same age, but without cognitive defects. Considering the utility of these tests in identifying cognitive problems, we propose that since the GIN test seems to be less influenced by intervening factors, this test can therefore, be a useful tool for the early screening of elderly people with cognitive problems.

• 한국동물위생학회지
• /
• 제39권2호
• /
• pp.107-116
• /
• 2016

In the study, we developed and evaluated a uracil N-glycosylase (UNG)-supplemented single-tube nested reverse transcription-polymerase chain reaction (UsnRT-PCR) assay that can carried out first-round RT-PCR and second-round nested PCR in a reaction tube without reaction tube opening and can simultaneously detect EU- and NA-PRRSV. The UsnRT-PCR confirmed to have a preventing ability of mis-amplification by contamination of pre-amplified PRRSV DNA from previous UsnRT-PCR. Primer specificities were evaluated with RNAs extracted from 8 viral strains and our results revealed that the primers had a high specificity for both genotypes of PRRSV. The sensitivity of the UsnRT-PCR was 0.1 $TCID_{50}$/0.1 mL for EU- or NA-PRRSV, respectively, which is comparable to that of previously reported real time RT-PCR (RRT-PCR). Clinical evaluation on 110 field samples (60 sera and 50 lung tissues) by the UsnRT-PCR and the RRT-PCR showed that detection rates of the UsnRT-PCR was 70% (77/110), and was relatively higher than that of the RRT-PCR (69.1%, 76/110). The percent positive or negative agreement of the UsnRT-PCR compared to RRT-PCR was 96.1% (73/76) or 90.9% (30/33), showing that the test results of both assays may be different for some clinical samples. Therefore, it is recommend that diagnostic laboratory workers use the two diagnostic assays for the correct diagnosis for the relevant samples in the swine disease diagnostic laboratories. In conclusion, the UsnRT-PCR assay can be applied for the rapid, and reliable diagnosis of PRRSV without concerns about preamplified DNA carryover contamination that can occurred in PCR process in the swine disease diagnostic laboratories.

• Imaging Science in Dentistry
• /
• 제40권1호
• /
• pp.33-38
• /
• 2010

Purpose : The purpose of this study was to evaluate the diagnostic efficacy of panoramic radiographs for detection of mandibular fractures. Materials and Methods : The sample was comprised of 65 patients (55 fractured, 10 non-fractured) with 92 fracture sites confirmed by multi-detector computed tomography (CT). Panoramic radiographs were evaluated for mandibular fractures by six examiners; two oral & maxillofacial radiologists (observer A&B), two oral & maxillofacial surgeons (observer C&D), and two general dentists (observer E&F). Results : Sensitivity of panoramic radiography for mandibular fractures was 95.7% in observer A&B, 93.5% in observer C&D and 80.4% in observer E&F. The lowest sensitivity was shown in symphyseal/parasymphyseal areas, followed by subcondylar/condylar regions. Conclusion : Panoramic radiography is adequate for detection of mandibular fractures. However, additional multidetector CT is recommended to ascertain some indecisive fractures of symphysis and condyle, and in complicated fractures.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권8호
• /
• pp.4007-4011
• /
• 2012

Purpose: Retinoblastoma-interacting zinc finger gene (RIZ1) is a tumor suppressor gene which is highly inactivated by promoter hypermethylation in patients with liver fluke-related cholangiocarcinoma (CCA). Epigenetic aberration of this gene might withdraw the ability to restrain tumor cell proliferation and migration. We aimed to define the role of RIZ1 on cell proliferation and migration in CCA cell line. Materials and methods: Small interference RNA (siRNA) was used to knock down the expression of RIZ1 in a CCA-derived cell line in which cell proliferation and cell migration were performed. Results: A predominant nuclear localization of RIZ1 was observed. Reduction of RIZ1 by siRNA augmented cell proliferation and migration. Conclusion: The result suggested that RIZ1 might play a role in regulating cell proliferation and migration in CCA. Reduction of RIZ1 expression may aggravate the progression of CCA.

• 한국수학교육학회지시리즈A:수학교육
• /
• 제46권1호
• /
• pp.33-52
• /
• 2007

This study is based on the grade 3 National Diagnostic Assessment of Basic Competency(NDABC) in 2005. The purpose of this study is to analyze the results of NDABC by students' gender. It was 19,257 grade 3 students that participated in this study. The average scores are 89.41 and 88.34 for each male and female. The percentage of Below-Basic level for male students is 4.6% and for female 5.6%. The percentage of female students at Below-Basic level is increasing for 3 years. In particular, the percentage of females at Below-Basic level is higher than that of males in the content of measurement, the cognitive domain of reasoning and problem solving, and the situation of real life. The item difficulty for males is lower in fraction, polygon, and right triangle than for females. But female students need to improve the space sense and the problem solving ability in real life. As for the background of students, males think that mathematics is exciting and not difficult in comparison with what females think. And parents of mates are more concerned about children's learning than those of females.

• 대한후두음성언어의학회지
• /
• 제29권2호
• /
• pp.67-69
• /
• 2018

The development of office-based, unsedated transnasal esophagoscopy (TNE) has proven to be a major technological advance and with time and experience the application of this technology is becoming more widespread. TNE has allowed otolaryngologists to perform a variety of diagnostic and therapeutic procedures in the office setting. Studies consistently demonstrate that the image quality and diagnostic capability of TNE is equivalent to conventional esophagoscopy. The modern TNE endoscopes offer high quality optics, air-insufflation, and irrigation capability through a 2-mm working channel, and the ability to perform biopsies and select procedures. In general, the role of TNE in the head and neck patient is three-fold : to screen for synchronous and metachronous esophageal squamous cell carcinoma (ESCC) ; to differentiate post-treatment changes/symptoms from malignancy ; and to perform certain office-based procedures. TNE offers many specific advantages to the head and neck patient that are not afforded by conventional esophagoscopy. Because of surgical and postirradiation changes, many HNSCC patients have trismus or neck stiffness preventing completion of conventional transoral esophagoscopy. Perhaps most importantly, TNE provides enhanced patient safety, increased tolerability, better practice efficiency, and cost savings. For these reasons, TNE has become a particularly useful tool in the otolaryngologist's armamentarium.

• 대한의생명과학회지
• /
• 제25권3호
• /
• pp.256-266
• /
• 2019

In this study, obese adults were compared for their ability to predict obesity and lipid related variables and their optimal cutoff values to predict metabolic syndrome and insulin resistance. In this study, 9,256 adults aged 20 years or older and less than 80 years old, who were in the Gyeonggi region from January 2014 to December 2016 and who were examined at a general hospital, were enrolled. The diagnostic criteria for obesity were WHO (World Health Organization), and BMI $25kg/m^2$ or more presented in the Asia-Pacific region. Metabolic syndrome was diagnosed based on the criteria of American Heart Association / National Heart, Lung, and Blood Institute (AHA / NHLBI). According to the results of receiver operating characteristic curve (ROC) analysis, Triglyceride / HDL-cholesterol (TG / HDL-C), Triglyceride and Glucose (TyG) index, lipid accumulation product (LAP) and visceral adiposity index (VAI) showed high predictive power for diagnosing metabolic syndrome. The diagnostic accuracy of LAP (AUC: 0.854) for males and VAI (0.888) for females was the highest. The optimal cutoff value of LAP was 42.71 for male and 35.44 for female, and the cutoff value of VAI was 1.92 for male and 2.15 for female. In addition, WHtR (waist to height ratio), TyG index, and LAP were used as predictors of insulin resistance in obese adults. Therefore, LAP and VAI were superior to other indicators in predicting metabolic syndrome in obese adults.

• 융합보안논문지
• /
• 제12권4호
• /
• pp.25-31
• /
• 2012

정보보호수준 검증방법은 프로세스를 중심으로 정보보호 제품, 시스템, 서비스를 개발하려는 조직의 개발능력을 평가하는 SSE-CMM(System Security Engineering-Capability Maturity Model)모델이 있다. CMM은 소프트웨어 개발업자의 개발능력을 평가하고 개선시키며 조직 전체의 성숙도 수준을 측정하는 모델이다. 그러나 이 방법은 보안엔지니어링 프로세스의 개선과 능력을 평가하는데 조직차원이 아닌 개별 프로세스의 능력수준 평가에 그치고 있다. 본 연구과제에서는 이들 기존연구를 근간으로 기술적 관점에서 정보보호수준 성숙단계를 정의하고자 한다. 연구방법은 정보보호취약점 진단, 기술보안체계 검증, 기술보안 이행실태 진단으로 구성한다. 제안하는 방법론은 업무현장에서의 범위와 수준에서 정보시스템의 현재 상태, 취약점 실태, 정보보호 기능 이행과 기능만족도 수준을 평가한다. 제안된 방법에 의한 평가결과는 정보보호 개선대책 권고모델 수립 근거로 활용하여 정보보호 개선의 활용을 목표로 하고 있다.

• 대한간호학회지
• /
• 제43권4호
• /
• pp.526-535
• /
• 2013

Purpose: This study was done to compare clinical nurses' knowledge and visual differentiation diagnostic ability for the pressure ulcer classification system (PUCS) and incontinence-associated dermatitis (IAD). Methods: A convenience sample of 602 nurses took the pressure ulcer classification system and incontinence-associated dermatitis knowledge test (PUCS & IAD KT) and completed the visual differentiation tool (VDT), consisting of 21 photographs with clinical information. Results: The overall mean score for correct answers was 14.5 (${\pm}3.2$) in PUCS & IAD KT and 11.15 (${\pm}4.9$) in PUCS & IAD VDT. Incorrect responses were most common for statements related to stage III, IAD for PUCS & IAD KT, and suspected deep tissue injury (SDTI), unstageable, and stage III for PUCS & IAD VDT. Significant correlations were found between PUCS & IAD KT and VDT (r=.48, p<.001). Factors affecting scores for PUCS & IAD VDT were PUCS & IAD KT, frequency of pressure ulcer, IAD management and participation in wound care education programs. Conclusion: Results indicate that nurses have an overall understanding of PUCS & IAD, but low visual differentiation ability regarding stage III, SDTI, and unstageable ulcers. Continuing education is needed to further improve knowledge and visual differentiation ability for PUCS & IAD.

• 한국의학물리학회지:의학물리
• /
• 제17권4호
• /
• pp.238-245
• /
• 2006

CT 검사에서 조영제 혈관외유출을 예방하기 위해 EDA 시스템을 개발하여 가토를 대상으로 실험적으로 혈관외유출의 검출 효율을 평가하였다. 7마리의 가토 IV 정맥 부위에 EDA 시스템의 스트레인게이지를 부착하여 조영제를 주입하면서 혈관외유출 검출 효율을 평가하였다. 조영제의 혈관외유출은 7건으로 혈관외유출 용량 $14{\sim}23ml$ (평균 18.86 ml), 혈관외유출 발생시간 평균 11.29초, 평균압력 109.71 psi, EDA 시스템에서 스트레인게이지의 분해능 평균 512.18, 진양성 7건, 진음성 19건, 위양성 2건이었고, 민감도 100%, 특이도 90%로 나타났다. 개발된 EDA 시스템을 가토에 실험적으로 적용하여 소량의 혈관외유출 조영제를 검출하는 효율이 있어 혈관외유출을 예방하는 효과가 있다.