• Mycobiology
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• 제49권2호
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• pp.183-187
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• 2021

The Shine Muscat is a table grape, popular in South Korea for its unique mango-flavor taste. Flyspeck is a disease that is characterized by small, black, and circular specks on the grape cuticle was first observed in several commercial orchards in Sangju, South Korea, in August 2019. Here we identified the causal agent of flyspeck based on an advanced diagnosis approach, comprised of both morphological and molecular analyses. Morphological characteristics of the cultures isolated from grape flyspeck were identical to the fungus Cladosporium perangustum. The concatenated sequences of ITS, ACT, and EF1-α were used for molecular phylogenetic analysis, BLAST searches along with Bayesian inference-based phylogeny, confirmed that the causal agent of grape flyspeck is C. perangustum. The cultured fungal isolates also produced flyspeck symptoms on healthy fruits in pathogenicity tests. To the best of my knowledge, this is the first documented evidence of any Cladosporium sp. producing flyspeck symptoms on any plant.

• 전자공학회논문지SC
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• 제45권6호
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• pp.117-122
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• 2008

맥진은 한의 진단에 있어 중요한 요소이나 맥진 교육에 있어서 수련자와 교육자 간에 언어적 표현 외에는 적절한 교육 정보 소통의 도구가 없어 정량적이며 과학적 교육이 어려운 실정이다. 이에 본 논문에서는 맥진 시 한의사가 세 손가락을 통해 맥진 부위에 가하는 가압력 프로파일을 정량적으로 측정할 수 있는 하드웨어와 이를 기반으로 맥진 동작을 트레이닝할 수 있는 프로그램을 개발하였다. 가압력 프로파일 측정 하드웨어는 인조 팔 속 맥진 위치에 놓인 3개의 로드셀과 맥진 가압력 신호를 증폭하는 증폭부 및 상용 A/D 변환 모듈인 NI-USB 6009로 구성하였으며, 3채널 가압력 신호는 200Hz로 샘플링하였다. 하드웨어 출력 신호를 질량 값으로 교정할 수 있도록 $50{\sim}500g$ 범위의 8개 추를 인조 팔에 올려놓았을 때의 질량 대비 출력전압 테이블을 작성하였다 또한, 이 시스템을 통해 한방 전문의 3명의 맥진 가압 프로파일을 각 3회씩 측정해 보았으며, 이를 통해 한의사의 맥진은 크게 3개의 구간으로 나눌 수 있고 최대 가압력이 약 $500g{\cdot}f$인 것 등을 알 수 있게 되었다. 맥진 가압트레이닝 프로그램은 LabView를 통해 구현하였으며, 수련자가 미리 저장된 목표 맥진 가압 프로파일과 유사하도록 인조 팔을 맥진할 때의 가압 프로파일이 목표 가압 프로파일과 유사한 정도를 평가하여 일정 범위를 벗어나면 경고하고, 실습이 끝나면 목표 프로파일과 유사도 점수를 화면에 표시하도록 하였다. 더 나아가 유사도 점수의 추이를 통해 숙련 추이를 관찰 할 수 있도록 하였다. 이 시스템을 맥진 교육에 활용한다면 보다 정량적이며 과학적인 교육이 가능해질 뿐만 아니라 교육의 효율도 크게 향상될 것으로 기대된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권5호
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• pp.462-469
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• 2000

Positron Emission Tomography(PET) is a new diagnostic method that can create functional images of the distribution of positron emitting radionuclides, which when administered intravenously in the body, makes possible anatomical and functional analysis by quantity of biochemical and physiological process. After genetic and biochemical changes in initial stage, malignant tumor undergoes functional changes before undergoing anatomical changes. So, early diagnosis of malignant tumors by functional analysis with PET can be achieved, replacing traditional anatomical analysis, such as computed tomography(CT) and magnetic resonance image(MRI), etc. Similarly, PET can identify malignant tumor without confusion with scar and fibrosis in follow up check. In the Korea Cancer Center Hospital(KCCH) from October 1997 to September 1999, clinical study was performed in 79 cases that underwent 89 times PET evaluation with [18F]-Fluorodeoxyglucose for diagnosis of oral and maxillofacial tumors, and the data was analysed by Bayesian $2{\times}2$ Classification Table. The results were as follows : Evaluation for initial diagnosis with FDG-PET (P<0.005) 1. Agreement rate or accuracy rate is 88.9%. 2. Sensitivity is 95.2%, and specificity 66.7%. 3. Positive predictive rate is 90.9%, and negative predictive rate 80.0%. 4. In consideration of tumor stage, diagnostic rate in less than stage II was 90% and in greater than stage III 100%. 5. In consideration of tumor size, diagnostic rate in less than T2 was 92.3% and in greater than T3 100%. After primary treatment, evaluation for follow up check with FDG-PET (P < 0.001) 1. Agreement rate or accuracy rate is 85.4%. 2. Sensitivity is 87.5%, and specificity 82.4%. 3. Positive predictive rate is 87.5%, and negative predictive rate 82.4%. 4. In 24 recurred cases, 6 had distant metastasis, and 5 of them were diagnosed with FDG-PET, resulting in diagnostic rate of FDG-PET of 83.3%. From the above results, Positron Emission Tomography with [18F]- Fluorodeoxyglucose appears to be more sensitive and accurate for detecting the presence of oral and maxillofacial tumors, and has various clinical applications such as early diagnosis of tumor in initial and follow up check and detection of distant metastasis.

• 대한방사선기술학회지:방사선기술과학
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• 제34권4호
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• pp.277-285
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• 2011

위장조영검사(UGIS)의 품질관리(quality control)를 위해 우리나라를 대표하는 종합검진기관 21곳에서 수검자 105명에 대한 위장조영촬영 영상 표본을 획득하였다. 표본 영상을 두 나라의 위장조영검사 화질평가표에 의해 각각 평가한 결과 우리나라 화질평가표(Image Quality Evaluation Table; IQET)에 의한 평균점수는 73.3점에 표준 오차 4.49로 21개 검진기관 중 19개 기관이 적격 판정을 받았다. 이에 반해 일본의 화질평가표에 의한 평균점수는 58점에 표준오차 4.45로 적격판정을 받은 기관은 불과 8곳 밖에 되질 않았다. 동일한 영상을 다른 평가표로 평가한 결과에 큰 차이를 보였다. 원인을 알아보기 위해 화질 평가표를 각각 항목별로 분석하여 위 전체영역의 묘출확인과 촬영기술에 대한 문제점을 파악하였고 획득된 영상으로 각 종합검진기관의 위장조영검사의 실태를 분석하였다. 우리나라 위장조영검사의 가장 큰 문제점은 명확한 검진방법 없이 검사가 시행되고 있다는 점이었다. 종합검진기관 21곳 모두 위장조영촬영방법이 모두 다를 뿐더러 앞벽 이중조영 촬영은 대부분 시행하지 않고 있었고 우리나라 화질 평가표에 포함하도록 명시된 점막상이나 식도영상을 포함하지 않는 종합검진기관도 있었다. 또한 체위에 따른 중복촬영이 시행되고 있어 수검자에 대한 무분별한 피폭선량에 대한 문제도 발생하고 있었다. 이에 적절한 위장조영검사의 품질관리를 통해 진단정보가 충분한 영상을 획득할 수 있도록 노력해야 할 것이다.

• Clinical and Experimental Pediatrics
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• 제56권1호
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• pp.32-36
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• 2013

Purpose: Chronic day-to-day symptoms of orthostatic intolerance are the most notable features of postural orthostatic tachycardia syndrome (POTS). However, we have encountered patients with such symptoms and excessive tachycardia but with no symptoms during the tilt-table test (TTT). We aimed to investigate whether POTS patients with chronic orthostatic intolerance always present orthostatic symptoms during the TTT and analyze the factors underlying symptom manifestation during this test. Methods: We retrospectively examined patients who presented with POTS at the Gyeongsang National University Hospital between 2008 and 2011. Diagnosis of POTS was based on chronic day-to-day orthostatic intolerance symptoms as well as excessive tachycardia during the TTT. The patients were divided two groups depending on the presentation of orthostatic symptoms during the TTT. Clinical data and the results of the TTT were compared between these groups. Results: In 22 patients, 7 patients (31.8%) did not present orthostatic symptoms during the test. Diastolic blood pressure (BP) was significantly lower in the symptom-positive group. The head-up tilt resulted in a significant increase in diastolic BP in the symptom-negative group (P=0.04), while systolic BP had a tendency to decrease in the symptom-positive group (P=0.06). Conclusion: Significant patients with POTS did not present orthostatic symptoms during the TTT despite having chronic daily symptoms. This finding may be important for establishing definitive diagnostic criteria for pediatric POTS. Development of symptoms during TTT might be related to low diastolic BP and abnormal compensatory responses to orthostasis.

• Journal of Chest Surgery
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• 제18권2호
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• pp.241-249
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• 1985

Twenty-one patients with Double Chambered Right Ventricle [DCRV] associated with Ventricular Septal Defect [VSD] were treated by open heart surgery under cardiopulmonary bypass with moderate hypothermia in the Department of Thoracic and Cardiovascular Surgery, Hanyang University Hospital between June 1982 and October 1984. The following results were obtained 1. The symptoms and physical signs, specific for DCRV, could not be identified. 2. The radiologic findings on simple chest X-ray, specific for DCRV, could not be identified. 3. Electrocardiographic findings, specific for DCRV, could not be identified. 4. Cardiac catheterization was found to be the most important diagnostic method, revealing pressure gradient between proximal chamber and distal chamber in the right ventricle. The average pressure gradient between two chambers showed 48.1523.29 mmHg[varying from 15mmHg to 94mmHg]. 5. Cardiac angiography was found to visualize the anomalous muscle bundles in right ventricle [in 17 cases, 81%] but the evidence of pressure gradient between two chambers within right ventricle is considered necessary for the diagnosis of DCRV. 6. Via surgical observation, anatomical and pathologic findings of the anomalous muscle bundles, associated DCRV were identified. 7. As the direct pressure was measured on the operating table before and after surgery, the average pressure gradient across the muscle bundles showed 40.5219.75mmHg [varying from 16 to 89mmHg] preoperatively and 8.909.72mmHg [varying from 0 to 32mmHg] postoperatively, indicating significant surgical correction of the obstruction present. 8. The presence of anomalous muscle bundles, dividing the right ventricle into two separated chambers, and the presence of the pressure gradient over 15mmHg are considered necessary for the diagnosis of DCRV.

• 대한한의학회지
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• 제33권1호
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• pp.90-106
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• 2012

Objectives: Eight constitution medicine (ECM), which was first introduced in 1965, has been further developed and refined over the decades, and has consolidated its foundation through many studies on theories, diagnosis and clinical application. However, there have been few reviews on dissertations of ECM. In this study, we reviewed previously published studies related to ECM. Methods: We reviewed a total of 55 ECM-related studies published from 1965 to 2010 found on PubMed and various domestic Oriental medicine journals. Each thesis was classified as a theoretical, diagnostic, or remedy-related study. Results: 1. In the review of theoretical studies, shortly after ECM's introduction in 1965 by Kwon, the authors found studies on constitutional diseases, diets and food table which helped establish the background of ECM. ECM has further developed by comparing its theories with Sasang constitutional medicine, Huang-di-nei-jing, Saam, and Taegeuk acupuncture theories. 2. Research on diagnosis has been focused on its objectivity and accuracy. Constitution could be diagnosed by pulse-taking. To compensate for the lack of accuracy innate in pulse-taking, the Eight Constitution Questionnaire has been invented. 3. Remedies can be largely divided into acupuncture and diet. There were case studies comparing treatment effect of ECM acupuncture to other treatments. Diet related studies were carried out in the fields of immunology and nutrition. Conclusions: The authors reviewed studies that contributed to improved understanding of theories and clinical implications of ECM. Although there were various approaches to its theoretical and clinical grounds, more clinical research is needed. There is also a need to evaluate the accuracy of the experts' diagnoses of the constitution. The relationship between the diet and constitution also needs further research.

• 기본간호학회지
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• 제4권1호
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• pp.119-131
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• 1997

This study was conducted to analyze the nursing diagnoses applied for case studies of nursing students through their clinical practices, and to provide the educational basis of nursing diagnoses with its results. The data were collected for two years(1995 and 1996) from 70 case studies reported by the 2nd and 3rd year nursing junior college students. The students made 259 nursing diagnoses among which 230 diagnoses qualified NANDA classification and were taken for analysis. The results of the analysis were as follows : 1. The number of diagnoses indicating response patterns was 35(35.7%), whereas 98 diagnoses in NANDA table. Among the 35 diagnoses, the pattern of exchange was most frequent, then feeling, moving, knowing in rank. 2. The diagnoses were analyzed in the categories of response patterns. For Instance, 'Altered in Nutrition' was most frequent in exhange, then Risk for Infection', 'Ineffective Airway Clearance', in rank. 3. Among 230 diagnoses, 'Knowle Deficit' was most frequently mentioned, then 'Activity Intolerance' 'Anxiety', 'Pain', 'Altered in Nutrition', 'Risk for Infection', 'Ineffective airway clearance', in rank. 4. The types of word expression of each diagnoses were various. 'Activity Intolerance' was expressed in 6 types. 5. The relating factors applied to each diagnosis were analyzed. For Instance, the relating factor of 'Knowledge Deficit' were illness, and therapeutic process, lack of motivation, occurrance of complication, short experience, operation, and so on. From the above study, the researcher would like to recommend as follows : 1) The current diagnoses need to be verified its content validity, when they are applied to our culture. 2) The most effective educational method for applying nursing diagnoses should be explored. 3) Further study could be focused on not only 'relating factors' but also 'sign and symptoms'.

• Journal of Korean Neurosurgical Society
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• 제52권1호
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• pp.48-51
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• 2012

Intravascular papillary endothelial hyperplasia (IPEH) is a rare vascular benign lesion that rarely involves the central nervous system with or without skull invasion. We report a rare case of IPEH on the skull bone, which displayed destructive radiologic development associated with hemorrhage. A 14-year-old male presented with an incidentally detected a small enhancing, left frontal osteolytic lesion. Previously, he underwent operation and received adjuvant chemoradiation therapy for cerebellar medulloblastoma. Follow-up magnetic resonance imaging revealed a left frontal bone lesion, which expanded to an approximately 2 cm-sized well-circumscribed osteolytic lesion associated with hemorrhage for 20 months. Frontal craniectomy and cranioplasty were performed. Destructive change was detected on the inner table and diploic space of the skull. The mass had a cystic feature with hemorrhagic content without dural attachment. Pathologic examination showed the capsule consisted of parallel collagen lamellae representing a vascular wall, vascular lumen, which was pathognomonic for IPEH. Immunohistochemical staining revealed that the capsule was positive for CD34 and factor VIII, which favor the final diagnosis of IPEH. This was the first case of intracalvarial IPEH.

• International Journal of Aeronautical and Space Sciences
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• 제10권2호
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• pp.34-42
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• 2009

Gas turbine performance diagnostics is a method for detecting, isolating and quantifying faults in gas turbine gas path components. On-line precise fault diagnosis can promote greatly reliability and availability of gas turbine in real time operation. This work proposes a GUI-type on-line diagnostic program using SIMULINK and Fuzzy-Neuro algorithms for a helicopter turboshaft engine. During development of the diagnostic program, a look-up table type base performance module are used for reducing computer calculating time and a signal generation module for simulating real time performance data. This program is composed of the on-line condition monitoring program to monitor on-line measuring performance condition, the fuzzy inference system to isolate the faults from measuring data and the neural network to quantify the isolated faults. Evaluation of the proposed on-line diagnostic program is performed through application to the helicopter engine health monitoring.