• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1977년도 제11차 학술대회연제 순서 및 초록
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• pp.3.3-3
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• 1977

1976년 1월부터 동년 12월까지 본병원 당뇨병진료실을 방문하여 당뇨병으로 진단된 환자 중 청력검사를 시행한 43례(남자 25례, 여자 18례)와 그중 청각장애자 8례를 대상으로 임상적 소견 및 그 상호관계를 관찰하여 다음과 같은 결론을 얻었다. 1) 당뇨병환자 43례 중 청각장애자는 8례이며, 청력형은 고음급추형 및 고음점경향이 대부분이다. 2) 중연속 및 고연령층에 청각장애자의 출현빈도가 높다. 3) 이식기간과는 무관하나, 혈당치 및 혈청총 cholesterol치와는 어느 정도 상관관계가 있다. 4) 강막증, 고혈압증 및 신경증 등 합병증을 동반한 례에 청각장애자가 많다. 5) 당뇨병환자의 청각장애의 성립요인은 단일한 것이 아니고 여러가지 요소가 관여하는 것으로 생각된다.

• 한방안이비인후피부과학회지
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• 제33권3호
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• pp.125-137
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• 2020

Objectives : Charcot neuroarthropathy(CN) is condition characterized by a progressive joint deformation with sensorial and autonomic neuropathy. This study is to report a case of CN improved by Korean medical treatment. Methods : The patient's left foot with CN was treated by Shudihuangkushen-tang, Haifu-san wet dressing, acupuncture and herbal acupuncture. We evaluated the progress by laboratory investigation, radiograph and photograph comparison, visual analogue scale(VAS) of edema and pain sensation. Results : After treatment, VAS score of edema dropped from 6 to 1, of pain sensation slightly improved from 0 to 1. Average blood sugar level decreased and rebounded, but Hemoglobin A1c level improved from 9.5% to 7.7%. Improvement of the left foot was recognized from the radiograph and photograph comparison. Conclusions : This study suggests Korean medicine is effective in treating CN, especially using Shudihuangkushen-tang, Haifu-san wet dressing.

• 대한간호학회지
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• 제30권3호
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• pp.741-749
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• 2000

This study was performed to investigate the relationship between reversed circadian blood pressure and risk factors of peripheral vascular disease in non-insulin-dependent diabetes mellitus (NIDDM) subjects. The subjects in this study were 18 NIDDM patients who were hospitalized in a medical unit of an university medical center located in Incheon, Korea, between November, 1998 and March, 1999. Blood pressure was measured with a mercury sphygmomanometer by 2 trained examiners every 2 hours during 24 hours. NIDDM subjects were divided into a dipper group and non-dipper group. Dippers are defined as those who show a mean nighttime blood pressure(BP) drop of more than 10% compared with daytime BP. Non-dippers are defined as those who show a mean nighttime BP drop of less than 10%, or an elevation in BP compared with daytime BP. Daytime BP included values obtained between 6 a.m. and 10 p.m. Night time BP included values obtained between 10 p.m. and 6 a.m. Data was analyzed by SPSS/PC package. Chi-square( $^2$) test was used for the comparison of sex between The dipper group and non-dipper group. Mann-Whitney test was used for comparisons of values of the risk factors of peripheral vascular disease and the frequency of complications of diabetes between the dipper group and non-dipper group. The results are as follows. There were no significant differences in daytime systolic, diastolic, and mean blood pressures between the dipper group and non-dipper group. However, night time systolic, diastolic, and mean blood pressures in the non-dipper group were significantly nigher than those in the dipper group (p=.021). There were no differences in sex, age, body, weight, duration of diabetes, serum lipid levels, BUN and HbA1c between the two groups. On the contrary, 87.5% of non-dipper group subjects showed having hypertension, 30% of dipper group subjects showed having hypertension and this difference was statistically significant (p=.018). All of the non-dipper group subjects (N=8) showed having at least one diabetic complication. However, 40% of the dipper group subjects (N=10) showed having no diabetic complication at all and this difference was also statistically significant (p=.049). There were no significant differences in frequency of nephropathy, neuropathy and retinopathy between the dipper group and non-dipper group.

• 전자공학회논문지SC
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• 제43권3호
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• pp.60-66
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• 2006

본 논문은 photoplethysmography(PPG)와 Laser doppler(LD)를 이용하여 당뇨병 환자의 신경병증을 조기 진단하기 위한 시스템을 구성하여 손가락과 발가락의 혈류량을 측정하고 그 비율을 이용하는 방법을 제안하였다. 당뇨병 환자의 신경병증 진단을 위해 임상에서는 신경전도검사(NCV)가 사용되고 있으나 이 검사는 피부에 전기자극을 가하므로 환자에게 스트레스와 고통을 준다. 이에 본 논문에서는 고통이 전혀 없으며, 비관혈적이고 측정방법이 간단한 PPG와 LD를 이용하여 신경병증 진단법을 제안하였다. PPG가 LD에 비해 손가락 및 발가락의 혈류량 및 온도와의 상관관계, 민감도 및 특이도에서 더 우수하였다. 분석결과 50명의 신경병성 당뇨환자의 혈류비($0.96{\pm}0.20$)가 64명의 정상인의 혈류비($0.46{\pm}0.15$)에 비해 유의하게 높았다(p<0.000). 또한 신경병성 당뇨환자의 발가락 온도($30.5{\pm}1.4^{\circ}C$)가 정상인의 발가락 온도($29.3{\pm}2.0^{\circ}C$)에 비해 유의하게 높았다(p<0.000). 본 연구로부터 도출된 최적 혈류비(0.678)에 대한 측정 방법의 높은 민감도(95.3%)와 특이도(95.3%)를 확인하였다. 마지막으로 신경병성 당뇨환자 그룹의 경우 모두 손가락과 발가락의 온도차가 $4.5^{\circ}C$ 미만이었다.

• 대한약침학회지
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• 제13권1호
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• pp.103-120
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• 2010

Objective : To review the trend of the study related to Leech therapy and to establish the hereafter direction for the study on Leech therapy. Methods : I reviewed and analyzed all the theses published in Domestic and Foreign research institution from 1990 to 2009. Results : The following results were obtained in this study. 1. Analyzed number of theses published, there was no significance per year. 2. Classified by theme of journal, journals related to surgery were most(41 journals, 75.92%) among 54 kinds. 3. Classified by theses by research method and thesis types, case report accounted for nearly twothirds (52 pieces, 68.42%) of all theses and consideration of document was next(9 pieces, 11.84%). 4. With the most case of venous congestion after plastic and reconstructive surgery(33 pieces, 63.46%), leech therapy was effective on illnesses such as haematoma, macroglossia, purpura, varicous vein, avulsion injury, neurovascular compression, diabetic neuropathy, penoscrotal oedema, buerger's disease, rheumatoid arthritis. 5. Two most appeared adverse effects were anemia and infection. Immediate blood transfusion was done for recovering anemia and prophylactic 3rd generation antibiotics to infection were emphasized in more than half of case reports. 6. All of consideration of documents was retrospective study of cases related leech therapy and 3 pieces of them emphasized prophyratic antibiotic treatment for preventing infection. 7. The study of clinical trail type started first in 2002 and osteoarthritis of knee and carpometacarpal joint were main target. As see above result, Leech therapy was effective cure and could be used in disease induced by venous congestion. And I think that it is necessary to perform additional study related to solution of problems about leech therapy and protocol for using in clinical practice.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.115-115
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• 1997

A new capsaicin analog modified with 4-hydroxyl and alkyl chain of capsaicin was a very potent antiinflammatory analgesic drug and may be clinically useful for those who have rheumatoid arthritis, diabetic neuropathy and cancer. The purpose of this study was to investigate histopathology after short and long term application of poloxamer-based gels, and percutaneous absorption of various topical formulations. Poloxamer-based gel was prepared by cold method using poloxamer 407. The poloxamer gels was applied to dorsal sites of hairless mouse skin during one week or one month for the evaluation of skin irritation. The applied site was then sectioned for histopathologic examination. The topical formulations were also prepared using CMC, HPMC, MC, carbopol and glycerylmono stearate. Skin variation of poloxamer gels was studied using excised hairless mouse, rat, hamster and human penis skin. Franz-type diffusion cells were used far skin penetration of drug against receptor phase filled with about 10$m\ell$ of 0.9% saline solution kept at 32$^{\circ}C$. The concentration of drug was determined by the reverse phased C18, Symmetry HPLC with fluorometeric detector. No skin erythema was observed after dorsal application of poloxamer-based gels for one week or one month. No histopathologic changes was also examined, suggesting no skin toxicity of poloxamer-based gels. The order of flux rate was HPMC > MC ( CMC > poloxamer >> glycerylmono stearate ( carbopol. There was a skin variation of poloxamer gels. The flux rate of poloxamer gels was highest in case of hairless mouse followed by rat, human and hamster skin. The Partial support-Ministry of Science and Engineering (HAN project).

• The Korean Journal of Pain
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• 제11권2호
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• pp.201-209
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• 1998

Background: Tricyclic antidepressants (TCA) have been used for various pain syndromes for their analgesic effects. They, however, often have anticholinergic side effects and therefore search for more selective drugs with fewer side effects is justified. Paroxetine, a selective serotonin reuptake inhibitor devoid of autonomic side effects, was evaluated for its role as an analgesic adjuvant in the management of neuropathic pain. Method: According to individual diagnostic group as diabetic neuropathy, postherpetic neuralgia, central pain syndrome and cancer related plexopathy, 10 patients per each group were equally accumulated. Patients have been stabilized in their analgesic regimen at least four weeks prior to enrollment into study. TCA, if taken, was discontinued for two weeks for wash out period. Baseline four point verbal pain intensity score was obtained and oral administration of paroxetine 20 mg was initiated. At two weeks follow-up visit, pain intensity scores, pain improvement scores judged by family, drug efficacy, tolerability and overall evaluation were assessed. The incidence of side effects were also obtained. Result: After two weeks of treatment, pain intensity scores decreased in 77.5% of patients and no patients experienced aggravation. These findings were objectively reflected in pain improvement scores judged by family members. But, the number of nonresponders was different among groups. In drug efficacy, tolerability and overall evaluation, the proportions of patients who scored as excellent or good were 75%, 80% and 80% respectively. Incidence of side effects was 27.5%, but the side effects spontaneously disappeared after discontinuation of medication. Conclusion: Paroxetine, a selective serotonin reuptake inhibitor, appears to be effective as adjuvant analgesic for the management of various neuropathic pain syndromes.

• Journal of Korean Neurosurgical Society
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• 제29권1호
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• pp.113-117
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• 2000

Objective : Asymptomatic cyst of the pineal gland is a common incidental finding in adults on computerized tomography or magnetic resonance image(MRI) or at postmortem examination. This study was conducted to identify MRI findings of the benign pineal cysts and to determine the proper management of asymptomatic pineal cysts. Methods : From January 1995 to March 1999, 13 cases of asymptomatic pineal cysts were diagnosed incidentally on MRI. The mean age of the patients at diagnosis was 43 years(ranged 8 to 69 years). Five patients were females and eight patients were males. We analyzed the clinical presentations and MRI findings. Results : Clincal features were not related to pineal cysts in all 13 cases included posttraumatic headache in seven cases, headache related to brain tumor in two cases, one of facial palsy, one of diabetic neuropathy, and two of other diseases. MRI demonstrated a well-demarcated mass lesion(mean 1.3cm in diameter) of low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Gadolinium-enhanced MRI, performed in 10 cases, demonstrated a rim enhancement. Hydrocephalus was not present in all cases. Follow-up MRI(ranged 12 to 36 months) obtained in 3 of the 13 patients showed stability of cyst size. After symptomatic treatment, presenting symptoms were resolved in all patients and symptom related to pineal cysts have not been developed during follow up period(mean 27 months). Conclusion : The long-term behavior of asymptomatic pineal cysts is still unknown. But we advocate conservative management of these benign pineal cysts that may be developmental variants of normal pineal gland.

• 한국산학기술학회논문지
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• 제14권4호
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• pp.1774-1780
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• 2013

본 연구는 당뇨 환자를 대상으로 신경병증 통증과 혈당조절정도 및 자가관리간의 관계를 파악하는 서술적 상관관계 연구이다. 자료는 일 대학교 병원의 내분비 내과에서 2011년 5월 10일부터 5월 31일까지 당뇨로 방문한 환자 중 연구기준에 적합한 108명을 대상으로 자가보고식 설문지와 의무기록을 이용하여 수집되었다. 자료분석은 SPSS WIN 18.0을 이용하여 서술통계와 Pearson's correlation coefficient를 실시하였다. 연구 결과 당뇨환자의 통증은 $9.3{\pm}0.4$점이었으며 당화혈색소 수치는 7.5% 이상인 군이 33.3%를 차지하였고 자가관리는 $5.40{\pm}0.76$점이었다. 당뇨환자의 신경병증 통증은 혈당조절 정도가 양호할수록(r=.18, p=.035), 자가관리 수행정도가 높을수록(r=-.19, p=.023) 적었다. 결론적으로 당뇨환자의 신경병증 통증을 조절하기 위하여 보다 엄격한 혈당관리와 자가관리를 향상시키는 노력이 필요하다.

• Journal of Applied Biological Chemistry
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• 제62권4호
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• pp.361-366
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• 2019

Isorhamnetin 3-O-glucoside는 플라보놀 그룹에 속하는 물질로서 염증이나 궤양에 효과가 있을 뿐만 아니라 신경장해, 신장병증, 망막증과 같은 당뇨합병증을 완화하는 것으로 보고되었다. Isorhamnetin 3-O-glucoside는 Tetraena aegyptia, Salsola oppositifolia, Salicornia herbacea, Sambucus ebulus와 같은 몇몇 식물에서 발견된다. 생물전환은 저렴한 화합물로부터 고부가가치 물질을 생산할 수 있는 유용한 방법이다. 본 연구에서 생물전환을 통해 quercetin으부터 isorhamnetin 3-O-glucoside를 생합성 하기 위해 두 개의 유전자(PGT E82L과, ROMT-9)를 각각의 대장균에 도입하였다. 대장균의 공조배양시스템을 이용하여 isorhamnetin 3-O-glucoside 생산 배양법의 최적화를 위해 생물전환배지, 배양온도, 세포의 혼합비율, 재조합 단백질 유도시간, 기질 공급 농도 등을 테스트하였다. 최적화된 생물전환 조건하에서 생물전환을 실시하였으며, 배양의 12시간 후 181.2 mg/L의 isorhamnetin 3-O-glucoside가 생합성 되었다. 이는 이전의 연구에서 보고된 isorhamnetin 3-O-glucosie (39.6 mg/L)의 생합성보다 4.7배 높았다.