• Journal of the Korean association of regional geographers
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• v.16 no.5
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• pp.610-622
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• 2010

The proportion of overweight and obese individuals in the United States has been continuously increasing up to recently. Many studies related to obesity have concentrated on jurisdictional levels of aggregation, making it very difficult to dearly illustrate at risk regions. In other words, little research has been conducted in relation to spatial patterns considering spatial dependency and heterogeneity by spatial autocorrelation models over space. In response, this research analyzes spatial patterns between overweight/obesity and risk factors, such as high blood pressure and diabetes, over space. Specifically, the Moran''s I and Geary''s C will be conducted for global and local measures. What is more, the Ordinary Least Square (OLS) linear regression and Geographically Weighted Regression methods will be applied to identify spatial dependency and spatial heterogeneity. Data provided by the Behavioral Risk Factor Surveillance System (BRFSS) have Body-Mass Index (BMI) rates, containing 4 rates of under, healthy, overweight, and obesity. In addition, high blood pressure and diabetes rates in the United States will be used as independent variables. Lastly, we are confident that this research will be beneficial for a decision maker to make a prevention plan for obesity.

• Nutrition Research and Practice
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• v.11 no.3
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• pp.180-189
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• 2017

BACKGROUND/OBJECTIVES: Recent living condition improvements, changes in dietary habits, and reductions in physical activity are contributing to an increase in metabolic syndrome symptoms including diabetes and obesity. Through such societal developments, humankind is continuously exposed to metabolic diseases such as diabetes, and the number of the victims is increasing. This study investigated Cordyceps militaris water extract (CMW)-induced glucose uptake in HepG2 cells and the effect of CMW treatment on glucose metabolism. MATERIALS/METHODS: Colorimetric assay kits were used to determine the glucokinase (GK) and pyruvate dehydrogenase (PDH) activities, glucose uptake, and glycogen content. Either RT-PCR or western blot analysis was performed for quantitation of glucose transporter 2 (GLUT2), hepatocyte nuclear factor 1 alpha ($HNF-1{\alpha}$), phosphatidylinositol 3-kinase (PI3k), protein kinase B (Akt), phosphorylated AMP-activated protein kinase (pAMPK), phosphoenolpyruvate carboxykinase, GK, PDH, and glycogen synthase kinase 3 beta ($GSK-3{\beta}$) expression levels. The ${\alpha}-glucosidase$ inhibitory activities of acarbose and CMW were evaluated by absorbance measurement. RESULTS: CMW induced glucose uptake in HepG2 cells by increasing GLUT2 through $HNF-1{\alpha}$ expression stimulation. Glucose in the cells increased the CMW-induced phosphorylation of AMPK. In turn, glycolysis was stimulated, and glyconeogenesis was inhibited. Furthermore, by studying the mechanism of action of PI3k, Akt, and $GSK-3{\beta}$, and measuring glycogen content, the study confirmed that the glucose was stored in the liver as glycogen. Finally, CMW resulted in a higher level of ${\alpha}-glucosidase$ inhibitory activity than that from acarbose. CONCLUSION: CMW induced the uptake of glucose into HepG2 cells, as well, it induced metabolism of the absorbed glucose. It is concluded that CMW is a candidate or potential use in diabetes prevention and treatment.

• Clinical and Experimental Pediatrics
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• v.51 no.6
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• pp.569-575
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• 2008

Type 1 diabetes mellitus (T1 DM) develops in genetically susceptible individuals as a result of progressive autoimmune destruction of beta cells. There is larger global variation in incidence among children aged 0-14 years. The incidence of T1 DM in Korea is very low. The latest survey in Korea was conducted in 2001 by Korean Society of Pediatrics to analyse the childhood (0-14 years) national-wide incidence during 1 995-2000. The average childhood incidence (/100,000 and year) was 1.36 (95% CI: 1.23-1.48), higher than 1.06 of Korea in 1 994. This survey reported that higher mean annual incidence was observed in female (girls, 1.67 vs boy 1.07), older age group (10-14 years, 1.98; 5-9 years, 1.43; 0-4 years, 0.73), Kangwondo (2.09) and Seoul (1.99), and more new patients developed in spring (spring, 27.1%; winter, 26.6%; summer, 24.8%; autumn, 21.5%). The increase of childhood T1 DM incidence has occurred in every region (4.0% in Asia, 3.2% in Europe during 1990-1999). Also, steady increase in incidence was observed during 1985-2000 in Korea. This trends may be maintained or accelerated by environmental factors, known as triggers, modifiers and promoters of the T1 DM occurrence. The rising incidence of T1 DM suggests the need for continuous monitoring of incidence by using standardized methods in order to plan or assess prevention strategies.

• Korean Journal of Health Education and Promotion
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• v.5 no.2
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• pp.52-62
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• 1988

The purpose of this study was to improve the motivation for prevention of adult chronic disease through identifying the relationship between health awareness and health behavior. These data was based on the survey of 524 men, This study employed 90 questions, related to general cheracteristics, health awareness, health behavior, dietary habit, mass media utilizing health information, The data were analyzed by using t-test, ANOVA, Contingency-Coefficient, Duncan's multiple range test. The result of this study revealed the follows: 1. The contingency coefficient between health awareness and health behavior showed that total(C=0.3272), 30-39 age group(C=3949), 40-49 age group(C=0.3978), which(C.) mean higher scores, had a [used to visit whenever they were ill], that 50-59 age group(C=0.4165) demonstrate higher score concerned with [Smoking]. 2, The general dietary habit related to statistically significant difference in men's age, educational status, income, economic status, job, concern of adult chronic disease(p<0.01). 3. The general dietary habit related to statistically significant difference in cancer patients arrounding them, knowledge of diabetes, hypertensiom and cancer (p<0.01). 4, Dietary habit for preventing obesity related to statistically significant difference in men's age, income(p<0.05). 5, Dietary habit for preventing obesity related to statistically significant difference in sensitivity of diabetes, hypertension and knowledge of diabetes, cancer(p<0.01). In conclusion, health education which were emphasis of health behavior formation is reguired.

• Nutrition Research and Practice
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• v.12 no.1
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• pp.20-28
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• 2018

BACKGROUND/OBJECTIVES: Perilla frutescens (L.) Britton var. (PF) sprout is a plant of the labiate family. We have previously reported the protective effects of PF sprout extract on cytokine-induced ${\beta}-cell$ damage. However, the mechanism of action of the PF sprout extract in type 2 diabetes (T2DM) has not been investigated. The present study was designed to study the effects of PF sprout extract and signaling mechanisms in the T2DM mice model using C57BL/KsJ-db/db (db/db) mice. MATERIALS/METHODS: Male db/db mice were orally administered PF sprout extract (100, 300, and 1,000 mg/kg of body weight) or rosiglitazone (RGZ, positive drug, 1 mg/kg of body weight) for 4 weeks. Signaling mechanisms were analyzed using liver tissues and HepG2 cells. RESULTS: The PF sprout extract (300 and 1,000 mg/kg) significantly reduced the fasting blood glucose, serum insulin, triglyceride and total cholesterol levels in db/db mice. PF sprout extract also significantly improved glucose intolerance and insulin sensitivity, decreased hepatic gluconeogenic protein expression, and ameliorated histological alterations of the pancreas and liver. Levels of phosphorylated AMP-activated protein kinase (AMPK) protein expression also increased in the liver after treatment with the extract. In addition, an increase in the phosphorylation of AMPK and decrease in the phosphoenolpyruvate carboxykinase and glucose 6-phosphatase proteins in HepG2 cells were also observed. CONCLUSIONS: Our results sugges that PF sprout displays beneficial effects in the prevention and treatment of type 2 diabetes via modulation of the AMPK pathway and inhibition of gluconeogenesis in the liver.

• Mass Spectrometry Letters
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• v.5 no.1
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• pp.16-23
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• 2014

Liquid chromatography based mass spectrometry (LC-MS) is a key technology for analyzing highly complex and dynamic proteome samples. With highly accurate and sensitive LC-MS analysis of complex proteome samples, efficient data processing is another critical issue to obtain more information from LC-MS data. A typical proteomic data processing starts with protein database search engine which assigns peptide sequences to MS/MS spectra and finds proteins. Although several search engines, such as SEQUEST and MASCOT, have been widely used, there is no unique standard way to interpret MS/MS spectra of peptides. Each search engine has pros and cons depending on types of mass spectrometers and physicochemical properties of peptides. In this study, we describe a novel data process pipeline which identifies more peptides and proteins by correcting precursor ion mass numbers and unifying multi search engines results. The pipeline utilizes two open-source software, iPE-MMR for mass number correction, and iProphet to combine several search results. The integrated pipeline identified 25% more proteins in mouse epididymal adipose tissue compared with the conventional method. Also the pipeline was validated using control and colitis induced colon tissue. The results of the present study shows that the integrated pipeline can efficiently identify increased number of proteins compared to the conventional method which can be a breakthrough in identification of a potential biomarker candidate.

• Journal of Nutrition and Health
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• v.50 no.3
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• pp.203-216
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• 2017

Purpose: This literature review was performed to assess the effect of raisins on human health. Methods: A review of Medline was conducted using the keywords: 'raisins, raisins and health, raisins and cardiovascular disease (CVD), raisins and cancer, raisins and diabetes, raisins and fiber, raisins and colon health, raisins and antioxidants, raisins and inflammation, raisins and dental caries'. The reference lists from previous review articles on raisins and human health and the California Raisin Marketing Board files were reviewed for additional studies. Results: Raisins have one of the highest polyphenolic content and antioxidant ORAC levels compared to other traditional dried fruits. Many of the polyphenols in raisins are well assimilated and bioavailable. Raisin consumption reduces low density lipoprotein (LDL) cholesterol, blood pressure and blood sugar, when compared to equal caloric carbohydrate snacks and is associated with a reduced risk of CVD. The anti-inflammatory and cancer chemopreventive effects of raisins are mixed. Raisin consumption reduces intestinal transit time and positively affects gut microbiota. Raisins produce sustained energy during long term athletic competitions equal to traditional sports energy gels, shots and jelly beans. Raisins produce a non-cariogenic oral environment and do not fit the American Academy of Pediatrics criteria to be considered a choking hazard. Conclusions: Based on the review of literature, consumption of raisins provide numerous health benefits for promoting general wellness and in the prevention of many chronic diseases including: CVD, type 2 diabetes mellitus (T2DM) gastrointestinal diseases, and dental caries.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.461-470
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• 2019

In diabetes mellitus, renal disease is a common complication, characterized by increased urinary albumin excretion and reduced eGFR. According to KDIGO CKD stage classification, Korean characteristics were analyzed according to urinary albumin and eGFR using the National Health and Nutrition Examination Survey VI raw data. According to KDIGO classification, diabetic patients were classified as Low risk 72.0%, Moderate risk 19.3%, High risk 5.6% and Very high risk 3.0%. Low risk decreased from 74.7% to 52.2%, and moderate to very high risk increased from 25.4% to 47.8% as the duration of diabetes mellitus was prolonged. The risk factors were CKD stage 1 (HR 2.064) to stage 4 (HR 11.049), the highest risk of hypertension. The incidence of renal disease was elevated according to duration of hypertension and HR 0.42 of kidney disease was decreased in the group maintaining proper blood pressure. In the hypertensive patients, the group administered with target blood pressure had a reduction of the kidney disease by 42% than the group with the hypertension. Therefore, controlling and managing hypertension to target blood pressure is important for the prevention of kidney disease.

• Korean Journal of Community Nutrition
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• v.27 no.2
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• pp.132-145
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• 2022

Objectives: This study examined trends in the health status and dietary behavior changes by region using the raw data from the 2008 ~ 2019 Community Health Survey. Methods: This study analyzed the data of 2,738,572 people among the raw data of the Community Health Survey from 2008 to 2019. The regional differences in health status and dietary behavior were examined by classifying the regions into capital and non-capital regions, and the non-capital regions were classified into metropolitan cities and provinces. A chi-square test was conducted on the body mass index (BMI), diagnosis of diabetes and hypertension, frequency of eating breakfast, salty taste in usual diet, recognition of nutrition labeling, reading of nutrition labeling, and utilization of nutrition labeling. Results: In determining obesity using the BMI, the normal weight by year decreased, and the obesity rate by year was 34.6% in 2019, which increased by 13% compared to 2008. In addition, the diabetes diagnosis rate and hypertension diagnosis rate continued to increase with the year. Both diabetes and hypertension diagnosis rates were higher in the non-capital regions than in the capital region. Eating breakfast five to seven times per week was most common and showed a significant decreasing trend by year (P < 0.001). The percentage of respondents who said they eat slightly bland foods increased from 19.5% in 2008 to 19.9% in 2010 and then to 22.1% in 2013. The percentage then decreased to 19.9% in 2019, but showed an overall increasing trend (P < 0.001). According to the region, the capital region had a higher percentage than the non-capital region. The nutrition labeling's recognition rate and utilization rate increased yearly, whereas the reading rate decreased. Conclusions: The study results presented the primary data necessary to develop nutrition education programs and establish strategies for local nutrition management projects to improve disease prevention and dietary problems.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.2
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• pp.181-196
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• 2023

Purpose : The purpose of this study was to investigate the effects of physical activity on impaired fasting glucose in adults aged 20 years or older. Methods : This study utilized raw data from the 8th National Health and Nutrition Examination survey (2019~2021). The subjects of this study were 5,344 adults aged 20 years or older who were confirmed to be free of diabetes. The control variables in this study model are health behavior characteristics (subjective health status, smoking, drinking), anthropometric characteristics (body mass index), and personal background characteristics (gender, age, income level, education level, marital status). As for the analysis method, the degree of physical activity was made into a dummy variable, and a probit model was used. Results : As a result of this study, compared to quartile 1 of the relative grip strength value obtained by dividing the grip strength by the body mass index (body mass index, kg, m²), fasting blood glucose levels were significantly higher in quartile 2 (.05, p<.01), quartile 3 (.04, p<.01), and quartile 4 (.04, p<.01). It was found that the probability of belonging to the normal category was higher than that of impaired fasting glucose. In addition, in the group of adults aged 20 or older who had a lot of aerobic and anaerobic physical activity, fasting blood sugar was more likely to be in the normal category. Conclusion : Based on the results of this study, it was suggested that diabetes should be managed through physical activity in the pre-diabetic stage, as prevention is important as well as treatment. From a practical point of view, muscle strength, such as grip strength, can be identified as a reliable indicator for identifying impaired fasting glucose.