• Proceedings of the Korean Society of Sericultural Science Conference
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• 2003.10a
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• pp.19-22
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• 2003

Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We found that Drosaphiia FACT, a heterodimer of dSPT16 and dSSRPl, is associated with GAGA factor through its dSSRPl subunit, binds to a nucleosome and facilitates GAGA factor-directed chromatin remodeling. Immunostaining of polytene chromosomes revealed colocalization of GAGA factor and FACT in many specific loci. (omitted)

• Journal of People, Plants, and Environment
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• v.23 no.1
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• pp.77-85
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• 2020

The purpose of this study was to examine the effects of a healing garden program based on internal factors of vocational adaptation on career attitude for college students with developmental disabilities. First, healing garden program was defined by a group of experts related to education for developmental disabilities in the industry and academia through the focus group interview. Second, the healing garden program for college students with developmental disabilities was carried out for 15 weeks. Third, this study examined the effects of healing garden program based on internal factors of vocational adaptation on career attitude for college students with developmental disabilities. The participants of this study were 55 college students with developmental disabilities in N University, with 25 students placed in the experimental group and the other 30 in the control group. As a result of examination, the difference between before and after the program, it was found that factors of career attitude were improved significantly after the program in the experimental group, with Factor 1 (determination) increased from 2.08 to 3.39, Factor 2 (finality) from 2.28 to 3.19, Factor 3 (confidence) from 2.20 to 3.69, Factor 4 (preparation) from 2.12 to 3.79, and Factor 5 (independence) from 1.88 to 3.63. But the control group did not show a significant improvement after 15 weeks of the program except Factor 3 (confidence) and Factor 5 (independence). It was found that the healing garden program based on internal factors of vocational adaptation had effects on career attitude for college students with developmental disabilities. Finally, the program will contribute to vocational rehabilitation for college students with disabilities. The findings further suggest that healing gardening programs that facilitate career attitudes must be continuously developed and applied in order to establish effective transition from school to the world of vocational adaptation.

• Molecules and Cells
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• v.42 no.11
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• pp.810-819
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• 2019

For physiological or pathological understanding of bone disease caused by abnormal behavior of osteoclasts (OCs), functional studies of molecules that regulate the generation and action of OCs are required. In a microarray approach, we found the suppression of tumorigenicity 5 (ST5) gene is upregulated by receptor activator of nuclear $factor-{\kappa}B$ ligand (RANKL), the OC differentiation factor. Although the roles of ST5 in cancer and ${\beta}-cells$ have been reported, the function of ST5 in bone cells has not yet been investigated. Knockdown of ST5 by siRNA reduced OC differentiation from primary precursors. Moreover, ST5 downregulation decreased expression of NFATc1, a key transcription factor for osteoclastogenesis. In contrast, overexpression of ST5 resulted in the opposite phenotype of ST5 knockdown. In immunocytochemistry experiments, the ST5 protein is colocalized with Src in RANKL-committed cells. In addition, ST5 enhanced activation of Src and Syk, a Src substrate, in response to RANKL. ST5 reduction caused a decrease in RANKL-evoked calcium oscillation and inhibited translocation of NFATc1 into the nucleus. Taken together, these findings provide the first evidence of ST5 involvement in positive regulation of osteoclastogenesis via Src/Syk/calcium signaling.

• Culinary science and hospitality research
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• v.13 no.1 s.32
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• pp.99-111
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• 2007

This study aims at inquiring into the effect of kitchen employees' conflict factors in deluxe hotels on turnover to present a improvement plan. For this, it made a survey of 292 kitchen employees in deluxe hotels from December 1 to 10, 2006. The results were as follows: First, it showed that the service welfare conflict had a positive effect on the compensational turnover, and high compensational turnover was caused by high conflict of welfare or benefits. Second, it showed that the cooking job conflict had a positive effect on the developmental turnover. Third, it showed that the colleague relationship conflict had a positive effect on the developmental turnover. Consequently, each factor of compensational and developmental turnover had significantly positive correlation to the cooking job conflict, service welfare conflict and colleague relationship conflict. Considering the above results, the employees' turnover produced results that are contrary to negative and positive effects traditionally discussed various effects or results on organization.

• Fashion & Textile Research Journal
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• v.14 no.3
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• pp.390-399
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• 2012

The purpose of this study is to find the connectional structure of mentoring perceived by the 2-year college students who are majoring in fashion, and to develop the scale with which the mentoring effect can be measured on the basis of the results. To achieve the purpose, research was conducted through a survey questionnaire. The research was carried out obtaining data from the 2-year college students. Responses from this questionnaire were gathered from 265 students. The questionnaire was made with 31 mentoring scales and removed inadequate 18 questions for statistics analysis. The remaining questionnaires consisting of 13 questions were categorized into three factors. The first factor (5questions) relates to the sensitivity developmental function. The second factor (5questions) pertains to the psychosocial function and the third factor (3questions) was for the fashion career developmental function. The results derived from the analysis of the questionnaire survey are as follows: First, the role model function is not enticing enough for the student to continue role model or professor for future student. The students are more interested into discovering their own capability in fashion by entering a fashion company. Second, the result of this study was confirmed through descriptive statistics, exploratory factor analysis and confirmatory factor analysis. Third, the results of this study can be a guide-line for professors to help student to which is fashion in spite of outside comment and own future career task.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2005.10a
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• pp.130-130
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• 2005

• Proceedings of the Korean Society of Developmental Biology Conference
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• 1998.07a
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• pp.63-65
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• 1998

생쥐의 초기발생과정에서 배아 세포질의 제거로 nucleus/cytoplasm ratio를 증가시켰을 경우, 발생과 gene expression에는 영향을 미치지 않았으나 형태형성은 촉진되었다. 또, nucleus/cytoplasm ratio의 변화 없이 발생후기의 cytoplasm으로 일부 치환된 배아에서 발생과 gene expression, 형태형성은 모두 촉진되었다. 이상의 결과로 보아 초기배아의 gene expression과 형태형성과정에서 일어나는 time schedule의 조절은 nucleus/cytoplasm ratio가 직접적으로 영향을 미치지 않고 난자와 배아 내에 존재하는 cytoplasm factor에 의해 조절 받으며, 특히 형태 형성의 time schedule은 cytoplasmic factor와 이들에 의해 조절되는 물질의 상대적인 농도에 의해 조절될 것으로 여겨진다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.43 no.2
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• pp.63-69
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• 2017

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in $Nfic^{-/-}$ mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-${\beta}1$, $Kr{\ddot{u}}ppel$-like factor 4, and ${\beta}$-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

• International Journal of Advanced Culture Technology
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• v.12 no.3
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• pp.271-277
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• 2024

The purpose of this study was to empirically analyze the effect of gender perception on the life satisfaction of people with developmental disabilities. Based on the results, it was intended to suggest practical measures to improve the developmentally disabled's awareness of their gender and quality of life. To achieve the purpose of the study, a survey was conducted with a significant sample of people with developmental disabilities aged 30 or older in Ulsan City. It was done. Of the collected questionnaires, 58 copies were used as final analysis data, excluding unfaithful responses. The collected data were factor analysis, reliability analysis, frequency analysis, Pearson correlation analysis, t/F-test, and regression analysis using SPSS 20.0 It was implemented. Based on the analysis results, the development of gender education programs for people with developmental disabilities to provide knowledge and information about gender and developmental disabilities. It suggested establishing experts and counseling institutions dedicated to gender and implementing and promoting social education for the general public.

• Molecules and Cells
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• v.45 no.10
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• pp.749-760
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• 2022

Osteoclast generation from monocyte/macrophage lineage precursor cells needs to be tightly regulated to maintain bone homeostasis and is frequently over-activated in inflammatory conditions. PARK2, a protein associated with Parkinson's disease, plays an important role in mitophagy via its ubiquitin ligase function. In this study, we investigated whether PARK2 is involved in osteoclastogenesis. PARK2 expression was found to be increased during the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. PARK2 gene silencing with siRNA significantly reduced osteoclastogenesis induced by RANKL, LPS (lipopolysaccharide), TNFα (tumor necrosis factor α), and IL-1β (interleukin-1β). On the other hand, overexpression of PARK2 promoted osteoclastogenesis. This regulation of osteoclastogenesis by PARK2 was mediated by IKK (inhibitory κB kinase) and NF-κB activation while MAPK (mitogen-activated protein kinases) activation was not involved. Additionally, administration of PARK2 siRNA significantly reduced osteoclastogenesis and bone loss in an in vivo model of inflammatory bone erosion. Taken together, this study establishes a novel role for PARK2 as a positive regulator in osteoclast differentiation and inflammatory bone destruction.