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http://dx.doi.org/10.5125/jkaoms.2017.43.2.63

The role of nuclear factor I-C in tooth and bone development  

Roh, Song Yi (Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University)
Park, Joo-Cheol (Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.43, no.2, 2017 , pp. 63-69 More about this Journal
Abstract
Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in $Nfic^{-/-}$ mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-${\beta}1$, $Kr{\ddot{u}}ppel$-like factor 4, and ${\beta}$-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
Keywords
Nuclear factor I-C; Dentinogenesis; Osteogenesis; Osteoporosis;
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