Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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The role of nuclear factor I-C in tooth and bone development

  • Roh, Song Yi (Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Park, Joo-Cheol (Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University)
  • Received : 2017.04.04
  • Accepted : 2017.04.06
  • Published : 2017.04.30
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Abstract

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in $Nfic^{-/-}$ mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-${\beta}1$, $Kr{\ddot{u}}ppel$-like factor 4, and ${\beta}$-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

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References

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