• Reproductive and Developmental Biology
• /
• 제36권4호
• /
• pp.275-281
• /
• 2012

Embryonic stem cell-preconditioned microenvironment is important for cancer cells properitities by change cell morphology and proliferation. This microenvironment induces cancer cell reprogramming and results in a change in cancer cell properties such as differentiation and migration. The cancer microenvironment affects cancer cell proliferation and growth. However, the mechanism has not been clarified yet. Using the ES-preconditioned 3-D microenvironment model, we provide evidence showing that the ES microenvironment inhibits proliferation and reduces oncogenic gene expression. But ES microenvironment has no effect on telomerase activity, cell viability, cellular senescence, and methylation on Oct4 promoter region. Furthermore, methylation of Nanog was increase on ES-preconditioned microenvironment and supports results that no difference on RNA expression levels. Taken together, these results demonstrated that in the ES-preconditioned 3-D microenvironment is a crucial role for cancer cell proliferation not senescence.

• BMB Reports
• /
• 제51권11호
• /
• pp.549-556
• /
• 2018

Mitochondria are ubiquitous and multi-functional organelles involved in diverse metabolic processes, namely energy production and biomolecule synthesis. The intracellular mitochondrial morphology and distribution change dynamically, which reflect the metabolic state of a given cell type. A dramatic change of the mitochondrial dynamics has been observed in early development that led to further investigations on the relationship between mitochondria and the process of development. A significant developmental process to focus on, in this review, is a differentiation of neural progenitor cells into neurons. Information on how mitochondria-regulated cellular energetics is linked to neuronal development will be discussed, followed by functions of mitochondria and associated diseases in neuronal development. Lastly, the potential use of mitochondrial features in analyzing various neurodevelopmental diseases will be addressed.

• 한국발생생물학회지:발생과생식
• /
• 제15권3호
• /
• pp.187-195
• /
• 2011

X chromosome inactivation (XCI) is a process that enables mammalian females to ensure the dosage compensation for X-linked genes. Investigating the mechanism of XCI might provide deeper understandings of chromosomal silencing, epigenetic regulation of gene expressions, and even the course of evolution. Studies on mammalian XCI conducted with mice have revealed many fundamental findings on XCI. However, difference of murine and human XCI necessitates the further investigation in human XCI. Recent success in reprogramming of differentiated cells into pluripotent stem cells showed the reversibility of XCI in vitro, X chromosome reactivation (XCR), which provides another tool to study the change in X chromosome status. This review summarizes the current knowledge of XCI during early embryonic development and describes recent achievements in studies of XCI in reprogramming process.

• 한국도서관정보학회지
• /
• 제34권3호
• /
• pp.67-92
• /
• 2003

이 연구는 현재 우리 나라 학교도서관 영역에서 일어나고 있는 변화의 배경과 그 성격, 그리고 그 양상 속에 내재된 과제에 대해 분석적으로 밝혀낸다. 논의는 교육인적자원부가 수립하여 시행하는 학교도서관 활성화 정책의 탄생 배경과 그 영향, 그리고 그 한계를 중심으로 전개된다. 연구자는 현재의 긍정적인 변화 속에서도 여러 가지 도전의 요소가 잔존하고 있으며 이를 적절하게 해결해 나가야 학교도서관이 활성화되고 정착할 수 있다고 주장한다.

• 한국국방경영분석학회지
• /
• 제31권1호
• /
• pp.93-106
• /
• 2005

The complexity of modern weapon systems using the IT(intelligence technology) demands that rapid and effective transition from force requirements to deployment and fielding. Thus this paper deals with the DT&E(developmental test & evaluation), OT&E(operational test & evaluation) and SBT(simulation based test) procedure using the case study in the test & evaluation of weapon systems. This study is aimed to produce the effective test & evaluation method of weapon systems in the change of acquisition environment.

• Journal of Contemporary Eastern Asia
• /
• 제12권1호
• /
• pp.35-47
• /
• 2013

During the last a few decades, internationalisation of universities has emerged as an important issue not only in developed countries but in developing countries. South Korea as a fast catch-up country has experienced a remarkable change in its higher education system. This change is largely related to the South Korean government's higher education policy and to economic developmental stages. Against this backdrop, in order to assess the internationalisation of Korean higher education, we focus on international student mobility rather than other criteria such as infrastructure or programmes for international students and faculties. According to the recent statistics, the number of inbound foreign students involved in Korean higher education has increased significantly since 2005. Nevertheless, compared to other OECD and Asian countries, the number of outbound students in Korean higher education is high, whereas the number of inbound foreign students in higher education in Korea is very low. Against these observations, Korean government's recent policies and efforts of Korean universities to improve internationalization are discussed. Finally, some policy implications are put forward.

• 영어어문교육
• /
• 제12권4호
• /
• pp.31-68
• /
• 2006

The present research investigates the acquisition of the English locative alternation by Korean EFL learners, which poses a learnability paradox, taking Pinker's framework of learnability theory as its basis. It addresses two questions (1) how lexical knowledge is represented initially and at different levels of interlanguage development and (2) what kinds of difficulty Korean learners find in the acquisition of English locative verbs and their constructions. Three groups of learners at different proficiency levels with a control group of English native speakers are examined by two instruments: elicited production task and grammaticality judgment task. According to different levels of proficiency, the learners exhibit gradual sensitivity to a change-of-state meaning and obtain complete perception of the meanings of locative verbs (manner-of-motion and change-of-state) and their constructions. Overgeneralization errors are observed in their performance. The errors are due to misinterpretations of particular lexical items in conjunction with the universal linking rules. More fundamental cause of difficulty is accounted for by partial use of learning mechanisms, caused by insufficient L2 input.

• 교육시설
• /
• 제2권2호
• /
• pp.7-15
• /
• 1995

The main theme of this paper is to evaluate the relevance of Educational Facilities in terms of university change in near future. The paper reviewed the changing process of higher education and its role in Korean society briefly, proposed the developmental directions of higher education in future in several perspectives, and introduced educational reform plan in the field of higher education proposed on May 30, 1995 by advisory group to the president. In this context, the irrelevance of university and college education facilities was pointed out, and proposed some new and modernizing guide lines of educational facilities such as flexibility, openness, corelationships and consortium among related institutes, optimization of related laws and rules, exemption from the direct ruling and control of government. This paper also suggested some ideas of facilitating educational facilities in accordance with the future change trends of university and college education.

• Archives of Plastic Surgery
• /
• 제41권2호
• /
• pp.163-170
• /
• 2014

Background The septal cartilage is the most useful donor site for autologous cartilage graft material in rhinoplasty. For successful nasal surgery, it is necessary to understand the developmental process of the nasal septum and to predict the amount of harvestable septal cartilage before surgery. Methods One hundred twenty-three Korean patients who underwent three-dimensional (3D) facial bone computed tomography (CT) were selected for evaluation of the midsagittal view of the nasal septum. Multiple parameters such as the area of each component of the nasal septum and the amount of harvestable septal cartilage were measured using Digimizer software. Results The area of the total nasal septum showed rapid growth until the teenage years, but thereafter no significant change throughout the lifetime. However, the development of the septal cartilage showed a gradual decline due to ossification changes with aging after puberty in spite of a lack of change in the total septal area. The area of harvestable septal cartilage in young adults was $549.84{\pm}151.26mm^2$ and decreased thereafter with age. Conclusions A 3D facial bone CT scan can provide valuable information on the septal cartilage graft before rhinoplasty. Considering the developmental process of the septal cartilage identified in this study, septal surgery should not be performed until puberty due to the risk of nasal growth impairment. Furthermore, in elderly patients who show a decreased cartilage area due to ossification changes, septal cartilage harvesting should be performed carefully due to the risk of saddle nose deformity.

• 한국의류산업학회지
• /
• 제19권2호
• /
• pp.109-120
• /
• 2017

In the textile industry located in Gyeonggi-do, 85% of small-sized firms have less than 10 employees; in addition, the most of them are characterized by a vendor relying specialization system that conducts foundry from the vendor that managed marketing, textile design development, and quality checks according to unit stream. The breakaway of these vendors accelerated over the last 7 years; however, industry survival is at stake because the specialization system and orders have collapsed. The following four main policies must be implemented to overcome industry hardship. Policies have been derived from survey and analysis (present condition and trends) from industrial statistics and related policies in advanced and developing countries. First, a policy to promote cooperation between small-sized foundry unit-streams. Second, unification of the marketing support function with a textile design and development support system. Third, the introduction of policy support-management system customized according to developmental stages (tall process${\rightarrow}$fabric production${\rightarrow}$sales${\rightarrow}$clothing production sales). Fourth, foundation of a control tower that puts these tasks in a vehicle and runs them and the division of roles with the central government. We must propel main tasks to manifest the developmental potential (develop eco-friend dyeing and processing technologies, change to the young next CEO in business environment, and grow the of knit market) of the Gyeonggi Textile Industry in a short period to present a condition where these four main policies are running.