Reproductive and Developmental Biology

The Korean Society of Animal Reproduction (한국동물번식학회)
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Embryonic Stem Cell-Preconditioned Microenvironment Effects on Epidermoid Carcinoma

  • Ryoo, Zae Young (School of Ecology and Environmental Sciences, School of Life Sciences and Biotechnology, Kyungpook National University) ;
  • Kim, Myoung Ok (School of Ecology and Environmental Sciences, School of Life Sciences and Biotechnology, Kyungpook National University)
  • Received : 2012.12.12
  • Accepted : 2012.12.24
  • Published : 2012.12.31
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Abstract

Embryonic stem cell-preconditioned microenvironment is important for cancer cells properitities by change cell morphology and proliferation. This microenvironment induces cancer cell reprogramming and results in a change in cancer cell properties such as differentiation and migration. The cancer microenvironment affects cancer cell proliferation and growth. However, the mechanism has not been clarified yet. Using the ES-preconditioned 3-D microenvironment model, we provide evidence showing that the ES microenvironment inhibits proliferation and reduces oncogenic gene expression. But ES microenvironment has no effect on telomerase activity, cell viability, cellular senescence, and methylation on Oct4 promoter region. Furthermore, methylation of Nanog was increase on ES-preconditioned microenvironment and supports results that no difference on RNA expression levels. Taken together, these results demonstrated that in the ES-preconditioned 3-D microenvironment is a crucial role for cancer cell proliferation not senescence.

Keywords

References

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