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Embryonic Stem Cell-Preconditioned Microenvironment Effects on Epidermoid Carcinoma  

Ryoo, Zae Young (School of Ecology and Environmental Sciences, School of Life Sciences and Biotechnology, Kyungpook National University)
Kim, Myoung Ok (School of Ecology and Environmental Sciences, School of Life Sciences and Biotechnology, Kyungpook National University)
Publication Information
Reproductive and Developmental Biology / v.36, no.4, 2012 , pp. 275-281 More about this Journal
Abstract
Embryonic stem cell-preconditioned microenvironment is important for cancer cells properitities by change cell morphology and proliferation. This microenvironment induces cancer cell reprogramming and results in a change in cancer cell properties such as differentiation and migration. The cancer microenvironment affects cancer cell proliferation and growth. However, the mechanism has not been clarified yet. Using the ES-preconditioned 3-D microenvironment model, we provide evidence showing that the ES microenvironment inhibits proliferation and reduces oncogenic gene expression. But ES microenvironment has no effect on telomerase activity, cell viability, cellular senescence, and methylation on Oct4 promoter region. Furthermore, methylation of Nanog was increase on ES-preconditioned microenvironment and supports results that no difference on RNA expression levels. Taken together, these results demonstrated that in the ES-preconditioned 3-D microenvironment is a crucial role for cancer cell proliferation not senescence.
Keywords
ES cells; Microenvironment; 3D culture; Reprogramming;
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1 Bamberger AM, Milde-Langosch K, Rossing E, Goemann C, Loning T (2001): Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. J Cancer Res Clin Oncol 127: 545-550.   DOI   ScienceOn
2 Burova EB, Smirnova IS, Gonchar IV, Shatrova AN, Nikolsky NN (2011): Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFN gammainduced apoptosis. Cell Cycle 10:2197-2205.   DOI   ScienceOn
3 Campbell A, Wicha MS, Long M (1985): Extracellular matrix promotes the growth and differentiation of murine hematopoietic cells in vitro. J Clin Invest 75: 2085-2090.   DOI   ScienceOn
4 De Wilde J, De-Castro Arce J, Snijders PJ, Meijer CJ, Rosl F, Steenbergen RD (2008): Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesis. Cell Oncol 30:77-87.
5 Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira- Smith O, et al. (1995): A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA, 92:9363-9367.   DOI   ScienceOn
6 Flaim CJ, Chien S, Bhatia SN (2005): An extracellular matrix microarray for probing cellular differentiation. Nat Methods 2:119-125.   DOI   ScienceOn
7 Glover JN, Harrison SC (1995): Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c- Jun bound to DNA. Nature 373:257-261.   DOI   ScienceOn
8 Haylock DN, Nilsson SK (2005): Stem cell regulation by the hematopoietic stem cell niche. Cell Cycle 4: 1353-1355.   DOI   ScienceOn
9 Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, Postovit LM (2007): Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer 7:246-255.   DOI   ScienceOn
10 Kihara T, Hirose M, Oshima A, Ohgushi H (2006): Exogenous type I collagen facilitates osteogenic differentiation and acts as a substrate for mineralization of rat marrow mesenchymal stem cells in vitro. Biochem Biophys Res Commun 341:1029-1035.   DOI   ScienceOn
11 Kim MO, Kim SH, Oi N, Lee MH, Yu DH, Kim DJ, Cho EJ, Bode AM, Cho YY, Bowden TG, Dong Z (2011): Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells. Pigment Cell Melanoma Res 24:922-931.   DOI   ScienceOn
12 Kulesa PM, Kasemeier-Kulesa JC, Teddy JM, Margaryan NV, Seftor EA, Seftor RE, Hendrix MJ (2006): Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. Proc Natl Acad Sci USA 103:3752-3757.   DOI   ScienceOn
13 Kyo S, Klumpp DJ, Inoue M, Kanaya T, Laimins L A (1997): Expression of AP1 during cellular differentiation determines human papillomavirus E6/E7 expression in stratified epithelial cells. J Gen Virol 78 (Pt 2):401-411.   DOI
14 Lee LM, Seftor EA, Bonde G, Cornell RA, Hendrix MJ (2005): The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation. Dev Dyn 233:1560-1570.   DOI   ScienceOn
15 Naugle JE, Olson ER, Zhang X, Mase SE, Pilati CF, Maron MB, Folkesson HG, Horne WI, Doane KJ, Meszaros JG (2006): Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling. Am J Physiol Heart Circ Physiol 290:H323-330.
16 Neyns B, Teugels E, Bourgain C, Birrerand M, De Greve J (1999): Alteration of jun proto-oncogene status by plasmid transfection affects growth of human ovarian cancer cells. Int J Cancer 82:687-693.   DOI   ScienceOn
17 Rapp UR, Troppmair J, Beck T, Birrer MJ (1994): Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant. Oncogene 9:3493-3498.
18 Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ (2008): Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451:141-146.   DOI   ScienceOn
19 Postovit LM, Seftor EA, Seftor RE, Hendrix MJ (2006): A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells 24:501-505.   DOI   ScienceOn
20 Prusty BK, Das BC (2005): Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Int J Cancer 113:951-960.   DOI   ScienceOn
21 Risse-Hackl G, Adamkiewicz J, Wimmel A, Schuermann M (1998): Transition from SCLC to NSCLC phenotype is accompanied by an increased TRE-binding activity and recruitment of specific AP-1 proteins. Oncogene 16:3057-3068.   DOI   ScienceOn
22 Shaulian E, Karin M (2002): AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131-136.   DOI   ScienceOn
23 Suzuki A, Iwama A, Miyashita H, Nakauchi H, Taniguchi H (2003): Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development 130:2513-2524.   DOI   ScienceOn
24 Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe MH, Kameda T, Ichinose M, Miki K, Iba H (1994): Analysis of AP-1 function in cellular transformation pathways. J Virol 68: 3527-3535.
25 Yagi T, Tokunaga T, Furuta Y, Nada S, Yoshida M, Tsukada T, Saga Y, Takeda N, Ikawa Y, Aizawa S (1993): A novel ES cell line, TT2, with high germline- differentiating potency. Anal Biochem 214:70-76.   DOI   ScienceOn
26 Vleugel MM, Greijer AE, Bos R, Van Der Wall E, Van Diest PJ (2006): c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer. Hum Pathol 37:668-674.   DOI   ScienceOn
27 Wang HL, Wang J, Xiao SY, HaydonR, Stoiber D, He TC, Bissonnette M, Hart J (2002): Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. Int J Cancer 101:301-310.   DOI   ScienceOn