• 한국발생생물학회지:발생과생식
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• 제19권2호
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• pp.69-77
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• 2015

Cell-cell direct communication through channel-forming molecules, connexin (Cx), is essential for a tissue to exchange signaling molecules between neighboring cells and establish unique functional characteristics during postnatal development. The corpus epididymis is a well-known androgen-responsive tissue and involves in proper sperm maturation. In the present research, it was attempted to determine if expression of Cx isoforms in the corpus epididymis in the adult is modulated by exposure to estrogenic or anti-androgenic compound during the early postnatal period. The neonatal male rats at 7 days of age were subcutaneously injected by estradiol benzoate (EB) at low-dose ($0.015{\mu}g/kg$ body weight) or high-dose ($1.5{\mu}g/kg$ body weight) or flutamide (Flu) at low-dose ($500{\mu}g/kg$ body weight) or high-dose (50 mg/kg body weight). The corpus epididymis collected at 4 months of age was subjected to evaluate expressional changes of Cx isoforms by quantitative real-time PCR. Treatment of low-dose EB resulted in increases of Cx32, Cx37, and Cx45 transcript levels, while exposure to high-dose EB decreased expression of Cx26, Cx30.3, Cx31, Cx31.1, Cx32, Cx40, Cx43, and Cx45. Treatments of Flu caused significant decreases of expression of all examined Cx isoforms, except Cx37 and Cx43 shown no expressional change with high-dose Flu treatment. These findings imply that expression of most Cx isoforms present in the corpus epididymis would be transcriptionally regulated by actions of androgen and/or estrogen during postnatal period.

• 공학교육연구
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• 제11권4호
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• pp.34-45
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• 2008

국내 공과대학 여자 졸업생의 전공분야 진출이 낮은 원인을 탐색하기 위하여 공과대학 여학생의 전공진로 장벽과 관련된 심리적 특성을 파악하고 이를 남학생과 비교하였다. 전국 8개 대학 1,968명의 남 여학생을 대상으로 설문조사를 실시하여 전공에 대한 가치와 기대, 열망, 만족도 및 자기 효능감을 조사하였고 이러한 심리적 특성들이 대학 경험을 통해 어떻게 변화하는지를 조사하기 위하여 학년에 따라 그 수준을 비교하였다. 그 결과 전공에 대한 가치에 대해서는 남 여 학생간의 뚜렷한 성차가 발견되지 않았으나 기대, 열망, 만족도 및 자기 효능감 등을 비롯한 대부분의 전공 관련 심리적 특성에서 여학생들이 남학생들에 비해 낮음을 알 수 있었다. 또한 남학생들의 경우 전공에 대한 기대, 열망, 만족도, 자기효능감 등이 공과대학 경험과 교육을 통해, 학년이 증가 할수록 일관되게 증가하는 반면 여학생들의 경우 거의 변화하지 않거나 오히려 낮아지는 경향을 보였다. 따라서 이와 같은 공대 여학생들의 심리적 특성을 개선하기 위한 교육 환경 개선 노력이 제안되었다.

• 대한수학교육학회지:학교수학
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• 제14권3호
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• pp.315-330
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• 2012

다양한 수준에 있는 학생 모두에게 일정 정도의 수학을 가르치기 위해서 제7차 교육과정부터 우리나라에서는 수준별 수업을 교육과정에서 권장하고 있다. 주로 사용되는 수준별 수업 방식은 학생들을 그 수준에 따라 두 세 그룹으로 분리한 후 각 수준에 맞는 별도의 활동과 과제를 제시하는 것이다. 본 연구에서는 이런 분리된 수준별 수업을 개선하기 위하여 여러 수준의 학생들을 통합하여 지도하는 방안을 모색하고자 하였다. 영재아를 지도하거나 창의성을 신장하기 위한 수학 수업과 관련해서만 열린 문제에 관한 연구가 이루어져왔다. 그러나 본 연구는 보통의 수학 교실에서 열린 문제는 다양한 수준의 학생들도 반응을 보일 수 있고, 이러한 다양한 반응을 교사가 통합할 수 있다면 낮은 수준의 학생이 잠재적 발달수준으로 수준 상승이 이루어지도록 도울 수 있다는 논의를 바탕으로 열린 문제와 병행 과제를 활용하는 방안을 생각하여 보았다.

• 한국환경생태학회지
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• 제24권2호
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• pp.202-208
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• 2010

본 연구는 박쥐의 연령 증가에 따른 발성 초음파의 변화를 파악하기 위하여 집박쥐(Pipistrellus abramus)를 대상으로 생후 어린 개체가 발산하는 음을 이용하여 세부 분석을 실시하였다. 분석결과 어린 개체는 성체와 다른 복합적이고 다양한 형태의 시그널을 발산하는 것으로 확인되었다. 펄스의 형태는 생후 2일차에는 하모니의 수가 많고 불규칙적인 시그널 형태를 보였으며, 생후 10일차부터 20일 까지는 완만한 FM 시그널 형태를 보였다. 생후 30일 경에는 짧은 시간의 FM 시그널 형태를 보였으며, 40일 이후 점차 성체와 유사한 형태의 시그널을 발산하였다. 어린개체의 성장에 따른 발성 시그널을 분석한 결과 각각의 분석 항목별로 유의적인 차이가 있는 것으로 나타났다. 즉, 펄스의 지속시간(p<0.001), 펄스 간격(p<0.001), 하모니의 수(p<0.001)는 새끼의 연령이 증가할수록 감소하는 경향을 보였으며, 최고진동수(p<0.001), 개시진동수(p<0.001), 종말진동수(p<0.001)는 증가하는 결과를 보였다. 특히 펄스 간격은 생후 5일차에 가장 큰 변화를 보였으며, 그 외 펄스 지속시간, 최고진동수, 개시진동수, 종말진동수는 생후 25일차에 가장 큰 변화를 나타내었다.

• 한국동물학회지
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• 제37권3호
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• pp.324-330
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• 1994

The multicatalvtic 205 proteasome consisting of 12-15 subunits of 22-35 kDa is the catalytic core of the ATP/ubiquitin-dependent 26S protease complex that also is comprised of multiple subunits of 22-110 KDa. In order to determine whether the proteolvtic activities change during muscle development, the enzyme preparations were obtained from 11-, 14- and 17-day old chick embryonic muscle using a BioGel A-1.5m column. The 26S complex preparation from 14- or 17-day old muscle hvdr olvz e d both N -s uccinvl- Le u- Le u -Val-Tvr-7- amido -4- methvlco umarin ( Suc- LLVY- AMC) and ubiquitin-Ivsozvme conjugates about 50% as well as that from 11-day old muscle. In addition, the activity of 20S proteBsome against Suc-LLVY-AMC also decreased by about 20-30%. However, the protein level of 265 complex remained constant during the entire development period, while that of 205 proteasome increased 5- to 6-fold, as analyzed by nondenaturins polyacrvlamide gel elenrophoresis followed by immunoblot analysis using the antibodies raised against the purified enzymes. Thus, the specific activity of 20S proteasome against the peptide must decrease rather dramatically during the muscle development. These results suggest that the development-dependent changes in the proteolytic activities of both 20S proteasome and 26S protease complect from embryonic muscle are due to alterations in the expression of certain subunits in the enzvmes that are responsible for their specific cataIVtic functions but not to overall changes in the enzyme amounts.

• 디지털융복합연구
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• 제16권10호
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• pp.223-233
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• 2018

군은 적으로부터 국민의 생명과 재산을 보호하기 위해 헌법에서 규정한 조직으로서 조직의 특성상 군사보안은 전쟁에서의 성패를 결정지을 중요한 요소이다. 그런데 최근 제4차 산업혁명으로 대변되는 급격한 문명과 기술의 진보는 군내부 군사보안 환경에도 영향을 끼쳐 다양한 변화들을 일으키고 있다. 이런 환경의 변화에 자칫 적절한 대응을 하지 못할 경우, 군조직과 내부 보안에 치명적인 위해를 끼칠 수도 있는 상황이다. 이런 측면에서 군에 새로운 위협으로 대두되고 있는 군사보안위협 요소들을 살펴보고, 그중에서도 최근 가장 기술 진보적이면서도 광범위하게 유입되어질 수 있는 드론에 대해서 보다 중점적인 논의를 진행할 예정이다. 이를 위해 군의 지휘통제 정보작전 기동 화력 작전지속 지원에 이르기까지 그 범위를 광범위하게 확장시켜 나가는 드론이 가지고 있는 취약점과 문제점을 분석하고, 군사보안적인 측면에서 이러한 보안위협 요소에 대한 발전적 보안 대응방안 수립을 목표로 하고자 한다.

• 기본간호학회지
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• 제5권1호
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• pp.19-31
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• 1998

Nursing science is focusing increasingly on family health care. Especially during the launching stage of family the grown-up sons daughters, and middlescent parents daughters have experienced a lot of change. The purpose of this study is to investigate the family health during the launching stage of the family by utilizing the family health assessment tool based on Roy's adaptation model. The Roy adaptation model was used as it is the best practice-based framework for Family Health Nursing Care. The data was collected using a structured questionnaire. The structure of the questionnaire was developed from the Family Health Assessment Tool by S.O. Jang(1996). The sample of 276 subjects was a convenient sample and data was obtained from November 14, 1996 to December 4, 1996. In order to analyze the collected data, this study utilized frequency, percentile, average, ANOVA, Cronbach's, and factor analysis. The results from this research are summarized as follows : 1. The degree of family health is average $95.24{\pm}9.40$ ranged in middle. 2. The significant difference between general characteristics and family health was only revealed with the major decision making person in the family. This research thus suggests the following : 1. The legal system is needed in order to check the family members' health state regularly. 2. With family nursing care, it has to identify who is the major decision maker in that family. 3. There is a need to redefine the family health assessment tool. 4. Further research will attempt to investigate family health in each family's developmental stage.

• 대한간호학회지
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• 제24권2호
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• pp.278-302
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• 1994

This article reviewed and analyzed 39 studies on self efficacy theory applied to health related behavior. The following analysis was done : 1) study subjects 2) measurement tools 3) analysis according to the type of research design(intervention re-search, explanatory research). Some findings are summarized as follows : The study subjects were both healthy people in various developmental stages and patients with various illnesses. The health related behaviors examined in the studies were also various including exercise, smoking cessation, self care behaviors, etc. The measurement of self efficacy was done with specific tools in most studies. In the tools, activities that measured the health behavior domain were listed according to increasing difficulty or contexual arrangement or in combination of both of them The analysis of 17 intervention research studies showed that generally the intervention program increased the self efficacy level of subjects and then the increased strongly self efficacy influenced behavioral changes. Most studies used more than one intervention method for increasing the self efficacy level. these were derived from sources of self efficacy suggested by Bandura. The analysis of 21 explanatory research studies showed that self efficacy strongly influenced behavior change and persistence. The major independent variable to affect the self efficacy was performance accomplishment in the past. Self efficacy explained more of the variance in health related behavior when it was applied with the variables in the health belief model, health promotion model, and reasoned action theory. On the basis of the above findings, the following suggestions are made : 1. For a desirable research design, self efficacy should be the intervening variable. That is, desirable designs would include intervention-self efficacy-behavior in intervention research studies and antecedent-self efficacy-behavior in explanatory research studies. 2. More prospective, longitudinal studies are needed to test the effect of self efficacy on persistence in health related behavior. 3. Studies comparing the effects of intervention methods are needed for each health related behavior, subject group, and context. 4. It is necessary to develop a reliable, valid measurement tool for self efficacy for each health related behavior. 5. Studies to differenciate the effect of self efficacy from that of outcome expectation on the health related behavior are necessary. 6. The antecedents of self efficacy should be investigated further.

• Child Health Nursing Research
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• 제8권3호
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• pp.313-321
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• 2002

We would like to suggest the guideline of use of materials of sexual education for adolescent in school by examining the status of use of materials and by evaluating the video materials frequently used. Survey was done by enquetes on status of use of materials of sexual education from school nurses in 190 primary, 44 middle and 50 high schools in Seoul, Kyonggi-do and Kangwon-do from August 1999 to February 2000. The frequently used 84 videotapes were evaluated on their contents. As for the status of use, 99.3% of subjected schools possessed the materials for sexual education. Decision of purchase was determined according to the review of contents (92.6%). Information about materials was received by the advertisement in newspapers or broadcasting (46.1%) or recommendation of peer teacher (32.4%). Videotape was most frequently used (64.1%) rather than books or CD. Teachers concerns on the materials were the educational content according to developmental stage of students (41.9%), content provoking interest (33.5%) and concrete guide for teacher (10.6%). As for the evaluation of the contents of videotapes, a subject of education was not described out of 46.6%. Videotape producer were mostly the Government-affiliated institutes or non-profit organizations (86.8%). The year of production was indicated from 41.7%. Running time range of 21-30 minutes was highest (55.9%). The price was marked in only one videotape. Subjects of contents were general sexual education (34.5%), sexual violence or sexual harassment (21.4%), pregnancy and contraception (14.2%) and AIDS and sexually transmitted diseases (8.3%) and dating and adolescent change (4. 8%), and etc (11.9 %). According to above results, we suggested that materials for sexual education should be completed with a description on the subjected group, summary of content, information on the tape producer, year of production, running time and sale price.

• Molecules and Cells
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• 제40권8호
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• pp.558-566
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• 2017

Regular monitoring on experimental animal management found the fluctuation of ART outcome, which showed a necessity to explore whether superovulation treatment is responsible for such unexpected outcome. This study was subsequently conducted to examine whether superovulation treatment can preserve ultrastructural integrity and developmental competence of oocytes following oocyte activation and embryo culture. A randomized study using mouse model was designed and in vitro development (experiment 1), ultrastructural morphology (experiment 2) and functional integrity of the oocytes (experiment 3) retrieved after PMSG/hCG injection (superovulation group) or not (natural ovulation; control group) were evaluated. In experiment 1, more oocytes were retrieved following superovulation than following natural ovulation, but natural ovulation yielded higher (p < 0.0563) maturation rate than superovulation. The capacity of mature oocytes to form pronucleus and to develop into blastocysts in vitro was similar. In experiment 2, a notable (p < 0.0186) increase in mitochondrial deformity, characterized by the formation of vacuolated mitochondria, was detected in the superovulation group. Multivesicular body formation was also increased, whereas early endosome formation was significantly decreased. No obvious changes in other microorganelles, however, were detected, which included the formation and distribution of mitochondria, cortical granules, microvilli, and smooth and rough endoplasmic reticulum. In experiment 3, significant decreases in mitochondrial activity, ATP production and dextran uptake were detected in the superovulation group. In conclusion, superovulation treatment may change both maturational status and functional and ultrastuctural integrity of oocytes. Superovulation effect on preimplantation development can be discussed.