• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.23 no.4
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• pp.175-180
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• 2012

Early detection and intervention is critical in improving prognosis of developmental disorders. Developmental delay can have many different causes and the clinical features of developmental delay are diverse according to its etiologic causes and severity. The vast and rapid growth of the child's neurobehavioral repertoire from birth through adolescence requires the physician's abundant experience, knowledge, and understanding of development. Here, we summarize instruments for use in neurodevelopmental assessment of infants and toddlers, focusing on motor development, which is the most frequent complaint listed in the developmental clinic.

• The Journal of Korean Academic Society of Nursing Education
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• v.27 no.3
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• pp.261-273
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• 2021

Purpose: This study used a descriptive investigative design to identify educational needs for developmental supportive care for the purpose of establishing a developmental supportive care education program for nurses in neonatal intensive care units. Methods: A survey was conducted on 93 nurses working in neonatal intensive care units located in a metropolitan area, and the collected data were analyzed using descriptive statistics and a paired t-test with the SPSS 25.0 program. For the purpose of analyzing educational needs, we further analyzed data through an importance-performance analysis (IPA) and the Borich needs assessment and the locus for focus models. Results: The average importance of the developmental supportive care of nurses in neonatal intensive care units was 3.74±0.78 out of 5, and the average performance was 3.46±0.81 out of 5. A t-test on the difference between the IPA and Borich needs assessment showed the highest educational need in the categories of 'individualized care', and 'I serve on the Developmental Care Committee at my institution'. In addition, according to the results of deriving the priorities of educational needs using the Borich needs assessment and the locus for focus model, the highest priority was 'I provide appropriate pain management when noxious procedures are necessary'. Conclusion: These findings can be used as basic data to design a developmental supportive care program suitable for nurses in neonatal intensive care units to meet the educational needs for developmental supportive care.

• Toxicological Research
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• v.29 no.4
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• pp.221-227
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• 2013

Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.

• Child Health Nursing Research
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• v.10 no.3
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• pp.321-331
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• 2004

Purpose: To develop an Infant Developmental Assesment Scale appropriate for Korean infants that includes cultural context. Method: The total sample included 990 infants aged birth to 24months. The developmental tests were conducted at hospital well baby clinic, daycare centers, public health centers and homes located in city, urban and rural areas. Item analysis was done to examine content validity of the scale. Test responses were analyzed by SPSS to examine the inter-rater reliability, and construct validity. Result: Based on the naturalistic observation and analysis of other developmenta l instruments, 260 Korean infant developmental items were created. The mean score of the developmental quotient of 966 infants was 101.63±10.89. Correlation coefficient of inter-rater reliability was .99. In addition, 84.6％ of total items showed Kappa .70 and above. The development quotient was significantly different depending upon the residential area and father's occupation, therefore, construct validity using known group technique was supported. Conclusion: The developed instrument can be used to assess the development of handicapped infants, as well as normal infant's general abilities and to study individual differences within the normal range for Korean.

• Journal of Information Technology Services
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• v.3 no.1
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• pp.21-41
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• 2004

The technical proposal suggested and published by MIC(Ministry of Information and Communication, henceforth MIC) contains too general assessment elements, which causes qualitative and subjective assessment of technical proposals. Thus, in terms of the technical proposal assessment. It lacks In fairness, validity and accuracy. Furthermore, it has a great deal of difficulty in assessment caused by the inconsistency between proposal planning and assessment methods. Also, each company has different writing format, so it is impossible to make use of its maneuvering data for the assessment. To overcome these weaknesses, our research focused on a quantitative evaluation on development organization, which is a part of organizational and administrative part of the technical proposal suggested and published by MIC. In this research, we divided development organization for the technical proposal into organization, teams, and team members, and then studied addition, deletion and merging for the assessment criteria. For the related study, we chose especially CMM(Capability Maturity Model) from a lot of international and national references, which is a model measuring the maturity of organization, and then we focused on Small-CMM which is available in the small-sized organization. We also suggested input form, description method, assessment elements for the quantitative assessment in the chosen developmental organization, and finally we proposed standard referencing criteria for the assessment. Our study concludes that our assessment method are valid and available in comparison with the previous Delphi method through a validity evaluation test.

• Proceedings of the Korean Society of Toxicology Conference
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• 2005.05a
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• pp.107-107
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• 2005

• The Journal of Korean Association of Computer Education
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• v.9 no.2
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• pp.57-67
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• 2006

The purpose of the research is to designing of web-based expert system in assessment, programming, evaluation for infants and young children with developmental disability. For this purpose, research articles such as curriculum-based assessment evaluation, web-based expert system, use of the computer technology in special education were analyzed. The design of web-based expert system for infants and young children with developmental disability connected with information analysis, optimum levels, data collection, data analysis, decision-making, and intervention.

• Environmental Analysis Health and Toxicology
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• v.25 no.2
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• pp.145-151
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• 2010

Perfluorinated chemicals (PFCs) is a kinds of persistent organic pollutants, and have the potential toxicity of which is causing great concern. In this study, we employed Oryzias latipes embryos to investigate the developmental toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)s compound using flowthrow system for 14 day. O. latipes embryos were exposed to solvent control, 20, 40 and 80 mg/L of PFOS and 62.5, 130, 260 mg/L of PFOA respectively. After exposure, hatchability, mortality, total length and heart beats were examined. Hatching rates were reduced approximately 27% in the 80 mg/L PFOS-treated group and 17% in the 62.5, 130 mg/L PFOA-treated groups. Heart beats in the PFOS-treated groups were reduced at 7 day but, PFOA-treated groups were increased heart beats. 80 mg/L PFOS treated group showed significant reduction in growth (total length) level to 90% of control. But PFOA did not showed significant effect on growth. In the 14 days $LC_{50}$ of PFOS and PFOA was 22.74 mg/L and 173 mg/L, respectively. The overall results indicated that the early stage of O. latipes might be a reliable model for the testing of developmental toxicity to perfluorinated chemicals.

• The Korean Nurse
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• v.17 no.4 s.96
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• pp.55-59
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• 1978

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.33 no.1
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• pp.16-23
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• 2022

Objectives: Early detection of developmental issues in infants and necessary intervention are important. To identify the comorbid conditions, a comprehensive evaluation is required. The study's objectives were to 1) generate scale items by identifying and eliciting concepts relevant to young children (12-71 months) with developmental delays, 2) develop a comprehensive screening tool for developmental delay and comorbid conditions, and 3) assess the tool's validity and cut-off. Methods: Multidisciplinary experts devised the "Infant Comprehensive Evaluation for Neurodevelopmental Delay (ICEND)," an assessment method that comes in two versions depending on the age of the child: 12-36 months and 37-71 months, through monthly seminars and focused group interviews. The ICEND is composed of three parts: risk factors, resilience factors, and clinical scales. In parts 1 and 2, there were 41 caretakers responded to the questionnaires. Part 3 involved clinicians evaluating ten subscales using 98 and 114 questionnaires for younger and older versions, respectively. The Child Behavior Checklist, Strengths and Difficulties Questionnaire, Infant-Toddler Social Emotional Assessment, and Korean Developmental Screening Test for Infants and Children were employed to analyze concurrent validity with the ICEND. The analyses were performed on both typical and high-risk infants to identify concurrent validity, reliability, and cut-off scores. Results: A total of 296 people participated in the study, with 57 of them being high-risk (19.2%). The Cronbach's alpha was positive (0.533-0.928). In the majority of domains, the ICEND demonstrated a fair discriminatory ability, with a sensitivity of 0.5-0.7 and specificity 0.7-0.9. Conclusion: The ICEND is reliable and valid, indicating its potential as an auxiliary tool for assessing neurodevelopmental delay and comorbid conditions in children aged 12-36 months and 37-71 months.