• Biomolecules & Therapeutics
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• 제32권2호
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• pp.183-191
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• 2024

The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins, amplifying the ER's folding capacity, and eliminating slow-folding proteins. Prolonged ER stress and UPR irregularities have been linked to a range of neuropsychiatric disorders, including major depressive disorder, bipolar disorder, and schizophrenia. This review offers a comprehensive overview of the UPR pathway, delineating its activation mechanisms and its role in the pathophysiology of neuropsychiatric disorders. It highlights the intricate interplay within the UPR and its profound influence on brain function, synaptic perturbations, and neural developmental processes. Additionally, it explores evolving therapeutic strategies targeting the UPR within the context of these disorders, underscoring the necessity for precision and further research to effective treatments. The research findings presented in this work underscore the promising potential of UPR-focused therapeutic approaches to address the complex landscape of neuropsychiatric disorders, giving rise to optimism for improving outcomes for individuals facing these complex conditions.

• 한국지역지리학회지
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• 제23권1호
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• pp.168-177
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• 2017

본 연구는 타포니의 형성 요인 및 발달 과정을 밝히기 위해 경주시 골굴사 일대에 발달하고 있는 타포니를 대상으로 그 분포 특징을 파악하고 광학현미경 관찰을 포함한 암석학적 분석, 함수율 측정, 수질 분석을 실시하였다. 현무암질 응회암류에 발달하고 있는 연구지역 내의 타포니는 입구의 경사 방향이 사면향과 일치하여 발달하고 있으며 이는 풍향 및 그에 따른 수분 공급과 관련이 깊은 것으로 판단된다. 따라서 타포니의 초기 발달 과정에 있어서는 층리 및 암석 내 균열을 따라 응회암 내 암편들이 이탈한 지점을 중심으로 발달하였으며 이후 풍향에 따라 수분 공급이 충분한 지점들을 중심으로 타포니가 성장하였다. 연구지역 내 나마에 고인 정체수의 수질 분석 결과는 다른 내륙지역에 비해 높은 Na, Cl 용해량을 보이며 이는 인접한 해안으로부터 공급된 것으로 추정된다. 이러한 염류가 암석 풍화 및 타포니 발달에 미치는 직접적 영향에 대해서는 전자현미경 분석 및 지화학적 연구가 현재 진행 중에 있다.

• 한국경제지리학회지
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• 제17권1호
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• pp.1-27
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• 2014

본 논문은 1960년대 말과 70년대 초기의 구미공단 조성과정을 다중스케일적 관점에서 분석하는 것을 목적으로 한다. 흔히 한국의 발전주의 시기 산업화 과정을 "발전주의 국가론"의 관점에서 분석하면서 국가 스케일의 정치-사회-경제적 과정에 주목하거나, 혹은 국가관료의 계획합리성에 입각하여 설명하는 경향이 있는데, 본 논문에서는 전략관계적 국가론과 다중스케일적 인식론을 바탕으로 이러한 관점을 비판하면서, 국가 안에서, 혹은 국가를 통해서, 작동하는 다양한 사회세력들이 다양한 공간적 스케일에서 복합적으로 서로 경합하고 타협하면서 산업화와 관련된 국가의 행위들이 결정되었다고 주장한다. 본 논문은 이러한 견해를 구미공단이 조성되던 과정에 대한 사례연구를 통해 실증적으로 밝힌다. 구미공단 조성과정은 전자산업을 육성하려는 국가관료들의 계획합리성에 의해서만 설명될 수 있는 것도 아니고, 박정희 대통령의 고향이라는 정치적 이유만으로 설명될 수 있는 것도 아니다. 국가의 정치지도자와 관료들의 역할뿐만 아니라, 구미지역에 장소의존적 이해를 가진 로컬 행위자들과 한국과 일본을 오가면서 활동하던 재일교포 사업가, 지역과 국가 스케일에 모두 연결된 지역구 국회의원 등 다중스케일적 행위자의 역할이 구미공단의 조성에 매우 중요한 영향을 주었음을 이 논문은 밝힌다.

• Parasites, Hosts and Diseases
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• 제54권5호
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• pp.653-658
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• 2016

This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E. granulosus; however, the fold difference was significantly increased at the microcysts in monophasic culture medium and the germinal layer of infected sheep in comparison with other stages. The findings demonstrated that the 2 aforementioned genes evaluated in the present study were differentially expressed at different developmental stages of the parasite and may contribute to some important biological processes of E. granulosus.

• 영어어문교육
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• 제6호
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• pp.35-47
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• 2000

This study questions the validity of Crosslinguistic Influence (CLI) in EFL Learning. A ten-minute grammaticality judgement test involving resumptive pronouns in English relative clauses was given to 15 female subjects. The research results, which were analysed in terns of language transfer and universalist arguments, support the existence of a universal process that guides L2 learning, and some common developmental patterns between the two processes of L1 and L2 learning. Hence, the universalist view should be given at least equal Weight as the CLI approach.

• 한국식물학회:학술대회논문집
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• 한국식물학회 1987년도 식물생명공학 심포지움 논문집 Proceedings of Symposia on Plant Biotechnology
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• pp.81-101
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• 1987

In an attempt to revies the informations about genes involved in symbiotic nitrogen fixation, developmental processes in which host plant interact with microbe during nodule formation were introduced first. The structure, function and regulation of the genes discussed were mainly about microbial genes; those involved in the process of nodule formation (nod-genes) and of nitrogen fixation (nif-genes). Informations about the host genes involved in the symbiosis were discussed briefly.

• Reproductive and Developmental Biology
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• 제32권4호
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• pp.229-235
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• 2008

Silencing of Dicer1 by siRNA did not inhibit development up to the blastocyst stage, but decreased expression of selected transcription factors, including Oct-4, Sox2 and Nanog, suggesting that Dicer1 gene expression is associated with differentiation processes at the blastocyst stage (Cui et al., 2007). In order to get insights into genes which may be linked with microRNA system, we compared gene expression profiles in Gapdh and Dicer1 siRNA-microinjected blastocysts using the Applied Biosystem microarray technology. Our data showed that 397 and 737 out of 16354 genes were up- and down-regulated, respectively, following siRNA microinjection (p<0.05), including 24 up- and 28 down-regulated transcription factors. Identification of genes that are preferentially expressed at particular Dicer1 knock down embryos provides insights into the complex gene regulatory networks that drive differentiation processes in embryos at blastocyst stage.

• Journal of Plant Biotechnology
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• 제42권1호
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• pp.1-5
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• 2015

The biological roles of glycogen synthase kinase 3 (GSK3) proteins have long been extensively explored in eukaryotic organisms including fungi, animals and plants. This gene family has evolutionary well conserved kinase domain and shares similar phosphorylation properties to their substrate proteins. However, their specific biological roles are surprisingly distinct in different organisms. GSK3s play key role in key regulating the cytoskeleton and metabolic processes in animal systems, but plant GSKs are involved in quite different processes, such as flower development, brassinosteroid signaling, abiotic stresses, and organogenesis. In particular, recent studies have reported the critical multiple functions of BIN2 and its related paralogues plant GSK3s during organogenesis via connecting hormonal or developmental programs. In this review, we outline the recent understanding in the versatile functions related in physiological and biochemical relevance, which are mediated by plant GSK3s in various cellular signaling.

• Genes and Genomics
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• 제40권11호
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• pp.1199-1211
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• 2018

Soil acidification is one of major problems limiting crop growth and especially becoming increasingly serious in China owing to excessive use of nitrogen fertilizer. Only the STOP1 of Arabidopsis was identified clearly sensitive to proton rhizotoxicity and the molecular mechanism for proton toxicity tolerance of plants is still poorly understood. The main objective of this study was to investigate the transcriptomic change in plants under the low pH stress. The low pH as a single factor was employed to induce the response of the wheat seedling roots. Wheat cDNA microarray was used to identify differentially expressed genes (DEGs). A total of 1057 DEGs were identified, of which 761 genes were up-regulated and 296 were down-regulated. The greater percentage of up-regulated genes involved in developmental processes, immune system processes, multi-organism processes, positive regulation of biological processes and metabolic processes of the biological processes. The more proportion of down-regulation genes belong to the molecular function category including transporter activity, antioxidant activity and molecular transducer activity and to the extracellular region of the cellular components category. Moreover, most genes among 41 genes involved in ion binding, 17 WAKY transcription factor genes and 17 genes related to transport activity were up-regulated. KEGG analysis showed that the jasmonate signal transduction and flavonoid biosynthesis might play important roles in response to the low pH stress in wheat seedling roots. Based on the data, it is can be deduced that WRKY transcription factors might play a critical role in the transcriptional regulation, and the alkalifying of the rhizosphere might be the earliest response process to low pH stress in wheat seedling roots. These results provide a basis to reveal the molecular mechanism of proton toxicity tolerance in plants.

• 한국발생생물학회지:발생과생식
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• 제4권1호
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• pp.7-12
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• 2000

수정에 의한 배 발생은 정자가 난자 내로 침입하여 정자와 난자의 반수체 핵질이 융합되고 이어 유사분열로 이어지는 과정에서 시작된다. 하지만 수정 및 초기 배 발생 동안 자웅 핵질과 난 세포질 구성 요소 상호간의 작용기전에 관해서는 명확히 알려져 있지 않은 부분이 많다. 수정보조기법인 세포질 내 정자 직접 주입법의 개발은 남성불임치료에 혁신적인 기술로 자리잡고 있을 뿐만 아니라 포유동물의 수정과정을 이해하는데 많은 도움을 주고 있다. 핵치환에 의한 복제동물 생산기법도 분화된 핵이 난 세포질 내에서 재 분화 (reprogramming)하여 발생하는 유일한 과정으로 세포질 구성요소들의 상호작용과 발생 조절 기능을 이해하는데 도움을 준다. 최근 몇 년간 돼지 난자 세포질에 정자 및 원형정자 직접주입, 세포질 이식, 세포질 융합 및 핵치환 한 후 난자의 발생과정을 간접 면역형광 분석법과 주사 전자현미경으로 조사하였다. 이러한 연구를 통해 체외수정, 세포질 이식 및 정자직접 주입법 등과 같은 임상치료기술 과 핵치환에 의한 복제동물생산 기법의 개선에 필요한 기초자료를 얻을 수 있었고, 포유동물 난자의 후생적 발생과정 (epigenesis)에 관해 공부할 수 있었다.