• 한국지형학회지
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• 제28권1호
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• pp.67-81
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• 2021

Geomorphological development and distribution at the macro scale provide a clue to the geotectonic characteristics that have affected the geomorphological system. This is because the developmental characteristics and distribution of the landform at the macro scale remain spatial characteristics due to tectonic processes, such as fault activity. From the perspective of tectonic geomorphology, this study identified the developmental characteristics and distribution of the Quaternary landforms in central-southern Yangsan fault and discussed its relevance to fault activity. In this paper, we presented examples and results of morphotectonic analysis of the Yangsan fault, and will present the results of age dating, stratigraphic relationship of the Quaternary landforms, and calculation of cumulative slip rate in the next paper.

• 통합자연과학논문집
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• 제17권1호
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• pp.31-41
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• 2024

Calcium ions play an important role in development and intracellular signaling. Dictyostelium discoideum has 14 genes encoding calcium -binding proteins (CBPs), but the function of most CBPs during development has not yet been studied. In this study, we investigated the specific functions of CBP7, one of 14 CBPs, in development using RNA interference cell lines of CBP7, cell lines overexpressing CBP7, cell lines with point mutations in the EF-hand domain, and cell lines expressing fragment proteins. was intended to reveal. CBP7 consists of 169 amino acids and contains 4EF-hand domains. The CBP7-overexpressing cells showed complete loss of developmental process. These cells remained in the single-cell growth stage under development -inducing conditions, while wild-type cells formed aggregations within 6-8h of development and eventually formed fruiting bodies. The experiments using point-mutated CBP7 protein showed that all EF-hand domains of CBP7 were important for CBP7 to function during developmental process. These results suggest that CBP7 plays an important role in developmental processes across all EF-hand domains.

• BMB Reports
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• 제32권2호
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• pp.103-111
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• 1999

Hh proteins represent a new signaling paradigm in metazoan development. In species ranging from fruit flies to humans, Hh proteins mediate multiple processes vital to appropriate pattern formation in the developing embryo. Hh proteins undergo an autoprocessing event in which the full-length protein is cleaved into N-terminal and C-terminal domains (Hh-N and Hh-C, respectively), and a cholesterol moiety becomes covalently attached to Hh-N. All known signaling activities of Hh proteins are mediated by Hh-N while both the cleavage and cholesterol transfer reactions are mediated by Hh-C. The cholesterol attached to Hh-N is required to retrict the range of Hh signaling and may be involved in ensuring appropriate reception of the Hh signal in target tissues. Disruptions of Hh signaling pathways lead to severe developmental defects in newborns and cancers in adults. While studies of Hh proteins have yielded a wealth of new insight into the molecular mechanisms of metazoan development, many outstanding questions concerning Hh signaling mechanisms ensure that unraveling the secrets of this molecule will keep scientists well entertained for the foreseeable future.

• BMB Reports
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• 제51권7호
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• pp.317-318
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• 2018

Plants are unable to relocate themselves to a more favorable location and thus have to deal with developmental programs and environmental cues wherever they happen to be. It is yet largely unknown how plant cells coordinate cellular activities and architectures to accomplish developmental processes and respond to environmental changes. By identifying and establishing a new cellular model system, we have discovered that two neighboring cell types in the abscission zone (AZ) of Arabidopsis flowers coordinate their activities to ensure a precise "cut" through a highly restricted area of plant tissue to bring about organ separation. From this perspective, we further discuss the essence of cellular coordination in AZ, the key molecules controlling the organ separation, and relevant implications.

• 한국가축번식학회지
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• 제27권4호
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• pp.349-357
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• 2003

Although nuclear transfer (NT) techniques are used to clone animals, its efficiency is very low. Moreover, nuclear transfer has resulted in offspring with severe developmental problems, probably due to incomplete nuclear reprogramming. Nuclear reprogramming is characterized by functional modification of the transferred nucleus to allow it to direct normal embryo development with the potential to grow to term. Although the nature of the reprogramming factor(s) in mammals is not clear, various nuclear as well as cytoplasmic components are involved in the processes. In this article we review recent data on factors involved in the nuclear reprogramming of cloned embryos.

• 음성과학
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• 제7권2호
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• pp.7-18
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• 2000

The purpose of this study was to investigate the phonological error patterns of korean children with and without specific phonological disorders(SPD). In this study, 29 normally developing children and 10 SPD children were involved. The children were matched the percentage of consonants correct(PCC). 22 picture cards were used to elicit korean consonants in word initial syllable initial, word medial syllable initial, word medial syllable final, word final syllable final positions. The findings were as follows. First, the phonological error patterns of SPD were 1) similar to those of normal children with the same PCC, 2) similar to those of normal children with the lower PCC, or 3) unusual to those of normal children. Second,. korean children showed phonological processes reflecting the korean phonological characteristics: tensification, reduction of the word medial syllable final consonant. This study suggests that both the PCC and error patterns should be considered in assessing phonological abilities of children.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 1998년도 제4차 학술발표대회 및 정기총회
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• pp.59-60
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• 1998

A DNA construct containing rat T $\alpha$ 1 $\alpha$ -tuulin gene 5'-flanking sequence and GFP reporer gene was microinjected into 1-cell loach embryos. Neuron-specific FGP expression was observed in developing loach embryos and early stage fry. The results demonstrated that rat T $\alpha$ 1 $\alpha$ -tubulin gene promoter may be sufficient to specify gene expression to neurons in loach embryos. Thus, the use of GFP reporter controlled by T $\alpha$ 1 $\alpha$ -tubulin gene promoter may facilitate visualization of the dynamic processes of neural tissue development.

• 영재교육연구
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• 제5권2호
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• pp.17-36
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• 1995

The present study examined preschooler's (3-5yrs) representation and evaluation skills in a puzzle completion task. The puzzle contained panels of four children dressed for each seacon and the key to success was using a body scheme to reconstruct the panels (head, torso, legs, feet and sky on top). Baseline data (Study 1) revealed a developmental pattern of increasing bydy scheme representation along with more careful attention to season consitent construction. Spontaneous verbalization also shifted from more guiding statements (where'the head?) to move evaluative statements (this isn't right). Study 2 examined different intervention techniques for increasing representation (verbal laveling) and evaluative processes (error detection practice), along with a control group that had unassisted practice. Three year olds benefited from verbal labeling, four year olds from both types of training. Verbalizations also showed appropriated shifts toward increasing evaluation, particularly for the older children. These findings are discussed in terms of a developmental hypothesis that representation precedes evaluation skills and that training techniques should take into account the relative balance between representation and evaluation skills in the individual for the task at hand.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제43권2호
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• pp.63-69
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• 2017

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in $Nfic^{-/-}$ mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-${\beta}1$, $Kr{\ddot{u}}ppel$-like factor 4, and ${\beta}$-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

• Archives of Pharmacal Research
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• 제22권3호
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• pp.229-231
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• 1999

Recessive oncogenes are genetic functions important in the regulation of tissue growth and differentiation. These genetic functions are defined on the basis of the phenotype expressed by homozygotes. Defining the role of these genes in normal developmental and physiological processes is important to the development of accurate models of the normal regulation of growth and differentiation. Drosophila can be a good system to investigate the neoplastic mechanism of oncogenes and provide a greater understanding in the developmental progression of both invertebrates and vertebrates and vertebrates. The lethal (2) giant larvae gene is a recessive oncogene of Drosophila and temperature sensitive mutations of this gene have been isolated. Here, the application of temperature-sensitive mutations in Drosophila oncogene studies is discussed.