• Journal of Korean Society of Transportation
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• v.30 no.2
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• pp.67-78
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• 2012

The current traffic regulations in Korea stipulate that traffic should keep to the right according to the Road Traffic Act; thus, customarily, the 'seat-on-the-left' system has been maintained. However, an increased number of 'seat-on-the-right' vehicles are being imported via a variety of routes from foreign countries, especially from Japan. According to the data from July 2004, 1,343 cargo vehicles and 593 passenger vehicles (for diplomats, etc.) were currently being driven on domestic road. As these 'seat-on-the-right' vehicles are not compatible with the domestic transportation system of driving on the right side of the road, there is a high risk of accidents. Experiments show that such system-driver mismatch causes longer operation time for directional signals, higher error frequency in yielding due to additional mental adjustments for 'seat-on-the-right' vehicle drivers. These are, therefore, influential factors which can lead to possible accidents. Furthermore, when the experiments test the visual range during overtaking maneuvers, the visual range of the drivers in the 'seat-on-the-left' vehicle was 2.95 meters as opposed to 1.7 meters for the drivers in the 'seat-on-the-right' vehicle. (In the experiment, the drivers were instructed to look at the paper cup 10 meters away from the back of drivers' seat.) The results demonstrate that it is necessary to have additional safety measures be implemented for the 'seat-on-the-right' vehicles.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.367-373
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• 2015

Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH-13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13-AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.

• Journal of Ginseng Research
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• v.39 no.1
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• pp.46-53
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• 2015

Background: Glucocorticoids (GCs) are commonly used in many chemotherapeutic protocols and play an important role in the normal regulation of bone remodeling. However, the prolonged use of GCs results in osteoporosis, which is partially due to apoptosis of osteoblasts and osteocytes. In this study, effects of Korean Red Ginseng (KRG) on GC-treated murine osteoblastic MC3T3-E1 cells and a GC-induced osteoporosis mouse model were investigated. Methods: MC3T3-E1 cells were exposed to dexamethasone (Dex) with or without KRG and cell viability was measured by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Realtime polymerase chain reaction was performed to evaluate the apoptotic gene expression; osteogenic gene expression and alkaline phosphatase (ALP) activity were also measured. Western blotting was performed to evaluate the mitogen-activated protein kinase (MAPK) proteins. A GC-induced osteoporosis animal model was used for in vivo study. Results and conclusion: The MTT assay revealed that Korean Red Ginseng (KRG) prevents loss of cell viability caused by Dex-induced apoptosis in MC3T3E1 cells. Real-time polymerase chain reaction data showed that groups treated with both Dex and KRG exhibited lower mRNA levels of caspase-3 and -9, whereas the mRNA levels of Bcl2, IAPs, and XIAP increased. Moreover, groups treated with both Dex and KRG demonstrated increased mRNA levels of ALP, RUNX2, and bone morphogenic proteins as well as increased ALP activity in MC3T3-E1 cells, compared to cells treated with Dex only. In addition, KRG increased protein kinase B (AKT) phosphorylation and decreased c-Jun N-terminal kinase (JNK) phosphorylation. Moreover, microcomputed tomography analysis of the femurs showed that GC implantation caused trabecular bone loss. However, a significant reduction of bone loss was observed in the KRG-treated group. These results suggest that the molecular mechanism of KRG in the GC-induced apoptosis may lead to the development of therapeutic strategies to prevent and/or delay osteoporosis.

• 한국노년학
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• v.38 no.3
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• pp.783-799
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• 2018

The purpose of this study is to examine the major academic activities of the Korean Gerontological Society (KGS) during the last 40 years in comparison to changes in elderly policies in Korea and also academic trends in gerontology worldwide and the academic activities of the International Association of Gerontology and Geriatrics (IAGG); based on this analysis, this study aims to propose future directions for the academic progress of the KGS. We examined the major academic activities of the KGS by analyzing the contents of biannual conferences, international conferences, and irregular seminars and policy meetings, using conference booklets, KGS websites, and literature on KGS history. Second, we analyzed the academic activities of the KGS in comparison to changes in elderly policies in Korea, using databases of major newspapers and also the BigKinds search offered by the Korea Press Foundation. Third, the academic activities of the KGS were reviewed in comparison to those of the IAGG and the major aging policy agendas of key international organizations. The study results demonstrate that the KGS has been proactive in conducting diverse multi-disciplinary and international academic activities while promptly responding to both domestic and international changes in elderly policies. But some issues were not properly addressed due to the lack of diversity in its members, and it also should be noted that some issues were not discussed in depth for a sufficient length of time. Henceforth, as the leading academic organization in gerontology with a multi-disciplinary orientation in Korea, the KGS should continue to lead the development and evaluation of aging policies and also actively carry out diverse academic activities in collaboration with international academic societies and organizations.

• The Journal of the Korea Contents Association
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• v.19 no.8
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• pp.473-482
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• 2019

People's leisure activities have increased due to changes in perception of social life. Camping cars are becoming popular due to the development of camping culture and traveling. However, there are not many users compared to the population of the camper due to the difficulty of economy and usability. Making it not easy to purchase or rent a camping car. Therefore, this study researches on camping service by combining shared services. It is aimed to provide a user centered camping shared service considering usage and economic efficiency. This study analyzed the concept, characteristics and current status of shared service and camping car with reference to domestic, overseas literature and internet data to provide basic data of camping car using shared service. In addition, through case study of shared vehicles, it is possible to grasp the current market. Integrate P2P, B2C, renting company and individuals to derive the design of A2P (All to People)service which connects and shares all. The user can have its own space available at the desired place and time. This study is a camping or unique mobile space service design that can be easily experienced in everyday life. It will reduce the strain of maintaining expenses and also process of pick up, return is freely making user-centered service design. This service design will lead to a diverse range of leisure activities and contribute to the upsweep of the camper industry.

• Journal of the Korean Orthopaedic Association
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• v.53 no.6
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• pp.466-477
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• 2018

Orthopaedics is an area where 3-dimensional (3D) printing technology is most likely to be utilized because it has been used to treat a range of diseases of the whole body. For arthritis, spinal diseases, trauma, deformities, and tumors, 3D printing can be used in the form of anatomical models, surgical guides, metal implants, bio-ceramic body reconstruction, and orthosis. In particular, in orthopaedic oncology, patients have a wide variety of tumor locations, but limited options for the limb salvage surgery have resulted in many complications. Currently, 3D printing personalized implants can be fabricated easily in a short time, and it is anticipated that all bone tumors in various surgical sites will be reconstructed properly. An improvement of 3D printing technology in the healthcare field requires close cooperation with many professionals in the design, printing, and validation processes. The government, which has determined that it can promote the development of 3D printing-related industries in other fields by leading the use of 3D printing in the medical field, is also actively supporting with an emphasis on promotion rather than regulation. In this review, the experience of using 3D printing technology for bone tumor surgery was shared, expecting orthopaedic surgeons to lead 3D printing in the medical field.

• Industry Promotion Research
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• v.6 no.4
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• pp.39-45
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• 2021

This study presented the role of the counselor's transitional object through literature research, focusing on Winnicott's theory. In the process of development, infants experience anxiety when they move from absolute dependence to relative dependence with their mother. In this way, the counselor's role as an transitional object buffers separation anxiety and depressive anxiety about the loss experience, and mediates from the omnipotent fantasy to the real world. transitional objects are new objects and have a function of contributing to adaptation in reality. And it leads to the stage of separation and individualization through transitional object and transitional phenomena. It can be said that he acquires a sense of the real other that exists in order to create and destroy omnipotent, and to adapt to reality. A good enough mother makes the child's omnipotence meaningful. In this case, the true self helps the infant's weak self to grow and lead him to live his own life. When the mother fails to satisfy the infant's needs, her fantasies and spontaneous impulses are lacking. In other words, when the mother fails to reflect the infant's needs, the infant looks at her mother's mood, giving up her true self and creating a false self. The pathology of the absolute dependence phase is caused by the failure of a good enough mother's empathy and nurturing environment. At this time, the child experiences the collapse of the omnipotence illusion and experiences annihilation anxiety. Therefore, effective counseling can be carried out when providing a comfortable and stable environment by reducing separation anxiety and depressive anxiety of clients through the role of the counselor's transitional object in the counseling field.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.31 no.3
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• pp.202-212
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• 2021

Objectives: The reproductive health of female workers has been extensively investigated in South Korea and other countries worldwide. However, few studies have discussed the reproductive health of male workers. In this study, we reviewed the recent literature that reports on the effects of occupational exposure on the reproductive health of male workers and the health of their children. Methods: In May 2020 we used the PubMed search engine to search the literature over the last 10 years and chose case-control, cohort, and cross-sectional studies and reviews. We selected epidemiological studies that investigated the association between pre-pregnant occupational exposure and the reproductive health of male workers and the health of their children. We excluded case reports, non-epidemiological studies (animal experiments, cellular-level experiments, and similar articles), and studies that described postnatal occupational exposure. Results: We eventually selected 23 studies. The studies that included exclusively male workers reported that those employed in the agricultural sector or those exposed to pesticides showed lower blood levels of reproductive hormones and a high risk of lympho-hematopoietic system cancer in their children. Male workers exposed to complex organic solvents and organic compounds showed a high risk of poor semen quality, increased time to pregnancy, decreased blood levels of reproductive hormones, and a high risk of lympho-hematopoietic system cancer in their children. Male workers employed in occupations that involved significant social contact, or in the leather and livestock industries, and in occupations with high levels of exposure to lead and organic solvents showed a high risk of malignancies, including lympho-hematopoietic system cancer, neuroblastoma, and central nervous system tumors in their children. Studies that investigated both male and female workers reported that children of male smelters showed a high risk of premature birth, and children of male workers exposed to metals showed a high risk of hypospadias and cryptorchidism. Children of male welders and workers employed in the glass, ceramic, and tile industries showed a high risk of premature birth. Conclusion: The findings of this study will serve as basic data for further research on male workers' reproductive health and provide a scientific basis for the development of strategies to protect the reproductive health of males employed in high-risk occupations. Moreover, the results of this study may provide guidelines to improve the understanding of and knowledge on male workers' reproductive health.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.286-308
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• 2021

For a long time, dramas that everyone has enjoyed at home have become the most popular cultural contents due to the development of digital technology and the influence of Hallyu.(Korean Wave) This study was conducted in-depth interviews and participatory observations on the background, role, identity, and labor experience of TV planning producers who appeared in the drama production process with the implementation of outsourcing production policy in 1991. The number of dramas produced increased sharply in the mid-2000s due to the Korean Wave. Against this backdrop, the planning producer has expanded their scope in the drama production process and emerged as a new drama producer. The planning producer plays a role in creating an environment in which writers and directors can be selected with the identity of "not a creator but a producer of dramas" and lead drama planning. OTT and watching TV on the Internet have made it possible to watch dramas without TV. As this phenomenon accelerates and becomes commonplace, fewer consumers adhere to the traditional way of watching dramas using TV, and consumers' emotional tastes become more demanding. In this environment, TV planning producers are leading the production of dramas, exerting as much influence as writers and directors. They are also building new power relationships among drama producers by securing planning and financial power.

• Journal of Internet Computing and Services
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• v.20 no.5
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• pp.105-111
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• 2019

Core technologies that lead the Fourth Industrial Revolution era, such as artificial intelligence, big data, and autonomous driving, are implemented and serviced through the rapid development of computing power and hyper-connected networks based on the Internet of Things. In this paper, we implement two different models for drivable area segmentation in various environment, and propose a better model by comparing the results. The models for drivable area segmentation are using DeepLab V3+ and Mask R-CNN, which have great performances in the field of image segmentation and are used in many studies in autonomous driving technology. For driving information in various environment, we use BDD dataset which provides driving videos and images in various weather conditions and day&night time. The result of two different models shows that Mask R-CNN has higher performance with 68.33% IoU than DeepLab V3+ with 48.97% IoU. In addition, the result of visual inspection of drivable area segmentation on driving image, the accuracy of Mask R-CNN is 83% and DeepLab V3+ is 69%. It indicates Mask R-CNN is more efficient than DeepLab V3+ in drivable area segmentation.