• Molecules and Cells
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• v.41 no.8
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• pp.753-761
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• 2018

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is identified as a signaling adaptor protein that regulates bone metabolism, immunity, and the development of several tissues. Therefore, its functions are closely associated with multiple diseases. TRAF6 is also involved in the regulation of hematopoiesis under steady-state conditions, but the role of TRAF6 in modulating hematopoietic stem and progenitor cells (HSPCs) during the developmental stages remains unknown. Here, we report that the deletion of TRAF6 in hematopoietic lineage cells resulted in the upregulation of HSPCs in the fetal liver at the prenatal period. However, in the early postnatal period, deletion of TRAF6 drastically diminished HSPCs in the bone marrow (BM), with severe defects in BM development and extramedullary hematopoiesis in the spleen being identified. In the analysis of adult HSPCs in a BM reconstitution setting, TRAF6 played no significant role in HSPC homeostasis, albeit it affected the development of T cells. Taken together, our results suggest that the role of TRAF6 in regulating HSPCs is altered in a spatial and temporal manner during the developmental course of mice.

• Journal of Home Health Care Nursing
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• v.23 no.2
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• pp.233-242
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• 2016

Purpose: The purpose of this study was to identify professional competencies of visiting nurses in public health centers. Methods: A methodological study for the development of visiting nurses' professional competency was conducted through the review of literature and construction of a conceptual framework for the development of professional competence. After reviewing the content validity of each question and confirming the items of the preliminary tool, the construct validity of the tool was verified through exploratory factor analysis and internal reliability was confirmed. Results: After constructing 5 factors relating to the visiting nurse's professional competence, 25 items were developed, based on verification of content validity by experts. The results of the exploratory factor analysis showed that the professional competence of the visiting nurse was influenced by factors such as "health assessment and screening," "health teaching and counseling," "interprofessional communication", "program planning and implementation", and "Professional development". These five factors accounted for 76.38% of the professional competencies of the visiting nurse. Conclusion: The professional competence of the visiting nurse is consistent with the aim of the visiting nursing project. Also our results will contribute to baseline data used to evaluate the quality of work of the visiting nurse.

• Journal of the Korean Society of Clothing and Textiles
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• v.29 no.2
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• pp.328-339
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• 2005

The purpose of this study were to extract and empirically examine the effect variables on phase performance of relationship development process by identifying relationship development process between apparel store and customer. The questionnaires was asministered to 333 women frequency use of a department store, big shopping mall, discount store in Gwang-ju city during March 4-11, 2003. The data was analyzed by factor analysis, correlation analysis, and Structural Equation Model using LISREL 8.30 program. As the results, the perceived service quality with attractive factor of relationship explration phase direct positively influenced customer satisfaction among relationship expansion phases. However, relational benefit directly influenced customer satisfaction with the primary phase of relationship maintain as well as trust, customer commiment and long-term orientation. Also, customer satisfaction direct positively influenced trust, and customer' trust direct positively influenced customer commitment. Finally, the customer commitment direct positively influenced long-term orientation.

• Journal of the Korea Institute of Building Construction
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• v.9 no.3
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• pp.117-125
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• 2009

With construction industry recession, many construction companies are increasingly conducting the development projects by themselves. However, housing projects requested by developers still stand large portion. Although many studies on feasibility analysis were released, they mainly focused on economic feasibility and lacked research on factors and criterions of overall project. Also, because previous studies overly break downed factors related to project, they rarely used in practice. Therefore, this study developed the feasibility analysis model of housing development projects to help main contractors to easily and effectively decide if it is feasible enough to promote the projects requested by developers, and verified the reliability of the model. In this study, thirty one driving factors were identified under seven different categories and the criterion of each factor was also developed. The survey on important index of each factor found 'salability', 'economic feasibility', 'site location' and 'method of raising fund' significant. 12 projects were tested by the model and its results showed resonable reliability.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.1
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• pp.149-158
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• 2019

Due to the rapid development of IT (information technology) and internet, products become smart and able to collect, process and produce information and can think of themselves to provide better service to consumers. However, research on the characteristics of smart product is still sparse. In this paper, we report the systemic development of a scale to measure the perceived product smartness associated with smart product. To develop product smartness scale, this study follows systemic scale development processes of item generation, item reduction, scale validation, reliability and validity test consequently. And, after acquiring a large amount of qualitative interview data asking the definition of smart product, we add a unique process to reduce the initial items using both a text mining method using 'r' s/w and traditional reliability and validity tests including factor analysis. Based on an initial qualitative inquiry and subsequent quantitative survey, an eight-factor scale of product smartness is developed. The eight factors are multi-functionality, human-like touch, ability to cooperate, autonomy, situatedness, network connectivity, integrity, and learning capability consequently. Results from Korean samples support the proposed measures of product smartness in terms of reliability, validity, and dimensionality. Implications and directions for further study are discussed. The developed scale offers important theoretical and pragmatic implications for researchers and practitioners.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.1
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• pp.321-328
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• 2019

The purpose of the study is to analyze the main approaches to assessing human capital and develop proposals for its most objective assessment of it at the different levels of manifestation - individual, microeconomic and macroeconomic. The article considers the basic approaches to the evaluation of human capital, used in practice: retrospective (costly) and prospective (income based). Cost based methods involve measuring the value of human capital based on the total costs associated with its formation. The proposed additional evaluation criteria, in particular, the use of the expert approach and the developed indicators of a qualitative assessment of the human capital of the enterprise will allow development that is more efficient and use of available human resources. Human capital is becoming a major factor in the formation and development of an innovative economy and knowledge economy. Accordingly, the proposed additions to the assessment of human capital at the country level are aimed at assessing it from a new angle, taking into account the current global trends in the formation of an innovative economy and digitalization. They meet qualitatively new requirements for human capital as the main productive factor in the creation of new highly efficient technologies that promote the active development of the social sphere, science, education, health, etc.

• Journal of the Korean Society of Propulsion Engineers
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• v.20 no.4
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• pp.34-39
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• 2016

Arrhenius kinetic constants, the activation energy and the pre-exponential factor, of energetic material $BKNO_3$ are estimated using Differential Scanning Calorimetry (DSC). Different from the conventional way, the activation energy was estimated more precisely through DSC aging trial, and the consumed fraction by heat was calculated by comparing the integration of heat flow. We suggested the condition of accelerated aging test for the energetic material $BKNO_3$ and reconsidered the meaning of the thermal accelerated aging.

• Development and Reproduction
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• v.23 no.3
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• pp.285-295
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• 2019

Junction-mediating and regulatory protein (JMY) is a regulator of both transcription and actin filament assembly. The actin-regulatory activity of JMY is based on a cluster of three actin-binding Wiskott-Aldrich syndrome protein homology 2 (WH2) domains that nucleate actin filaments directly and promote nucleation of the Arp2/3 complex. In addition to these activities, we examined the activity of JMY generation in early embryo of mice carrying mutations in the JMY gene by CRISPR/Cas9 mediated genome engineering. We demonstrated that JMY protein shuttled expression between the cytoplasm and the nucleus. Knockout of exon 2, CA (central domain and Arp2/3-binding acidic domain) and NLS-2 (nuclear localization signal domain) on the JMY gene by CRISPR/Cas9 system was effective and markedly impeded embryonic development. Additionally, it impaired transcription and zygotic genome activation (ZGA)-related genes. These results suggest that JMY acts as a transcription factor, which is essential for the early embryonic development in mice.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.2
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• pp.771-781
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• 2021

The purpose of this study is to identify major drivers of Myanmar's long-term economic growth and draw implications to implement development policies. This study investigated Myanmar, as the country is the most recently opened economy in Southeast Asia. This study conducted simulation analysis based on scenarios by applying World Bank's Long-Term Growth Model, Penn World Table 9.1, and World Development Indicator data. This study makes extensive use of LTGM and the LTGM-TFP extension to improve the validity of models for data calibration. This study confirms the validity of the model with data calibration and specifies scenarios for simulation analyses by setting the growth trajectory of Vietnam due to common geographical, political, and economic conditions. Main findings include that Myanmar's economic growth rate will continue to fall below 3% in 2040 without proper improvement of growth drivers. The results of this study also provide that total factor productivity growth and female labor participation are key factors for Myanmar's long-term economic growth. This study advises policymakers in Myanmar to strengthen human capital, which is crucial for total factor productivity growth in Myanmar's context and directly affects economic growth. Further, labor market policies to promote female labor participation is important to sustain economic growth.

• Journal of Agricultural Extension & Community Development
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• v.30 no.1
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• pp.31-41
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• 2023

This study aims to examine the structural relationships among rurality perception, tourism attitude, and behavioral intention in rural healing tourism. Particularly, this study focused on the mediation effect of attitude. Data were collected from 658 rural healing tourists by online survey. SPSS 28.0 and AMOS 28.0 were used for frequency, exploratory factor, confirmatory factor, and structural equation modeling analyses. The results of structural equation modeling indicate perception of rurality had a positive effect on attitude and behavioral intention. In addition, attitude mediated the relationships between perception of rurality and behavioral intention. The results of this study suggest the importance of understanding the interests and pursuits of rural healing tourists and providing them with the values they want. Since rurality has a direct influence on attracting healing tourists, it is necessary to establish a positive image of rural healing tourism.