• Reproductive and Developmental Biology
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• v.39 no.4
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• pp.105-115
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• 2015

Toll-like receptor 7 (TLR7) is critical for the triggering of innate immune response by recognizing the conserved molecular patterns of single-stranded RNA (ssRNA) viruses and mediated antigenic adaptive immunity. To understand how TLR7 distinguish pathogen-derived molecular patterns from the host self, it is essential to be able to identify TLR7 receptor interaction interfaces, such as active sites or R848-agonist binding sites. The functional interfaces of TLR7 can serve as targets for structure-based drug design in studying the TLR7 receptor's structure-function relationship. In contrast to mammalian TLR7, chicken TLR7 (chTLR7) is unknown for its important biological function. Therefore, it has been targeted to mediate contrasting evolutionary patterns of positive selection into non-synonymous SNPs across eleven species using TLR7 conservation patterns (evolutionary conserved and class-specific trace residues), where protein sequence differences to the TLR7 receptors of interest record mutation that have passed positive section across the species. In this study, we characterized the Lys609 residue on chTLR7-ECD homodimer interfaces to reflect the current tendency of evolving positive selection to be transfer into a stabilization direction of the R848-agonist/chTLR7-ECDs complex under the phylogenetically variable position across species and we suggest a potential indicator for contrasting evolutionary patterns of both the species TLR-ECDs.

• Journal of Navigation and Port Research
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• v.31 no.6
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• pp.515-521
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• 2007

To increase the stevedore efficiency and service level at container terminal, it is essential to reduce working time of container crane which has a bottle neck in the logistic flow of container. The working speed and safety are required to be improved by controlling the movement of the trolley as quick as possible without big overshoot and any residual swing motion of container in the vicinity of target position. This paper presents optimal state feedback control using RCGAs in the case of existing constrained conditions

• Journal of Korean Medicine Rehabilitation
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• v.27 no.4
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• pp.111-119
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• 2017

Objectives Clinical pathway (CP), is management plans that display goals for patients and have led to improve outcomes for many diseases. In Korea, Interest in Korean medicine's stabilization (Clinical pathway, Clinical Practice Guideline) is increasing, But the number of studies is scare. Method and Analysis This trials composes nonequivalent control group pretest-posttest design to conduct clincal pathway trial for the acute pain after back surgery. The subjects were 10 control patients with back surgery, and 10 experimental patients with application of integrative CP. Each group patient will observed 6 weeks. We check validation of CP. Also we compared the patient's status using the pain, function, Quality of life index between the two groups. Discussion This trial is the first CP for the acute pain after back surgery using integrative medicine concepts. Aim of this trial is to find the effectiveness and validity of clincal pathway for acute pain after back surgery.

• The Korean Journal of Malacology
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• v.28 no.3
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• pp.187-196
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• 2012

Recently, for the purpose of constructing artificial ecosystem, the public aquarium and experimental mesocosm systems are receiving attention. To design and establish an aquarium and mesocosm system, there is need of several materials for simulating the environment, such as sediments, rocks, and plants. Expecially for sessile mollusks, there must be proper materials to which sessile invertebrates can adhere. Nowadays, many aquariums and mesocosm systems are using dead coral skeletons for sessile mollusks. This study was proceeded to have data on the effect of dead coral skeletons on water qualities with the experiment on the environmental factors. For this purpose, I made glass tank for experiment, chose two types of dead coral skeletons imported from the Indonesia and observed the change of water qualities and decomposition efficiency of TAN (total ammonia-nitrogen), nitrite ($NO_2{^-}$) and nitrate ($NO_3{^-}$). As a result, the lager the surface area was, the more TAN, nitrite and nitrate decomposition rate increased. In addition, coral skeletons covered with crustose algae and bacteria in the tank showed faster TAN, nitrite and nitrate removal rate and stabilization. Accordingly, this experiment suggested that dead coral skeletons could be used as a sub filter for the closed system as well as an adhering plate.

• Geotechnical Engineering
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• v.14 no.2
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• pp.21-30
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• 1998

The settlement characteristics of refuse landfills are peculiar because considerable amount of settlement occurs due to the decomposition of refuse organic solids for very long period. The total amount of compression that occurs due to the decomposition in refuse landfill is mainly dependent on the amount of biodegradable refuse solids and fill Ige of the refuse landfill, and the settlement stabilization speed is dependent on the decomposition condition. In order to figure out the settlement characteristics of refuse landfills. a proposed mathematical model is applied to settlement data of refuse landfills with different fill ages. A data bank of model parameters was obtained and the trends were analyzed. The long-term settlement behavior of refuse landfills can be estimated fairly well by the proposed model. The total remaining amount of settlement may be predicted on the basis of the fill age and appropriate two design parameters.

• Journal of the Korean GEO-environmental Society
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• v.16 no.10
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• pp.23-32
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• 2015

Most studies on slope collapsed have focused on collapse cases that occur on stabilized slopes in public use. Few studies have been conducted on the collapse characteristics of slopes that occur during construction before stabilization of the slope. In this study, detailed investigation was conducted for 79 sites where slope collapse occurred during or immediately after construction in the Chungcheong region, and their geometrical characteristics, collapse characteristics, design and reinforcement methods were evaluated. As a result of this analysis, it was found that the Chungbuk (CB) area was marked by plane-type collapse and surface layer collapse whereas the Chungnam (CN) area was marked by surface layer collapse or loss of sedimentary rocks. Furthermore, the major collapse factors of the Chungbuk region were joint alternations (53%) and weathering (25%), and the blocking due to multidirectional joints and foliation was also an influencing factor. In the phyllite area, too, the development of joints (55%) was a major factor, but the geological characteristics (36%) of sedimentary rocks such as faults and coaly shale also had considerable effects. Therefore, the geological, climatic, and environment characteristics were found to have affected the stability of slopes.

• Journal of the Korean GEO-environmental Society
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• v.4 no.3
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• pp.41-49
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• 2003

If MSW(Municipal Solid Waste) landfill is used as a foundation ground of construction site, the change of loading condition may cause a large amount of compression in MSW landfill. Therefore, the reinforcement for the loose compression nature of MSW landfill would be very important design factor to geotechnical engineers in considering the end-use of the landfill. In this study, a possible technique for stabilizing MSW landfill with use of codisposal of municipal solid waste and Fly Ash is discussed. In order to estimate the stabilization of compression characteristic of codisposed landfill, large compression test and lysimeter test were performed. According to the test results, as the proportion of Fly Ash increases, the compression might be reduced, but the permeability might be also reduced. Therefore, it is necessary to take into account the both characteristics changes in real application.

• Physical Therapy Rehabilitation Science
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• v.5 no.3
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• pp.113-119
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• 2016

Objective: The effect of abdominal expansion maneuver (AEM) and abdominal draw-in maneuver (ADIM) on postural control in an unsupported position in stroke patients. Design: Randomized controlled trial. Methods: A total of 36 persons with hemiplegic stroke participated in this study. The subjects were randomly divided into an AEM experimental group (n=12), an experimental ADIM group (n=12), and a control group (n=12). We collected the general characteristics of all subjects and the pre-test results before the intervention and after 4 weeks of the intervention. The trunk stabilization training of the ADIM and AEM group were performed 15 minutes a day, 3 times a week for 4 weeks, and general physical therapy was performed 2 times a day, 30 minutes per session, 5 times a week for all three groups. The control group received joint mobilizations, muscle strengthening, endurance strengthening, and gait exercises along with treatment of the central nervous system, such as neuro-developmental treatment, mat, and gait training. The AEM is an inspiratory phase of tidal breathing expanding the lateral lower ribcage in a lateral direction with minimal superior movements of the chest. Then the lower abdomen expands and the navel moves in an anterior-caudal direction. The ADIM is a repeated contraction and relaxation of the anal sphincter during inspiration. The navel pulls the lower abdomen to the direction of the spine without the movement of the trunk and pelvis. Results: Before and after the interventions, medial-lateral axis movement distance, anterior-posterior axis movement distance, sway mean velocity, and sway area 95% was a statistically significant change in all three groups (p<0.05). The post-hoc test showed a significant improvement in medial-lateral axis movement distance, anterior-posterior axis movement distance, sway mean velocity, and sway area in the AEM group compared with the control group, and in the ADIM group compared with the control group (p<0.05). Conclusions: In conclusion, both AEM training and ADIM training are necessary interventions to maintain the independent sitting position according to the characteristics of the patient.

• Journal of Fisheries and Marine Sciences Education
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• v.9 no.2
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• pp.167-178
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• 1997

It has been expected not only for crew but also for passengers to realize a ship whose rolling and other motions are small as much as possible. Restricting our consideration to the roll reduction, the conventional roll stabilization system, fins or anti-rolling tanks hve been utiized as the actuator. Excessive motions would interfere with the recreational activities of passengers on a cruise ship. Often more than half of the load of a containership is stowed above deck where it is subjected to large acclerations due to rolling. In some situations this may cause some internal damage to the contents of the containers; in more severe situations failure of the lashing can occur and containers may be lost over-board. Underdeck cargo in ordinary cargo ships and bulk commodities in colliers, ore ships and grain ships can shift if the motions become too severe. The purpose of this study is to concentrate on the additions. either internal or external to the hull, that reduce or otherwise improve the motion responses of the hull. It is assumed that the additions are such that their benefit to the motions of the ship outweights any impact on the ability of the ship to perform its assigned task. It is particularly challenging to obtain large improvements in the motion characteristics of existing ships that are being rebuilt or modified for some task not anticipated in their original design. Further the authors will statistically analyze the influence of ruder-roll-yaw coupling motion in the case of application of this advanced control method to various kinds of ship.

• Advances in Computational Design
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• v.5 no.2
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• pp.195-207
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• 2020

The present study focuses on the application of artificial neural network (ANN) and Multiple linear Regression (MLR) analysis for developing a model to predict the unconfined compressive strength (UCS) and split tensile strength (STS) of the fiber reinforced clay stabilized with grass ash, fly ash and lime. Unconfined compressive strength and Split tensile strength are the nonlinear functions and becomes difficult for developing a predicting model. Artificial neural networks are the efficient tools for predicting models possessing non linearity and are used in the present study along with regression analysis for predicting both UCS and STS. The data required for the model was obtained by systematic experiments performed on only Kaolin clay, clay mixed with varying percentages of fly ash, grass ash, polypropylene fibers and lime as between 10-20%, 1-4%, 0-1.5% and 0-8% respectively. Further, the optimum values of the various stabilizing materials were determined from the experiments. The effect of stabilization is observed by performing compaction tests, split tensile tests and unconfined compression tests. ANN models are trained using the inputs and targets obtained from the experiments. Performance of ANN and Regression analysis is checked with statistical error of correlation coefficient (R) and both the methods predict the UCS and STS values quite well; but it is observed that ANN can predict both the values of UCS as well as STS simultaneously whereas MLR predicts the values separately. It is also observed that only STS values can be predicted efficiently by MLR.