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Heart Rate Variability and Autonomic Activity in Patients Affected with Rett Syndrome (Rett 증후군 환자에서의 자율신경 활성도 및 심박수 변이도 측정)

  • Choi, Deok Young;Chang, Jin Ha;Chung, Hee Jung
    • Clinical and Experimental Pediatrics
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    • v.46 no.10
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    • pp.996-1002
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    • 2003
  • Purpose : In Rett syndrome patients, the incidence of sudden death is greater than that of the general population, and cardiac electrical instability including fatal cardiac arrhythmia is a main suspected cause. In this study, we are going to find out the possible cause of the higher risk of sudden death in Rett patients by the evaluation of heart rate variability, a marker of cardiac autonomic activity and corrected QT intervals. Methods : Diagnosis of Rett syndrome was made by molecular genetic study of Rett syndrome (MECP2 gene) or clinical diagnostic criteria of Rett syndrome. Heart rate variability and corrected QT intervals were measured by 24 h-Holter study in 12 Rett patients, and in 30 age-matched healthy children with chief complaints of chest pain or suspected heart murmurs. The were compared with the normal age-matched control. Results : Patients with total Rett syndrome, classic Rett syndrome, and Rett variants had significantly lower heart rate variability(especially rMSSD)(P<0.05) and longer corrected QT intervals than age-matched healthy children(P<0.05). Sympathovagal balance expressed by the ratio of high to low frequency(LF/HF ratio) also showed statistically significant differences between the three groups considered(P<0.05). Conclusion : A significant reduction of heart rate variability, a marker of autonomic disarray, suggests a possible explanation of cardiac dysfunction in sudden death associated with Rett syndrome.

Clinical features of congenital muscular torticollis (선천성 근성 사경의 임상적 특징)

  • Jun, Ji Eun;Ryu, Hye Kyeong;Shim, Jae Won;Shim, Jung Yeon;Jung, Hye Lim;Park, Moon Soo;Kim, Deok-Soo
    • Clinical and Experimental Pediatrics
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    • v.50 no.3
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    • pp.241-247
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    • 2007
  • Purpose : Congenital muscular torticollis (CMT) is a common and benign congenital disorder of the musculoskeletal system in neonates and infants. The pathophysiology is that the sternocleidomastoid muscle (SCM) is shortened on the involved side by fibrosis, leading to ipsilateral tilt and contralateral rotation of the face and chin. In this study, we investigated the clinical features of CMT, the role of ultrasonography (USG) in prediction of prognoses and the clinical significance of early detection and treatment. Methods : Forty seven patients (M:F=31:16) were diagnosed as a CMT between March 2003 and May 2006. We reviewed age at diagnosis, physical findings, USG findings, treatment and therapeutic outcome from their medical records. Results : The median age at diagnosis was 90 days (18 days-9 years, 7 months) and the right side of neck was affected in more patients (right : left=26:21). Of 24 patients with a palpable neck mass, 21 had USG; 19 cases showed sternocleidomastoid tumor (SMT). In cases with no neck mass, USG was performed in 11 patients; seven had postural torticollis (POST), three had SMT and one had muscular torticollis (MT). Among 40 patients with follow-up, 36 had total resolution. There was negative correlation between the age at diagnosis and the recovery time, whereas the final outcome was not correlated with USG findings. However, the patients without positive findings in USG had earlier resolution (1 month vs 2.6 months, P=0.0008). The patients with SMT had earlier diagnosis and excellent outcomes. The patients with MT were delayed to diagnosis and had the longest time to resolve. Lastly, the patients with POST had delayed diagnoses, but they had excellent outcomes. Conclusion : Since the patients with delayed diagnoses, in despite of benign courses, may take a long time to resolve and rarely need surgical treatment, it is important to diagnose and treat early. This study showed that USG findings of the SCM may be used as predictive factors.

A Study on Antecedents of Ethical Leadership of Power Retailers, : Focusing on the Relationship between Discount Stores and Their Suppliers (대형 유통업체 윤리적 리더십의 선행변수에 관한 연구 : 할인점과 공급업체 간 관계를 중심으로)

  • Kim, Sang-Deok
    • Journal of Distribution Research
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    • v.17 no.3
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    • pp.59-92
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    • 2012
  • With accumulated research evidence, there is little doubt that leadership behavior is related to a wide variety of positive individual and organizational outcomes. Indeed, leadership behavior has been empirically linked to increased employee satisfaction, organizational commitment, extra effort, turnover intention, organizational citizenship behavior, and overall employee performance. Although leadership behavior has been linked to a number of positive organizational outcomes, research regarding the antecedents of such behavior is limited. Especially there is little research dealing with the antecedents of inter-organizational leadership behavior. This study interests in inter-organizational ethical leadership among marketing channel members. In both the mass media and the academic association, there has been a surge in interest in the ethical and unethical behavior of leaders. Although the corporate scandals in recent years may explain much of the mass media and popular focus, academics' interest has been limited by evidence that ethical leadership behavior is associated with both positive and negative inter-organizational processes and performances. This study tried to contribute to this body of knowledge by examining antecedents of ethical leadership. Ethical leadership is defined "the demonstration of normatively appropriate conduct through personal actions and interpersonal relationships, and the promotion of such conduct to followers through two-way communication, reinforcement, and decision-making." Ethical leaders not only inform individuals of the behefits of ethical behavior and the cost of inappropriate behavior, such leaders also set clear standards and use rewards and fair and balanced punishment to hold followers accountable for their ethical conduct. Despite the assume importance and prominence of ethical leadership among organizations, there are still many questions relating to its antecedents and consequences. One is whether the likelihood of an leading organization being perceived as an ethical leader among other following organizations in marketing channels can be predicted using its characteristics and inter-organizational relationship maintenance skills. Identifying trait and skill antecedents will aid in the development of strategies for selecting and developing ethical leaders and determining the best means to reinforce ethical behaviors. The purpose of this study is to investigate the effects of three categorized variables on ethical leadership of channel leader. To be concrete, this study develops a model of the antecedents of three conceptually distinct forms of channel leader characteristics, such as organizational traits, inter-organizational relationship maintenance strategies, and supplier management strategies, and tests the hypothesized differential effects on ethical leadership of marketing channel leaders. The reason why this study deals with discount store channel is that there is very strong inter-dependence between a discount store and its suppliers. Their strong inter-dependence makes their relationship as the relationship between a leader and suppliers and creates an atmosphere that leadership occur without difficulty. The research model is as follows. For the purpose of empirical testing, 295 respondents of suppliers of discount store channel in Korea were surveyed. The procedures included scale reliability, and discriminant and convergent validity were used to validate measures. Also, the reliability measurements traditionally employed, such as the Cronbach's alpha, were used. All the reliabilities were greater than .70. This study conducted confirmatory factor analyses to assess the validity of our measurements. All items loaded significantly on their respective constructs(with the lowest t-value being 15.2), providing support for convergent validity. We then examined composite reliability and average variance extracted(AVE). The composite reliability of each construct was greater than .70. The AVE of each construct was greater than .50. This study tested research model using Partial Least Square(PLS). The estimation of the structural equation model revealed an acceptable fit of the model to the data($r^2$=.851). Thus, This study concluded that the model fit was considered acceptable. The results of PLS are as follows. The results indicated that conscientiousness, openness, conflict management, social networks, training, fair reward had positive effects on ethical leadership of channel leaders. On the other hand, emotional insecure had negative effect and agreeableness, assurance, and inter-organizational communication had no significant effect on supply chain leadership.

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Study of Stress Changes in Nanocrystalline CoW Thin/Thick Film Alloys Eletrodeposited from Citrate Baths (Citrate Baths로부터 전기도금된 나노결정립 CoW 합금 박막/후막의 응력변화에 대한 연구)

  • Cho, Ik-Jong;Park, Deok-Yong;Ihn, Hyun-Man
    • Journal of the Korean Electrochemical Society
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    • v.9 no.4
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    • pp.141-150
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    • 2006
  • Nanocrystalline CoW thin/thick film alloys were electodeposited from citrate baths to investigate the influences of metal ion concentration, current density and solution pH on chemical composition, current efficiency, residual stress, surface morphology, and microstructure of the film. Deposit W (tungsten) content in CoW thin/thick film increased with increasing W ion concentration, current density, and solution pH in the plating bath. It was observed that residual stress in CoW thin/thick film decreased with increasing W ion concentration and solution pH. CoW thin film exhibited mixed phases of hop Co [(100) and (002)] and hcp $Co_3W$ [(002) and (201)] at W ion concentration with 0.02 to 0.08 M. The microstructure of CoW thin film at W ion concentration of 0.1 to 0.2 M was close to amorphous phase. The dominant phases were found to be hop Co (002) and hop $Co_3W$ [(200), (002) and (201)] at the current densities of 5, 10, 25, and $100mA{\cdot}cm^{-2}$ CoW thin film at the current densities of 50 and $75mA{\cdot}cm^{-2}$ was close to amorphous phase. At solution pH 8.7, CoW thin film exhibited hcp Co (002) and hop $Co_3W$ [(200), (002) and (201)]. Below solution pH 8.7, CoW thin film exhibited amorphous microstructure. The optimum electrodeposition conditions for CoW thin/thick film were found to be W ion concentration of 0.08 M, current density of $10mA{\cdot}cm^{-2}$, and solution pH 8.7.

Quality Evaluation of the Home-made Soy-Sauce Jangachi, Korean Traditional Pickle, Prepared by the Head-Families of Andong, Korea (안동지역 종가에서 전통적으로 제조된 간장 장아찌의 품질 특성)

  • Kim, Deok-Jin;Kim, Mi-Sun;Lee, Ye-Seul;Sohn, Ho-Yong
    • Microbiology and Biotechnology Letters
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    • v.41 no.3
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    • pp.311-319
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    • 2013
  • In an effort to characterize the physicochemical properties and microbial risks associated with the soy sauce jangachi (Korean traditional pickle), 15 different home-made products, which were prepared from medicinal plants and wild edible vegetables, from head-families of Andong, Kyungsangbuk-do Province in Korea, and 6 different commercial products sold at supermarket, were investigated. The average pH of the mature soaking solutions and plants soaked in the 21 jangachi were $3.99{\pm}0.38$ and $3.51{\pm}0.41$, and the average acidity of the mature soaking solutions and soaked plants were $1.59{\pm}0.54$ and $1.65{\pm}0.76$, respectively. The average brix of the mature soaking solutions and plants soaked were $27.67{\pm}8.38$ and $25.61{\pm}6.60$, respectively. In salinity, which is a major factor in jangachi industry production, the average salinity of the mature soaking solutions and soaked plants were $7.55{\pm}3.26$ and $5.75{\pm}2.23$, respectively. In particular, the hot-peppers, eusuri, du-rup, kaet-ip, kuji-ppong, myeng-i and sancho jangachi were amongst the home-made products, and the salinity was above 8.8%, which was 2 folds-higher than that of the commercial sterilized products, and 1/3-lower than commercial non-sterilized products. The color difference and turbidity of jangachi were dependent on the plant parts used. In microbial risk assessment, the microorganisms related with food-borne disease, such as Escherichia coli, Salmonella sp, and Shigella sp., were not detected. After some time, total cell count analysis revealed that the commercial products sold at supermarkets were more vulnerable than the home-made products.

Effect of Different Cultivation Region, Transplanting and Harvesting Date on Yield and Quality of "Shinongheugchal", "Shinmyeongheugchal" (재배지역, 이앙 및 수확시기가 신농흑찰, 신명흑찰 수량 및 품질에 미치는 영향)

  • Song, Young-Eun;Lee, Deok-Ryeol;Cho, Seung-Hyun;Lee, Ki-Kwon;Lee, Jae-Heung;Song, Young-Ju;Jeung, Jong-Sung
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.57 no.3
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    • pp.248-253
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    • 2012
  • Demand is increasing for new functional and health food such as natually colored or flavored rices. Shinongheugchal, Shinmyeongheugchal, colored glutinous rice, were breed as new variety in Jeollabuk-do ARES. Shinongheugchal and Shinmyeongheugchal are medium to late maturing cultivars and higher than Heugnambyeo in term of C3G content. It was conducted to improve the quality of Shinongheugchal, Shinmyeongheugchal in different cultivation regions, transplanting time. The cultivation regions was Jinan (mid-mountainous area) and Iksan (plain area). Transplanting time was May. 20, May. 25 May 30 and Jun. 5 in Jinan, that of Iksan was Jun. 5, Jun. 10, Jun. 15 and Jun. 20. The average heading date of Shinongheugchal and Shinmyeongheugchal was Aug. 13, Aug. 19 and Aug. 15, Aug. 22 in Jinan and Iksan. The average yield of Shinongheugchal(brown rice) in Jinan was 514 $kg\;10a^{-1}$ and that of in Iksan was 529 $kg\;10a^{-1}$. The average yield of Shinmyeongheugchal(brown rice) in Jinan was 508 $kg\;10a^{-1}$ and that of in Iksan was 511 $kg\;10a^{-1}$. The average C3G content of Shinongheugchal in Jinan was 273.9 mg/100g, that of in Iksan was 228.2 mg/100g. The average C3G content of Shinmyeongheugchal in Jinan was 126.3 mg/100g, that of in Iksan was 101 mg/100g. The optimal transplanting date was May 30 in Jinan and June 10 in Iksan considering the yield and C3G content in Shinongheugchal. The optimal harvesting date of Shinongheugchal in Iksan was 50 days after heading.

Geology and Distribution of Crushed Aggregate Resources in Korea (국내 골재석산의 분포와 유형 분석)

  • Hong Sei Sun;Lee Chang Bum;Park Deok Won;Yang Dong Yun;Kim Ju Yong;Lee Byeong Tae;Oh Keun Chang
    • Economic and Environmental Geology
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    • v.37 no.5
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    • pp.555-568
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    • 2004
  • The demand of aggregate resources in Korea has been increased with a rapid economic growth since the 1980s. About 25% of the total aggregate production is derived from riverine aggregates, 20% to 25% from marine sands, 40% to 45% from crushed aggregate and the rest 5% to 15% from old fluvial deposits. The abundance of crushed coarse aggregates varies in the uniform distribution of country, but in general it can be concentrated in the most densely populated areas, five main cities. Typical rock types of the Korean crushed stones are classified as plutonic rocks of 27%, metamorphic rocks of 32%, sedimentary rocks and volcanic rocks of 18%, respectively. The most abundant coarse aggregate used in the country is obtained from granite (25% of total) and subordinately gneiss (20%), sandstone (10%) and andesite (10%). Although rock types using as dimension stone are only fifteen, those as aggregate amount up to twenty nine rocks. These rocks consist of plutonic rocks such as granite, syenite, diorite, aplite, porphyry, felsite. dike and volcanic rocks such as rhyolite, andesite, trachyte, basalt, tuff, volcanic breccia and metamorphic rocks such as gneiss, schist, phyllite, slate, meld-sandstone, quartzite, hornfels, calc-silicate rock, amphibolite. And sandstone, shale, mudstone, conglomerate, limestone, breccia, chert are main aggregate sources in tile sedimentary rocks. The abundance of plutonic rocks is the highest in Chungcheongbuk-do, and decreases as the order of Jeollabuk-do, Gangwon-do and Gyeonggi-do. In Jeollanam-do, volcanic aggregates occupy above 50%, on the contrary sedimentary aggregates are above 50% in Gyeongsangnam-do.

Toxic Effects of Binary Mixtures of Heavy Metals on the Growth and P Removal Efficiencies of Alcaligenes sp. (Alcaligenes sp.의 생장과 인 제거에 미치는 이종 중금속 혼합의 독성 효과)

  • Kim, Deok Hyun;Yoo, Jin;Chung, Keun Yook
    • Korean Journal of Environmental Agriculture
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    • v.35 no.1
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    • pp.79-86
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    • 2016
  • BACKGROUND: This study was initiated to quantitatively evaluate the effects of five heavy metals on the growth and P removal efficiencies of Alcaligenes sp., known as the Phosphorus Accumulating Organisms (PAOs). It was cultivated in the batch system with five heavy metals, such as Cd, Cu, Zn, Pb and Ni, added in single and binary mixtures, respectively.METHODS AND RESULTS: IC50 (half of inhibition concentration of bacterial growth) and EC50 (half of effective concentration of phosphorus removal Efficiencies) were used to quantitatively evaluate the effects of heavy metals on the growth and phosphorus removal Efficiencies of Alcaligenes sp. In addition, Additive Index Value (A.I.V.) method was used to evaluate the interactive effects between Alcaligenes sp. and heavy metals. As a result, as the five heavy metals were singly added to Alcaligenes sp., the greatest inhibitory effects on the growth and P removal efficiencies of each bacteria was observed in the cadmium (Cd). In the binary mixture treatments of heavy metals, the treatments of lowest IC50 and EC50 were the Cd + Cu treatment. Based on the IC50 and EC50 of the binary mixtures of heavy metals treatments, most interactive effects between the heavy metals were found to be antagonistic.CONCLUSION: Based on the results obtained from this study, it appears that they could provide the basic information about the toxic effects of the respective treatments of single and binary mixtures of heavy metals on the growth and P removal efficiencies of Alcaligenes sp. through further study about the characterization of functional proteins involved in toxic effects of heavy metals.

The characteristics on dose distribution of a large field (넓은 광자선 조사면($40{\times}40cm^2$ 이상)의 선량분포 특성)

  • Lee Sang Rok;Jeong Deok Yang;Lee Byoung Koo;Kwon Young Ho
    • The Journal of Korean Society for Radiation Therapy
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    • v.15 no.1
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    • pp.19-27
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    • 2003
  • I. Purpose In special cases of Total Body Irradiation(TBI), Half Body Irradiation(HBI), Non-Hodgkin's lymphoma, E-Wing's sarcoma, lymphosarcoma and neuroblastoma a large field can be used clinically. The dose distribution of a large field can use the measurement result which gets from dose distribution of a small field (standard SSD 100cm, size of field under $40{\times}40cm2$) in the substitution which always measures in practice and it will be able to calibrate. With only the method of simple calculation, it is difficult to know the dose and its uniformity of actual body region by various factor of scatter radiation. II. Method & Materials In this study, using Multidata Water Phantom from standard SSD 100cm according to the size change of field, it measures the basic parameter (PDD,TMR,Output,Sc,Sp) From SSD 180cm (phantom is to the bottom vertically) according to increasing of a field, it measures a basic parameter. From SSD 350cm (phantom is to the surface of a wall, using small water phantom. which includes mylar capable of horizontal beam's measurement) it measured with the same method and compared with each other. III. Results & Conclusion In comparison with the standard dose data, parameter which measures between SSD 180cm and 350cm, it turned out there was little difference. The error range is not up to extent of the experimental error. In order to get the accurate data, it dose measures from anthropomorphous phantom or for this objective the dose measurement which is the possibility of getting the absolute value which uses the unlimited phantom that is devised especially is demanded. Additionally, it needs to consider ionization chamber use of small volume and stem effect of cable by a large field.

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Removal of water pollutants and its application to swine wastewater treatment through the establishment of best optimal growth conditions of Ankistrodesmus bibraianus (Ankistrodesmus bibraianus의 최적 배양조건 설정을 통한 수질오염물질 제거 및 축산 폐수 처리 적용)

  • Hwang, In-Seong;Park, Young-Min;Lee, Ye-Eun;Kim, Deok-Won;Park, Ji-Su;Oh, Eun-Ji;Yoo, Jin;Chung, Keun-Yook
    • Korean Journal of Environmental Biology
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    • v.38 no.1
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    • pp.82-92
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    • 2020
  • Since swine wastewater contains high concentrations of nutrients and heavy metals, it deteriorates water quality when discharged. Compared to conventional methods, bioremediation can be a promising method for its treatment. Specifically, microalgae have the potential to remove these pollutants. In this study, the removal of nutrients (nitrogen (N) and phosphorus (P)) and heavy metals (copper (Cu) and zinc (Zn)) from swine wastewater by Ankistrodesmus bibraianus was evaluated and the organism's optimal growth conditions were investigated. The optimal growth conditions were established at 28℃, pH 7, and light and dark cycles of 14:10 h. The removal efficiencies of N and P by a single treatment (500, 1,000, 5,000, and 10,000 mg L-1) ranged from 22.9 to 80.6% and from 11.9 to 50.0%, respectively. The removal efficiencies of N and P in the binary treatments ranged from 16.4 to 58.3% and from 7.80 to 49.8%, respectively. The removal efficiencies of Cu and Zn by a single treatment(10, 30, and 50 mg L-1) ranged from 15.5 to 81.5% and from 6.28 to 34.3%, respectively. Similarly, the removal efficiencies of Cu and Zn in the binary treatments ranged from 16.7 to 74.5% and from 5.58 to 27.5%, respectively. In addition, the study showed the optimal growth conditions for microalgae and the removal efficiency of nutrients (N and P) and heavy metals (Cu and Zn), which could be applied to swine wastewater. Based on the results in this study, it appears that Ankistrodesmus bibraianus could be used for the removal of nutrients and heavy metals present in swine wastewater.