• Journal of the korean academy of Pediatric Dentistry
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• v.44 no.2
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• pp.228-234
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• 2017

Hydrocephalus is a condition in which the volume of cerebrospinal fluid in the cerebral ventricles is abnormally elevated. Hydrocephalus patients may show macrocephaly and delayed development. Ventriculoperitoneal shunt is the most commonly used treatment but ventriculoatrial shunt is another treatment option. This report discusses the dental management process employed for a 7-year, 6-month old patient with ventriculoperitoneal shunt-treated hydrocephalus. This patient showed dental caries on the deciduous molars, facial swelling, macrocephaly and delayed development. Pulpectomy was performed on the deciduous molars under nitrous oxide sedation and mild protective stabilization. This patient did not appear to have any specific complications until the latest follow-up and was scheduled for the management of overall oral hygiene, development of permanent teeth, and craniofacial asymmetry through periodic follow-up. During dental treatment of shunt-treated patients, care should be taken to avoid applying excessive force to the catheter running along the patient's neck to prevent the displacement of the catheter. A referral to a neurosurgeon is recommended for patients with ventriculoatrial shunts for prophylactic antibiotics. As hydrocephalus patients grow, they may show craniofacial asymmetry or differences in the calcification of the permanent teeth, and require periodic oral and craniofacial assessment.

• The Journal of the Korean dental association
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• v.50 no.3
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• pp.126-139
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• 2012

Loss of dentition can lead to not only compromised esthetics and functions of the patient, but also alveolar bone resorption. Bone grafting with prosthetic reconstruction of the gingiva can be selected for the treatment, and it provides many benefits as prosthetic gingival reconstruction does not require a complicated surgical process and is available within a short period of time, with stable clinical results. However, conventional porcelain fused to metal prosthesis has certain limits due to its size, and deformation after several firing procedures. In this clinical report, the author would like to introduce a patient with severe alveolar resorption who was treated with gingiva-shaped zirconia/titanium CAD/CAM implant fixed prosthesis for esthetic and functional rehabilitation. Clinical reports Clinical report 1, 2 : A case of loss of anterior dentition with atrophied alveolar bone. Implant retained zirconia bridge applied with Procera implant bridge system to simulate the gingiva. Upper structure was fabricated with zirconia all ceramic crown. Clinical report 3, 4 : A case of atrophied maxillary alveolus was reconstructed with fixed implant prosthesis, a CAD/CAM designed titanium structure covered wi th resin on its surface. Anterior dentition was reconstructed with zirconia crown. Conclusion and clinical uses. All patients were satisfied with the outcome, and maintained good oral hygiene. Zirconia/titanium implant fixed prosthesis fabricated by CAD/CAM system was highly accurate and showed adequate histological response. No critical failure was seen on the implant fixture and abutment overall. Sites of severe alveolar bone loss can be rehabilitated by implant fixed prosthesis with CAD/CAM system. This type of prosthesis can offer artificial gingival structure and can give more satisfying esthetics and functions, and as a result the patients were able to accept the outcome more fondly, which makes us less than hard to think that it can be a more convenient treatment for the practitioners.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.1
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• pp.21-26
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• 2014

When iodine container for dental mouth treatment is opened, thread for treatment is cut by the blade in cap of container. Due to the problem of corrosion in a short period time after the reaction of metal blade to iodine solution, it gives impact on patient hygiene. In order to solve the problem, alternative products such as ceramic blade are developed and produced recently. In case of ceramic blade, it is produced by handwork and machine work. In this study, for the quantity production of ceramic blade with powder injection molding, we proposed a delivery system to have uniform charge of 20 cavity. Using Moldflow, simulation on 20 Cavity flow was performed. And then the mold was obtained through mold production and modification.(based on simulation) After injection molding, debinder, sintering process was achieved for ceramic blade, and the cap product was completed via insert injection on ceramic blade. In this study, we verified possibility of quantity production of ceramic blade which showed effective performance for cutting.

• International Journal of Oral Biology
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• v.37 no.3
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• pp.146-152
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• 2012

MicroRNAs (miRNAs, miRs) are about 21-25 nucleotides in length and regulate mRNA translation by base pairing to partially complementary sites, predominantly in the 3'-untranslated region (3'-UTR) of the target mRNA. In this study, the expression profile of miRNAs was compared and analyzed for the establishment of miRNA-related odontoblast differentiation using MDPC-23 cells derived from mouse dental papilla cells. To determine the expression profile of miRNAs during the differentiation of MDPC-23 cells, we employed miRNA microarray analysis, quantitative real-time PCR (qRT-PCR) and Alizaline red-S staining. In the miRNA microarray analysis, 11 miRNAs were found to be up- or down-regulated more than 3-fold between day 0 (control) and day 5 of MDPC-23 cell differentiation among the 1,769 miRNAs examined. In qRT-PCR analysis, the expression levels of two of these molecules, miR-194 and miR-126, were increased and decreased in the control MDPC-23 cells compared with the MDPC-23 cells at day 5 of differentiation, respectively. Importantly, the overexpression of miR-194 significantly accelerated mineralization compared with the control cultures during the differentiation of MDPC-23 cells. These results suggest that the miR-194 augments MDPC-23 cell differentiation, and potently accelerates the mineralization process. Moreover, these in vitro results show that different miRNAs are deregulated during the differentiation of MDPC-23 cells, suggesting the involvement of these genes in the differentiation and mineralization of odontoblasts.

• Journal of the Korea Convergence Society
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• v.11 no.6
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• pp.95-103
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• 2020

The aim of this study was to confirm the association between obesity and periodontitis in adults and identify the convergence relationship between periodontal disease and health-related behavior at each stage of obesity among 10,058 adults aged 30-79 years from the 7th National Health and Nutrition Survey data. We performed chi-square tests and multivariate logistic regression analyses, adjusting for demographic characteristics and health status. We found that the higher the obesity stage, the higher the risk of periodontitis. Smoking, not using oral care products, and not attending dental check-ups were associated with periodontitis. In addition, we found a difference in influence factors according to the stage of obesity. Increase in obesity stage is a negative influence on the prevalence of periodontitis. Hence, an oral health program should be applied to the obesity management process.

• Applied Microscopy
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• v.47 no.4
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• pp.242-250
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• 2017

The purpose of this study was to characterize the prenatal and postnatal development of the mouse parotid salivary gland and tooth, and to investigate the relationship between the developmental timing of the two organs. Development of parotid salivary gland begins on embryonic day 15 (E15), which is the prebud stage; E17 is the initial bud stage; E21 to postnatal day 3 (PN3) is the pseudoglandular stage; PN5 to PN10 is the canalicular stage; and PN21 is the terminal bud stage. At E15, the developing maxillary molar tissue is at the bud stage; at E17, it is at the cap stage; at E21, it is at the early bell stage; PN3 to PN5 comprises the advanced bell stage; at PN10, it is at the crown stage; at PN21, it is at the functional stage. Therefore, unlike the other major salivary glands, the development of mouse parotid salivary gland is completed through a process of prenatal and postnatal morphogenesis and becomes functional at about the same time as the developing tooth. The developmental completion times of the parotid salivary gland and tooth are closely related to the weaning time of animal.

• International Journal of Oral Biology
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• v.46 no.1
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• pp.30-38
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• 2021

Cudraxanthone D (CD) is a natural xanthone compound derived from the root barks of Cudrania tricuspidata. However, the biological functions of CD in human metabolism have been rarely reported until now. Autophagy is the self-degradation process related to cancer cell metastasis. Here, we elucidated the effects of CD on human oral squamous cell carcinoma (OSCC) cells' metastatic ability. We confirmed that CD effectively decreased the proliferation and viability of SCC25 human OSCC cells in time- and dose-dependent manners. Also, the metastasis phenotype of the SCC25 cell (migration, invasion, and epithelial-mesenchymal transition [EMT]) was inhibited by CD. To further investigate the mechanism by which CD inhibited the metastatic capacity, we detected the relationship between EMT and autophagy in the SCC25 cells. The results revealed that CD inhibited the metastasis of the SCC25 cells by attenuating autophagy. Thus, our findings produced a potential novel agent for the treatment of human OSCC metastasis.

• Journal of Convergence for Information Technology
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• v.11 no.10
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• pp.230-238
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• 2021

This study sought to understand the mediating effect of job enthusiasm in relation to work-life balance and job performance of hospital workers. The data collected through a self-contained survey using structured questionnaires for employees of medical institutions in Busan and South Gyeongsang Province were analyzed using SPSS 26.0 and Process Macro programs. As a result of the analysis, job performance and non-role performance were the most influenced by passion (+), and work-life balance was evaluated as a factor that increased job enthusiasm. In addition, work-life balance directly influenced job performance, but indirectly influenced job performance as a medium. In particular, the work-life balance and the relationship between performance other than roles were fully mediated. In order to improve the job performance of hospital workers at the organizational level, it is necessary to increase job enthusiasm, which means that efforts are needed to establish an organizational culture that values work-life balance.

• Korean Journal of Dental Materials
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• v.45 no.4
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• pp.311-320
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• 2018

The purpose of this study is to evaluate the flow ability of the thermoplasticized Gutta Percha in different temperatures. Four Gutta Percha products were classified by its hardness (soft, medium, and hard) and were experimented by the Rheometer (Melt flow indexer MFI-10, DAVENPORT, England) measuring apparatus, in $(23{\pm}2)^{\circ}C$, and in a relative humidity of ($50{\pm}5$) %, following the guidelines of ISO 1133-1:2011. The heating temperature ranged from $108^{\circ}C$, $160^{\circ}C$ to $200^{\circ}C$, and the load at 2.16 kg and 3.8 kg. The Gutta Percha was cut in 5 mm to be suitable for the rheometer pressurization process. After the experiment was conducted with a preheating time of 5 minutes, a cutting time of 5-240 seconds, and a sample of 10 grams, the Gutta Percha did not show any changes in fluidity for $108^{\circ}C$, $160^{\circ}C$, but showed a change in its flow ability in $200^{\circ}C$. Also, the Gutta Percha did not show any changes in its fluidity when it was pressurized by 2.16 and 3.8 kilograms. Therefore, this experiment shows that the heating temperature and the cut-off time showed a significance while measuring the melt flow rate.

• Journal of the Korea Convergence Society
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• v.12 no.4
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• pp.95-103
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• 2021

This study was aimed to investigate the education needs for prevention and control of infectious diseases by lifecycle based on age group and to provide the fundamental data to develop the educational programs. A research was conducted with 328 adults over 19 years old for a month of February 2021 through online and mobile survey by Gallup Korea. Research contents include the general characteristics, personal hygiene practices related to infection, perceived risks related to infection, importance and level of knowledge on infectious diseases, and education needs for prevention and control of infectious diseases. For the research data analysis, PASW Statistics Ver 20.0 was used as a statistical program. Ranks from analysis upon conversion as the formula of Borich needs to sum up with importance and knowledge level showed first (Borich 3.11) with treatments for infectious diseases; second (Borich 2.15) with process in case of suspicion and diagnosis of infectious diseases; third (Borich 1.75) with transmission routes of infectious diseases; fourth (Borich 1.73) with preventive ways of infectious diseases; fifth (Borich 1.50) with diagnostic and test methods of infectious diseases; sixth (Borich 1.45) with characteristics of infectious diseases; and seventh (Borich1.38) with main symptoms of infectious diseases. It is anticipated that development of educational programs applying education needs for prevention and control of infectious diseases in this research can contribute to enhance the physical health, mental health, and psychological well-being of the subjects.