• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.35 no.2
• /
• pp.189-195
• /
• 2012

Parcel delivery services are a bit different from general vehicle routing problems since the services require a deliver's walking time to give the parcel to the customer. This time takes more than 1/4 of total delivery time, but it is ignored for the convenience of algorithm design in general. The walking time is too big to be ignored if we need to estimate necessary delivery time precisely as much as possible, or to design a heuristic with varying vehicle moving speeds in metropolitan area. For these reasons, the walking times are surveyed and analyzed to use on the design of VRP heuristic for parcel delivery services in this research.

• International conference on construction engineering and project management
• /
• 2009.05a
• /
• pp.1440-1445
• /
• 2009

Clients demands have been changed by construction circumstances such as high-technology, megaprojects, and the complexity of construction. Advanced foreign nations have already introduced and applied new project delivery systems (i.e, CM, DB, etc.) to deal with the change of such that. Korea has also promoted variation of the delivery systems for the progressive measure to the rapid changeable situation. Even though government has made his efforts as stated above, some clients have uniformly used those to public construction projects. That is because there are not selection criteria of project delivery system for clients. Therefore, this study presented the selection criteria of project delivery system based on project types in the public large construction projects. In addition, the study has verified the viability of the presented models through consultation with professionals and experts.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.36 no.3
• /
• pp.133-141
• /
• 2013

The revitalization of e-business via Internet brings big changes to the postal business, and leads to a tremendous increase of heavy and large sized postal mails with continuing growth of home delivery business. Thus, even though the number of intermediate storages for mail delivery that mailmen use for picking up mails in the middle of mail delivery has been being increased, it has still many problems such as insufficient number and size of the storages as well as avoidance of mail keeping of trust agents. It is necessary that safety of mail keeping, seamless mail delivery, and individual parcel pick-up process reestablishment should be made through an improved counter plan for the problems described previously. This study presents the efficient and right operational plan for the intermediate storage for mail delivery with providing the number and size of intermediate storages per mail delivery sequence according to four different types of post offices.

• Advances in nano research
• /
• v.13 no.1
• /
• pp.87-96
• /
• 2022

Drug self-delivery systems can easily realize combination drug therapy and avoid carrier-induced toxicity and immunogenicity because they do not need non-therapeutic carrier materials. So, designing appropriate drug self-delivery systems for specific diseases can settle most of the problems existing in traditional drug delivery systems. Retinal pigment epithelium is very important for the homeostasis of retina. However, it is vulnerable to oxidative damage and difficult to repair. Worse still, the antioxidants can hardly reach the retina by non-invasive administration routes due to the ocular barriers. Herein, the targeted group (folic acid) and antioxidant (melatonin) have been grafted on the surface of ZnO quantum dots to fabricate a new kind of drug self-delivery systems as a protectant via eyedrops. In this study, the negative nanoparticles with size ranging in 4~6 nm were successfully synthesized. They could easily and precisely deliver drugs to retinal pigment epithelium via eyedrops. And they realized acid degradation to controlled release of melatonin and zinc in retinal pigment epithelium cells. Consequently, the structure of retinal pigment epithelium cells were stabilized according to the expression of ZO-1 and β-catenin. Moreover, the antioxidant capacity of retinal pigment epithelium were enhanced both in health mice and photic injury mice. Therefore, such new drug self-delivery systems have great potential both in prevention and treatment of oxidative damage induced retinal diseases.

• Journal of Korean Clinical Nursing Research
• /
• v.16 no.1
• /
• pp.167-175
• /
• 2010

Purpose: This study investigated nursing care delivery systems in 44 university affiliated hospitals and satisfactions with the systems perceived by 226 unit managers (head nurses) of general medical surgical wards. Methods: Data were collected with questionnaires consisting of checklists asking the unit managers their nursing care delivery systems and their satisfactions with the systems. Results: Four models of nursing care delivery systems (primary, modified primary, team, and functional models) were drawn from the participants' responses. Among the four key models 35% of the units adopted team model whereas 24.3% adopted primary model and 22.6% adopted modified primary model. In spite of 35% of team model being under use, 60.6% (n=137) of the unit managers answered the nursing delivery system of their units as team model and only 6.2% (n=14) answered their units having primary or modified primary models, instead of 46.9% combining both. In regard to the satisfaction, critical thinking ability of staff nurses (members in their units) was the most dissatisfactory area regardless of models of service delivery. Conclusion: Introducing team model supplemented with core concepts of primary model (primary team delivery model) into nursing practice will reform the workplace and therefore deliver safe health care services to patients.

• Journal of Ginseng Research
• /
• v.39 no.2
• /
• pp.116-124
• /
• 2015

Background: Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent and treat various diseases. Panax ginseng has pharmacological effects on neurodegenerative diseases such as Alzheimer's disease (AD). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced AD in a rat model. Methods: Advanced glycation end products were injected bilaterally into the CA3 region of the rats' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell (NF-${\kappa}B$). Results: Behavioral results showed that PG (1 g/kg, 0.5 g/kg, and 0.25 g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in rats with AGE-induced AD. Panax ginseng also significantly reduced the malondialdehyde level, increased the glutathione content, and increased superoxide dismutase activity in the hippocampus. Panax ginseng significantly decreased the expression of RAGE and NF-${\kappa}B$. The blockade of anti-RAGE antibody could significantly reduce AGE-induced impairments and regulate these expressions. Conclusion: Our results demonstrated that PG significantly inhibits AGE-induced memory impairment and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the RAGE/NF-${\kappa}B$ pathway. Our results provided the experimental basis for applying PG in preventing and treating AD.

• Journal of Korean Public Health Nursing
• /
• v.17 no.1
• /
• pp.5-16
• /
• 2003

This policy alternatives for establishment of rehabilitation health care delivery system for the disabled in the community were developed based on the data of current health status and situations of health care management for disabled persons in Korea. This research was conducted with secondary data analysis for identifying health status and current situations of managing health of disabled persons, and discussed current issues for establishing rehabilitation health care delivery systems in the community. Observing the health status and current situations of managing health of disabled persons, scope and target population of disabled person extended. so prevalence rates increased. and the severity of disability intensified and specified. The summary of issues of health management for disabled persons included; 1) absence of comprehensive and systematic policy in rehabilitation health care systems. 2) absence of consumer based rehabilitation health care facilities and delivery systems that are considered as the characteristics of disabled persons 3) fixed form of projects based on the provider and lack of variety in the programs. Hereafter. to overcome these problems. policy alternatives should 1) establish a comprehensive rehabilitation health care policy for disabled persons. 2) establish comprehensive and specific community based rehabilitation health care delivery systems that can promote preventing disability. providing medical care for disabled persons, establishing rehabilitation management for disabled persons and health care when returning to society. 3) provide training and secure manpower for rehabilitation, but the training case managers who will take the roles as an expert rehabilitation nurse mediators for multidisciplinary team work are needed immediately. and 4) include efficient connection and provision of independent services for welfare rehabilitation service and health care. Conclusively. a community based rehabilitation health care delivery system should be comprehensive policy vision of the government on rehabilitation health care delivery System rehabilitation service has to be constructed systematically under suitable facilities con consumer characteristics and rehabilitation health care policy. By doing this, consumer comprehensive community rehabilitation health care delivery system could be constructed disabled person.

• The Journal of Information Systems
• /
• v.12 no.1
• /
• pp.67-85
• /
• 2003

In the recent a mobile internet makes a change in internet business. The mobile internet service is resulting in M-commerce. Even if M-commerce provides only information service, there will be much possibilities to make applications in various areas such as, delivery service, trading service, banking service etc. in the near future. Delivery service requires many steps in processing, originally. This study is designed to implement a mobile system which makes short in delivery process. It includes that a delivery man receives a signature on a paper and input data at the delivered place by using PDA at hand. The mobile system will be contributed to shorten delivery speed. It is proposed to implement the mobile office system for improving service efficiency in the business of delivery service. This study is designed to implement a mobile system which make short in delivery process. It includes that a delivery man receives a signature on a paper and input data at the delivered place by using PDA at hand. The mobile system will be contributed to shorten delivery speed. It is proposed to implement the mobile office system for improving service efficiency in the business of delivery service.

• Journal of Biomedical Engineering Research
• /
• v.7 no.2
• /
• pp.109-110
• /
• 1986

Polymers are widely applied in bioseparation processes as well as in drug delivery systems. These two fields have a certain commonality, in that they involve either removal or delivery of specific biomolecules from or to an aqueous environment It is also to be noted that therapeutic toxin renloval is an example of a bioseparation process. This presentation will focus on the use of polys!ors in physical as well as biospecific separations and delivery of biomolecules. Several new systems will also be described.

• Journal of Dairy Science and Biotechnology
• /
• v.38 no.4
• /
• pp.189-196
• /
• 2020

Milk proteins, such as casein and whey protein, exhibit significant potential as natural emulsifiers for the preparation and stabilization of emulsion-based delivery systems. This can be attributed to their unique functional properties, such as the amphiphilic nature, GRAS (generally recognized as safe) status, high nutritional value, and viscoelastic film-forming ability around oil droplets. In addition, milk protein has been used as a coating material in emulsion-based delivery systems to protect bioactive compounds during food processing and storage owing to its unique functional properties. These properties include the ability to bind lipophilic bioactive compounds and antioxidant activity. In this review, we present the use of milk proteins as emulsifiers for the formation of emulsions and food applications of milk protein-stabilized emulsion delivery systems.