• Title/Summary/Keyword: Delivery efficiency

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Explicit Multicast Extension (Xcast+) for Efficient Multicast Packet Delivery

  • Shin, Myung-Ki;Kim, Yong-Jin;Park, Ki-Shik;Kim Sang-Ha
    • ETRI Journal
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    • v.23 no.4
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    • pp.202-204
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    • 2001
  • In this letter, we propose a new multicast scheme, named Xcast+, which is an extension of Explicit Multicast (Xcast) for an efficient delivery of multicast packets. The mechanism incorporates the host group model and a new control plane into existing Xcast, and not only does it provide the transparency of traditional multicast schemes to senders and receivers, but it also enhances the routing efficiency in networks. Since intermediate routers do not have to maintain any multicast states, it results in a more efficient and scalable mechanism to deliver multicast packets. Our simulation results show distinct performance improvements of our approach compared to Xcast, particularly as the number of receivers in a subnet increases.

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Characterization of Biocompatible Lipid-Based Vesicles Contained with Medicinal Herb Extracts

  • Lee, Kyu-Jin;Park, Sun young;Park, Geuntae
    • Journal of Environmental Science International
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    • v.27 no.10
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    • pp.853-863
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    • 2018
  • In order to increase the medicinal herbs efficiency of drug delivery, vesicles contained with medicinal herbs were prepared by phosphatidylcholines and surface active agent. Vesicles loaded with medicinal herbs were characterized by UV-spectroscopy, Zetasizer. The antioxidant activity of vesicles was measured by DPPH assay and ABTS radical scavenging assays. Also, an analysis was conducted to determine the effects of anti-inflammatory of vesicles contained medicinal herbs. In addition, the whitening effects of vesicles contained medicinal herbs extract were studied via tyrosinase inhibition assay. The results of vesicles were as follows. Vesicles appeared an average diameter of approximatively 164-599 nm. All studied vesicles contained with medicinal herbs showed antioxidant, anti-inflammatory and whitening effects in a dose-dependent manner. Therefore, this experiment achieves its purpose of synthesizing of vesicles. In conclusion, we recommended that the vesicles loaded with medicinal herbs have ability for anti-aging materials. Specifically, it will apply to cosmetic ingredients.

Characterization of Linear Polymer-Dendrimer Block Copolymer/Plasmid DNA Complexes: Formation of Core-shell Type Nanoparticles with DNA and Application to Gene Delivery in Vitro

  • Choi, Joon-Sig;Choi, Young-Hun;Park, Jong-Sang
    • Bulletin of the Korean Chemical Society
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    • v.25 no.7
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    • pp.1025-1030
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    • 2004
  • A hybrid linear polymer-dendrimer block copolymer, poly(ethylene glycol)-block-poly(L-lysine) dendrimer, was synthesized and introduced to form polyionic complexes with DNA. The copolymer formed core-shell type nanoparticles with plasmid DNA. From dynamic light scattering experiments, the mean diameter of the polyplexes was observed to be 154.4 nm. The complex showed much increased water solubility compared to poly(L-lysine). The plasmid DNA in polyplexes was efficiently protected from the enzymatic digestion of DNase I. The cytotoxicity and transfection efficiency for 293 cells was measured in comparison with poly(Llysine).

Synthesis and Antibacterial Activity of Polyacrylic Acid (PAA)-Sulfacetamide (Polyacrylic acid(PAA)-Sulfacetamide 의 합성과 항균성)

  • 김종완;김용렬;이우윤
    • Journal of Environmental Health Sciences
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    • v.27 no.1
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    • pp.106-111
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    • 2001
  • Recently there were many studies not only to enhance drug delevery effect but to reduce side effect. Drug delivery system efficiency with decreasing side effect of drug dosage. It made possibility to use for a long term. Polymer drug was prepared by acid halide method with polymer in such of polyacylic acid and sulfacetamide. Its chemical properties were identified by means of IR, TGA. The antibacterial activities of polymer drug were studied by MICs and disk susceptivility test. The antibacterial activities by clean zone were increased in order of Staphyloccus aures

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Network Synchronization for Collaborative Work in Distributed Environment (분산 환경에서의 협업을 위한 네트워크 동기화 기법)

  • Song, Jung-Wook;Kwon, Yong-Moo
    • Journal of Information Technology Services
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    • v.10 no.3
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    • pp.203-212
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    • 2011
  • In the every day life of the people, the Internet is widely used. Currently over 1.9 billion people have one or more email addresses and over 600 million people use the Facebook. People are collaborating via the Internet more and more. When people are collaborating through the Internet, the differences of the message delivery delay are the biggest problem that disturbs the collaborative work over the network. To solve the differences of the message delivery delay, we introduce the delay-gap method. An experimental code have been implemented and the efficiency of the delay-gap is presented through the results from the experiment that have many participants.

The Improvement of Delivery System for International Sports Complex Facility (국제종합경기 시설공사 발주방법의 개선 방안)

  • Choi Yong-Ho;Lee Soo-Yong
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2005.05a
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    • pp.107-112
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    • 2005
  • Renovation of existing sports facilities or construction of temporary ones for international complex games requires a wide variety of hundreds of sub construction projects to be awarded at the same time but there are few precedents required regarding the study of tendering process required in such cases. As award of construction contracts to build sports facilities for various international complex games is a critical determinant of fate of international complex games in the initial phase, it is very critical that adequate construction tendering process bedetermined. This research is aimed to study tendering cases for renovation or construction of critical international sports facilities to enhance efficiency of facility construction and define most reasonable tendering approach to satisfy schedule constraints often associated with international complex games and contribute to improvement of international competitiveness of their host cities and propose a direction for further development. This study also provides inputs to subsequent sports events of comparable scale to minimize trial and error.

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Parenteral Docetaxel Emulsion System and Its Stability

  • Kim, Hyun-Jo
    • Journal of Pharmaceutical Investigation
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    • v.39 no.1
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    • pp.13-18
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    • 2009
  • Docetaxel is an anticancer agent with low aqueous solubility. More extensive clinical use of this drug is somewhat delayed due to lack of appropriate delivery vehicles. An attempt was made to adopt an o/w emulsion as the drug carrier which incorporated docetaxel in the propyleneglycerol stabilized by a mixed-emulsifier system. A suitable formulation was found in this study: 10 mg/mL docetaxel, 10% (w/v) oil blend, 4% (w/v) PG, 3% (w/v) Solutol HS 15 in 2.25% (w/v) glycerol solution. The formulated emulsion has very good stability when stored at $40^{\cird}C$, and the docetaxel containment efficiency can be maintained above 95% and the mean emulsion diameter around $10{\mu}m$ for at least 3 months. The formulated emulsion is a promising carrier for docetaxel and other lipophilic drugs.

Encapsulation of Plasmid DNA in Erythrocyte Ghosts (플라스미드 유전자 함유 혈구 세포 입자의 제조)

  • Byun, Hyang-Min;Park, Sang-Eun;Kim, Jung-Mogg;Ko, Jung-Jae;Oh, Yu-Kyoung
    • Journal of Pharmaceutical Investigation
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    • v.32 no.3
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    • pp.181-184
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    • 2002
  • This study reports the encapsulation of plasmid DNA in erythrocyte ghosts. The plasmid DNA was encapsulated into erythrocyte ghosts using three methods; osmotic shock, electroporation in isotonic medium, and e1ectroporation in hypotonic medium. Of three methods, electroporation in hypotonic medium resulted in the highest encapsulation efficiency of plasmid DNA. The morphology of erythrocyte ghosts prepared by electroporation in hypotonic medium was similar to that by osmotic shock alone. The circulation time of plasmid DNA in mice was prolonged by administration in erythrocyte ghost-encapsulated forms. These results indicated the potential of erythrocyte ghosts for biocompative nonviral delivery system of therapeutic genes for hematological diseases.

Transdermal Delivery of Diclofenac Using Microemulsions

  • Kweon, Jang-Hoon;Chi, Sang-Cheol;Park, Eun-Seok
    • Archives of Pharmacal Research
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    • v.27 no.3
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    • pp.351-356
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    • 2004
  • A transdermal preparation containing diclofenac diethylammonium (DDA) was developed using an O/W microemulsion system. Of the oils tested, lauryl alcohol was chosen as the oil phase of the microemulsion, as it showed a good solubilizing capacity and excellent skin permeation rate of the drug. Pseudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant and cosurfactant for microemulsion formation, and the effect of these additives on skin permeation of DDA was evaluated with excised rat skins. The optimum formulation of the microemulsion consisted of 1.16% of DDA, 5% of lauryl alcohol, 60% of water in combination with the 34.54% of Labrasol (surfactant)/ethanol (cosurfactant) (1:2). The efficiency of formulation in the percutaneous absorption of DDA was dependent upon the contents of water and lauryl alcohol as well as Labrasol: ethanol mixing ratio. It was concluded that the percutaneous absorption of DDA from microemulsions was enhanced with increasing the lauryl alcohol and water contents, and with decreasing the Labrasol:ethanol mixing ratio in the formulation.

Controlled Release Behavior of Temperature Responsive Composite Hydrogel Containing Activated Carbon

  • Yun, Ju-Mi;Im, Ji-Sun;Jin, Dong-Hwee;Lee, Young-Seak;Kim, Hyung-Il
    • Carbon letters
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    • v.9 no.4
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    • pp.283-288
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    • 2008
  • The composites of temperature-sensitive hydrogel and activated carbons were prepared in order to improve both the mechanical strength of hydrogel matrix and the loading capacity of drug in a hydrogel drug delivery system. The swelling of composite hydrogel was varied depending on the temperature. Both the swelling and the release behavior of the composite hydrogel were varied depending on the kind of activated carbon. The release behavior showed the high efficiency which is important for practical applications.