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Transdermal Delivery of Diclofenac Using Microemulsions  

Kweon, Jang-Hoon (College of Pharmacy, Sungkyunkwan University)
Chi, Sang-Cheol (College of Pharmacy, Sungkyunkwan University)
Park, Eun-Seok (College of Pharmacy, Sungkyunkwan University)
Publication Information
Archives of Pharmacal Research / v.27, no.3, 2004 , pp. 351-356 More about this Journal
Abstract
A transdermal preparation containing diclofenac diethylammonium (DDA) was developed using an O/W microemulsion system. Of the oils tested, lauryl alcohol was chosen as the oil phase of the microemulsion, as it showed a good solubilizing capacity and excellent skin permeation rate of the drug. Pseudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant and cosurfactant for microemulsion formation, and the effect of these additives on skin permeation of DDA was evaluated with excised rat skins. The optimum formulation of the microemulsion consisted of 1.16% of DDA, 5% of lauryl alcohol, 60% of water in combination with the 34.54% of Labrasol (surfactant)/ethanol (cosurfactant) (1:2). The efficiency of formulation in the percutaneous absorption of DDA was dependent upon the contents of water and lauryl alcohol as well as Labrasol: ethanol mixing ratio. It was concluded that the percutaneous absorption of DDA from microemulsions was enhanced with increasing the lauryl alcohol and water contents, and with decreasing the Labrasol:ethanol mixing ratio in the formulation.
Keywords
Microemulsion; Diclofenac; Transdermal delivery; Topical application;
Citations & Related Records

Times Cited By Web Of Science : 28  (Related Records In Web of Science)
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