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http://dx.doi.org/10.4333/KPS.2009.39.1.013

Parenteral Docetaxel Emulsion System and Its Stability  

Kim, Hyun-Jo (R&D Center, Jeil Pharmaceutical Co. Ltd.)
Publication Information
Journal of Pharmaceutical Investigation / v.39, no.1, 2009 , pp. 13-18 More about this Journal
Abstract
Docetaxel is an anticancer agent with low aqueous solubility. More extensive clinical use of this drug is somewhat delayed due to lack of appropriate delivery vehicles. An attempt was made to adopt an o/w emulsion as the drug carrier which incorporated docetaxel in the propyleneglycerol stabilized by a mixed-emulsifier system. A suitable formulation was found in this study: 10 mg/mL docetaxel, 10% (w/v) oil blend, 4% (w/v) PG, 3% (w/v) Solutol HS 15 in 2.25% (w/v) glycerol solution. The formulated emulsion has very good stability when stored at $40^{\cird}C$, and the docetaxel containment efficiency can be maintained above 95% and the mean emulsion diameter around $10{\mu}m$ for at least 3 months. The formulated emulsion is a promising carrier for docetaxel and other lipophilic drugs.
Keywords
Emulsion; Docetaxel; Anticancer therapy; Drug delivery system; Stability;
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1 G.H. Yoo, G. Subramanian, M.P. Piechocki, J.F. Ensley, O. Kucuk, O.E. Tulunay, F. Lonardo, H. Kim, J. Won, T. Stevens and H.S. Lin, Effect of docetaxel on the surgical tumor microenvironment of head and neck cancer in murine models. Arch Otolaryngol Head Neck Surg., 134(7), 735-42 (2008)   DOI   ScienceOn
2 J. Baker, J. Ajani, F. Scotte, D. Winther, M. Martin, M.S. Aapro and G. von Minckwitz, Docetaxel-related side effects and their management.Eur J Oncol Nurs., 12(3), 253-68 (2008)   DOI   ScienceOn
3 L. Chew and V.S. Lee Chuen, Cutaneous reaction associated with weekly docetaxel administration. J Oncol Pharm Pract. 2008 Aug 27. [Epub ahead of print]
4 F. Esmaeili, M.H. Ghahremani, S.N. Ostad, F. Atyabi, M. Seyedabadi, M.R. Malekshahi, M. Amini and R. Dinarvand, Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate. J Drug Target., 16(5), 415-23 (2008)   DOI   ScienceOn
5 R.M. Strother and C. Sweeney, Lessons learned from development of docetaxel. Expert Opin Drug Metab Toxicol. 4(7), 1007-19 (2008 Jul)   DOI   ScienceOn
6 V. Gebbia, C. Gridelli, C. Verusio, L. Frontini, E. Aitini, B. Daniele, T. Gamucci, G. Mancuso, M. Di Maio, C. Gallo, F. Perrone and A. Morabito, Weekly docetaxel vs. docetaxelbased combination chemotherapy as second-line treatment of advanced non-small-cell lung cancer patients The DISTAL-2 randomized trial. Lung Cancer. 2008 Jul 14. [Epub ahead of print]
7 Y. Qiu, Y. Gao, K. Hu and F. Li, Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes. J Control Release., 129(2), 144-50 (2008)   DOI   ScienceOn
8 M.V. Lozano, D. Torrecilla, D. Torres, A. Vidal, F. Dominguez, and M.J. Alonso, Highly efficient system to deliver taxanes into tumor cells: docetaxel-loaded chitosan oligomer colloidal carriers. Biomacromolecules., 9(8), 2186-93 (2008)   DOI   ScienceOn
9 J. Vial, M. Cohen, P. Sassiat and D. Thiebaut, Pharmaceutical quality of docetaxel generics versus originator drug product: a comparative analysis. Curr Med Res Opin., 24(7), 2019-33 (2008). PMID: 18544188 [PubMed - indexed for MEDLINE]   DOI   ScienceOn
10 H.Y. Hwang, I.S. Kim, I.C. Kwon and Y.H. Kim, Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles.J Control Release., 128(1), 23-31 (2008)   DOI   ScienceOn
11 F. Esmaeili, R. Dinarvand, M.H. Ghahremani, M. Amini, H. Rouhani, N. Sepehri, S.N. Ostad and F. Atyabi, Docetaxel-albumin conjugates: Preparation, in vitro evaluation and biodistribution studies. J Pharm Sci. 2008 Oct 28. [Epub ahead of print]
12 K. Gao, J. Sun, K. Liu, X. Liu and Z. He, Preparation and characterization of a submicron lipid emulsion of docetaxel: submicron lipid emulsion of docetaxel. Drug Dev Ind Pharm., 34(11), 1227-37 (2008).   DOI   ScienceOn
13 M. Senthilkumar, P. Mishra and N.K. Jain, Long circulating PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate delivery of Docetaxel to solid tumors. J Drug Target. Jun; 16(5), 424-35 (2008)   DOI   ScienceOn
14 S.S. Chandran, S.R. Banerjee, R.C. Mease, M.G. Pomper and S.R. Denmeade, Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA). Cancer Biol Ther. Jun; 7(6), 974-82 (2008)   DOI   ScienceOn
15 A. Fernaìndez-Botello, F. Comelles, M.A. Alsina, P. Cea and F. Reig, A Monolayer Study on Interactions of Docetaxel with Model Lipid Membranes. J. Phys Chem B., 112(44), 13834-13841 (2008)   DOI   ScienceOn
16 Y. Gao, L. Chen, W. Gu, Y. Xi, L. Lin and Y. Li, Targeted Nanoassembly Loaded with Docetaxel Improves Intracellular Drug Delivery and Efficacy in Murine Breast Cancer Model. Mol Pharm. 2008 Oct 9. [Epub ahead of print]
17 J.Y. Joung, I.G. Jeong, K.S. Han, T.S. Kim, S.O. Yang, H.K. Seo, J. Chung, K.S. Cho and K.H. Lee, Docetaxel Chemotherapy of Korean Patients with Hormone- refractory Prostate Cancer:Comparative Analysis between 1st-line and 2nd-line Docetaxel.Yonsei Med J., 49(5), 775-82 (2008)   DOI
18 E. Saloustros and V. Georgoulias, Docetaxel in the treatment of advanced non-small-cell lung cancer. Expert Rev Anticancer Ther. 8(8), 1207-22 (2008).   DOI   ScienceOn
19 B. Liu, M. Yang, R. Li, Y. Ding, X. Qian, L. Yu and X. Jiang, The antitumor effect of novel docetaxel-loaded thermosensitive micelles. Eur J Pharm Biopharm., 69(2), 527-34 (2008)   DOI   ScienceOn
20 J. Chen, L. Qiu, M. Hu, Y. Jin and J. Han, Preparation, characterization and in vitro evaluation of solid dispersions containing docetaxel. Drug Dev Ind Pharm., 34(6), 588-94 (2008)   DOI   ScienceOn
21 Z. Xu, L. Chen, W. Gu, Y. Gao, L. Lin, Z. Zhang, Y. Xi and Y. Li, The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma. Biomaterials., 30(2), 226-32 (2009)   DOI   ScienceOn