• 환경영향평가
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• 제23권3호
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• pp.187-196
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• 2014

The objective of this study is to evaluate and analyze Osu stream watershed water environment system. The data were collected from January 2009 to December 2011 including water temperature, pH, DO, EC, BOD, COD, TOC, SS, T-N, T-P and discharge. The data were used for principle component analysis and factor analysis. The results are as followes. The primary factors obtained from both the principal component analysis and the factor analysis were BOD, COD, TOC, SS and T-P. Once principal component analysis and factor analysis have been performed with the collected data and then the results will be applied to both simple regression model and multiple regression model. The regression model was developed into case 1 using concentrations of water quality parameters and case 2 using delivery loads. The value of the coefficient of determination on case 1 fell between 0.629 and 0.866; this was lower than case 2 value which fell between 0.946 and 0.998. Therefore, case 2 model would be a reliable choice.The coefficient of determination between the estimated figure using data which was developed to the regression model in 2012 and the actual measurement value was over 0.6, overall. It can be safely deduced that the correlation value between the two findings was high. The same model can be applied to get TOC concentrations in future.

• 한국가스학회지
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• 제17권2호
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• pp.28-35
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• 2013

대도시 내에 밀집하여 증가하고 있는 대형 복합 건축물은 그 규모와 복잡성으로 인해 유해가스 관련 사고발생시 대형 재난으로의 확대 가능성이 상존한다. 이에 대한 대응책으로, 다종의 유해가스를 감지하는 복합 가스 센서와 이로부터 수집한 정보를 활용한 조기 경보 시스템이 연구되고 있다. 이와 같은 센서 기반 재난 전조 감시 시스템의 효과적인 적용과 운영을 위해서는 적합한 기준이 먼저 마련되어야 한다. 본 연구에서는 유해가스의 감지와 조기 경보 발령을 위한 경보 기준 농도를 제시하고, 각 경보 단계별로 대응 활동과 정보 전파 등 재난 대응 체계를 제안하였다. 재난 감시 기준을 통해 유해가스 관련사고 발생 시 조기에 위험을 감지하여 사고의 경과에 따라 효과적인 대응을 이끌어 낼 수 있다.

• 한국응용과학기술학회지
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• 제32권4호
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• pp.694-701
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• 2015

In order to get stabilized pure retinol in skin care cosmetics, developing the three layered matrix bead capsules were studied. This study relates to make a cosmetic composition using the three layered matrix capsule that could increase the stability of the active ingredient. A primary encapsulation, vitamin A (pure retinol) of active ingredient was perfectly capsulated into water-in-oil (Water-in-Oil: W/O) emulsion vesicle using PEG-10 dimethicone copolyol emulsifier. A secondary encapsulation of multiple emulsion of the water-in-oil-in-water (W/O/W) emulsion blending W/O emulsion using sucrose distearate of surfactant was developed using homogenizing emulsifying system. Pure retinol of active ingredient was stably capsulized to inside the W/O/W-multiple emulsion in order to load the triple matrix capsulation. By coating it with a polymer matrix base, encapsulated in the triple layered type, which were developed bead encapsulation of 2~10mm uniformly size. To show beautifully appearance capsulated bead type, these finish particles in this triple matrix layer were developed as a gold, green, dark brown, silver and blue color were encapsulated in the bead types. Structural particle certification of triple matrix layer was observed through SEM analysis. Stability of pure retinol was remained stable more than 99.7% for 30 days at $42^{\circ}C$ incubating conditions compared with non-capsule. This technology was applied in different formulations such as various sizes and colors that by applying the skin care cosmetics. In the future, this technology to encapsulate an unstable active ingredient, we expect to be expanded this application in the food and drug as a time delivery system.

• Macromolecular Research
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• 제11권3호
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• pp.183-188
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• 2003

The controlled delivery of anticancer agents using biodegradable polymeric implant has been developed to solve the problem of penetration of blood brain barrier and severe systemic toxicity. This study was performed to prepare 5-FU-loaded poly (L-lactide-co-glycolide) (PLGA) wafer fabricated microparticles prepared by two different method and to evaluate their release profile for the application of the treatment of brain tumor. 5-FU-loaded PLGA microparticles were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). SEM observation of the 5-FU-loaded PLGA microparticles prepared by rotary solvent evaporation method showed that 5-FU was almost surrounded by PLGA and significant reduction of crystallinity of 5-FU was confirmed by XRD. In case of release profile of 5-FU from 5-FU-loaded PLGA wafer fabricated microparticles prepared by mechanical mixing, the release profile of 5-FU followed near first order release kinetics. In contrast to the above result, release profile of 5-FU from 5-FU-loaded PLGA wafer fabricated microparticles prepared by rotary solvent evaporation method followed near zero order release kinetics. These results indicate that preparation method of the 5-FU-loaded PLGA microparticles to fabricate into wafers was contributed to drug release profile.

• 정보처리학회논문지C
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• 제11C권7호
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• pp.937-950
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• 2004

본 논문에서는 프로토콜 조합 및 서비스 참조 기법을 지원하는 Customizable Architecture for Flexible Execution Environment(CAFEs) 실행환경을 실제 및 구현한다. CAFEs 실행환경은 프로토콜 및 서비스 소프트웨어의 재사용성을 높이기 위하여 기존 프로토콜의 기능 또는 알고리즘을 구현한 마이크로 프로토콜과 기존 응용과 호환하고 액티브 네트워크 서비스를 배포하기 위한 수단으로 동작하는 액티브 서비스라는 새로운 개념을 제시한다. 제안된 액티브 네트워크 실행환경은 기능에 따라 세 부분으로 설계되어 있다. 첫째, 가상 네트워크 시스템은 기존의 다양한 프로토콜 계층을 기반으로 가상 네트워크 채널을 형성하고 이를 바탕으로 액티브 노드를 연결한다. 둘째, 프로토콜 및 서비스 관리자는 마이크로 프로토콜 및 액티브 서비스를 합성함으로써 새로운 프로토콜과 서비스를 제공하는 역할을 담당한다. 마지막으로 이벤트 엔진은 이벤트 위임 모델을 사용하여 서비스에 존재하는 컴보넌트의 상태전이를 자동으로 감지한다. 그리고 개발된 CAFEs 실행환경을 검증하기 위하여 무선 인터넷 환경에서 사용자 단말에 적합한 웹 컨텐츠를 전달하기 위한 실험을 수행하여 가용성을 확보하였다.

• KSBB Journal
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• 제19권3호
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• pp.178-186
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• 2004

복합한방 재료인 옥용산에 대해 UV 흡수능, tyrosinase 저해활성 그리고 free radical 소거활성을 측정함으로서 미백활성을 검정하고 비교 시험군으로서 비타민C와 함께 Eudragit 이 코팅된 coconut oil을 이용한 SLN을 제조할 수 있었다. 실험 결과, 옥용산은 UV 영역에서 흡수능을 가지며 tyrosinase 저해 활성과 free radical 소거활성을 가진 것으로 확인되었다. 제조된 E-SLN을 TEM을 이용하여 관찰한 결과 크기 50∼300 nm인 구형의 양호한 입자를 형성하고 있음을 확인하였다. 또한 그 크기분포와 캡슐화 효율 분석을 통해 EUD의 농도가 2.0% (w/v), w/o 비율은 1 ： 9, emulsion과 pour solution의 비율은 1 : 10, 그리고 실온에서 제조한 E-SLN의 캡슐화 효율이 가장 높고 크기의 분포가 가장 양호한 것을 알 수 있었다. E-SLN을 이용하여 in vitro 방출시험을 실시한 결과 E-SLN은 pH와 온도 의존적으로 약물을 방출하는 경향을 나타냈다. 결과적으로 제조된 E-SLN은 pH와 온도 의존적으로 약물을 전달할 필요가 있는 계에 대한 약물전달 시스템으로 적합할 것으로 보인다. 폐쇄 첩포시험과 자외선 조사에 의한 인공색소침착과 시료도포에 의한 미백효능 판정에 의한 임상시험 결과 옥용산과 비타민C, 그리고 이를 포함하는 E-SLN은 대조군의 경우와 비교하여 미백효과를 가지는 것으로 확인되었으며 이는 기능성화장품에의 응용 가능성을 높여주었다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.317-318
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• 1998

The purpose of this study is to design and develop the circuit of the dual mode syringe pump. Syringe pump is used in intensive care unit, delivery room, pediatric room, operating theater and other fields of hospital at present. Normally the syringe pump delivers one medicine in one case, but in case of intensive care unit, it is necessary to deliver more than two kinds of medicines at a time. Therefore we have designed dual mode syringe pump. We used RISC type microcontroller, PIC17C44 as master controller, and PIC16C73 as slave cpu using for the low power consumption. The performance of system is evaluated by analysis of the linearity and accuracy which is the most important factors in application. While the proposed system shows a acceptable linearity and accuracy, a further research about reducing the errorr should be done.

• 한국연초학회지
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• 제31권1호
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• pp.18-28
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• 2009

This study describes the manufacturing method of antioxidant filter and evaluate the reduction of free radical and biological activity from mainstream smoke. When we used spray-brush for the application of antioxidant solution to the filter, cv(coefficient of variation) levels of antioxidant added to filter ranged within 3 %, which means stable and constant feeding process. 0.3~0.5mg per cigarette of antioxidant were sprayed to acetate and active carbon part in the filter plug, respectively. It was considered that the use of antioxidant added filter resulted in the reduction of the gaseous compounds of free radicals from 17 % to 19 % in the mainstream smoke. Variation for removal efficiency of free radical in antioxidant filter added to acetate part was more pronounced than that of filter added to active carbon part. Smoking deliveries of tar, nicotine for the antioxidant added filters were similar when comparing to the non-antioxidant added filter, but the delivering amounts of isoprene were significantly reduced. The estimation of consumed GSH(glutathion) showed that the gaseous toxicity of the antioxidant added filter was 14 % ~ 23 % lower than that of non-antioxidant added filter. No significant differences were observed for the total taste quality in sensory evaluation.

• 품질경영학회지
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• 제43권4호
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• pp.589-606
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• 2015

Purpose: In developing new products, reducing performance variation is important for competitiveness factors such as quality, cost, and delivery. This paper aims at evaluating three performance variations; measurement, performance evaluation, and manufacturing variations, and then improving product and process design, focused on paper helicopter making case study. Methods: For measurement system analysis, gage R&R (repeatability and reproducibility), linearity, stability are evaluated. Since gage R&R are not satisfactory, the measurement system is improved by adopting voice memos application of iPhone and providing standard measurement procedure. To evaluate performance variation, product deterioration and environment factor (wind speed) is considered. Since the existing design is sensitive to these noise factors, a new product design is developed, which is proven to be robust to the noise factors. Finally, manufacturing variations are evaluated with five factors which can cause variation in flight time. To reduce the impact of three significant factors, three improvement methods are applied. Results: Three performance variations are evaluated and robust paper helicopter design is presented. Conclusion: To reduce measurement and process variations, improved measurement method and paper helicopter making procedure are proposed. A new product design is also presented which is robust to deterioration and environmental variation. This paper is expected to benefit students and practitioners who want to have hands-on knowledge on new product quality improvement.

• 융합보안논문지
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• 제10권4호
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• pp.31-37
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• 2010

IT에서 보안은 위험 및 위협으로부터 시스템을 보호하고, 피해를 방지하며 Risk를 최소화해야한다. 이와 같은 맥락으로 정보보안 제품의 정보가 처리, 저장, 전달되는 과정에서 정보와 시스템의 보안기준, 즉 기본적인 기밀성, 가용성, 무결성과 부차적인 명확성, 증명가능성, 감지, 경보 및 방어능력 등이 충분히 보장될 수 있도록 하여야 한다. 웹 서비스에서 보안은 가장 중요한 요소이며, 웹 특성상 서비스를 위해 80번 포트 같은 통로를 열어놔야 하는 구조로서, 웹 어플리케이션, 웹 소스 및 서버, 네트워크 모든 요소가 근본적인 취약점을 안고 있다. 이에 따라 이런 요소를 통해 웹 프로그램의 설정오류나 개발 오류 및 웹 애플리케이션 자체의 취약점을 이용한 홈페이지 와 웹 서버 해킹을 방지하며, 효율성을 높이는 웹서비스 보안 BMT 수행 방법론을 제시하고자 한다.