[KSCI] Korea Science Citation Index Service

Preparation and Application of Wnitening Ingredient Entrapped in Solid Lipid Nanoparticle ［SLN］

한성철 (전남대학교 물질 생물화학공학과)
김연주 (광주보건대학 피부미용과 & 전남대학교 고분자공학)
이기영 (전남대학교 응용화학공학부 & 전남대학교 촉매연구)
김동운 (광양보건대학 보건위생과, (주) 나노바이오메드)

Publication Information

KSBB Journal / v.19, no.3, 2004 , pp. 178-186 More about this Journal

Abstract

The aim of this study was to investigate the skin-whitening effect of okyong-san and to develop new drug delivery carrier The extracts of okyong-san were found to have the whitening effect and Eudragit $\^$ ⓡ/ L 100-55 (EUD) coated solid lipid nanoparticle (E-SLN) was prepared by solvent evaporation method and melt dispersion technique. As a result, E-SLN have a 144-170 nm of particle size, spherical shape, and 33-41% encapsulation efficiency, After release test in vitro, release profile of E-SLN depended on pH and temperature. Lastly, closed patch test and skin-whitening test was peformed clinically. In conclusion, test sample had non-stimulation and high % whiteness. The results suggest that okyong-san and E-SLN is useful as cosmeceuticals for whitening cosmetics.

Keywords

SLN; okyong-san; eudragit; encapsulation; cosmetics;

Citations & Related Records

Reference

1	Dipigmentation Acitivity of Kakamseosiokyong-san / [ Son, D. S. ] / M. S. Thesis, Dept. of Oriental Medicine, Kyung Hee University
2	Effect of formulation and processing varibles on the characteristics of microspheres for water-soluble drugs prepared by w/o/o double emulsion solvent diffusion method / [ Lee, J. H.;T. G. Park;H. K. Choi ] / Intern. J. Pharm. DOI ScienceOn
3	Effective and controlled transdermal delivery of ephedrine / [ Sanjay, K. J.;P. V. Suresh;V. K. Dixit ] / J. Controlled Release DOI ScienceOn
4	Lyophilized aqueous based polymer matrices for transdermal delivery of captopril / [ Dubey, B. K.;O. P. Katare;S. Ranjit;K. J. Sanjay ] / J. Dermatol. Sci. DOI ScienceOn
5	Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations / [ Muller, R. H.;M. Radtke; S. S. Wissing ] / Adv Drug Delivery Rev. DOI
6	Trend and view of nano technology / [ Kim, B. G.;H. J. Park ] / Food Sci. Ind.
7	pH profiles in human skin : influence of two in vitro test systems for drug delivery testing / [ Heike W.;K. H. Kowtka;C. M. Lehr;U. F. Schaefer ] / Eur. J. Pharm. Biopharm.
8	Antioxidant activity of the ethanolic exract of Striga orobanchioides / [ Shrishailappa B.;K. G. Mahesh;B. Suresh ] / J. Ethnophamacol. DOI ScienceOn
9	Topical transfection using plasmid DNA in a water-in-oil nanoemulsion / [ Huailiang, W.;R. Chandrasekharan;U. B. Anna;K. Kristen;S. Rong; D. W. Norman;J. R. Blake ] / Int. J. Pharm. DOI
10	Microsphere design for the colonic delivery of 5-fluorocuracil / [ Alf, L.;Y. Hiromitsu;T. Hirofumi;K. Yoshiaki ] / J. Controlled Release
11	Analysis of ascorbate in plant tissues by high-performance capillary zone electrophoresis / [ Mark, W. G.;B. Davey;V. M.;Marc ] / Anal. Biochem. DOI ScienceOn
12	Studies on side effects of various soaps, cosmetics, and topical medicaments; I. Patch tests with some materials / [ Lee, Y. S. ] / Kor. J. Dermatol.
13	A study on analysis of patch test positive reactivity according to the reading time / [ Kim, J. A. ] / Kor. J. Dermatol.
14	In vitro study on the transfer of volatile oil components / [ Szentmihalyi, K. E.;Forgacs;M. Hajdu;M. Then ] / J. Pharm. Biomed. Anal. DOI ScienceOn
15	Production of lipospheres as carriers for bioactive compounds / [ Rita, C.;E. Elisabetta;L. Giovanni; N. Claudio ] / Biomaterials
16	Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations / [ Muller, R. H.; M. Radtke;S. A. Wissing ] / Adv. Drug Delivery Rev. DOI
17	Preparation and Charcterization of Solid Lipid Nanoparticle (SLN) made from Coconut Butter Stabilized Curdlan / [ Kim, B. D. ] / M. S. Thesis, Depat. of Pharmacy, Chosun University
18	The regulatory basis of melanogenic switching / [ Leiv, O.;P. Erik;I. V. Dag;W. O. Stig ] / J. Theor. Biol.
19	Application of Plant Extracts for Whitening Cosmetics (Cosmeceuticals) / [ Park, S. N.;J. A. Koh;Y. J. Park ] / M. S. Thesis, Seoul National University
20	Effect of Seosiokyongsan on the melanogenesis of B16 melanoma cell line / [ Park, J. S.;W. Y. Nam;Y. J. Moon;K. H. Kim;B. H. Jeon;W. H. Woo ] / Kor. J. Orient. Med. Pathol.
21	/ [ Heo, J. ] / Dongeuibogam
22	/ [ Moon, S. M. ] / Chemical product dictionary
23	Formulation study of a transdermal delivery system of primaquine / [ Mayorga, F. P.;G. Couarraze ] / Inter. J. Pharm. DOI

KSCI

Preparation and Application of Wnitening Ingredient Entrapped in Solid Lipid Nanoparticle ［SLN］ 미백성분이 포함된 나노입자의 제조와 응용

Preparation and Application of Wnitening Ingredient Entrapped in Solid Lipid Nanoparticle ［SLN］