• Journal of Intelligence and Information Systems
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• v.13 no.1
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• pp.49-58
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• 2007

MDPDPTW (Multi-Depot Pickup and Delivery Problem with Time Windows) is a typical model among the optimization models based on the pickup and delivery flow in supply chains. It is based on multi-vehicles in multi-depots and does not consider moving vehicles near pickup and delivery locations. In ubiquitous environments, it is possible to obtain information on moving vehicles and their baggage. Providing the proper context from the perspective of moving vehicles and their baggage allows for more effective vehicle routings. This study proposes Integer Programming-based MDPDPTW including the information on moving vehicles and their baggage in a ubiquitous environment: u-MDPDPTW, and shows the viability and effectiveness of u-MDPDPTW through comparative experiments of MDPDPTW and u-MDPDPTW.

• Journal of Microbiology and Biotechnology
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• v.29 no.3
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• pp.489-499
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• 2019

Subunit vaccines are safer and more stable than live vaccines although they have the disadvantage of eliciting poor immune response. To develop a subunit vaccine, an effective delivery system targeting the key elements of the protective immune response is a prerequisite. In this study, oxidized carbon nanospheres (OCNs) were used as a subunit vaccine delivery system and tuberculosis (TB) was chosen as a model disease. TB is among the deadliest infectious diseases worldwide and an effective vaccine is urgently needed. The ability of OCNs to deliver recombinant Mycobacterium tuberculosis (Mtb) proteins, Ag85B and HspX, into bone marrow derived macrophages (BMDMs) and dendritic cells (BMDCs) was investigated. For immunization, OCNs were mixed with the two TB antigens as well as the adjuvant monophosphoryl lipid A (MPL). The protective efficacy was analyzed in vaccinated mice by aerosol Mtb challenge with a virulent strain of Mtb and the bacterial burdens were measured. The results showed that OCNs are highly effective in delivering Mtb proteins into the cytosol of BMDMs and BMDCs. Upon immunization, this vaccine formula induced robust Th1 immune response characterized by cytokine profiles from restimulated splenocytes and specific antibody titer. More importantly, enhanced cytotoxic $CD8^+$ T cell activation was observed. However, it did not reduce the bacteria burden in the lung and spleen from the aerosol Mtb challenge. Taken together, OCNs are highly effective in delivering subunit protein vaccine and induce robust Th1 and $CD8^+$ T cell response. This vaccine delivery system is suitable for application in settings where cell-mediated immune response is needed.

• Medical Lasers
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• v.10 no.3
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• pp.161-169
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• 2021

Background and Objectives Fractional microneedle radiofrequency systems are popular options to increase elasticity in aging skin. Laser-assisted drug delivery is a promising method for the epidermal injection of topically applied drugs and cosmetic ingredients. This study assesses the safety and efficacy of topical delivery of L-ascorbic acid, vitamin E, and ferulic acid after fractional microneedle radiofrequency treatment for reducing photodamage. Materials and Methods In this prospective, single-center, split-face, controlled pilot study, six women (mean age, 48.0 years; range, 35-57 years; Fitzpatrick skin types III and IV) exhibiting mild to moderate photodamage, underwent a single session of fractional microneedle radiofrequency treatment. The patients were instructed to apply the antioxidant formulation to only one side of the face. Patients were evaluated 3 days, 7 days, and 4 weeks thereafter, using three-dimensional imaging and ultrasound. Ex vivo, the full-thickness human skin was used for molecular and histological evaluation. Statistical analysis was achieved by applying t-tests, Mann-Whitney U tests, and one-way analyses of variance. Results Compared to the untreated side, the antioxidant-treated side exhibited a significant increase in dermal thickness (10.32% vs. 17.54%, p < 0.05), but not in skin elasticity (4.76% vs. 4.69%, p > 0.05). The difference in erythema between the sides was statistically not significant (p > 0.05). In the ex vivo model, expression of FGF2 in the skin was significantly increased after application of the antioxidant formulation, as compared to results obtained subsequent to fractional microneedle radiofrequency treatment only (p < 0.01). Conclusion This study demonstrates that for the treatment of photodamaged skin, laser-assisted delivery of the antioxidant formulation is a safe and effective adjuvant modality following fractional microneedle radiofrequency.

• Korean Management Science Review
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• v.21 no.3
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• pp.101-113
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• 2004

In the rapidly propagating Internet based electronic transaction environment. the importance of real time order confirmation has been more emphasized, In this paper, using data mining techniques, we develop intelligent operations decision model to allow real time order confirmation at the time the customer places an order with required delivery terms. Among various operation plannings used for order fulfillment. mill routing is the first interface decision point to link the order receiving at the marketing with the production planning for order fulfillment. Though linear programming based mathematical optimization techniques are mostly used for mill routing problems, some early orders should wait until sufficient orders are gathered for optimization. And that could effect longer order fulfillment lead-time, and prevent instant order confirmation of delivery terms. To cope with this problem, we provide the intelligent decision model to allow instant order based mill routing decisions. Data mining techniques of decision trees and neural networks. which are more popular in marketing and financial applications, are used to develop the model. Through diverse computational trials with the industrial data from the steel company. we have reported that the performance of the proposed approach is effective compared to the present heuristic only mill routing results. Various issues of data mining techniques application to the mill routing problems having linear programming characteristics are also discussed.

• Korean Journal of Construction Engineering and Management
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• v.6 no.4 s.26
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• pp.91-100
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• 2005

Design-build that a single entity performs whole construction process under singular responsibility is one of the project delivery system comes to take expectation effects of time savings, cost saving, and quality assurance. On the other hand, a current domestic method for selecting a design-build contractor is difficult to reflect the purpose of owner and the project characteristics when owner selects the design-build contractor. The purpose of this research is to suggest a model for deciding evaluation weights in design-build which can reflect the purpose of owner and the project characteristics. This research can help owner to select the best suitable design-build contractor for the project.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.5
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• pp.1790-1806
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• 2015

Utility-based routing is a special type of routing approach using a composite utility metric when making routing decisions in ad hoc and sensor networks. Previous studies on the utility-based routing all use fixed retry limit and a very simple distance related energy model, which makes the utility maximization less efficient and the implementation separated from practice. In this paper, we refine the basic utility model by capturing the correlation of the transmit power, the retry limit, the link reliability and the energy cost. A routing algorithm based on the refined utility model with adaptive transmit power and retry limit allocation is proposed. With this algorithm, packets with different priorities will automatically receive utility-optimal delivery. The design of this algorithm is based on the observation that for a given benefit, there exists a utility-maximum route with optimal transmit power and retry limit allocated to intermediate forwarding nodes. Delivery along the utility-optimal route makes a good balance between the energy cost and the reliability according to the value of the packets. Both centralized algorithm and distributed implementations are discussed. Simulations prove the satisfying performance of the proposed algorithm.

• Journal of Environmental Science International
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• v.25 no.10
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• pp.1433-1444
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• 2016

South Korea is a maritime nation, surrounded by water on three sides; hence, it is important to preserve in a sustainable manner. Most areas, especially those bordering the East Sea, have been suffering from severe coastal erosion. Information on the sediment yield of a river basin is an important requirement for water resources development and management. In Korea, data on suspended sediment yield are limited owing to a lack of logistic support for systematic sediment sampling activities. This paper presents an integrated approach to estimate the sediment yield for ungauged coastal basins by using a soil erosion model and a sediment delivery rate model in a geographic information system (GIS)-based platform. For applying the sediment yield model, a basin specific parameter was validated on the basis of field data, that, ranging from 0.6 to 1.2 for the 19 gauging stations. The calculated specific sediment yield ranged from 17 to $181t/km^2.yr$ in the various basin sizes of Korea. We obtained reasonable sediment yield values when comparing the measured data trends around the world with those in Korean basins.

• Journal of Korea Multimedia Society
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• v.24 no.8
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• pp.1101-1113
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• 2021

The rapid growth of sense-and-respond applications and the emerging cloud computing model present a new challenge: providing publish/subscribe middleware as a scalable and elastic cloud service. The publish/subscribe interaction model is a promising solution for scalable data dissemination over wide-area networks. In addition, there have been some work on the publish/subscribe messaging paradigm that guarantees reliability and availability in the face of node and link failures. These publish/subscribe systems are commonly used in information-centric networks and edge-fog-cloud infrastructures for IoT. The IoT has an edge-fog cloud infrastructure to efficiently process massive amounts of sensing data collected from the surrounding environment. In this paper. we propose a quorum-based hierarchical fault-tolerant publish/subscribe systems (QHFPS) to enable reliable delivery of messages in the presence of link and node failures. The QHFPS efficiently distributes IoT messages to the publish/subscribe brokers in fog overlay layers on the basis of proposing extended stepped grid (xS-grid) quorum for providing tolerance when faced with node failures and network partitions. We evaluate the performance of QHFPS in three aspects: number of transmitted Pub/Sub messages, average subscription delay, and subscritpion delivery rate with an analytical model.

• Quality Improvement in Health Care
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• v.3 no.2
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• pp.52-59
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• 1997

Background : In many Nursing Delivery System, Nursing Department at D Hospital had used to traditional nursing practice model what is called functional activities based system. It has a lot of merit that carried out specialized and rapid works but tend to ignore indivisual professional responsibility and task-based work assignments. In addition this system showed high turnover rates due to heavy workload, timesum of handing over duties, lack of support from peers and interstaff communication. So we performed conversion of Nursing Delivery System to My Patients Nursing Care System for providing comprehensive nursing to patient and reducing turnover rates and increasing job satisfaction to nurse. Method : 1. 1st step(96.4.9): Detected the problem of Nursing delivery System and estabilished improving planning 2. 2nd step(96.4.26): Visited other hospital on job training 3. 3th step(96.4.29): Discussed to premonitoring problem after conversion Nursing Delivery System and prepared structure 4. 4th step(96.5.6): My Patients Nursing Care System practical application 5. 5th step(96.7.20): Held complementary meeting 6. 6th step(96. 7): The other ward application 7. 7th step(96. 10): Extended application to whole wards Results: 1. Workload: (1) reduction(55.6%) (2) addition(44.4%) 2. Strong points after conversion: (1) decreased timesum of handing overduties (35.2%) (2) increased responsibility(33%) (3) broaden nurse's outlook to duties(14.8%) 3. Shortcoming after conversion: (1) understanding difficulties except my patient(57.8%) (2) weak teamwork(23.3%) (3) intensive stress to low grade nurse(12.2%) 4. Effective complemental way: (1) manpower(76.7%) (2) conversion of though (8.9%) (3) education(14.4%) 5. Patient's satisfaction: (1) satisfaction(64%) (2) no effect(36%) 6. Physician and peer's satisfaction: (1) satisfaction(12.5%) (2) dissatisfaction(21.6%) (3) no interest(44.3%) 7. Nurse's satisfaction: (1) satisfaction(74.7%) (2) dissatisfaction(5.5%) (3) unknown(20.5%) 8. Want to continued: (1) want(76.4%) (2) try to any other system(18%) Conclusion : Even though Nursing Delivery System conversion still has many problem, we gained more merits than traditional nursing delivery system. So we suggest that My Patients Nursing Care System should be encouraged for comprehensive nursing care and satisfaction to nurses.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.14 no.24
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• pp.141-147
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• 1991

This paper presents extended model for the vehicle routing problem, which allows multiple visits to a node by multiple vehicles. Multiple visits enables us split delivery. After formulating this multiple visits model mathematically, a two stage heuristic algorithm is developed by decomposition approach. This model consists of two sub-problem. The one is fixed cost transportation problem and the other is transportation problem.