Medical Lasers

  • 제10권3호
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  • Pages.161-169
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  • 2021
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  • 2287-8300(pISSN)
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  • 2288-0224(eISSN)
대한의학레이저학회 (Korean Society for Laser Medicine and Surgery)
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Laser-assisted Delivery of a Combined Antioxidant Formulation Enhances the Clinical Efficacy of Fractional Microneedle Radiofrequency Treatment: A Pilot Study

  • Kim, Jihee (Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Soo Min (Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine) ;
  • Jung, Bok Ki (Department of Plastic and Reconstructive Surgery, Yongin Severance Hospital) ;
  • Oh, Sang Ho (Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Young-Koo (Yonsei Star Skin and Laser Clinic) ;
  • Lee, Ju Hee (Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine)
  • 투고 : 2021.05.25
  • 심사 : 2021.06.07
  • 발행 : 2021.09.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives Fractional microneedle radiofrequency systems are popular options to increase elasticity in aging skin. Laser-assisted drug delivery is a promising method for the epidermal injection of topically applied drugs and cosmetic ingredients. This study assesses the safety and efficacy of topical delivery of L-ascorbic acid, vitamin E, and ferulic acid after fractional microneedle radiofrequency treatment for reducing photodamage. Materials and Methods In this prospective, single-center, split-face, controlled pilot study, six women (mean age, 48.0 years; range, 35-57 years; Fitzpatrick skin types III and IV) exhibiting mild to moderate photodamage, underwent a single session of fractional microneedle radiofrequency treatment. The patients were instructed to apply the antioxidant formulation to only one side of the face. Patients were evaluated 3 days, 7 days, and 4 weeks thereafter, using three-dimensional imaging and ultrasound. Ex vivo, the full-thickness human skin was used for molecular and histological evaluation. Statistical analysis was achieved by applying t-tests, Mann-Whitney U tests, and one-way analyses of variance. Results Compared to the untreated side, the antioxidant-treated side exhibited a significant increase in dermal thickness (10.32% vs. 17.54%, p < 0.05), but not in skin elasticity (4.76% vs. 4.69%, p > 0.05). The difference in erythema between the sides was statistically not significant (p > 0.05). In the ex vivo model, expression of FGF2 in the skin was significantly increased after application of the antioxidant formulation, as compared to results obtained subsequent to fractional microneedle radiofrequency treatment only (p < 0.01). Conclusion This study demonstrates that for the treatment of photodamaged skin, laser-assisted delivery of the antioxidant formulation is a safe and effective adjuvant modality following fractional microneedle radiofrequency.

키워드

과제정보

This study was supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Evergy, the Ministry of Health & Welfare, Republic of Korea, the Ministry of Food and Drug Safety) (Project Number: 202014X4502). This work was also supported by the grant of the Korea Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (2020-31-0659) and Yonsei University Faculty Research (Grant 6-2020-0081).

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