• Journal of Pharmaceutical Investigation
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• 제36권3호
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• pp.185-192
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• 2006

The purpose of this study was to determine the effects of iontophoresis on transdermal delivery of procaine hydrochloride in healthy volunteers, as well as to the synergic effect of high voltage current or ultrasound on the efficacy of transdermal delivery of iontophoresis. Forty healthy volunteers were randomly assigned to four groups topical application group (TA), iontophoresis group (IT), pre-treatment of high voltage current stimulation with iontophoresis (HVS + IT), and pre-treatment of ultrasound application with iontophoresis (US + IT). All subjects received procaine iontophoresis on the forearm using direct current with 4 mA f3r 15 minutes. All subject was measured the duration of local anesthesia, pressure pain threshold, pain perception threshold using rectangular wave at 0.2 ms, 1 ms, 50 ms of rectangular current stimulation after procaine iontophoresis. For comparisons of the sensory characteristics and efficacy of iontophoresis between the groups, an one-way ANOVA and Kruskal-Wallis were used. The significant difference the duration of local anesthesia were found between the groups (p<0.001). The local anesthetic duration of IT, HVS+IT were significantly longer than TA. Meanwhile, the local anesthetic duration of US+IT was significantly longer than HVS+IT, IT and TA group (p<0.05). Also, the pressure pain threshold, pain perception threshold at 0.2 ms, 1 ms, 50 ms were significant difference between the groups (p<0.001). All sensory characteristics including pressure pain threshold, pain perception threshold of IT, HVS+IT was significantly increased than TA, whereas, US+1T was significantly increased HVS+1T, IT and TA (p<0.05). This study showed that the procaine iontophoresis have increase the duration of local anesthesia concomitantly pressure pain threshold and pain perception threshold of sensory nerve fibers such as $A-{\beta}$, $A-{\delta}$ and C fiber. This findings suggest that the iontophoresis enhanced the transdermal delivery of drug ions in vivo. The combination of ultrasound application and iontophoresis synergized the transdermal delivery of drug ions. It is suggests that an electric field, mechanical and heating property of ultrasound may contribute to synergic effect due to temporary changes of structure in the stratum corneum.

• Journal of Pharmaceutical Investigation
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• 제37권2호
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• pp.85-94
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• 2007

The objective of this study is to prepare a stable delivery systems containing polyethoxylated retinamide(PERA) - derivatives of retinoic acid, effective anti-wrinkle and anti-acne agent. Cubic liquid crystalline phase gel (CLCPG) and cubosomes containing various concentrations of PERA were prepared to investigate the physicochemical properties. Furthermore, stability and transdermal absorption efficacy of the CLCPG containing PERA were investigated in comparison with oil-in-water (O/W) emulsions which are predominantly used as a topical formulation. CLCPG increase the stability of PERA in comparison with O/W emulsion. For tropical application, CLCPG containing PERA shows higher moisturizing effect than that of O/W emulsion. In skin permeation test, CLCPG shows higher PERA deposit on epidermis. With its specific physicochemical property caused by the glyceryl oleate, CLCPG itself could be used for stabilizer of various actives and applied as an effective delivery system for topical application. Cubosome, nano-sized dispersed CLCPG, is also expected to be applied in a various field of industry like food, cosmetics and pharmaceuticals.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권3호
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• pp.1406-1424
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• 2017

Recent advancements in network infrastructures provide increased opportunities to support data delivery over multiple paths. Compared with multi-homing scenario, overlay network is regarded as an effective way to construct multiple paths between end devices without any change on the underlying network. Exploiting multipath characteristics has been explored for TCP with multi-homing device, but the corresponding exploration with overlay network has not been studied in detail yet. Motivated by improving quality of experience (QoE) for reliable data delivery, we propose a multipath message transport protocol based on application level relay (MPMTP-AR). MPMTP-AR proposes mechanisms and algorithms to support basic operations of multipath transmission. Dynamic feedback provides a foundation to distribute reasonable load to each path. Common source decrease (CSD) takes the load weight of the path with congestion into consideration to adjust congestion window. MPMTP-AR uses two-level sending buffer to ensure independence between paths and utilizes two-level receiving buffer to improve queuing performance. Finally, the MPMTP-AR is implemented on the Linux platform and evaluated by comprehensive experiments.

• 생체재료학회지
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• 제22권4호
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• pp.290-302
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• 2018

Background: The main purpose of drug delivery systems is to deliver the drugs at the appropriate concentration to the precise target site. Recently, the application of a thin film in the field of drug delivery has gained increasing interest because of its ability to safely load drugs and to release the drug in a controlled manner, which improves drug efficacy. Drug loading by the thin film can be done in various ways, depending on type of the drug, the area of exposure, and the purpose of drug delivery. Main text: This review summarizes the various methods used for preparing thin films with drugs via Layer-by-layer (LbL) assembly. Furthermore, additional functionalities of thin films using surface modification in drug delivery are briefly discussed. There are three types of methods for preparing a drug-carrying multilayered film using LbL assembly. First methods include approaches for direct loading of the drug into the pre-fabricated multilayer film. Second methods are preparing thin films using drugs as building blocks. Thirdly, the drugs are incorporated in the cargo so that the cargo itself can be used as the materials of the film. Conclusion: The appropriate designs of the drug-loaded film were produced in consideration of the release amounts and site of the desired drug. Furthermore, additional surface modification using the LbL technique enabled the preparation of effective drug delivery carriers with improved targeting effect. Therefore, the multilayer thin films fabricated by the LbL technique are a promising candidate for an ideal drug delivery system and the development possibilities of this technology are infinite.

• 국제학술발표논문집
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• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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• pp.187-194
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• 2011

Optimizing truck dispatching-intervals is imperative in ready mixed concrete (RMC) delivery process. Intervals shorter than optimal may induce queuing of idle trucks at a construction site, resulting in a long delivery cycle time. On the other hand, intervals longer than optimal can trigger work discontinuity due to a lack of available trucks where required. Therefore, the RMC delivery process should be systematically scheduled in order to minimize the occurrence of waiting trucks as well as guarantee work continuity. However, it is challenging to find optimal intervals, particularly in urban areas, due to variations in both traffic conditions and concrete placement rates at the site. Truck dispatching intervals are usually determined based on the concrete plant managers' intuitive judgments, without sufficient and reliable information regarding traffic and site conditions. Accordingly, the RMC delivery process often experiences inefficiency and/or work discontinuity. Automatic data collection (ADC) techniques (e.g., RFID or GPS) can be effective tools to assist plant managers in finding optimal dispatching intervals, thereby enhancing delivery performance. However, quantitative evidence of the extent of performance improvement has rarely been reported to data, and this is a central reason for a general reluctance within the industry to embrace these techniques, despite their potential benefits. To address this issue, this research reports on the development of a discrete event simulation model and its application to a large-scale building project in Abu Dhabi. The simulation results indicate that ADC techniques can reduce the truck idle time at site by 57% and also enhance the pouring continuity in the RMC delivery process.

• Journal of Acupuncture Research
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• 제20권5호
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• pp.82-92
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• 2003

Objective: To appreciate the effect of San-Yin-Jiao(SP-6) pressure on duratof delivery time and quantity of blood loss in order to verify the possibility of application to clinic of San-Yin-Jiao pressure. Methods: The design of this study is nonequivalent control group non- synchronized design. The subjects are 39 persons who are made up of SP-6 pressure applied(experimental) group 20 persons and to control group 19 persons. Collected data were analyzed as frequency, percentage, t-test, $x^2-test$ using SPSS 10.0 WIN Program. Conclusions: San-Yin-Jiao(SP-6) pressure not only make short duration of delivery time, but also decline quantity of blood loss in effect. 1. It could be necessary that the study of the effects of San-Yin-Jio(SP-6) pressure on duration of delivery time and quantity of blood loss for primipara be done repeatedly. 2. It could be necessary to increase this sort of study through free random experimental design in order to generalize this experimental result.

• Journal of Pharmaceutical Investigation
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• 제41권6호
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• pp.347-354
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• 2011

Repeated oral administration of loxoprofen can induce many side effects such as gastric disturbances and acidosis. Therefore, we considered alternative routes of administration for loxoprofen to avoid such adverse effects. The aim of this study was to develop an ethylene-vinyl acetate (EVA) matrix system containing a permeation enhancer for enhanced transdermal delivery of loxoprofen. The EVA matrix containing loxoprofen was fabricated and the effects of drug concentration, temperature, enhancer and plasticizer on drug release were studied from the loxoprofen-EVA matrix. The solubility of loxoprofen was highest at 40% (v/v) PEG 400. The release rate of drug from drug-EVA matrix increased with increased loading dose and temperature. The release rate was proportional to the square root of loading dose. The activation energy (Ea), which was measured from the slope of log P versus 1000/T, was 5.67 kcal/mol for a 2.0% loaded drug dose from the EVA matrix. Among the plasticizer used, diethyl phthalate showed the highest release rate of loxoprofen. Among the enhancers used, polyoxyethylene 2-oleyl ether showed the greatest enhancing effect. In conclusion, for the enhanced controlled transdermal delivery of loxoprofen, the application of the EVA matrix containing plasticizer and penetration enhancer could be useful in the development of a controlled drug delivery system.

• 한국물환경학회지
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• 제25권3호
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• pp.375-385
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• 2009

The estimation of delivery ratio is a essential part of Korean Total Maximum Daily Loads (TMDL) procedure which needs a number of observed stream flow and pollutants data. If observed data were not sufficient, researchers have to find other alternatives. One of them is to make indirect data by using watershed models, such as Soil and Water Assessment Tool (SWAT) and Hydrological Simulation Program - FORTRAN (HSPF) and so on. In this study, indirect daily data was made by using SWAT model. To build the Byongseong-SWAT model accurately, crop cultures are reflected by handling the MGT.file in SWAT model. Especially, mass of manure and schedule of crop culture are inputted through investigating domestic research papers as well as fieldwork. After calibrating SWAT model in comparison with the 22-years flow and pollutants observed outlet data, the delivery ratio of Byongseong watershed is calculated by using daily simulated data during 2004-2007. Empirical equations for delivery ratio through multi-regression analysis are developed by using meteorological and physical factors such as flow, watershed area, stream length, catchment slope, curve number (CN) and subbasin's pollutant discharge loads.

• 한국산학기술학회논문지
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• 제16권6호
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• pp.3999-4010
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• 2015

본 연구의 목적은 결혼이주민 산모에 대한 간호경험을, 실제 간호현장에서 이들을 간호하고 있는 산부인과 간호사들로부터의 진술을 통해 기술하고 설명함으로써, 결혼이주민 산모의 간호서비스 향상 방안 마련을 위해 필요한 기초자료를 제공하는 것이다. 초점집단의 면담을 통해 질적 내용분석을 적용하여 연구의 주요 질문을 중심으로 분석한 결과, 산보인과 간호사의 결혼이주민 산모 간호경험은 5개의 주요 면담 질문으로 부터 14개 범주 및 35개 하위범주로 설명할 수 있었다. 결혼이주민 산모 간호의 질적 향상을 위해 산부인과 간호사의 의사소통 능력과 문화적 역량을 증진시킬 수 있는 프로그램의 개발 및 적용 연구를 제언한다.

• 한국학교ㆍ지역보건교육학회지
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• 제20권2호
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• pp.53-67
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• 2019

Objectives: The purpose of this study is to obtain the basic data for the development of maternal health care by analyzing the status and needs of service target persons in Timor-Leste. Methods: The subjects were selected through the non-probability sampling method applying the FGI. Researchers interviewed 3 maternal health service managers, 6 midwives at Gleno and Railaco Health Centers and 2 women between 15 and 45 years of age. Results: In the results of on-site visit of the delivery facility and the FGI, we found poor sanitation in delivery room, lack of medical equipment related to antenatal consultation and delivery. In the case of the health center manager, the public health center provides various maternity health services, but the lack of the staff has difficulty in providing the service and managing the subjects. Midwives asked for regular maintenance education. Women in child bearing age living in mountainous areas had poor access to delivery facilities and lack of awareness of delivery services. Conclusions: It is necessary to increase the maternity management rate through regular maternity and maternal health check service and application to maternal management database, to improve the sanitation of the maternity clinic in the public health center, to strengthen the midwife competency program.