• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.2
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• pp.189-195
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• 2012

Parcel delivery services are a bit different from general vehicle routing problems since the services require a deliver's walking time to give the parcel to the customer. This time takes more than 1/4 of total delivery time, but it is ignored for the convenience of algorithm design in general. The walking time is too big to be ignored if we need to estimate necessary delivery time precisely as much as possible, or to design a heuristic with varying vehicle moving speeds in metropolitan area. For these reasons, the walking times are surveyed and analyzed to use on the design of VRP heuristic for parcel delivery services in this research.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 1997.10a
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• pp.225-231
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• 1997

This paper reports on the theoretical study of the delivery pressure ripples of a positive displacement vane pump which is widely used for automobile power steering. Pressure ripples occur due to the flow tipples which induced cam ring profiles and reverse flow from the delivery ports. In this paper, the mathematical model for analyzing the pressure ripples has been presented, and set of the differential equationshave been solved using the Runge-Kutta method. As the results of analysis, instant ideal flow ripples, internal pressure, delivery pressure ripples, and delivery flow ripples have been presented. Internal pressure was related to delivery pressure variations, and amplitude of pressure tipples was increased with rotational speed and delivery pressure.

• Journal of Korean Society on Water Environment
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• v.25 no.4
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• pp.580-588
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• 2009

In this study daily flow rates and delivered pollutant loads of Nakdong river basin are simulated with modified TANK model and minimum variance unbiased estimator. Based on the simulation results, flow duration curves, load duration curves, and delivery ratio duration curves have been established. Then GIS analysis is performed to obtain several hydrological geomorphic characteristics such as watershed area, stream length, watershed slope and runoff curve number. Finally, multiple regression analysis is carried out to estimate empirical equations for pollutants delivery ratio. The results show that there is positive relation between the flow rates and delivery ratios, and the proposed empirical formulas for delivery ratio can predict well river pollutant loads.

• Applied Chemistry for Engineering
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• v.2 no.2
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• pp.87-96
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• 1991

Controlled drug Delivery systems have been actively studied for the past twenty years. In the present article controlled drug delivery system was classified by the delivery mechanism and the drug delivery behavior was discussed. Also overall status of drug delivery system was introduced through the route of drug adiministration.

• Macromolecular Research
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• v.15 no.2
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• pp.100-108
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• 2007

Gene therapy has become a promising strategy for the treatment of genetically based diseases, such as cancer, which are currently considered incurable. A major obstacle in the field of cancer gene therapy is the development of a safe and efficient delivery system for therapeutic gene transfer. Non-viral vectors have attracted great interest, as they are simple to prepare, stable, easy to modify and relatively safe compared to viral vectors. In this review, an insight into the strategies developed for polyethylenimine (PEI)-based non-viral vectors has been provide, including improvement of the polyplex properties by incorporating hydrophilic spacer, poly(ethylene glycol) (PEG). Moreover, this review will summarize the strategies for the tumor targeting. Specifically, a targeted polymeric gene delivery system, PEI-g-PEG-RGD, will be introduced as an efficient gene delivery vector for tumor therapy, including its functional analysis both in vitro and in vivo.

• Journal of Pharmaceutical Investigation
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• v.19 no.2
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• pp.87-92
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• 1989

The multilayered monolithic type transdermal delivery device has been designed and analyzed by a numerical analysis. The device consists of three layered polymer matrices which posess the different diffusion parameters, respectively. The purpose of this study was to design an ideal transdermal drug delivery device which is capable of initial burst and zero order release later on. Numerical modelings were simulated for a dispersed and a dissolved multilayered monolithic system. The results showed that the dispersed multilayered monolithic system could meet the requirements for an ideal transdermal delivery device.

• IE interfaces
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• v.16 no.spc
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• pp.33-38
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• 2003

In this paper we study the delivery policy of internet bookstores and recommend the improved policy to increase customer satisfaction and sales revenue. We classify customers into two, the price-sensitive and the delivery time-sensitive, and develop a new shipping method, the unhurried shipping, for the price-sensitive who are reluctant to pay shipping fee for the small purchase but willing to wait extra time for the ordered goods. The customers could get discount on shipping fee by the unhurried shipping but have to accept the longer delivery lead-time. We investigate the possible ways to reduce costs with the prolonged delivery time and show that some costs regarding shipmentand inventory could be saved in order to make up for additional shipping costs for the price-sensitive.

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.1
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• pp.1-13
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• 2015

Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2009.05b
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• pp.203-207
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• 2009

These days Construction Industry is one of the major industry in public project and it has many problems. And Construction Industry highly respond to a chage of IT, politics, economy, domestic and international situation. And it causes an uncertainty in Korea economy. The goal of this paper is showing the efficiency application of BIM in Public Project. And this paper follow three steps. First, these day's trend of BIM and delivery method are researched. Second, major factors are thrived to appreciating BIM Third, delivery method based on BIM is proposed. Major factors of delivery method are researched to make guide line of delivery method in public project in the future.

• Journal of The Korea Institute of Healthcare Architecture
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• v.14 no.4
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• pp.47-54
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• 2008

Preconstruction process in a lean project delivery system was studied in one large healthcare project working for a general contractor. Researchers joined a new lean delivery project for approximately six weeks and participated in preconstruction process including design coordination, management coordination, and target costing while concurrently interviewing other project participants and employees, recording activity in meetings, and otherwise observing the process. The preconstruction process in lean project delivery system, called integrated project design, showed many benefits such as brining expertise of downstream players (i.e., mechanical and electrical contractors) into the design phase. However, lack of leadership and lack of design-integrator blocked the successful application of a new concept of design process.