• Nutrition Research and Practice
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• 제8권4호
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• pp.391-397
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• 2014

BACKGROUND/OBJECTIVE: Myocardial cell death due to occlusion of the coronary arteries leads to myocardial infarction, a subset of coronary heart disease (CHD). Dietary fiber is known to be associated with a reduced risk of CHD, the underlying mechanisms of which were suggested to delay the onset of occlusion by ameliorating risk factors. In this study, we tested a hypothesis that a beneficial role of dietary fiber could arise from protection of myocardial cells against ischemic injury, manifested after occlusion of the arteries. MATERIALS/METHODS: Three days after rats were fed apple pectin (AP) (with 10, 40, 100, and 400 mg/kg/day), myocardial ischemic injury was induced by 30 min-ligation of the left anterior descending coronary artery, followed by 3 hr-reperfusion. The area at risk and infarct area were evaluated using Evans blue dye and 2,3,5-triphenyltetrazolium chloride (TTC) staining, respectively. DNA nicks reflecting the extent of myocardial apoptosis were assessed by TUNEL assay. Levels of cleaved caspase-3, Bcl-2, and Bax were assessed by immunohistochemistry. RESULTS: Supplementation of AP (with 100 and 400 mg/kg/day) resulted in significantly attenuated infarct size (IS) (ratio of infarct area to area at risk) by 21.9 and 22.4%, respectively, in the AP-treated group, compared with that in the control group. This attenuation in IS showed correlation with improvement in biomarkers involved in the apoptotic cascades: reduction of apoptotic cells, inhibition of conversion of procaspase-3 to caspase-3, and increase of Bcl-2/Bax ratio, a determinant of cell fate. CONCLUSIONS: The findings indicate that supplementation of AP results in amelioration of myocardial infarction by inhibition of apoptosis. Thus, the current study suggests that intake of dietary fiber reduces the risk of CHD, not only by blocking steps leading to occlusion, but also by protecting against ischemic injury caused by occlusion of the arteries.

• 대한의생명과학회지
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• 제19권4호
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• pp.330-337
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• 2013

There are several methods currently being used to diagnose tuberculosis in patients, such as smear, PCR, tuberculosis culture and X-ray. For a proper medical treatment, antimicrobial susceptibility test and rapid drug susceptibility testing have been operated. Tuberculosis bacilli usually need 3~8 weeks of culture period because of delay in RNA synthesis and require 15~22 hours for generation. After a germ raises in culture, we initiated antimicrobial susceptibility test for a proper treatment. It has some difficulties to give a proper prescription for a tuberculosis patient because antimicrobial susceptibility test requires 4 weeks. To supplement this, we are practicing drug susceptibility testing which allow us to know the sensibility of RMP and INH after 2 or 3 days. But this is only possible when more than 2 positive germ. Therefore, we should practice rapid drug susceptibility testing with culture test. But if media is contaminated by other germs except Mycobacterium tuberculosis, it's hard to interpret result about culture test and to practice antimicrobial susceptibility test and rapid drug susceptibility testing. Because we have to practice again smear, culture test after extracting specimen from the patient, time is consumed and proper patient treatment is postponed. To address these problems and quick patient treatment, rapid drug susceptibility testing is practiced by using GenoType$^{(R)}$ MTDRplus method. As a result of this method we detected sensibility 10 and 7 cases and resistance 0 and 3 cases using RIM and INH respectively with other 1 case toward medicals out of the total 11 test. In conclusion rapid drug susceptibility testing can be used from the contaminated specimen after elimination of contaminated source from culture and proved that it can be practiced for rapid examination of a tuberculosis patient.

• 정보처리학회논문지C
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• 제14C권1호
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• pp.55-64
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• 2007

최근 높아져 가는 VoIP에 대한 관심 뒤에는 보안에 대한 과제들이 존재한다. 인증과 메시지 암호화는 PSTN 수준의 보안을 제공하기 위해 필수적인 요소이다. SIP는 VoIP에서 안전하게 호(call)을 생성하기 위한 책임을 가지고 있으며 SIP는 TCP와 UDP 그리고 SCTP에서 사용될 수 있는 TLS와 DTLS 혹은 IPSec과 같은 보안 메커니즘들을 통해 보안 서비스를 제공한다. 이들 보안 메커니즘의 적용이 SIP 성능에 추가적인 오버헤드를 가져올 수 있음에도 불구하고 현재 이에 대한 분석은 미미한 수준이다. 본 논문에서는 보안 메커니즘이 SIP 성능에 미치는 영향을 분석하였다. 영향 분석을 위해 SIP에서 사용되는 보안 메커니즘들과 전송 프로토콜들의 다양한 조합을 시뮬레이션으로 구현하였다. 그 결과 UDP를 사용하는 보안 메커니즘들이 높은 성능을 보였다. 또한 TLS가 SCTP 상위에서 동작할 때 SCTP의 스트림 수와 같은 수의 보안 채널을 생성해야 한다는 사실이 SIP의 성능에 큰 영향을 미칠 수 있다는 것을 확인하였다.

• Clinical and Experimental Pediatrics
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• 제53권4호
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• pp.598-602
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• 2010

신생아 일과성 고암모니아혈증은 고암모니아혈증을 특징으로 하며 대부분 호흡곤란 치료를 받는 미숙아에서 발생한다. 발생원인은 정확히 알려져 있지 않으나 생후 2-3일에 호흡 곤란, 기면, 경련, 혼수 등의 임상 증상을 보이고, 생화학적 검사 상 혈중암모니아 농도가 현저히 증가하며 요소회로 효소 치는 정상을 보인다. 치료가 늦으면 사망에 이르는 응급을 요하는 질환이나 즉각적이고 적절한 치료 시 신경학적 손상을 남기지 않고 호전 가능하다. 저자들은 호흡곤란을 보여 호흡기 치료를 받던 35주 미숙아에서 48시간 내에 경련과 함께 혼수상태에 빠지고 검사상 고암모니아혈증을 보여 신투석 등의 치료 후 회복되었으며 2년 추적관찰에서 정상을 보인 환아를 보고하는 바이다.

• 한국작물학회지
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• 제39권5호
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• pp.431-436
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• 1994

충남 예산지방에서 호밀을 답리작으로 재배할 때 파종기가 생육, 수량 및 식물체 부위별 건물구 성비율에 미치는 영향을 요약하면 다음과 같다. 1. 예산지방에서 파종기가 11월 5일 이후로 늦어지면 호밀의 출현일수가 길어지고 출현율 및 월동율이 감소하며 출수기가 지연되었다. 2. 호밀의 생장속도는 파종기가 빠를수록 증가하였고 파종기가 11월 5일 이후로 지연됨에 따라 생육량이 크게 감소하였다. 3. 호밀의 청예 및 건물수량은 파종기가 빠를수록 증가하나 다른 지역에서보다 파종적기의 폭이 넓어서 10월 5일에서 10월 25일 사이의 파종기간 차가 크지 않았다. 청예수량은 개화기 예취시, 건물수량은 유숙기 예취시 가장 높았다. 4. 호밀의 식물체 부위별 건물구성비율은 파종기가 빠를수록 그리고 수확시기가 늦을수록 엽신과 엽초의 비율이 감소하고 줄기와 이삭의 비율은 증가하였다.

• 대한의용생체공학회:의공학회지
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• 제26권6호
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• pp.399-406
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• 2005

In these days, HIS(Hospital Information System) raise the quality of medical services by effective management of medical records. As computing environment was developed, it is possible to search information quickly. But, standard medical data exchange is not completed between medical clinic and another organ so far. In case of patient transfer, past medical record was not efficiently transmitted. It be feasible treatment delay or medical accident. It is trouble that medical records is transferred by a person and communicate with each other. Extensible Markup Language (XML) is a simple, very flexible text format derived from SGML. Originally designed to meet the challenges of large-scale electronic publishing, XML is also playing an increasingly important role in the exchange of a wide variety of data on the Web and elsewhere. Form in system of company product, relative organs that handle bio-signal data is each other dissimilar and integration and to transmit to supplement bottleneck this research uses XML. In this study, it is discussed about sharing of medical data using XML web technology to standard medical record between hospital and relative organization The data structure model was designed to manage bio-signal data and patient record. We experimented about data transmission and all-in-one between different systems (one make use of MS-SQL database system and the other manage existent bio-signal data in itself form in file in this research). In order to search and refer medical record, the web-based system was implemented. The system that can be shared medical data was tested to estimate the merits of XML. Implemented XML schema confirms data transmission between different data system and integration result.

• 대한의용생체공학회:의공학회지
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• 제39권1호
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• pp.1-9
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• 2018

This study was carried out to evaluate the effect of micro-current therapy on muscle atrophy and delayed wound healing process caused by traumatic peripheral nerve injury. For this, twenty-five 5-week-old Sprague Dawley rat were used and assigned to five groups including the normal group (NOR, n=5), the wound group (WD, n=5), the wounded and treated with micro-current electrical therapy group (WD+MET, n=5), the sciatic nerve denervated and wounded group (WD+DN, n=5), and the sciatic nerve denervated, wounded and treated with micro-current electrical therapy group (WD+DN+MET, n=5). In order to assess the changes in length of incisional wound for 12 days and the muscle volume for 2 weeks, the ImageJ analysis of macroscopic analysis and micro-CT data were obtained and analyzed. As a result, significant delay in the process in wound healing were observed and micro-current therapy suppress the postponement of healing process. Furthermore, there were significant changes in muscle volume between electrically treated group and non-treated group. These result shows that electrical stimulation may improve the delayed healing process and muscle atrophy at once.

• Toxicological Research
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• 제17권3호
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• pp.225-234
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• 2001

The present study was conducted to investigate the effects of Korean red ginseng water extract (KRGWE) on developmental toxicity caused by the environmental estrogen bisphenol A (BPA) in Sprague-Dawley rats. fifty males successfully mated were randomly assigned to five experimental groups, 1.e., group I (vehicle control), group II (BPA 1000mg/kg), group III (KRGWE 400mg/kg), group IV (BPA 1000mg/kg & KRGWE 200mg/kg), and group V (BPA 1000mg/kg & KRGWE 400mg/kg). The test articles were administered by gavage to mated females from gestational days (GD) 1 through 20 (sperm vaginal lavage=day O). All females were subjected to caesarean section on GD 21 and their fetuses were examined for external, visceral, and skeletal abnormalities. In the group II, significant maternal toxic effects including suppressed body weight, decreased body weight gain during pregnancy, and reduced food consumption were observed in pregnant rats. The minimal developmental toxicity including fetal ossification delay was also found in fetuses. In addition, a tendency for increased pregnancy failure, increased pre-and postimplantation loss, and decreased fetal body weight was observed. However, no fetal morpho-logical abnormalities were seen in surviving fetuses at a dose level of 1000mg BPA/kg. On the other hand, the maternal toxicity and developmental toxicity found in the groups IV and V were comparable to those of the group II. There were no adverse signs of either maternal toxicity or developmental toxicity in the group III. These results showed that administration of BPA at a dose level of 1000mg/kg to pregnant rats resulted in significant maternal toxicity and minimal developmental toxicity, and that no protective effects on BPA-induced maternal toxicity and developmental toxicity were found by concomitant gavage dosing of KRGWE.

• 한국측량학회지
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• 제30권5호
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• pp.459-466
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• 2012

전리층에 의한 신호지연은 SA 해제이후 GPS 측위에 가장 큰 오차 요인이다. 전리층 오차는 이중주파수 수신기를 이용할 경우 무전리층 조합으로 쉽게 제거할 수 있지만 단일주파수 수신기는 무전리층 조합을 수행할 수 없기 때문에 전리층 오차를 쉽게 제거할 수 없다는 단점이 존재한다. 따라서 이 연구에서는 단일주파수 사용자를 위한 격자형 지역 전리층 모델을 개발하였다. 개발된 지역 전리층 모델을 평가하기 위해 IGS의 전지구 모델과 비교하였으며 그 결과 열흘 평균 3.8 TECU의 RMSE를 나타내었다. 그리고 측위 정확도에 미치는 영향을 평가하기 위해 생성된 지역 전리층 모델을 적용하여 L1 관측치만을 이용한 중 장기선 상대측위를 수행하였다. 전리층과 대류권 오차를 보정한 결과 두 오차를 보정하기 전의 측위 결과와 비교하여 평균 46.7%의 측위 정확도가 향상되었으며 대류권 오차만 보정한 측위 결과와 비교하여 전리층 오차 보정 후에는 평균 14.5%의 측위 정확도가 향상되었다.

• 한국축산식품학회지
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• 제33권2호
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• pp.181-188
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• 2013

The aim of this study was to investigate the quality properties of beef jerky replaced salt with soy sauce, red pepper paste, and soybean paste. The quality properties of beef jerky including final water activity ($a_w$), moisture content, pH, color, shear force, total plate counts, thiobarbituric acid reactive substance (TBARS) values, and sensory evaluations were investigated. The sliced beef samples were marinated in salt (control), soy sauce (T1), red pepper paste (T2), and soybean paste (T3) for 24 h and then dried at $70^{\circ}C$ for 6-8 h. The water activity of finished beef jerky varied from 0.72 to 0.70. The water activity for control and T1 samples decreased more rapidly as drying proceeded up to 6 h. The samples with salt replacement showed a lower pH and lightness than the control (p<0.05). The T1 sample showed a significant decrease in total plate counts after 21 d of storage (p<0.05). The TBARS for all treatments increased with storage days (p<0.05). The TBARS were significantly lower in T2 and T3 samples compared to control and T1 until 21 d of storage (p<0.05). The samples with salt replacement showed a lower intensity of saltiness than the control. Sensory evaluations found that the replaced soy sauce of beef jerky samples had better overall acceptability scores than the other treatment samples. It was concluded that replacing salt with soy sauce can delay lipid oxidation and enhance the sensory acceptance of beef jerkies.