• YAKHAK HOEJI
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• v.37 no.3
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• pp.278-285
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• 1993

The anticlastogenic effect of N-acetylcysteine was tested in vivo in mouse bone-marrow micronucleus assay. The frequencies of micronuclei induced by adriamycin (5 mg/kg i.p.) in bonemarrow cells were decreased by the oral administration of N-acetylcysteine at 12 h before adriamycin injection. The observed suppressing effect was not a reflection of a delay in the formation of micronuclei by the cytotoxic effect of N-acetylcysteine. The anticlastogenic effects of SH compound including N-acetylcysteine, cysteine, cystine, S-carboxy methylcysteine and glutathione were also investigated by the multiple pretreatment. Each SH compound was administered orally every day for 5 days and adriamycin (5 mg/kg i.p.) was injected at 24h after the last dose of test compound. N-acetylcysteine and glutathione showed significantly the suppressive effect at dose of 10 and 25 mg/kg for N-acetylcysteine and at the dose of 25 mg/kg for glutathione. Our study suggests that N-acetylcysteine is capable of protecting the chromosomal damages in the normal cells during cancer chemotherapy by adriamycin, and may act as an anticlastogen against induction of micronuclei by superoxide generating agent such as adriamycin.

• Journal of The Korean Society of Agricultural Engineers
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• v.60 no.4
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• pp.55-62
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• 2018

Problems on vibration due to blasting for infrastructure development are getting important because of a civil appeal. Blasting-induced vibration is representative construction pollution, hence, it is possible that a number of environmental damages occur. In this study, borehole test blasting was conducted at Sintanjin area, Daejeon and square root equation with 95% confidence level was proposed for prediction of blasting-induced vibration. The vibration value predicted from this equation was more conservatively evaluated than the values predicted from U.S. Department of Interior, Bureau of Mines (USBM) and Nippon Oil & Fats Co., Ltd. (NOF) equations. Therefore, the proposed equation in this study seems to contribute for safety blast design. However, for optimal blast design, inducing equation for prediction of blasting-induced vibration through the identical test blasting with field construction such as rock slope blasting would be required.

• Geomechanics and Engineering
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• v.18 no.5
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• pp.471-480
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• 2019

The constructions of engineering structures such as airports, highways and railway on clayey soils may create many problems. The economic losses and damages caused by these soils have led researchers to do many studies using different chemical additives for the stabilization of them. Lime is a popular additive used to stabilize the clayey soils. When the base course is stabilized by mixing with an additive, inevitable delays may occur during compaction due to reasons like insufficient workers, breakdown of compaction equipment, etc. The main purpose of this study is to research the effect of compaction delay time (7 days) on the strength, compaction, and dynamic properties of a clay soil stabilized with lime content of 0, 3, 6, 9, 12 and 15% by dry weight of soil. Compaction characteristics of these mixes were determined immediately after mixing, and after 7 days from the end of mixing process. Within this context, unconfined compressive strength (UCS) under the various curing periods (uncured, 7 and 28 days) and dynamic triaxial tests were performed on the compacted specimens. The results of UCS and dynamic triaxial tests showed that delayed compaction on the strength of the lime-stabilized clay soil were significantly effective. Especially with the lime content of 9%, the increase in the shear modulus (G) and UCS of 28 days curing were more prominent after 7 days mellowing period. Because of the complex forms of hysteresis loops caused by the lime additive, the damping ratio (D) values differed from the trends presented in the literature and showed a scattered relationship.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.4
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• pp.1377-1387
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• 2013

Most embankment of the reservoirs (99.1 %) have been constructed in the earth filled type in Korea because the construction of this type is less expensive and simpler than others such as concrete one. However, it has to be reinforced the slope to prevent the breach due to overtopping or piping under unexpected flood conditions. This study has been analyzed the retardation effect using three types (L, T, $L^*$ shape) of stiffener in order to reinforce embankment when they are collapsed by overtopping flow. Experimental results showed that L-type stiffener is the most effective in delaying the breaching of embankment and reducing the soil erosion when compared with others. The reinforced embankment breaching showed that time delay was occurred about 1.73 to 2.29 times and the peak flowrate was reduced compared to non-stiffener embankments due to energy dissipation by collision and less soil erosion. The embankment breaching mostly leads to major damages because of the lack of repair time. Thus, since these stiffeners can resist the rapid breach, it would be possible to earn the time to emergency repair and lifesaving, as well as reduction of damages of embankment in downward region with decreasing peak flowrate. Results from this study would be used for the basis when establishing the emergency action plan for the reservoirs on the verge of hazard.

• Journal of Korea Port Economic Association
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• v.25 no.2
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• pp.149-176
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• 2009

In Count case, the owners claimed from the charterers the amount of their loss resulting from the delay to the Count caused by the blockage of the channel due to stranding of the Pongola on the ground that this loss resulted from breach by the charterers of the safe port provisions. The Claim was referred to arbitration and dealt with on written submission. In a reasoned award, the arbitrators upheld the owners' claim. The charterers seek an order reversing the award or remitting it to the arbitrators for further consideration : (1) That the tribunal was wrong to find that the port of Beira was unsafe and that in consequence the charterers were liable to the owners in damages for detention. (2) That the tribunal was wrong to find that the port was unsafe in the abstract by reference to the fact that two other vessels had grounded there. (3) Having held that the Count was delayed for a little over four days by the fact that, after the charterers had nominated the port, the Pongola had grounded in the access channel, the tribunal should have held that the port was not prospectively unsafe. On the that the grounding the Pongola was caused by the characteristics which made the port an unsafe port to nominate for the Count. The court was held that it was not an independent event which broke the chain of causation between the breach of contract and the owner's loss. For those reasons, the court was upheld the arbitrator's award.

• Economic and Environmental Geology
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• v.54 no.2
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• pp.199-212
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• 2021

The Sebyeonggwan Hall (National Treasure No. 305) is located on the Naval Headquarter of Three Provinces in Tongyeong, and it has partly undergone with several rebuilding, remodeling, repairing and restorations since it's the first establishment in Joseon Dynasty (AD 1605) of ancient Korea. This study focuses on 50 foundation stones that comprise the Sebyeonggwan. These stones are made of six rock types and currently have various shapes of the surface damages. As the foundation stones, the dominant rock type was dacitic lapilli tuffs, and provenance-based interpretation was performed to supply alternative stones for conservation. Most of the provenance rocks for foundation stones showed highly homogeneity with their corresponding stones of petrography, mineralogy and magnetic susceptibility. According to surface deterioration assessments, the most serious damages of the stones were blistering and scaling. The deterioration mechanism was identified through the analysis of inorganic contaminants, and the primary reason is considered salt weathering caused by sea breeze and other combined circumstances. Based on the mechanical durability of the stones, there was no foundation stone that required the replacement of its members attributed to the degradation of the rock properties, but conservation treatment is considered necessary to delay superficial damage. The foundation stones are characterized by a combined outcome of multiple petrological factors that caused physical damage to surfaces and internal defects. Therefore, it's required to diagnosis and monitoring the Sebyeonggwan regularly for long-term preservation.

• Korean Journal of Construction Engineering and Management
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• v.13 no.6
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• pp.33-44
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• 2012

This study is as to payment improvement method of additional incidental cost to be occurred upon extension of public construction time. According to the result of analysis about the cause of non-payment of additional incidental cost of construction time extension through site examples, it was found that difficulties exist in disputes & proofing over the scope of actual cost recognition, and in this regard the result of experts opinion indicated that a construction extension pre-agreement system can be executed which agrees the scope of recognition of additional incidental cost of construction time extension once the statistical standard is clear and accurate. Accordingly, in this study, by totalling multiple sites data, calculations were implemented in terms of type of construction projects, amount of constructions, period of constructions. According to the result of calculation, the element of type of construction project and construction period appears to have none direct effect to the occurrence of additional cost of construction time extension, but direct relationship was indicated related to the contract amount element. In view of above, in this study a standard additional incidental cost of construction time extension was proposed, and presented a system improvement plan to implement the construction extension pre-agreement system.

• Korean Security Journal
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• no.25
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• pp.147-164
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• 2010

A variety of work zone including road single-sharing construction add surrounding disorder and increase inconvenience of vehicles and pedestrians and furthermore danger of traffic accidents, which sometimes result in human life damages. Traffic delay due to vehicles and users generating in the course of using large-scale multiplex facilities bring about a great economic loss. Now, a lot of regulations and laws related to traffic safety system on construction sites etc. are established, but can not display efficacy desirably. It brings about continuous economic loss due to human life accidents and delay. For the purpose of solving the problems, it is necessary to import systems such as traffic inducement Security (Japan) and traffic controller (CANADA, USA) This article suggest how improve civil safety and reduce Social cost. therefore This thesis aims at analyzing advanced cases of foreign countries, looking into Korean status, and presenting importing ways of traffic inducement Security appropriate to Korea. It is reasonable to grant grade1, grade2, and technical experts to traffic inducement Security who pass regulated educations and examinations. In addition, by reversing regulations and laws, it is necessary only those who have the licenses of traffic induction guarder etc. can establish construction sites and disordered places on roads. Theory educations for education time must include basic educations and expert educations. Basic educations must include understanding regulations and laws and understanding affairs. Expert educations must include traffic control, safety educations, understanding of traffic accidents, operation of traffic control facilities, and traffic accident settlements. Traffic affairs educations must include traffic induction affairs in sites (hand signals, safety material establishment, traffic accident settlements, and urgent treatments).

• Transactions of the Korean Society of Mechanical Engineers
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• v.11 no.1
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• pp.118-123
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• 1987

In relation to the dust detonatians which have imposed severe damages on the industry, the ignitability of various dusts has been investigated on a horizontal shock tube in this study. By using a newly designed air injector, very well-distributed clouds could be obtained. The proper reflected shock conditions have been generated by placing a reflector 1.5cm behind the air injector, which reflected the incident shock wave. The incident shock waves in the range of Mach number 2.8-3.3 created the postreflected shock temperature of 1200-1600K. Experimentally the ignition delay was defined as the time interval between the arrival of a reflected shock wave at dusts and the detection of visible light. Measured ignition delays of dusts investigated were located lower than 1msec under the above conditions. These values are one-order higher than those in the incident shock wave condition. In this type of ignitiion process the following three processes are considered to play important roles; heating of a particle, generation of volatile gas by endothermic devolatilization process, and its diffusion from the particle surface and the formation of stoichiometric mixture with oxidizer.

• Journal of Korean Medicine Rehabilitation
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• v.23 no.1
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• pp.1-13
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• 2013

Objectives : The pathophysiology of acute spinal cord injury(SCI) may be divided into primary and secondary mechanisms of injury. The secondary mechanism involves free radical formation, excitotoxicity, inflammation and apoptotic cell death, and sets in minutes after injury and lasts for weeks or months. During this phase the spinal tissue damages are aggravated. Therefore, secondary mechanisms of injury serve as a target for the development of neuroprotective drug against SCI. The present study investigated the effect of tetramethylpyrazine(TMP), an active ingredient purified from the rhizome of Ligusticum wallichii(川芎, chuanxiong), on neuronal apoptosis in spinal cord compression injury in rats. Methods : SCI was subjected to rats by a static compression method(35 g weight, 5 mins) and TMP was treated 3 times(30 mg/kg, i.p.) during 48 hours after the SCI. Results : TMP ameliorated the tissue damage in peri-lesion of SCI and reduced TUNEL-labeled cells both in gray matter and in white matter significantly. TMP also attenuated Bax-expressed motor neurons in the ventral horn and preserved Bcl-2-expressed motor neurons. Conclusions : These results indicate that TMP plays a protective role in apoptotic cell death of neurons and oligodendrocytes in spinal cord injury. Moreover, it is suggested that TMP and TMP-containing chuanxiong may potentially delay or protect the secondary spinal injury.