• 제목/요약/키워드: Degree-day method

검색결과 252건 처리시간 0.031초

한국흑염소에 있어서 DL-Ethionine으로 유발시킨 지방간에 관한 연구 (Clinical Pathologic Study on DL-Ethionine Induced Fatty Liver in Korean Black Goats)

  • 이경갑;최희인
    • 한국임상수의학회지
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    • 제8권2호
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    • pp.127-142
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    • 1991
  • This study was carried out to investigate fatty liver in Korean black goats. Adult female goats were divided into 3 test groups(A, B and C). Group A and B of goats each received 3 test consecutive daily doses of DL-ethionine at 75mg/kg and 150mg/kg body weight, respectively. Group C of goats was given 3 consecutive doses of the compound every 48 hours at 150mg/kg body weight. The clinical symptoms, hematological values, serum chemical values and histopathological study of the liver were investigated in the test animals. The results obtained are as follows ; 1. Fatty liver were observed in every test animal. 2. Some clinical symptoms( anorexia, depression) were appeared from 1st day to 7th day after administration of the compound in every test animal. In addition to these symptoms, diarrhea and salivation were generally observed in test animals which were given the compound at 150mg/kg body weight. The degree of these symptoms was dose dependent. 3. There was no significant variations in total WBC counts and fibrinogen values in the blood of test goats. The PCV values were significantly increased on 5th day of dosing in group A and B of goats. 4. The total lipid value was not changed but the concentration of NEFA was significantly increased on 3rd day of dosing with the compound and returned to normal value after 10 days hereafter. The value of triglycerides was significantly increased on 1st day and returned to normal value on 3rd day of dosing. The value of cholesterol was significantly decreased on 3rd day and returned to normal value on 10th day after treatment. 5. Total protein level was decreased on 10th day of dosing in the groups of B and C, and billirubin level was significantly increased on 7th day of dosing in every test group and returned to normal level after 13th day of administration. 6. The activity of GGT in serum was not changed while the activities of SDH and AST were significantly increased in every test goat and those values were returned to normal after 10~13th day of trestment. 7 The 35K-protein fraction in serum was not detected by SDS-polyacrylamide gel electrophoresis, but this protein fraction was detected by the same method after treating the 21st and 22nd fraction which were obtained by column chromatography with Sephadex G-100. 8. The affected liver was congested and swollen on 3rd day, and yellowish brown in color and mottled appearance on 7th day of treatment. Histopathologically, fat droplets were common in the hepatocytes, this change was intensive on 7th day after treatment in group B and C. Hepatic cell necrosis was observed in some livers but this pathological change was disappeared and returned to normal after 13 days of treatment.

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중합시간과 중합방법에 따른 자가중합형 상교정용 레진의 중합률의 비교에 관한 연구 (A STUDY ON THE DEGREE OF POLYMERIZATION OF AUTOPOLYMERIZED RESIN FOR REMOVABLE ORTHODONTIC APPLIANCE ACCORDING TO CURING TIME AND CURING METHOD)

  • 유종욱;장기택;김종철
    • 대한소아치과학회지
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    • 제26권2호
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    • pp.296-309
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    • 1999
  • 가철성 상교정 장치에 많이 사용되는 자가중합형 상교정용 레진의 미반응 단량체는 레진의 물성과 생물학적인 면에 많은 영향을 끼친다. 따라서 미반응 단량체를 최소화하고 중합률을 최대로 하는 중합방법에 대한 연구는 중요한 의의를 갖는다. 저자는 자가중합형 상교정용 레진의 중합시간과 중합방법에 따른 중합률을 비교해보기 위해 시편을 다음과 같이 5군으로 나누어 연구를 진행하였다. 상교정용 레진의 분말과 용액을 혼합하여 제 1군은 $28^{\circ}C$의 공기중에 보관하였고, 제 2군은 $28^{\circ}C$의 물에, 제 3군은 $28^{\circ}C$의 물과 30psi의 압력에, 제 4군은 $43^{\circ}C$의 물에, 제 5군은 $43^{\circ}C$의 물과 30psi의 압력하에 각각 보관하였고, 10분, 1시간, 12시간, 1일, 3일 경과 후에 각 시편을 Fourier 변환적외선분광법을 이용하여 중합률을 측정하여 다음과 같은 결론을 얻었다. 1. 모든 군에서 중합시간이 경과함에 따라 중합률도 지속적으로 증가하는 양상을 보였다. 10분 경과 후의 결과와 비교하여 볼 때, 제 1군은 12시간 경과 후부터 중합률의 증가가 유의성이 있었고, 제 2군과 3군, 4군, 5군은 1시간 경과 후부터 유의성이 있었다(p<0.05). 2. 10분과 1일, 3일 경과 후에 제 5군, 제 4군, 제 3군, 제 2군, 제 1군의 순서대로 중합률이 높았다. 3. 중합시 온도에 따른 비교에서, 1일 경과 후를 제외하고는 모든 시간에서 $43^{\circ}C$에서 중합시킨 군의 중합률이 $28^{\circ}C$에서 중합시킨 군의 중합률 보다 유의성 있게 높았다(p<0.05). 4. 압력은 12시간 경과 후를(p<0.05) 제외하고는 중합률에 영향을 주지 못했다. 5. 보관방법은 1시간 경과 후를(p<0.05) 제외하고는 중합률에 영향을 주지 못했다.

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CB(전환사채)의 투자효율성에 관한 실증연구 (A Study on the Investment Efficiency of CB(Convertible Bond))

  • 김선제
    • 서비스연구
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    • 제10권4호
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    • pp.71-88
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    • 2020
  • CB(전환사채)는 주식전환권을 행사한 이후부터는 채권이 아닌 주식으로 변한다는 점에서 채권과 주식의 성격을 갖고 있는 메자닌 증권이다. 본 연구는 투자자 입장에서 CB의 투자효율성 정도를 실증규명하고 효율적인 투자방안을 제시하는 것이 연구목적이다. 연구방법은 CB종목별로 표면이자율, 만기이자율, 채권만기일, 전환가격, 전환청구일 등을 조사한 후, 전환청구일 이후 발행회사의 일별 주가변동과 연결하여 CB에 대한 투자의 효율성과 CB의 주식전환효과가 어느 정도인지를 계량적으로 파악하고자 하였다. 연구 결과, 전환가격초과일수비율이 전환 가능한 날짜의 1/4 정도에 불과하여 투자효율성은 낮은 것으로 분석되었다. 전환일수익률은 평균 -6.3%, 만기일수익률은 평균 -5.2%여서 평균적으로 minus 수익률을 보여 투자자 기대와 다르게 산출되었다. 전환일수익률이 minus인 종목수가 plus인 종목수보다 2.4배 많았으며, 만기일수익률이 minus인 종목수가 plus인 종목수보다 3.7배 많아서 CB의 주식전환 기대수익률은 낮은 것으로 분석되었다. 연구기여도는 CB의 기대수익률이 높지 않다는 문제점을 도출하였고, 투자자 입장에서 CB를 매입할 때 유의사항을 정립한 데 있다.

치위생과 학생의 임상실습에 관한 의식실태조사 (Research on the Actual Condition of Consciousness that the Students in Dept. of dental hygiene have about Clinical Training)

  • 강용주;장계원
    • 한국치위생학회지
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    • 제4권1호
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    • pp.1-17
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    • 2004
  • The purpose of this study is to investigate the actual condition of consciousness that the students in Dept. of dental hygiene who will be engaged in dental hygiene at a dental office in the future have about a clinical training, to see whether there is any difference between the results, and then to provide fundamental data which can be helpful to develop more effective clinical training programs. For this, we investigated consciousness, that 114 daytime school students and evening school students(76 daytime school students and 38 evening school students) in Dept. of dental hygiene in J college have, using questionnaires on clinical training with Self-Administrated Method. SPSS 12.0 for Windows was used to analyze all of the questionnaires, and the results analyzed at meaningful level a=.05 are like followings: 1. The degree of satisfaction on clinical training was high as average 3.30 ; it was high in case of night training as 3.34, and of a dental office in a general hospital and an university hospital as 3.83. The degree of stress caused by clinical training was high as average 3.30, and it means that they are under relatively heavy pressure ; it was shown they got the most heavy stress as 3.39 at night, as 3.68 at a dental clinic 2. The students showed the highest tendency to recognize that clinical training is needed "for learning various clinical case experiences" as average 3.54 ; the students trained at daytime showed the highest average 3.55, and at a clinical hospital, the highest average 3.64. 3. In the study on an actual condition of consciousness about clinical training according to class difference by time(at day time and at night), there is meaningful difference between two kinds of class ; the students trained at day time showed average 2.68 that they don't like to attend, on the other hand the students at night showed higher average 2.84(p<.05). In the study on an actual condition of consciousness about clinical training according to the institutions they are trained, there is meaningful difference at satisfaction on learning method and amount of assignment : they show the highest degree of satisfaction on the learning method in case of working at a dental office in a general hospital and an university hospital as average 3.3(p<.0.1) ; the amount of assignment was shown most high at a dental clinic and a dental office in a general hospital and an university hospital as average 3.00 each(p<.05). 4. In the study of the degree of satisfaction on the clinical training, it has relatively high connections with learning contents(r=.656), learning methods(r=.497), special lessons and supplementary lessons(r=.472), the case they don't like attend at work (r=-.439), discriminatory treatment(r=-.25l), respectability on the senior dental hygienists(r=.464), a social status of a dental hygienist(r=.213), the degree of satisfaction from the relationship with other dental hygienists(r=.274), the degree of understanding which clinical training institutions have on the trained students(r=.494), trainers' ability to teach the students(r=.499). enthusiasm on guiding (r=.523), the amount of assignment(r=.333). 5. In the study on stress they got from a clinical training, it has relatively high connections with learning contents(r=-.399). learning methods(r=-.536), comprehension on training program(r=-.208), special lessons and supplementary lessons(r=-.306), the case they don't like attend at work(r=.467), discriminatory treatment(r=.366), respectability on the senior dental hygienists(r=-.341), a social status of a dental hygienist(r=-.l97), the degree of satisfaction from the relationship with another dental hygienists(r=-.289), the degree of understanding which clinical training institutions have on the trained students(r=-.430), trainers' ability to teach the students(r=-.396), enthusiasm on guiding(r=-.495).

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정맥내 통증 자가조절법에 의한 술후통증관리 1,590예에 대한 분석 (Analysis of 1,590 Patients of IV-PCA for Postoperative Pain Management)

  • 송선옥;지대림;구본업
    • The Korean Journal of Pain
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    • 제9권2호
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    • pp.354-362
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    • 1996
  • Background: We started postoperative pain management service using an intravenous patient-controlled analgesia (IV-PCA, PCA), which is known as convenient and effective analgesic method. In this report, we describe the efficacy and safety of PCA and the experience of developing an acute pain service to treat postoperative pain using a PCA. Methods: Practices of an acute pain service were started at a ward for general surgery after preparation of the standardized protocols for PCA. In each patient, PCA was connected following administration of initial loading doses of analgesics at recovery room after operation. All patients were checked by acute pain service team once or twice daily. The scope of acute pain service was gradually spread to other departments such as orthopedic, thoracic, obstetric and gynecologic departments by requests of patients or surgeons. We managed 1,590 patients during first 22 months. among them, nine hundred seventy two cases were prospectively evaluated for their analgesis efficacy and side effects of PCA. Results: The number of patients was increased day by day. the most common type of operation was gastrectomy (21.6%). Commonly used analgesics were nalbuphine (59%) and morphine (37%). The mean duration of PCA attachment was 3.3 days. The degree of analgesia on operation day was good in 44.8% and tolerable in 52.6% of patients. Only 3.9% of patients complained severe pain during their postoperative periods. One elderly patient experienced respiratory depression (0.06%) owing to accidental misuse of PCA by his relatives. Overall patient's satisfaction was over 93%. Conclusion: According to our experiences, we conclude that PCA is an effective, relatively safe and highly satisfactory method for postoperative pain management. Because of these advantages of PCA, the creation of our acute pain service using a PCA was successful and expanded rapidly.

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호소 및 하천에서 환경호르몬 Bisphenol-A의 분해거동에 관한 연구 (Degradation Behavior of Endocrine Disrupter Bisphenol-A in the Lake and Stream)

  • 강호;신경숙;김선기;진창숙
    • 환경생물
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    • 제19권1호
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    • pp.59-69
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    • 2001
  • 본 연구는 자연수중의 미생물을 식종원으로 하는 TOC-HANDAI법과 OECD 생분해법을 활용하여 자연수 환경내에서 환경호르몬물질인 비스페놀 A와 노닐페놀의 생분해성을 비교평가하였다. TOC-HANDAI법에 의한 BPA분해는 73-78% 이었고 OECD법은 이보다 다소 높은 77-81%를 나타내었다. 두 방법을 통한 BPA의 분해양상은 대체로 2단계를 거쳐 진행되었다. 즉 초기 1주일 이내에는 분해반응속도(k$_1$)가 0.24-0.34day$^{-1}$로 아주 빠르게 분해되었고, 그 후에는 아주 완만한 분해양상을 나타내었다(k$_2$는 0.02-0.05 $day^{-1}$). 이는 BPA가 자연수계에서 TOC로 약 20-25%가 중간생성물로 잔존하고 있음을 시사해 주고 있으며, 이 중간대사물이 완만한 분해과정에 기여하고 있다. 수계 환경에 따라 분해율이 현저하게 차이를 보이지만 노닐페놀은 20-48% 정도 밖에 분해되지 않는 난분해성 환경호르몬 물질임을 알 수 있다. 한편, 금강수계내 조사대상 하천과 대청호수의 조사지점에서 BPA는 모두 불검출되었다. 그러나 공단폐수 종말처리장 유입수에서 평균 25 ppb가 검출되었다.

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조혈모 세포 이식후 neutropenic fever환자에서의 aminoglycoside dosage에 관한 검토 (Aminoglycoside Dosage in Neutropenic Fever Patients after Tranplantation of Blood Stem Cells)

  • 최미영;김민정;김호순;신완균;김귀숙;손인자
    • 한국임상약학회지
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    • 제12권1호
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    • pp.7-12
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    • 2002
  • Pharmacokinetic parameters and dosage of aminoglycosides (AGs) were studied retrospectively in 36 patients with neutropenic fever after stem cell transplantation in Seoul National University Hospital from July 1996 to June 2001. AGs pharmacokinetic parameters were calculated with steady-state peak and trough serum drug concentrations by the method of Sawchuk and Zaske et at. The calculated aminoglycosides volume of distribution and clearance were greater than population value $(0.36\pm0.06\;L/kg,\;116\pm32\;ml/min/1.73\;m^2,\;respectively)$. The average dosage of aminoglycosides required to maintain optimal serum AGs concentration was also greater than recommended dose in insert paper. The average dosage of amikacin was $11\pm2.1$ mg/kg every 12 hours (In case of tobramycin, $2.09\pm0.37$ mg/kg every 8 hours or $2.59\pm0.20$ mg/kg every 12 hours). The relationship between AGs volume of distribution and sex, serum albumin (g/dl), body mass index $(kg/m^2)$, body weight change $(\%)$, the amount of fluid inpu (ml/kg/day), the degree of hematocrit decrease $(\%)$ were studied respectively. Univariate anlysis revealed that body mass index $(kg/m^2)$, the amount of fluid input (ml/kg/day) and the degree of hematocrit decrease $(\%)$ had significant correlation with aminoglycosides volume of distribution. But sex, serum albumin, body weight change $(\%)$ had no significant correlation with aminoglycosides volume of distribution.

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주가 예측 모델에서의 분할 예측을 통한 성능향상 탐구 (Exploring performance improvement through split prediction in stock price prediction model)

  • 여태건우;유도희;남정원;오하영
    • 한국정보통신학회논문지
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    • 제26권4호
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    • pp.503-509
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    • 2022
  • 본 논문의 연구 취지는 예측하고자 하는 다음 날과 이전 날의 시가 사이 변동률을 예측값으로 두고 시가를 예측하는 기존 논문들과는 다르게 예측하고자 하는 다음날의 주가 순위를 일정한 간격으로 분할하여 생성된 각 구간마다의 시가 변동률을 예측값으로 하는 모델을 통하여 최종적인 다음날의 시가 변동률을 예측하는 새로운 시계열 데이터 예측 방식을 제안하고자 한다. 예측값의 세분화 정도와 입력 데이터의 종류에 따른 모델의 성능 변화를 분석했으며 연구 결과 예측값의 세분화 정도에 따른 모델의 예측값과 실제값의 차이가 예측값의 세분화 개수가 3일 때 큰 폭으로 감소한다는 사실도 도출해 낼 수 있었다.

PDGF 함유매개체로서 탈회된 치근면의 효과 (The Effect of decalcified Root Surface as PDGF Carrier)

  • 우효상;이재목;서조영
    • Journal of Periodontal and Implant Science
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    • 제26권4호
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    • pp.889-905
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    • 1996
  • It is known that growth factors function as potent biologic mediators regulating numerous activities of wound healing via cell proliferation, migration and extracellular matrix formation and they also promote periodontal regeneration. But, method of growth factor application is controversial yet. So purpose of this study is to evaluate the effect of demineralized root surface as one of method of growth factor application. The ginigival fibroblasts were primary cultured and fifth or sixth subpassages were used in these experiments. In first experiment, root surface blocks demineralized with 100mg/ml tetracycline for 5 minutes and pH 1 citric acid for 3 minutes(experimental groups) and nonteminerilized root surface blocks (control groups) were placed in 100ng/ml PDGF-BB for 5 minutes. Then the cells were seeded on each root surface blocks and cultured for 6, 24, 48, 72 hours. In second experiment, root surface blocks deminerilized with tetracycline and citric acid and nondemineralized root surface blocks were placed in 200ng/ml PDGF-BB for 5 minutes and another non-demineralized root surfcae blocks were placed in DMEM without PDGF-BB. At 1, 2, 4, 6, 8 days, the cells were seeded in 24-well plate and using of each eluent, cultured for 72 hours. The results of the four determinants were presented as mean and S.D.. The results were as follows : The attachment and proliferation of human gingival fibroblast on root surface were more increased when PDGF-BB was applicated on root surfrace demineralized with tetracycline or citric acid than non-demineralized root surface. And, in comparision tetracycline with citric acid, there were more attachment and proliferation of human gingival fibroblast on root surface demineralized with tetracycline than citric acid, and proliferation of human gingival fibroblast on demineralized root surface was increased time dependently 1 day to 3 days. In second experiment using eluent, proliferation of human gingival fibroblast was more increased to 6 days when human gingival fibroblast was cultured in eluent that PDGF-BB was applicated on demineralized root surface than two control groups, and degree of proliferation was decreased time dependently 1 day to 6 days. Proliferation of human gingival fibroblast cultured in eluent without PDGF-BB was constant 1 day to 6 days. After 6 days, degree of proliferation of human gingival fibroblast was similar in four groups. This means that release duration of PDGF-BB from demineralized root surface is 6 days. And in comparision tetracycline with citric acid, there was more proliferation of human gingival fibroblast in tetracycline-treated group than citric acid. In conclusion, demineralized root surface as primary site for PDGF-BB application, especially demineralized with tetracycline has important roles in attachment and proliferation of human gingival fibroblast, and may be useful clinical applications in periodontal regenerative procedures.

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성인여성의 월경곤란증과 월경에 대한 태도 (Dysmenorrhea and Menstrual Attitudes in Adult Women)

  • 이은희;김증임;김혜원;이혜경;이숙희;강남미;허명행;박영숙
    • 여성건강간호학회지
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    • 제9권2호
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    • pp.105-112
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    • 2003
  • The survey was conducted to look out the characteristics of menstruation and it's management, menstrual attitudes and degree of dysmenorrhea in the adult women. The subjects were 601 women, aged 20 year old and over, selected by convenient sampling. The results were as follows; 1. The mean age of the subjects was 29.1 years, the subjects were consisted of 346 unmarried and 304 delivery experienced person. 2. The characteristics of menstruation were as follows ; irregular 167 person(27.8%), painful 451 person(75%), mean score of pain was 5.9 point and first day was most severe(45.1%). On the while, they have used the method to manage the pain such as "endure 50.8%", "to have a medicine 31.5%". 3. Menstrual attitudes were as follows; attitudes was negative such as it was meaningful as a woman (78.9%), only for birth a baby (51.6%), and menstruation was acceptable (42.9%), hope to get away(28.8%). 4. The degree of dysmenorrhea was a significant difference by age(F=4.0, P<0.01). Especially, in the subcategory, it was significant except for water retension. That is, lower concent ration(F=2.60, p<0.05), negative affect(F=3.09, p<0.05), behavior change(F=6.41, p<0.050), pain(F=3.89, p<0.01), autonomic nerve response(F=2.80, p<0.05). We can conclude there were many women to have negative attitudes to menstruation and first day was most severe dysmenorrhea and it was different by age. From this results, we may suggest as follows; 1. We suggest the program for women to have a positive attitudes will be developed. 2. We can suggest that we need to develop the active and effective method to control dysmenorrhea in the first day during menstruation.

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