• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.7
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• pp.1397-1404
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• 2015

Recently, high data rate transmission is required in maritime communication. In this paper, we consider multiple input multiple output (MIMO) spatial multiplexing (SM). However, the performance of SM is severly degraded due to spatial channel correlation and line-of-sight (LOS) component. In the maritime communication, the MIMO channel correlation and LOS are critical due to the lack of scatteres around the transmitter and/or the receiver. When the feedback of channel information is available, precoding can enhance the error performance by exploiting the channel information. However, it is difficult to derive closed-form solution considering both the correlation and LOS. In this paper, we present open-loop precoding-based spatial multiplexing transmission method by showing that the effect of performance for the correlation and LOS. It is shown that the open-loop precoding can mitigate the performance degradation due to the LOS as well as the correlation. Consequently, we expect that the proposed open-loop precoding can be adopted to the maritime communication system.

• The Journal of the Acoustical Society of Korea
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• v.21 no.5
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• pp.471-477
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• 2002

Recently, lip-reading has been studied actively as an auxiliary method of automatic speech recognition(ASR) in noisy environments. However, almost of research results were obtained based on the database constructed in indoor condition. So, we dont know how developed lip-reading algorithms are robust to dynamic variation of image. Currently we have developed a lip-reading system based on image-transform based algorithm. This system recognize 22 words and this word recognizer achieves word recognition of up to 53.54%. In this paper we present how stable the lip-reading system is in environmental variance and what the main variant factors are about dropping off in word-recognition performance. For studying lip-reading robustness we consider spatial valiance (translation, rotation, scaling) and illumination variance. Two kinds of test data are used. One Is the simulated lip image database and the other is real dynamic database captured in car environment. As a result of our experiment, we show that the spatial variance is one of degradations factors of lip reading performance. But the most important factor of degradation is not the spatial variance. The illumination variances make severe reduction of recognition rates as much as 70%. In conclusion, robust lip reading algorithms against illumination variances should be developed for using lip reading as a complementary method of ASR.

• Proceedings of the Korea Crystallographic Association Conference
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• 2003.05a
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• pp.18-18
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• 2003

Thioredoxin (Trx) is a small redox protein that is ubiquitously distributed from achaes to human. In diverse organisms, the protein is involved in various physiological roles by acting as electron donor and regulators of transcription and apoptosis as well as antioxidants. Sequences of Trx within various species are 27～69% identical to that of E. coli and all Trx proteins have the same overall fold, which consists of central five β strands surrounded by four α helices. The N-terminal cysteine in WCGPC motif of Trx is redox sensitive and the motif is highly conserved. Compared with general cysteine, the N-terminal cysteine has low pKa value. The result leads to increased reduction activity of protein. Recently, novel thio.edoxin-related protein (TRP14) was found from rat brain. TRP14 acts as disulfide reductase like Trx1, and its redox potential and pKa are similar to those of Trx1. However, TRP14 takes up electrons from cytosolic thioredoxin reductase (TrxR1), not from the mitochondrial thioredoxin reductase (TrxR2). Biological roles of TES14 were reported to be involved in regulating TNF-α induced signaling pathways in different manner with Trx1. In depletion experiments, depletion of TRP14 increased TNF-α induced phosphorylation and degradation of IκBα more than the depletion Trx1 did. It also facilitated activation of JNK and p38 MAP kinase induced by TNF-α. Unlike Trx1, TRP14 shows neither interaction nor interference with ASK1. Here, we determined three-dimensional crystal structure of TRP14 by MAD method at 1.8Å. The structure reveals that the conserved cis-Pro (Pro90) and active site-W-C-X-X-C motif, which may be involved in substrate recognition similar to Trx1 , are located at the beginning position of strand β4 and helix α2, respectively. The TRP14 structure also shows that surface of TRP14 in the vicinity of the active site, which is surrounded by an extended flexible loop and an additional short a helix, is different from that of Trx1. In addition, the structure exhibits that TRP14 interact with a distinct target proteins compared with Trx1 and the binding may depend mainly on hydrophobic and charge interactions. Consequently, the structure supports biological data that the TRP14 is involved in regulating TNF-α induced signaling pathways in different manner with Trx1.

• Korean Journal of Food Science and Technology
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• v.28 no.6
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• pp.1126-1134
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• 1996

The physical characteristics changes of carrots during drying were studied to minimize the quality degradation by applying improved drying process and pretreatment method. Physico-chemical properties of the product were analyzed, and then, drying mechanisms were explained by diffusion coefficients and drying models. In hot air drying process, the drying and rehydration efficiencies were high at low relative humidity and high temperature. Browning degree and specific volume also showed similar trend to drying efficiency. Diffusion coefficient, which describes moisture transfer, was also high at low relative humidity and at high temperature. It was verified using. Arrhenius equation that drying process was influenced by temperature. It was also observed during experiment that temperature changes were more effective in drying than relative humidity changes. Quadratic model was the most fittable in explaining the process. As a result of analyzing the experimental data with respect to the drying time, the contents of carotene and moisture could be modeled as a polynomial. As the air velocity increased, drying performance and rehydration efficiency increased.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.1
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• pp.20-33
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• 2002

Usage of ATM AAL2 packets becomes dominant to increase transmission efficiency of voice traffic in the backbone network. In case of voice service that uses AAL2 mechanism, if resources of network are enough, connection of new call is accepted. However, due to packets generated by the new call, transmission delay of packets from old calls can increase sharply. To control this behavior, in this paper we present an AAL2 buffer management scheme that allocates a virtual buffer to each call and after calculating its propagation delay variation(PDV), decides to drop packets coming from each call according to the PDV value. We show that this packet dropping algorithm can effectively prevent abrupt QoS degradation of old calls. To do this, we analyze AAL2 packet composition process to find a critical factor in the process that influences the end-to-end delay behavior and model the process by K-policy M/D/1 queueing system and MIN(K, Tc)-policy M/D/1 queueing system. From the mathematical model, we derive the probability generating function of AAL2 packets in the buffer and mean waiting time of packets in the AAL2 buffer. Analytical results show that the AAL2 packet dropping algorithm can provide stable AAL2 packetization delay and ATM cell generation time even if the number of voice sources increases dramatically. Finally we compare the analytical result to simulation data obtained by using the COMNET Ⅲ package.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.1
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• pp.30-39
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• 2014

HanPoong Leading (HPL)-04 were prepared with different oriental medicines (balk of Kalopanax pictus balk, Chaenomelis Fructus, Angelica gigas root, Zingiber officinale, Raphanus sativus Linne and Saururus chinensis Baill.) to investigate the protective effects of HPL-04 on cartilage degradation in knee osteoarthritis (OA). Rat articular chondrocytes incubated with rhIL-$1{\alpha}$ markedly increased matrix metalloproteinase (MMP)-2 and 9 activities, decreased cell viability and reduced chondrogenic gene expression. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, MMP-2 and 9 activities and real time RT-PCR indicated that HPL-04 counteracted these harmful effects in dose-dependent manner. In addition, for experimental OA in vivo, monosodium iodoacetate (MIA, 0.5 mg/50 ${\mu}L$) was injected into knee joints of rats and administered HPL-04 to rats for 4 consecutive weeks after MIA treatment. The experimental data showed that treatment with HPL-04 significantly prevented of MMP-2 and 9 activities in articular cartilage. Histopathological and micro-CT evaluations of the knee joints also revealed that HPL-04 effectively ameliorated MIA-induced degenerative OA. In conclusion, HPL-04 has potential applicability for the prevention and treatment of degenerative OA.

• Korean Chemical Engineering Research
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• v.51 no.5
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• pp.561-567
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• 2013

Mixed hardwood chips were pre-pulping extracted with green liquor prior to kraft pulping in order to recover hemicelluloses for use as biofuels. This green liquor solution containing mainly sodium sulfide and sodium carbonate was applied at different alkali charges (expressed as $Na_2O$) of 0, 1, 3, and 5% on dry wood weight. The extractions were performed at $160^{\circ}C$ for residence times ranging from about 1-2 h to determine the effect of extraction severity on composition of the pre-pulping extract. The severity of hemicellulose extraction time and green liquor charge controls the concentration of acetic acid and monosaccharide sugars available for downstream processing, the accumulation of degradation products such as organic acids and furans in the extract. As the alkali charge was increased, the amount of acetate side chains on the hemicelluloses and the dissolved lignin in the extract increased but the carbohydrate and sugars in the extract decreased appreciably. Hot water extraction (0% alkali addition) released the greatest amount of carbohydrates, up to 29.80 g/L measured as component sugars, but resulted in the greatest decrease in pulp yield. Meanwhile, pre-pulping extraction with 3% green liquor increased the pulp yield while greatly reducing the component sugars to 7.08 g/L. Fundamental data obtained in this study will allow selection of optimum hemicellulose extraction conditions for integrating the extraction operation into the Kraft pulping process.

• BMB Reports
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• v.53 no.6
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• pp.323-328
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• 2020

Matrix metalloproteinase 1 (MMP-1), a calcium-dependent zinccontaining collagenase, is involved in the initial degradation of native fibrillar collagen. Tissue necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine that is rapidly produced by dermal fibroblasts, monocytes/macrophages, and keratinocytes and regulates inflammation and damaged-tissue remodeling. MMP-1 is induced by TNFα and plays a critical role in tissue remodeling and skin aging processes. However, the regulation of the MMP1 gene by TNFα is not fully understood. We aimed to find additional cis-acting elements involved in the regulation of TNFα-induced MMP1 gene transcription in addition to the nuclear factor-kappa B (NF-κB) and activator protein 1 (AP1) sites. Assessments of the 5'-regulatory region of the MMP1 gene, using a series of deletion constructs, revealed the requirement of the early growth response protein 1 (EGR-1)-binding sequence (EBS) in the proximal region for proper transcription by TNFα. Ectopic expression of EGR-1, a zinc-finger transcription factor that binds to G-C rich sequences, stimulated MMP1 promoter activity. The silencing of EGR-1 by RNA interference reduced TNFα-induced MMP-1 expression. EGR-1 directly binds to the proximal region and transactivates the MMP1 gene promoter. Mutation of the EBS within the MMP1 promoter abolished EGR-1-mediated MMP-1 promoter activation. These data suggest that EGR-1 is required for TNFα-induced MMP1 transcriptional activation. In addition, we found that all three MAPKs, ERK1/2, JNK, and p38 kinase, mediate TNFα-induced MMP-1 expression via EGR-1 upregulation. These results suggest that EGR-1 may represent a good target for the development of pharmaceutical agents to reduce inflammation-induced MMP-1 expression.

• Journal of the Korea Society of Computer and Information
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• v.17 no.6
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• pp.1-11
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• 2012

As the process technology scales down, multi-core processors cause serious problems such as increased interconnection delay, high power consumption and thermal problems. To solve the problems in 2D multi-core processors, researchers have focused on the 3D multi-core processor architecture. Compared to the 2D multi-core processor, the 3D multi-core processor decreases interconnection delay by reducing wire length significantly, since each core on different layers is connected using vertical through-silicon via(TSV). However, the power density in the 3D multi-core processor is increased dramatically compared to that in the 2D multi-core processor, because multiple cores are stacked vertically. Unfortunately, increased power density causes thermal problems, resulting in high cooling cost, negative impact on the reliability. Therefore, temperature should be considered together with performance in designing 3D multi-core processors. In this work, we analyze the temperature of the cache in quad-core processors varying cache organization. Then, we propose the low-temperature cache organization to overcome the thermal problems. Our evaluation shows that peak temperature of the instruction cache is lower than threshold. The peak temperature of the data cache is higher than threshold when the cache is composed of many ways. According to the results, our proposed cache organization not only efficiently reduces the peak temperature but also reduces the performance degradation for 3D quad-core processors.

• Spatial Information Research
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• v.23 no.2
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• pp.11-20
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• 2015

Abstract Monitoring is the most critical element in implementing "forest carbon offset project" to enhance the visibility of CSR (Corporate Social Responsibility) in North Korea. This study is intended to explore monitoring potential in terms of forest carbon offset project using satellite image for Baekdu mountain of North Korea. The permanent record of standard satellite remote sensing system demonstrated its capability of presenting area-wide visual evidences of monitoring conditions in Mt. Baekdu mountain of North Korea (site suitability, carbon stock by forest biomass growth, carbon emission by forest biomass loss, deforestation and degradation, environmental, social and economic impact specified in the Carbon Sequestration Law). It doesn't seem very difficult to comply with monitoring requirements for "the forest carbon offset project" due to the probative value of satellite data. Therefore, it could be considerable or realistic approach to utilize CSR based forest carbon offset project as a point of reform and open-door in North Korea. It is anticipated that this research output could be used as a valuable reference for Korea-based enterprises to ensure monitoring potentials using satellite image in exploring forest carbon offset project sites in North Korea.