• Journal of Microbiology and Biotechnology
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• v.13 no.5
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• pp.778-782
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• 2003

In the course of screening anti-influenza agents from natural products, four neuraminidase inhibitors were isolated from the methanol extract of mushroom Microphorus affinis by purification using solvent partition, silica gel column chromatography, Sephadex LH-20, and semi-preparative HPLC. The chemical structures of these compounds were identified as ${\alpha}-lupeol$, methyl linoleate, methyl palmitate, and methyl oleate by means of spectral data including GC-MS, $^1H-,\;and\;^{13}C-NMR\;with\;IC_{50}$ values of 5.65, 7.07, 7.12, and $7.52\;\mu\textrm{M}$, respectively. They did not inhibit other glycosidases such as glucosidase, mannosidase, and galactosidase, indicating that they were relatively specific inhibitors of neuraminidase. The relationship between the fatty acid structure and inhibitory activity was investigated. The result showed that, in the case of an aliphatic linear hydrocarbon skeleton, at least one carboxyl (presumably any carbonyl) moiety and sixteen carbons were the necessary requirements for potent inhibition, whereas saturated, unsaturated, free, and ester forms did not have any significant effect on the activity.

• Archives of Plastic Surgery
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• v.33 no.3
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• pp.392-397
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• 2006

Orbital pseudotumor, also known as idiopathic orbital inflammatory syndrome(IOIS), may have protean clinical manifestations. IOIS should be determined with a diagnosis of exclusion, with evaluation directed toward eliminating other causes of orbital disease. Orbital MRI and CT are the important diagnostic tests, but serologic studies are necessary to exclude a systemic causes. Biopsy is usually not performed currently, as the risk of producing damage to vital structures within the orbital outweighs the benefits. Patients with multiple recurrences, or those unresponsive to therapy, should be treated of biopsy sample extraction. Corticosteroids are the mainstay of therapy and administered for several months to ensure remission. Radiotherapy may be used in patients who fail to respond to steroids or who have a rapidly progressive course. We analysed the data of two patients. There were no specific complications related to this treatment. We discussed the radiologic findings, treatment procedures, and other orbital diseases.

• Journal of Korean Academy of Nursing
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• v.37 no.7
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• pp.1212-1222
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• 2007

Purpose: The present study was done to discover the structure of universal actual experiences 'Considering tomorrow' of health and quality of life among North Korean refugees in terms of the socio-cultural context of South Korea. Method: The research question was 'what is the structure of the actual experience of 'Considering tomorrow?', which was examined based on the Parse's human becoming research method. Five North Korean adult refugees were recruited from a National Reconciliation Committee in Seoul/Incheon. The data was gathered from dialogues and collected from February, 2006 to November, 2006. Results: The structures found in this study were: 'hope for future life by taking responsibility and having harmony with South Koreans, by forming an integrated identification; having a chance for positive engagement, by attaining human freedom and hope; feeling respected, by assimilating self to the new world; getting freedom back, by facing a new challenge and preparing self for a new social role; overcoming cultural differences with fortified hardiness for survival, by making a decision for a life course with individual growth. In addition, conceptual integration was that 'Considering tomorrow is transforming the enabling-limiting values'. Conclusion: Health professionals need to know North Korean refugees' psychological difficulties, expectations of treatment, help seeking behavior, and expectations from mainstream culture. Additionally, understanding North Korean refugees' needs for reality, health education and a multi-disciplinary team approach are necessary to improve their health.

• Archives of Pharmacal Research
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• v.26 no.5
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• pp.367-374
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• 2003

In the course of screening neuraminidase inhibitors from herbal medicines, Reynoutria elliptica exhibited high inhibitory activity. Four active compounds were isolated from the ethyl acetate soluble fraction by consecutive purification using sillica gel, Sephadex LH-20 chromatography, and recrystallization. The chemical structures of these compounds were identified as 1,3,8-trihydroxy-6-methylanthraquinone (emodin) 1,8-dihydroxy-3-methoxy-6-methylanthraquinone (emodin 3-methyl ether; physcion), 1,3,8-trihydroxy-6-hydoxymethylanthraquinone ($\omega$-hydroxyemodin), and 3,5,4 -trihydroxystilbene (trans-resvertrol) by spectral data including MS, $^1 H-, and ^{13}C-NMR. The IC_{50}$ values of emodin, emodin 3-methyl ether, $\omega$-hydroxyemodin, and trans-resvertrol were 2.81, 74.07, 10.49, and 8.77 $\mu$M, respectively. They did not inhibit other glycosidase such as glucosidase, mannosidase, and galactosidase, indicating that they were relatively specific inhibitors of neuraminidase.

• Nuclear Engineering and Technology
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• v.40 no.2
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• pp.127-132
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• 2008

An experimental loop operating with water at supercritical conditions(25MPa, $600^{\circ}C$ in the test section) is designed for operation in the research reactor LVR-15 in UJV Rez, Czech Republic. The loop should serve as an experimental facility for corrosion tests of materials for in-core as well as out-of-core structures, for testing and optimization of suitable water chemistry for a future HPLWR and for studies of radiolysis of water at supercritical conditions, which remains the domain where very few experimental data are available. At present, final necessary calculations(thermalhydraulic, neutronic, strength) are being performed on the irradiation channel, which is the most challenging part of the loop. The concept of the primary and auxiliary circuits has been completed. The design of the loop shall be finished in the course of the year 2007 to start the construction, out-of-pile testing to verify proper functioning of all systems and as such to be ready for in-pile tests by the end of the HPLWR Phase 2 European project by the end of 2009.

• Journal of Welding and Joining
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• v.6 no.2
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• pp.30-39
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• 1988

Generally, as the welded region of weld structures has the incomplete bead and welded deposit which are able to behave like the surface cracks occasinally, there is a high possibility that the fatigue fracture of the weld structures is due to the surface cracks on the wlded region. This study was done to investigate the effects of post weld heat treatment (PWHT) on the fatigue behaviors of the surface crack of the heat affected zone (HAZ) for the multi-pass welds under the repetitive pure bending moment. The obtained results are summarized as follows : 1. The crack grows to the depth direction initially as the number of cylces increase, the amount of crack length is increased for the surface dir3ction and cive versa for the depth direction. 2. The fatigue life is increased in a order of as weld, PWHT specimens and parent. 3. As the number of cycles increase, the crack length is increased to th surface direction. The increase of the depth length is blunted at the center of specimen thickness. 4. The fatigue crack growth of PWHT specimens to the surface direction is dependent upon the holding time and applied stress during PWHT. In order words, the crack growth rate decreases with the holding time and increases with the applied stress during PWHT. 5. As the crack grows, the aspect formed in the course of crack propagation approaches to semicircle for parent and ellipse with the largest semidiameter for PWHT ($1/4hr, 15kgf/mm^2$) 6. At depth direction, it is difficult to apply to the paris' equation because of the scattered data between the crack growth rate and the stress intensity factor range.

• Applied Biological Chemistry
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• v.47 no.2
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• pp.164-169
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• 2004

In the course of our screening for biocontrol agent (BCA) against Streptomyces scabiei and S. turgidiscabies causing potato scab using 5,000 actinomtcete isolates, 9 antagonistic strains were selected as BCA candidates through in vitro and in vivo assay. An antagonistic strain, A020645 was highly resistant to some pesticides and antibiotics such as dazomet and mancozeb and showed high control value in vivo. Two bioactive compounds (compound A, B) were purified by anion exchange chromatography, solid phase (ODS) extraction, TLC and reverse phase HPLC. Their chemical structures are now thought to be nucleoside derivative as determined by $^1H-NMR$ data analysis. Their full chemical structures would be elucidated through $^{13}C-NMR$, HMQC and HMBC analyses. Further studies will be focused on fitness in soil and formulation of the BCA candidates.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.829-839
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• 2014

This study aims at investigating Korean EFL students' writing strategies through their rhetorical patterns and meaning-making for a writing task in an English writing classroom at a Korean university. The participants were the students and teacher in the course, and the data comprised nine pieces of students' opinion writing and interviews with the teacher. To analyze the data, a 'Claim-Support' pattern was adopted. The findings show that most students, 89%, demonstrated the same or similar elements in the 'Claim-Support' pattern for their textual structures and many parts of the meaning-making in their writing were originated from the textbook. These findings reflect that the students pursued the strategy of 'accommodation' in order to succeed in their academic writing regardless of the teacher's intention which focused on creativity and imagination in writing. The conclusion suggest that the students tend to establish their own ways of strategy to cope with the recontextualized setting for writing in English.

• Journal of KIISE:Computer Systems and Theory
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• v.31 no.3_4
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• pp.145-151
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• 2004

We present an efficient data structure to obtain the range minima in an away in constant time. Recently, suffix ways are extensively used to search DNA sequences fast in bioinformatics. In constructing suffix arrays, solving the range minima problem is necessary When we construct suffix arrays, we should solve the range minima problem not only in a time-efficient way but also in a space-efficient way. The reason is that DNA sequences consist of millions or billions of bases. Until now, the most efficient data structure to find the range minima in an way in constant time is based on the method that converts the range minima problem in an array into the LCA (Lowest Common Ancestor) problem in a Cartesian tree and then converts the LCA problem into the range minima problem in a specific array. This data structure occupies O( n) space and is constructed in O(n) time. However since this data structure includes intermediate data structures required to convert the range minima problem in an array into other problems, it requires large space (=13n) and much time. Our data structure is based on the method that directly solves the range minima problem. Thus, our data structure requires small space (=5n) and less time in practice. As a matter of course, our data structure requires O(n) time and space theoretically.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.495-500
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• 2006

Satellite systems for objects positioning appeared indispensable for performing basic tasks of maritime navigation. Navigation, understood as safe and effective conducting a vehicle from one point to another, within a specific physical-geographical environment. [Kopacz, $Urba{\acute{n}}ski$, 1998]. However, the systems have not solved the problem of accessibility to reliable and highly accurate information about a position of an object, especially if surveyed toward on-shore navigational signs or in sea depth. And it's of considerable significance for many navigational tasks, carried out within the frameworks of special works performance and submarine navigation. In addition, positioning precisely the objects other than vessels, while executing hydrographical works, is not always possible with a use of any satellite system. Difficulties with GPS application show up also while positioning such off-lying dangers as wrecks, underwater and aquatic rocks also other naturaland artificial obstacles. It is caused by impossibility of surveyors approaching directly any such object while its positioning. Moreover, determination of vessels positions mutually (mutual geometrical relations) by teams carrying out one common tasks at sea, demands applying the navigational techniques other than the satellite ones. Vessels'staying precisely on specified positions is of special importance in, among the others, the cases as follows: - surveying vessels while carrying out bathymetric works, wire dragging; - special tasks watercraft in course of carrying out scientific research, sea bottom exploration etc. The problems are essential for maritime economy and the Country defence readiness. Resolving them requires applying not only the satellite navigation methods, but also the terrestrial ones. The condition for implementation of the geo-navigation methods is at present the methods development both: in aspects of their techniques and technologies as well as survey data evaluation. Now, the classical geo-navigation comprises procedures, which meet out-of-date accuracy standards. To enable meeting the present-day requirements, the methods should refer to well-recognised and still developed methods of contemporary geodesy. Moreover, in a time of computerization and automation of calculating, it is feasible to create also such software, which could be applied in the integrated navigational systems, allowing carrying out navigation, provided with combinatory systems as well as with the new positioning methods. Whereas, as regards data evaluation, there should be applied the most advanced achievements in that subject; first of all the newest, although theoretically well-recognised estimation methods, including estimation [Hampel et al. 1986; $Wi{\acute{s}}niewski$ 2005; Yang 1997; Yang et al. 1999]. Such approach to the problem consisting in positioning a vehicle in motion and solid objects under observation enables an opportunity of creating dynamic and interactive navigational structures. The main subject of the theoretical suggested in this paper is the Interactive Navigational Structure. In this paper, the Structure will stand for the existing navigational signs systems, any observed solid objects and also vehicles, carrying out navigation (submarines inclusive), which, owing to mutual dependencies, (geometrical and physical) allow to determine coordinates of this new Structure's elements and to correct the already known coordinates of other elements.