Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Neuraminidase Inhibitors from Reynoutria elliptica

  • Lee, Chu-Hyun (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University) ;
  • Kim, Sang-In (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University) ;
  • Lee, Kyung-Bok (College of Medicine, Konyang University) ;
  • Yoo, Yung-Choon (College of Medicine, Konyang University) ;
  • Ryu, Si-Young (Korea Research Institute of Chemical Technology) ;
  • Song, Kyung-Sik (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University)
  • Published : 2003.05.01
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Abstract

In the course of screening neuraminidase inhibitors from herbal medicines, Reynoutria elliptica exhibited high inhibitory activity. Four active compounds were isolated from the ethyl acetate soluble fraction by consecutive purification using sillica gel, Sephadex LH-20 chromatography, and recrystallization. The chemical structures of these compounds were identified as 1,3,8-trihydroxy-6-methylanthraquinone (emodin) 1,8-dihydroxy-3-methoxy-6-methylanthraquinone (emodin 3-methyl ether; physcion), 1,3,8-trihydroxy-6-hydoxymethylanthraquinone ($\omega$-hydroxyemodin), and 3,5,4 -trihydroxystilbene (trans-resvertrol) by spectral data including MS, $^1 H-, and ^{13}C-NMR. The IC_{50}$ values of emodin, emodin 3-methyl ether, $\omega$-hydroxyemodin, and trans-resvertrol were 2.81, 74.07, 10.49, and 8.77 $\mu$M, respectively. They did not inhibit other glycosidase such as glucosidase, mannosidase, and galactosidase, indicating that they were relatively specific inhibitors of neuraminidase.

Keywords

References

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