• Journal of the Korea Society of Computer and Information
• /
• v.14 no.5
• /
• pp.37-44
• /
• 2009

Recently, as the quality of multimedia data gets higher, multimedia servers require larger storage capacity and higher I/O bandwidth. In these large scale multimedia servers, the load-unbalance problem among disks due to the difference in access frequencies to multimedia objects according to their popularities significantly affects the system performance. To address this problem, many data replication schemes have been proposed. In this paper, we propose a novel data migration/replication scheme to provide better storage efficiency and performance than the dynamic data replication scheme which is typical data replication scheme employed in multimedia servers. This scheme can reduce the additional storage space required for replication, which is a major defect of replication schemes, by decreasing the number of copies per object. The scheme can also increase the number of concurrent users by increasing the caching effect due to the reduced lengths of the intervals among requests for each object.

• Journal of the Korea Society of Computer and Information
• /
• v.17 no.5
• /
• pp.1-7
• /
• 2012

In this paper, we design and implement the simulator for WAN storage replication model performance evaluation in cloud computing environment. Each cloud of simulator is composed of virtual machine emulator and storage emulator. The virtual machine emulator is composed of read/write ratio module, the read/write sequence combination module, and the read/write request module. The storage emulator is composed of storage management module, data transfer module, read/write operations module, and overhead processing module. Using the simulator, we evaluate performance of migration scheme, pre-copy and the post-copy, considering about read/write ratio, network delay, and network bandwidth. Through simulation, we have confirmed that the average migration time of pre-copy was decreased proportional to the read operation. However, average migration time of post-copy was on the increase. Also, the average migration time of post-copy was increased proportional to the network delay. However, average migration time of pre-copy was shown uniformly. Therefore, we show that pre-copy model more effective to reduce the average migration time than the post-copy model. The average migration time of pre-copy and post-copy were not affected by the change of network bandwidth. Therefore, these results show that selects the storage replication model to be, the network bandwidth know not being the important element.

• The KIPS Transactions:PartD
• /
• v.12D no.2 s.98
• /
• pp.289-302
• /
• 2005

The mobile agent has very various performance according to the element of communication number of times between hosts, quantity of transmission data agent's size, network state etc. specially, migration method is caused much effect in whole performance of distributed system. Most existing migration methods have simplicity structure that it moves doing to accumulate continuously result after achieving task by visiting host in the fixed order. Therefore, in case there are situation such as fault, obstacle, and service absence etc. This can be inefficient due to mobile agent increased network required time. In this paper, we design and implementation Multicast Migration Model for minimizing network required time by solving this problems. Multicast Migration Model includes components such as mobile agent including call module and naming agent, which provides object replication information and distributed server's location transparence. And we evaluate and compare with existing migration method applying prototype system to verify implemented migration model.

• Journal of KIISE:Software and Applications
• /
• v.37 no.7
• /
• pp.503-517
• /
• 2010

Service-oriented computing, the effective paradigm for developing service applications by using reusable services, becomes popular. In service-oriented computing, service consumer has no responsibility for managing services, just invokes services what service providers are producing. On the other hand, service providers should manage any resources and data for service consumers can use the service anytime and anywhere. However, it is hard service providers manage the quality of the services because an unspecified number of service consumers. Therefore, service scalability for providing services with higher quality of services specified in a service level agreement becomes a potential problem in service-oriented computing. There have been many researches for scalability in network, database, and distributed computing area. But a research about a definition of service scalability and metrics of measuring service scalability is still not mature in service engineering area. In this paper, we construct a service network which connects multiple service nodes, and integrate all the resources to manage it. And we also present a service scalability framework for managing service scalability by using a mechanism of service migration or replication. In section 3, we, firstly, present the structure of the scalability management framework and basic functionalities. In section 4, we propose scalability enhancement mechanism which is needed to release functionality of the framework. In section 5, we design and implement the framework by using proposed mechanism. In section 6, we demonstrate the result of our case study which dynamically manages services in multi-nodes environment by applying our framework. Through the case study, we show the applicability of our scalability management framework and mechanism.

• Molecules and Cells
• /
• v.43 no.6
• /
• pp.551-571
• /
• 2020

Nuclear receptor-related 1 (Nurr1) protein has been identified as an obligatory transcription factor in midbrain dopaminergic neurogenesis, but the global set of human NURR1 target genes remains unexplored. Here, we identified direct gene targets of NURR1 by analyzing genome-wide differential expression of NURR1 together with NURR1 consensus sites in three human neural stem cell (hNSC) lines. Microarray data were validated by quantitative PCR in hNSCs and mouse embryonic brains and through comparison to published human data, including genome-wide association study hits and the BioGPS gene expression atlas. Our analysis identified ~40 NURR1 direct target genes, many of them involved in essential protein modules such as synapse formation, neuronal cell migration during brain development, and cell cycle progression and DNA replication. Specifically, expression of genes related to synapse formation and neuronal cell migration correlated tightly with NURR1 expression, whereas cell cycle progression correlated negatively with it, precisely recapitulating midbrain dopaminergic development. Overall, this systematic examination of NURR1-controlled regulatory networks provides important insights into this protein's biological functions in dopamine-based neurogenesis.

• Molecules and Cells
• /
• v.43 no.5
• /
• pp.469-478
• /
• 2020

Hepatitis C virus (HCV) propagation is highly dependent on cellular proteins. To identify the host factors involved in HCV propagation, we previously performed protein microarray assays and identified the LIM and SH3 domain protein 1 (LASP-1) as an HCV NS5A-interacting partner. LASP-1 plays an important role in the regulation of cell proliferation, migration, and protein-protein interactions. Alteration of LASP-1 expression has been implicated in hepatocellular carcinoma. However, the functional involvement of LASP-1 in HCV propagation and HCV-induced pathogenesis has not been elucidated. Here, we first verified the protein interaction of NS5A and LASP-1 by both in vitro pulldown and coimmunoprecipitation assays. We further showed that NS5A and LASP-1 were colocalized in the cytoplasm of HCV infected cells. NS5A interacted with LASP-1 through the proline motif in domain I of NS5A and the tryptophan residue in the SH3 domain of LASP-1. Knockdown of LASP1 increased HCV replication in both HCV-infected cells and HCV subgenomic replicon cells. LASP-1 negatively regulated viral propagation and thereby overexpression of LASP-1 decreased HCV replication. Moreover, HCV propagation was decreased by wild-type LASP-1 but not by an NS5A binding-defective mutant of LASP-1. We further demonstrated that LASP-1 was involved in the replication stage of the HCV life cycle. Importantly, LASP-1 expression levels were increased in persistently infected cells with HCV. These data suggest that HCV modulates LASP-1 via NS5A in order to regulate virion levels and maintain a persistent infection.

• KIISE Transactions on Computing Practices
• /
• v.22 no.1
• /
• pp.44-49
• /
• 2016

Recently, data has been growing dramatically along with the growth of social media and digital devices. A distributed memory processing system has been used to efficiently process large amounts of data. However, if a load is concentrated in a certain node in distributed environments, a node performance significantly degrades. In this paper, we propose a load balancing scheme to distribute load in a distributed memory environment. The proposed scheme replicates hot data to multiple nodes for managing a node's load and migrates the data by considering the load of the nodes when nodes are added or removed. The client reduces the number of accesses to the central server by directly accessing the data node through the metadata information of the hot data. In order to show the superiority of the proposed scheme, we compare it with the existing load balancing scheme through performance evaluation.