• BMB Reports
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• v.56 no.3
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• pp.178-183
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• 2023

Huntington's disease (HD) is a neurodegenerative disorder, of which pathogenesis is caused by a polyglutamine expansion in the amino-terminus of huntingtin gene that resulted in the aggregation of mutant HTT proteins. HD is characterized by progressive motor dysfunction, cognitive impairment and neuropsychiatric disturbances. Histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase, has been shown to induce transport- and release-defect phenotypes in HD models, whilst treatment with HDAC6 inhibitors ameliorates the phenotypic effects of HD by increasing the levels of α-tubulin acetylation, as well as decreasing the accumulation of mutant huntingtin (mHTT) aggregates, suggesting HDAC6 inhibitor as a HD therapeutics. In this study, we employed in vitro neural stem cell (NSC) model and in vivo YAC128 transgenic (TG) mouse model of HD to test the effect of a novel HDAC6 selective inhibitor, CKD-504, developed by Chong Kun Dang (CKD Pharmaceutical Corp., Korea). We found that treatment of CKD-504 increased tubulin acetylation, microtubule stabilization, axonal transport, and the decrease of mutant huntingtin protein in vitro. From in vivo study, we observed CKD-504 improved the pathology of Huntington's disease: alleviated behavioral deficits, increased axonal transport and number of neurons, restored synaptic function in corticostriatal (CS) circuit, reduced mHTT accumulation, inflammation and tau hyperphosphorylation in YAC128 TG mouse model. These novel results highlight CKD-504 as a potential therapeutic strategy in HD.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.66-69
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• 2000

• Clinics in Shoulder and Elbow
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• v.9 no.1
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• pp.96-104
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• 2006

Purpose: To evaluate and compare the results of children with displaced supracondylar fractures of humerus treated with open reduction and pinning with closed reduction and pinning. Materials and Methods: From March 2002, we treated 17 patients with completely displaced supracondylar fractures under the age of 7 with a minimal follow up period of 6 months. 9 patients were treated with closed reduction and pinning and 8 patients were treated with open reduction and pinning. The clinical results were evaluated with Flynn's criteria. Time to bone union was also analyzed for these two set of patients. Results: The group treated with open reduction had 6 excellent and 2 good results for change in carrying angles, 5 excellent, 2 good and 1 fair results for motion loss evaluated by Flynn's criteria. The average time to bony union for this group was 5.8 weeks. The group treated with closed reduction had 6 excellent, 2 good, and 1 fair results for change in carrying angles and 7 excellent, 1 good and 1 fair results for motion loss. The average time to bony uinon for this group was 3.7 weeks. Conclusion: In treating completely displaced supracondylar fractures of humerus in children, the closed reduction method and open reduction method all showed good results. But the operation time, duration of hospital stay and time to union was somewhat shorter for the patients treated with closed redution and pinning.

• The Journal of Internal Korean Medicine
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• v.37 no.5
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• pp.876-884
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• 2016

Objective: To report a case of a patient with a psychosomatic disorder who complained of hyperventilation and was treated with oriental medical treatments and emotional freedom techniques (EFTs). Methods: The patient was diagnosed as having a psychosomatic disorder through an interview and several psychological tests, such as the house-tree-person (HTP) and the person in the rain (PITR) tests. We treated the patient with oriental medical treatments that included herbal medications, western medications, moxibustion, cupping, and EFT. Results: After the treatments, the clinical symptoms of the patient were improved. Conclusions: Oriental medical treatments and EFT may be effective treatments for psychosomatic disorders.

• The Journal of Korean Society of Virology
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• v.27 no.2
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• pp.137-141
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• 1997

We evaluated Immunochromatographic assay kit to screen HBsAg in human serum. When the reference HBsAg was applyed to ICA, HA and EIA kits, the limit of detection for HBsAg were found out to be 4, 2 and 0.25 ng/ml respectively. But ICA kit required 5 minutes to read the result whereas HA and EIA kit more than one hour. The sensitivity was 97% (29 of 30 samples) and the specificity 100% (45 samples) compared with conventional EIA. The ICA kit needs no instrument or machine to perform the test contrary to the conventional methods. Therefore, this rapid and sensitive ICA kit can be used for HBsAg-screening, especially in the emergency room and in the scene of the accident.

• Journal of architectural history
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• v.25 no.4
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• pp.31-44
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• 2016

Geum'yeok-dang house in Andong was originally constructed in 1558. The original floor plan of the upper base featured a 90-degree tilted '日' shape, and had inner court(內庭) on each side of 'Jungdang(中堂, center hall)' building that was placed on the south-north axis. When designing the building, the Neo-Confucian client of Geum'yeok-dang applied his understanding of how Ga'rye("家禮") defined the structure of ritual space. Consequently, 'Daecheong(大廳)', the place where guests were greeted and ancestral rites and coming of age ceremonies for male were held, was built in a protruding fashion. 'Jungdang'[otherwise known as 'Jeongchim(正寢)'], where coming of age ceremonies for females were held, the master of the house faced death, and memorials for close ancestors were held, was placed at the center of the residence on the south-north axis. The Geum'yeok-dang today was greatly renovated in the early and mid 18th century, due to the spread of 'Ondol' heating system. As the Ondol heating system became popular, the pre-existing drawbacks and the inconvenience of the house stood out clearly. As a result, the house was renovated into today's structure consisting of '口' shape 'Anchae' and 'Daecheongchae' in separate building.

• Korean Institute of Interior Design Journal
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• v.15 no.6 s.59
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• pp.11-18
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• 2006

Ceaseless studies and efforts to verify today's Korean nature that has advanced into digital era of 21C are continued. At this point of time, it is required to look back our heritage in diverse points of view free from theoretical and formal studies on our traditional spaces. Phenomenology, which is rising as the important theme in recent modem Western philosophy, suggests interesting analyses from this standpoint. This study is intended to analyze Korea's traditional residents 'Dok Rak Dang' based on Marleau-Ponty's phenomenology, and explore phenomenological spatial principle and new point of view implied in it. Particularly, Marleau-Ponty's phenomenology is the philosophy that shows intersubjective and involved relations between space and human, and intended to accept coincidental incidents occurred by human's action truthfully as they are. With three spatial concepts of direction, depth, and movement in Ponty's phenomenology, and placement nature of the earth that intercombine with human's body who is subject of these three concepts as analyze tool, Korea's traditional residents, 'Dok Rak Dang' has been analyzed. More segmentalized analyses have been deduced, and principle of phenomenology, that perceptions such as direction, depth, movement, etc are working synthetically to be accepted as essence of experiences could also be found in Dok Rak Dang.

• Journal of Food Hygiene and Safety
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• v.37 no.6
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• pp.429-429
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• 2022

• 보존과학연구
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• s.29
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• pp.45-64
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• 2008

'No-An-Dang' in 'Un-Hyeun palace' was using as a guesthouse by 'dea-won-goon' built in 1864. 'No-An-Dang tablet' exhibited in 'No-An-Dang' seems to be made by using the letters which were written by 'Choo-sa Kim Jeong-Hee'. This tablet was manufactured by special processes; wood frame which was made of a Korean white pine was drawn patterns by variety pigment and latticed inside are joined with 3 of horizontal square wooden sticks and 7 of vertical square wooden sticks, then several sheets of the paper mulberry put on this frame and sheets cut along the edge of letter attached lastly. This structure of tablet could cause more conservation problems than only made in wooden structures. Therefore, replica was made and exhibited in bad condition and original one kept in museum storage for effective conservation of artefacts.

• Journal of architectural history
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• v.15 no.4
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• pp.87-105
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• 2006

Dok-Rak-Dang and Hyang-Dan, upper class houses of Chosun Dynasty on the early and mid 16th century, are generally known as specific style houses among traditional residences in Korea. Architectural singularities of these two residences are summarized as double facades, uncertain circulation, self-secluding construction, dilemmatic structure, and rotative circulation that are far from architectonic principle of that time. Characters of Deconstructionist Art, deconstruction of binary oppositions, double session, displacement without reversal, and paradox, are very similar to those of two residences both as a material phenomenon and as a metaphysical idea. Thus, this paper attempt to analyze architectural singularities of Dok-Rak-Dang and Hyang-Dan with the perspective of Deconstructionist Art Theory.