• Proceedings of the PSK Conference
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• 2003.04a
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• pp.252.3-252.3
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• 2003

An effective and convenient regioselective reduction of 5-benzylidene 2,4-thiazolidinedione derivatives to the corresponding 5-benzyl 2,4-thiazolidinedione derivatives has been accomplished using 3,5-dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine (Hantzsch dihydropyridine ester: HEH) with silica gel as an acid catalyst in a good yield.

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.237.2-237.2
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• 2001

• YAKHAK HOEJI
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• v.42 no.4
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• pp.437-446
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• 1998

The distribution, metabolism and excretion of CKD-602{20(S)-7-[2-(N-Isopropylamino)ethyl]camptothecin HCI), a new camptothecin derivative, were investigated in rats after a sing le administration of CKD-602. 1. The tissue levels of CKD-602 given to mice by the intravenous route at a dose of 20mg/kg were the highest in intestine, followed in descending order by kidney, liver, stomach,lung, heart, spleen and plasma. The concentrations of CKD-602 after 24hrs decreased to less than 2% of the peak level in most tissues except the skin. The urinary and fecal excretion of CKD-602 were 47.6% and 44.4% of the administered dose, respectively, with 0.7% remaining in the rinse. 2. After administration of CKD-602 at 10mg/kg in rats, metabolism of this compound was examined in plasma, urine, and feces. The plasma samples were collected for 24hr, urinary and fecal samples for 72hr. While any peak of CKD-602 in HPLC chromatograms was not detected from plasma and urine it was detected in feces (peaks, 9.8 min). However, additional peak area was about 0.5% of the peak area of parent CKD-602. Therefore, CKD-602 may be eliminated with the parent form and rarely metabolized in the body. 4. After I.v. administration of CKD-602 at 10mg/kg in rats, urinary and fecal excretions were examined for 72hrs post dose period. 87% of total urinary excretion of CKD-602 was excreted within 8hr after administration, 53%, and 32% of total fecal excreted amounts were determined in 0-24 hr and 24-48hr periods, respectively. The total excretion amounts of CKD-602 into urine and feces were 94% of the administered dose.

• Journal of architectural history
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• v.11 no.4 s.32
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• pp.21-34
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• 2002

Hoojo-dang is the Beol-dang of Gwangsan Kim's family in Gunja-ri, Yeaan This study aims to reconstruct the architectural drawings of the building through actual measurement, and by investigating documentary records of Kim's family, to trace and infer when the building was originally constructed. In doing this, it enables to identify and describe the architectural types and characteristics. The results are as follows, 1) Hoojo-dang was established in 1567 by Kim Bu-pil(1516-1577). From the beginning, Hoojo-dang, Byeol-myo(family shrine) and Ju-sa(shrine kitchen) were situated in the separate area from An-chae(main building). Later the Ik-rang(additional transept part) of Hoojo-dang was added to its main body as a room for entertainment. 2) The types of floor plan and windows of Hoojo-dang are similar to those of the lecture halls of Dosan-seowon, Sosu-seowon and Yeaan-hyangyo nearby. The main reason for the similarity of floor plan and window types in those buildings is that the students of the great Korean Confucian, Lee Hwang in 16th, managed and controlled those constructions. 3) The separate area composed of Hoojo-dang, Byeol-myo and Ju-sa was mainly designed for satisfying Confucian ceremonial principles. In addition, there are lifting doors designed for elevating the spatial flexibility.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.7
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• pp.1112-1118
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• 2004

This study was carried out to evaluate the free radical scavenging effect and antioxidant effect of Cham-Dang-Gui (Angelica gigas) on cyclophosphamide (CYP) injected rats. Rats were divided into five groups： CON (normal group), ANS (CYP-injected and normal diet group), AND (CYP-injected and normal diet and Cham-Dang-Gui-treated group), ALS (CYP-injected and low iron diet group), and ALD (CYP-injected and low iron diet and Cham-Dang-Gui-treated group). CYP (30 mg/kg) was intraperitoneally injected to rats for early 3 days. Saline or Cham-Dang-Gui was administrated orally for entire experimental period. DPPH radical scavenger activity was measured by DPPH method, it was shown higher in methanol extract (81.5％) than in water extract (66.3％) of Cham-Dang-Gui. We observed the preventive effects of Cham-Dang-Gui on lipid oxidation of liver and protein oxidation of plasma. Hepatic SOD and catalase activities were significantly higher in CYP-injected group (ANS) than CON group, but SOD activity was slightly lowered in Cham-Dang-Gui treated group than CYP-injected group (ANS). These results suggest that extract of Cham-Dang-Gui could be useful for functional materials to reduce the oxidation of lipids and protein induced by free radicals.

• Journal of the Korean Society of Costume
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• v.50 no.5
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• pp.5-24
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• 2000

The results from the consideration of this are as follows. 1. Silla Kingdom has been the name of chronolongical era, from king Bubhung 2nd years to Jinduck 4 years. 2. From Dang dynasty has been received to King of Silla, first class-third class of Dang's office and rank. 3. After unification of Silla Kingdom, Dang dynasty's envoy and missionary and many commercial men and artist come froze Dang to Silla, threfore, influenced their costume habbits and behabiers from royal families costumes and common peaples costume, without concern of that one's social position. 4. Ancient Silla Kingdom performed a religious service an emperor's ceremony, but after unification, performed King's level a religious service, therefor King's ceremonial costumes are Dang dynasty's king's level Myunryukwanbok.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.252-252
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• 2002

Radiation synovectomy is an useful alternative treatment to rheumatoid arthritis and Re$\^$188/ is suggested as an ideal radiopharmaceutical agents because beta ray (2.1 MeV) emitted from Re$\^$188/ is appropriate for synovial cell ablation and gamma ray (155 KeV) is ideal for dosimetry. Its' ideal particle size (2-5 mm) was achieved by conjugation with tin-colloid, In this study, we investigated the toxicity, stability and biodistribution to evaluate the suitability of DA-7911 as a synovectomy agent. (omitted)

• Journal of Microbiology and Biotechnology
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• v.32 no.5
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• pp.638-644
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• 2022

Probiotics modulate the gut microbiota, which in turn regulate immune responses to maintain balanced immune homeostasis in the host. However, it is unclear how probiotic bacteria regulate immune responses. In this study we investigated the immunomodulatory effects of heat-killed probiotics, including Lactiplantibacillus plantarum KC3 (LP3), Lactiplantibacillus plantarum CKDB008 (LP8), and Limosilactobacillus fermentum SRK414 (LF4), via phagocytosis, nitric oxide (NO), and pro-inflammatory cytokine production in macrophages. We thus found that heat-killed LP8 could promote the clearance of foreign pathogens by enhancing the phagocytosis of macrophages. Treatment with heat-killed LP8 induced the production of NO and pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β. In addition, heat-killed LP8 suppressed the production of NO and cytokines in LPS-induced RAW264.7 cells, suggesting that heat-killed LP8 exerts immunomodulatory effects depending on the host condition. In sum, these results indicate that heat-killed LP8 possesses the potential for immune modulation while providing a molecular basis for the development of functional probiotics prepared from inactivated bacterial cells.

• Korean Institute of Interior Design Journal
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• v.19 no.6
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• pp.241-248
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• 2010

The population of the elderly is rapidly increased because maturation of the social welfare system and development of medical technology. However, welfare environments for the elderly are poor either in its quality or its quantity. The aims of this study is to confirm the space improvement possibility to change the Gyung Ro Dang to the senior life support center as a community welfare service network. This study is done by the comparative analysis between existing Gyung Ro Dang in korea and former cases in Japan based on the elderly's facility preference. The facility's space reprogramming alternative from that analysis is applied to change the Gyung Ro Dang to a network facility for the regional senior life support. Afterward, it is proposed that first, facilities should be expanded scale by the new education and health improvement facilities functional room that the modern elderly need. second, Facility space will be reconstitution because the Gyung Ro Dang have to be extended it's role as a community welfare network.

• Journal of architectural history
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• v.26 no.2
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• pp.31-42
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• 2017

This study investigates how the spatial recognition structure is emerging through the case of rectangular plan combined with a combination of Dang-Sil(堂室) and Gong(工) shape roof, and identifies a type of architecture in the early Joseon Dynasty that has never been revealed. The conclusion of this study is as follows. First, the Dang and the Sil are connected to each other, but the architectural elements such as pillars, frame, and windows are distinguished and appear as separate buildings. Second, the distinction between Dang and Sil is evident by the difference in the number of ridges and the shape of the roof. In addition, the roof and roof framework of the independent rooms and the rooms were common in the right angled architecture where the direction and the expandability of each structure were maintained. Third, the construction of the Dang-Sil combined structure, in which two or more structure frameworks were combined with the rectangular combined flat roof structure, gradually changed into a single structure with a single ridge. Fourth, this change means that people of the early Joseon Dynasty recognized the Dang and Sil as separate architecture, but the strict sense of spatial separation has disappeared over time.