Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

DA-7911, rhenium-188 ($Re^{188}$) tin colloid. as a strong candidate agent for radiation synovectomy

  • Shin, Chang-Yell (Research Laboratories, Dang-A Pharm. Co. Ltd.) ;
  • Jung, Mi-Young (Research Laboratories, Dang-A Pharm. Co. Ltd.) ;
  • Lee, In-Ki (Research Laboratories, Dang-A Pharm. Co. Ltd.) ;
  • Son, Mi-Won (Research Laboratories, Dang-A Pharm. Co. Ltd.) ;
  • Kim, Soon-Hoe (Research Laboratories, Dang-A Pharm. Co. Ltd.) ;
  • Kim, Won-Bae (Research Laboratories, Dang-A Pharm. Co. Ltd.)
  • Published : 2002.10.01
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Abstract

Radiation synovectomy is an useful alternative treatment to rheumatoid arthritis and Re$\^$188/ is suggested as an ideal radiopharmaceutical agents because beta ray (2.1 MeV) emitted from Re$\^$188/ is appropriate for synovial cell ablation and gamma ray (155 KeV) is ideal for dosimetry. Its' ideal particle size (2-5 mm) was achieved by conjugation with tin-colloid, In this study, we investigated the toxicity, stability and biodistribution to evaluate the suitability of DA-7911 as a synovectomy agent. (omitted)

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